Muscle Fiber TypeMT-STNCT05108181
Muscle Typology and Strength Training Adaptations
A study testing Muscle typology + exercise training and Muscle typology + training frequency in people with Muscle Fiber Type and Exercise, run by University Ghent at 1 site in Belgium.
Trial summary
The overall aim of this project is to investigate if the responsiveness to chronic resistance training is dependent on the muscle typology. In a second aim we will investigate the most optimal training frequency for slow-twitchers and fast-twitchers. Read more about this study
- Who is it for?
- Ages 18 to 45 yearsHealthy volunteers can take part
- Conditions the study is for
- Muscle Fiber Type, Exercise, Training Frequency
- What is being tested?
- Muscle typology + exercise training and Muscle typology + training frequency
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 60 participants
- Where
- 1 siteBelgium
- Study dates
- 9 Sep 2021to 8 Dec 2023
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 45 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Fast or slow muscle typology
- 18 - 45 years old
- no strength training experience
Who cannot join
- Vegan/vegeterian diet
- Supplement intake
- chronic diseases
- Hypertension,
- Smoking
- Medication use
- Coagulation disorder, infectious diseases
Trial locations and contacts
1 site in 1 country.
Belgium1 site
Department of Movement and Sports Sciences, Ghent University
Ghent, Oost-Vlaanderen, 9000
About this study
Official title: Influence of Muscle Typology and Training Frequency on Chronic Strength Training Adaptations
The overall aim of this project is to investigate if the responsiveness to chronic resistance training is dependent on the muscle typology. In a second aim we will investigate the most optimal training frequency for slow-twitchers and fast-twitchers. For the latter we hypothesize that slow-twitchers might cope better with higher frequencies and higher volumes compared to fast-twitchers.
Male and female adult participants (18-45y) will be recruited. The subjects' muscle typology will be non-invasively estimated in the leg muscles by measurement of muscle carnosine using H-MRS. In total 21 subjects (11 slow and 10 fast subjects) will participate. Subjects will be assigned to a whole-body resistance training exercise protocol of 9 weeks in wich arm A and leg A will train 3 times per week and arm B and leg B will train 2 times per week. Before and following the training period, subjects will be subjected to different measurements (fitness level, muscle volume, strength tests, blood sampling, muscle biopsies).
- Conditions
- Muscle Fiber Type, Exercise, Training Frequency
- Being tested
- Muscle typology + exercise training, Muscle typology + training frequency
- Keywords
- Strength training, Muscle typology
- Medical subject headings
- Motor Activity
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Muscle typology + exercise trainingOther
Exercise training: Participants perform 9 weeks of strength training at 60% of their 1RM.
Muscle typology + training frequencyOther
Training frequency: leg A and arm A of the participants train 3 times per week, leg B and arm B train 2 times per week.
