AnesthesiaLiga-PACKNCT05136352
Postoperative Analgesic Benefit of iPACK Block in the Anterior Cruciate Ligament Reconstruction Surgery
A study testing adductor canal block and iPACK block in people with Anesthesia and Anterior Cruciate Ligament Reconstruction, run by University Hospital, Toulouse at 1 site in France.
Trial summary
This randomised clinical trial evaluates the analgesia provided by an iPack block associated with an adductor canal block in patients who undergo anterior cruciate ligament reconstruction surgery, compared to an adductor canal block alone. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Anesthesia, Anterior Cruciate Ligament Reconstruction
- What is being tested?
- adductor canal block and iPACK block
- Type of treatment
- Pill or oral medicine, Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 90 participants
- Where
- 1 siteFrance
- Study dates
- 13 Dec 2021to 31 Dec 2023
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Age ≥ 18 years
- ACL repair surgery under general anesthesia
- Person affiliated or beneficiary of a social security plan
- Free, informed and written consent
Who cannot join
- Age < 18 years
- Contraindication to ALR (allergy to local anesthetics, local infection of the puncture site, coagulopathy)
- Pre-existing opiate dependence
- Contraindication to non-steroidal anti-inflammatory drugs
- Pregnant or potentially pregnant women
- Patients under the protection of adults (guardianship, curatorship or safeguard of justice)
- Patients whose cognitive state does not allow evaluation by the scales used
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Postoperative Analgesic Benefit of iPACK Block in the Anterior Cruciate Ligament Reconstruction Surgery, the LIGA-PACK Study
This randomised clinical trial evaluates the analgesia provided by an iPack block associated with an adductor canal block in patients who undergo anterior cruciate ligament reconstruction surgery, compared to an adductor canal block alone. The objective is to prove the superiority of this locoregional anesthesia in terms of analgesia and functional rehabilitation.
Read the detailed description
The ideal loco-regional anesthesia for anterior cruciate ligament reconstruction ensuring a satisfying analgesia without compromising an early rehabilitation is still undetermined.
Femoral nerve block has been incriminated in a delayed postoperative mobilization whereas the adductor canal block gives an equivalent analgesia for a better preservation of the quadricipital muscular strength.
The iPACK block (infiltration between the popliteal artery and the capsule of the posterior knee) is a recently described technique. Few studies have assessed the iPACK block in ACL reconstruction, and none were randomized.
This randomized single blind clinical trial compares two groups of 45 patients who undergo ACL reconstruction surgery under general anaesthetic : one receives an iPACK block associated with an adductor canal block, and the other only has an adductor canal block.
Pain scores and opioid consumption are collected after surgery in the recovery room, then by telephone interview at 24 and 48 hours post-surgery. Functional rehabilitation is evaluated by scales (KOOS, LYSHOLM and iKDC) at 3, 6 and 9 months after surgery. Adverse effects, due to anesthesia or opioids, are collected from 30 min after loco-regional anesthesia until the second phone call at 48h post-surgery.
- Being tested
- adductor canal block, iPACK block
- Keywords
- loco-regional anesthesia, anterior cruciate ligament reconstruction, multimodal analgesia, motor sparing, iPACK block
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
adductor canal blockProcedure or surgery
Also called ACB
loco-regional anesthesia using adductor canal block
iPACK blockProcedure or surgery
loco-regional anesthesia using infiltration between the popliteal artery and the capsule of the posterior knee
| Study group | Role | What they receive |
|---|---|---|
| adductor canal block | Active comparator | loco-regional analgesia with adductor canal block (ACB) method (for anterior cruciate ligament reconstruction ) Receives: Procedure: adductor canal block |
| iPACK block | Experimental | loco-regional analgesia with iPACK block (infiltration between the popliteal artery and the capsule of the posterior knee) ((for anterior cruciate ligament reconstruction ) Receives: Procedure: iPACK block |
What is being measured
The primary outcome is the main question the study is designed to answer.
Cumulative opioid consumption at 48 hours after surgery
Cumulative opioid consumption in the first 48 hours after anterior cruciate ligament repair surgery
Measured: Hours 48
Secondary outcomes (6)
Cumulative opioid consumption at 2 hours after surgery
Cumulative opioid consumption in the recovery room after anterior cruciate ligament repair surgery
Measured: Hours 2
Cumulative opioid consumption at 24 hours after surgery
Cumulative opioid consumption in the first 24 hours after anterior cruciate ligament repair surgery
Measured: Hours 24
Cumulative opioid consumption at 3 months
total opioid consumption at 3 months after anterior cruciate ligament repair surgery
Measured: month 3
Maximum pain score in the recovery room
Maximum pain score evaluated by the numerical pain scale from 0 to 10 (0 lowest pain score / 10 highest pain score)
Measured: hours 2
Maximum pain score at 24 hours after surgery
Maximum pain score evaluated by the numerical pain scale from 0 to 10 (0 lowest pain score / 10 highest pain score)
Measured: hours 24
Maximum pain score at 48 hours after surgery
Maximum pain score evaluated by the numerical pain scale from 0 to 10 (0 lowest pain score / 10 highest pain score)
Measured: hours 48
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted29 Nov 2021
- Study start13 Dec 2021
- Primary completion30 Jun 2023
- Study completion31 Dec 2023
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for AnesthesiaStudies of the same condition, open and under way.