| Study group | Role | What they receive |
|---|---|---|
| Slow muscle typology group | Active comparator | The participants receive the same exercise training intervention, but they are divided in two groups: a slow typology group and a fast typology group based on their inherent physiological characteristics: their muscle fiber type. Receives: Other: Muscle typology + exercise training; Other: Muscle typology + training frequency |
| Fast muscle typology group | Active comparator | The participants receive the same exercise training intervention, but they are divided in two groups: a slow typology group and a fast typology group based on their inherent physiological characteristics: their muscle fiber type. Receives: Other: Muscle typology + exercise training; Other: Muscle typology + training frequency |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change from baseline muscle volume at 9 weeks
Muscle volume of the legs and the upper arms - MRI
Measured: Pre and post the 9 weeks training period
Change from baseline dynamic muscle strength at 3 weeks
Upper legs and upper arms - strength training devices
Measured: Pre, mid and post 9 weeks training period
Change from baseline dynamic muscle strength at 6 weeks
Upper legs and upper arms - strength training devices
Measured: Pre, mid and post 9 weeks training period
Change from baseline dynamic muscle strength at 9 weeks
Upper legs and upper arms - strength training devices
Measured: Pre, mid and post 9 weeks training period
Change from baseline isometric muscle strength at 9 weeks
Upper legs and upper arms - Biodex
Measured: Pre and post 9 weeks training period
Change in muscle fiber type specific hypertrophy at 9 weeks
Legs - Biopsy (vastus lateralis)
Measured: Pre and post 9 weeks training period
Secondary outcomes (5)
Change of baseline antropometry at 9 weeks
Height, weight, skinfolds
Measured: Pre and post 9 weeks training period
Change of baseline skeletal muscle protein content at 9 weeks
Histochemistry and protein content of markers of relevance for skeletal muscle function
Measured: Pre and post 9 weeks training period
Change of baseline histochemistry at 9 weeks
Histochemistry of markers of relevance for skeletal muscle function
Measured: Pre and post 9 weeks training period
Change from basline fatigue feeling over 9 weeks training period
Number of repetitions during every training, questionnaire (VAS-scale) before every training, RPE after every training
Measured: Assessed every training during the 9 weeks training period
Change from baseline fasting insulin, glucose, cholesterol and triglycerides at 9 weeks
Fasted blood samples
Measured: Pre and post 9 weeks training period
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted4 Nov 2021
- Study start9 Sep 2021
- Primary completion8 Dec 2023
- Study completion8 Dec 2023
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Muscle Fiber TypeStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- All participants will receive the same training intervention but the subjects are divided into two groups based on an inherent physiological characteristic: the muscle typology. A slow typology group (people with a lot of slow muscle fibers) and a fast typology group (people with a lot of fast muscle fibers). Each participant will train their legs and arms unilateral and one arm and one leg will train two times per week, while the other arm and leg will train three times per week for 9 weeks. The assignment of the limbs to the 3x/week condition and the 2x/week condition is randomized. The training outcomes of the two groups will be compared as well as the within subject differences between training two times per week or training 3 times per week.
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 60 participants (actual)
Sponsor and investigators
- Lead sponsor
- University Ghent
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Wim Derave, Principal investigator, University Ghent
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05108181
- Sponsor's protocol ID
- BC-10253
- Acronym
- MT-ST
- Status last verified
- Apr 2024
- First submitted
- 12 Oct 2021
- Last updated
- 12 Apr 2024
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 12 Apr 2024. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Influence of Muscle Typology and Training Frequency on Chronic Strength Training Adaptations
- ClinicalTrials.gov ID
- NCT05108181
- Acronym / sponsor ID
- MT-ST / BC-10253
- Conditions
- Muscle Fiber Type, Exercise, Training Frequency
- Keywords
- Strength training, Muscle typology
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 60 participants (actual)
- Lead sponsor
- University GhentUniversity, hospital or other
- Study start
- 9 Sep 2021 (actual)
- Primary completion
- 8 Dec 2023 (actual)
- Study completion
- 8 Dec 2023 (actual)
- First posted
- 4 Nov 2021 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The overall aim of this project is to investigate if the responsiveness to chronic resistance training is dependent on the muscle typology. In a second aim we will investigate the most optimal training frequency for slow-twitchers and fast-twitchers. For the latter we hypothesize that slow-twitchers might cope better with higher frequencies and higher volumes compared to fast-twitchers.
Male and female adult participants (18-45y) will be recruited. The subjects' muscle typology will be non-invasively estimated in the leg muscles by measurement of muscle carnosine using H-MRS. In total 21 subjects (11 slow and 10 fast subjects) will participate. Subjects will be assigned to a whole-body resistance training exercise protocol of 9 weeks in wich arm A and leg A will train 3 times per week and arm B and leg B will train 2 times per week. Before and following the training period, subjects will be subjected to different measurements (fitness level, muscle volume, strength tests, blood sampling, muscle biopsies).
Study design
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (participant)
- Number of arms
- 2
- Model description
- All participants will receive the same training intervention but the subjects are divided into two groups based on an inherent physiological characteristic: the muscle typology. A slow typology group (people with a lot of slow muscle fibers) and a fast typology group (people with a lot of fast muscle fibers). Each participant will train their legs and arms unilateral and one arm and one leg will train two times per week, while the other arm and leg will train three times per week for 9 weeks. The assignment of the limbs to the 3x/week condition and the 2x/week condition is randomized. The training outcomes of the two groups will be compared as well as the within subject differences between training two times per week or training 3 times per week.
| Arm | Type | Receives |
|---|---|---|
| Slow muscle typology group | Active comparator | Other: Muscle typology + exercise training, Other: Muscle typology + training frequencyThe participants receive the same exercise training intervention, but they are divided in two groups: a slow typology group and a fast typology group based on their inherent physiological characteristics: their muscle fiber type. |
| Fast muscle typology group | Active comparator | Other: Muscle typology + exercise training, Other: Muscle typology + training frequencyThe participants receive the same exercise training intervention, but they are divided in two groups: a slow typology group and a fast typology group based on their inherent physiological characteristics: their muscle fiber type. |
Who may qualify
- Ages
- 18 to 45 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (3 listed)
- Fast or slow muscle typology
- 18 - 45 years old
- no strength training experience
Key exclusion criteria (7 listed)
- Vegan/vegeterian diet
- Supplement intake
- chronic diseases
- Hypertension,
- Smoking
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Muscle typology + exercise trainingExercise training: Participants perform 9 weeks of strength training at 60% of their 1RM. | Other | Fast muscle typology group, Slow muscle typology group |
| Muscle typology + training frequencyTraining frequency: leg A and arm A of the participants train 3 times per week, leg B and arm B train 2 times per week. | Other | Fast muscle typology group, Slow muscle typology group |
Primary outcome
Change from baseline muscle volume at 9 weeks
Time frame: Pre and post the 9 weeks training period
Muscle volume of the legs and the upper arms - MRI
Change from baseline dynamic muscle strength at 3 weeks
Time frame: Pre, mid and post 9 weeks training period
Upper legs and upper arms - strength training devices
Change from baseline dynamic muscle strength at 6 weeks
Time frame: Pre, mid and post 9 weeks training period
Upper legs and upper arms - strength training devices
Change from baseline dynamic muscle strength at 9 weeks
Time frame: Pre, mid and post 9 weeks training period
Upper legs and upper arms - strength training devices
Change from baseline isometric muscle strength at 9 weeks
Time frame: Pre and post 9 weeks training period
Upper legs and upper arms - Biodex
Change in muscle fiber type specific hypertrophy at 9 weeks
Time frame: Pre and post 9 weeks training period
Legs - Biopsy (vastus lateralis)
5 secondary outcomes
Change of baseline antropometry at 9 weeks
Time frame: Pre and post 9 weeks training period
Change of baseline skeletal muscle protein content at 9 weeks
Time frame: Pre and post 9 weeks training period
Change of baseline histochemistry at 9 weeks
Time frame: Pre and post 9 weeks training period
Change from basline fatigue feeling over 9 weeks training period
Time frame: Assessed every training during the 9 weeks training period
Change from baseline fasting insulin, glucose, cholesterol and triglycerides at 9 weeks
Time frame: Pre and post 9 weeks training period
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 12 Apr 2024.
- Individual participant dataSharing planned: No
Related trials for Muscle Fiber Type
RecruitingObservational study
The Muscle Monitor: Early Skeletal Muscle Indicators of Insulin Resistance and Cardiometabolic Risk
Insulin Resistance, Insulin Resistance and Type 2 Diabetes
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Wim Derave principal investigator
University Ghent
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Muscle typology + exercise training and Muscle typology + training frequency in people with Muscle Fiber Type and Exercise, run by University Ghent at 1 site in Belgium.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 12 Apr 2024. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Belgium. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change from baseline muscle volume at 9 weeks (time frame: Pre and post the 9 weeks training period). The study lists 6 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 12 Apr 2024; AzTrials last refreshed its copy on 1 Nov 2026.