- More trials run by University Hospital, ToulouseThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 90 participants (actual)
Sponsor and investigators
- Lead sponsor
- University Hospital, Toulouse
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Fabrice FERRE, MD, Principal investigator, University Hospital, Toulouse
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05136352
- Sponsor's protocol ID
- RC31/21/0167
- Other IDs
- 2021-A01226-35
- Acronym
- Liga-PACK
- Status last verified
- Mar 2026
- First submitted
- 20 Oct 2021
- Last updated
- 6 Mar 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Publications
Ferre F, Boussaguet L, Vari N, Pillard F, Bosch L, Ferrier A, Ba C, Tissot B, Menut R, Kurrek M, Labaste F, Cavaignac E, Minville V. Comparison of femoral triangle plus iPACK blocks with femoral triangle block alone for anterior cruciate ligament reconstruction: a randomized controlled clinical trial on postoperative pain and knee function. Reg Anesth Pain Med. 2026 Jul 6;51(7):805-812. doi: 10.1136/rapm-2024-106108.
PubMed 40055004
Study at a glance
From the registry record, last updated by the sponsor on 6 Mar 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Postoperative Analgesic Benefit of iPACK Block in the Anterior Cruciate Ligament Reconstruction Surgery, the LIGA-PACK Study
- ClinicalTrials.gov ID
- NCT05136352
- Acronym / sponsor ID
- Liga-PACK / RC31/21/0167
- Keywords
- loco-regional anesthesia, anterior cruciate ligament reconstruction, multimodal analgesia, motor sparing, iPACK block
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 90 participants (actual)
- Lead sponsor
- University Hospital, ToulouseUniversity, hospital or other
- Study start
- 13 Dec 2021 (actual)
- Primary completion
- 30 Jun 2023 (actual)
- Study completion
- 31 Dec 2023 (actual)
- First posted
- 29 Nov 2021 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This randomised clinical trial evaluates the analgesia provided by an iPack block associated with an adductor canal block in patients who undergo anterior cruciate ligament reconstruction surgery, compared to an adductor canal block alone. The objective is to prove the superiority of this locoregional anesthesia in terms of analgesia and functional rehabilitation.
Detailed description
The ideal loco-regional anesthesia for anterior cruciate ligament reconstruction ensuring a satisfying analgesia without compromising an early rehabilitation is still undetermined.
Femoral nerve block has been incriminated in a delayed postoperative mobilization whereas the adductor canal block gives an equivalent analgesia for a better preservation of the quadricipital muscular strength.
The iPACK block (infiltration between the popliteal artery and the capsule of the posterior knee) is a recently described technique. Few studies have assessed the iPACK block in ACL reconstruction, and none were randomized.
This randomized single blind clinical trial compares two groups of 45 patients who undergo ACL reconstruction surgery under general anaesthetic : one receives an iPACK block associated with an adductor canal block, and the other only has an adductor canal block.
Pain scores and opioid consumption are collected after surgery in the recovery room, then by telephone interview at 24 and 48 hours post-surgery. Functional rehabilitation is evaluated by scales (KOOS, LYSHOLM and iKDC) at 3, 6 and 9 months after surgery. Adverse effects, due to anesthesia or opioids, are collected from 30 min after loco-regional anesthesia until the second phone call at 48h post-surgery.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (participant)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| adductor canal block | Active comparator | Procedure: adductor canal blockloco-regional analgesia with adductor canal block (ACB) method (for anterior cruciate ligament reconstruction ) |
| iPACK block | Experimental | Procedure: iPACK blockloco-regional analgesia with iPACK block (infiltration between the popliteal artery and the capsule of the posterior knee) ((for anterior cruciate ligament reconstruction ) |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (4 listed)
- Age ≥ 18 years
- ACL repair surgery under general anesthesia
- Person affiliated or beneficiary of a social security plan
- Free, informed and written consent
Key exclusion criteria (7 listed)
- Age < 18 years
- Contraindication to ALR (allergy to local anesthetics, local infection of the puncture site, coagulopathy)
- Pre-existing opiate dependence
- Contraindication to non-steroidal anti-inflammatory drugs
- Pregnant or potentially pregnant women
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| adductor canal blockAlso: ACBloco-regional anesthesia using adductor canal block | Procedure or surgery | adductor canal block |
| iPACK blockloco-regional anesthesia using infiltration between the popliteal artery and the capsule of the posterior knee | Procedure or surgery | iPACK block |
Primary outcome
Cumulative opioid consumption at 48 hours after surgery
Time frame: Hours 48
Cumulative opioid consumption in the first 48 hours after anterior cruciate ligament repair surgery
6 secondary outcomes
Cumulative opioid consumption at 2 hours after surgery
Time frame: Hours 2
Cumulative opioid consumption at 24 hours after surgery
Time frame: Hours 24
Cumulative opioid consumption at 3 months
Time frame: month 3
Maximum pain score in the recovery room
Time frame: hours 2
Maximum pain score at 24 hours after surgery
Time frame: hours 24
Maximum pain score at 48 hours after surgery
Time frame: hours 48
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 6 Mar 2026.
- Results publication: PubMed 40055004Ferre F, Boussaguet L, Vari N, Pillard F, Bosch L, Ferrier A, Ba C, Tissot B, Menut R, Kurrek M, Labaste F, Cavaignac E, Minville V. Comparison of femoral triangle plus iPACK blocks with femoral triangle block alone for anterior cruciate ligament reconstruction: a randomized controlled clinical trial on postoperative pain and knee function. Reg Anesth Pain Med. 2026 Jul 6;51(7):805-812. doi: 10.1136/rapm-2024-106108.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Fabrice FERRE, MD principal investigator
University Hospital, Toulouse
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing adductor canal block and iPACK block in people with Anesthesia and Anterior Cruciate Ligament Reconstruction, run by University Hospital, Toulouse at 1 site in France.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 6 Mar 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in France. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Cumulative opioid consumption at 48 hours after surgery (time frame: Hours 48). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT05136352, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 6 Mar 2026.