Blood DonationNCT05213130
Blood Donation and Subjective Well-being
A study testing Information in people with Blood Donation and Happiness, run by Guangzhou Blood Center at 1 site in China.
Trial summary
This study investigates the psychological effects of blood donation among adult donors at the Guangzhou Blood Center. The primary objective is to examine whether a brief gratitude-based intervention delivered after donation enhances donors' subjective well-being (SWB) and basic psychological need (BPN) satisfaction. Read more about this study
- Who is it for?
- Ages 18 to 60 years
- Conditions the study is for
- Blood Donation, Happiness
- What is being tested?
- Information
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 601 participants
- Where
- 1 siteChina
- Study dates
- 18 Jan 2022to 16 Mar 2022
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 60 years
- All sexes
- No healthy volunteers
- Adult
Who may be able to join
- Successfully completed a whole-blood donation at the Guangzhou Blood Center during the study period.
- Able to read and understand the study materials and provide informed consent.
- Provided the correct answer to a control question in the questionnaire
- Provided their phone number.
- Donated blood was successfully supplied to the hospitals.
Who cannot join
- Whole blood donors with positive or suspicious serological results.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: The Relationship Between Blood Donation and Subjective Well-being
This study investigates the psychological effects of blood donation among adult donors at the Guangzhou Blood Center. The primary objective is to examine whether a brief gratitude-based intervention delivered after donation enhances donors' subjective well-being (SWB) and basic psychological need (BPN) satisfaction. Participants who complete a whole-blood donation are randomly assigned to either an Intervention group, receiving a standardized gratitude reinforcement message accompanied by a vignette emphasizing the life-saving impact of donation, or a Control group that receives no additional message. All participants complete questionnaires at Time 1 (immediately after donation) and at Time 2 (4-22 days later), assessing SWB and related psychosocial variables.
- Conditions
- Blood Donation, Happiness
- Being tested
- Information
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
InformationOther
A reminder to inform donors that their blood has saved patient's life in a questionnaire.
| Study group | Role | What they receive |
|---|---|---|
| Gratitude-based intervention | Experimental | Participants in this group receive a standardized gratitude-based intervention immediately after completing whole-blood donation. The intervention consists of (1) a written gratitude reinforcement message acknowledging the donor's contribution and emphasizing the life-saving impact of their donation, and (2) a brief vignette illustrating how donated blood benefits patients in need. The purpose of this intervention is to enhance donors' subjective well-being and psychological need satisfaction by reinforcing their sense of autonomy, competence, and relatedness. Participants complete questionnaires at Time 1 (post-donation) and Time 2 (4-22 days later). Receives: Other: Information |
| No Message | No intervention | Participants in this group complete the standard post-donation procedure and receive no additional message or vignette. They complete the same questionnaires at Time 1 (post-donation) and Time 2 (4-22 days later) as the Intervention group. This arm serves as the comparison condition for evaluating the effect of the gratitude-based intervention on subjective well-being and related psychosocial outcomes. |
What is being measured
The primary outcome is the main question the study is designed to answer.
Score of Subjective Well-Being at Time 2
Subjective well-being (SWB) is assessed at follow-up using a validated multi-item measure capturing life satisfaction and affective well-being.
Affect-Adjective Scale (validated Chinese version): 9 items, each scored 1-7. Satisfaction with Life Scale (validated Chinese version): 5 items scored 1-7. An aggregate SWB score was calculated by standardizing and summing life satisfaction scores with positive affect scores and subtracting the negative affect score from them.
Scores range from low to high levels of well-being. The primary objective is to evaluate whether exposure to the gratitude-based intervention leads to higher SWB relative to the control condition.
Measured: 4-22 days after donation
Secondary outcomes (6)
Score of Subjective Well-being at Time 1
Baseline Subjective well-being (SWB) is measured using a validated multi-item measure capturing life satisfaction and affective well-being.
Affect-Adjective Scale (validated Chinese version): 9 items, each scored 1-7. Satisfaction with Life Scale (validated Chinese version): 5 items scored 1-7. An aggregate SWB score was calculated by standardizing and summing life satisfaction scores with positive affect scores and subtracting the negative affect score from them.
Scores range from low to high levels of well-being.
Measured: Immediately after donation
Score of Basic Psychological Needs Satisfaction at Time 1
Baseline basic psychological needs (BPN) satisfaction is measured using a 9-item Basic Psychological Needs Scale (validated Chinese version). The scale contains subscales for autonomy, competence, and relatedness, using a 7-point scale ranging from 1 (not at all true) to 7 (very much true). Each of the three subscales was averaged to form an index of general BPN satisfaction. This measure captures donors' immediate psychological experience following donation. Higher scores indicate greater psychological need satisfaction.
Measured: Immediately after donation
Score of Basic Psychological Needs Satisfaction at Time 2
The same basic psychological needs satisfaction (BPN) scale is administered at follow-up to examine changes after the intervention. It is measured using a 9-item Basic Psychological Needs Scale (validated Chinese version). The scale contains subscales for autonomy, competence, and relatedness, using a 7-point scale ranging from 1 (not at all true) to 7 (very much true). Each of the three subscales was averaged to form an index of general BPN satisfaction. Higher scores indicate greater psychological need satisfaction.
Measured: 4-22 days after donation
Score of Blood Donation Intention at Time 1
Intention to donate blood again in the future at Time 1 is measured using a single self-report intention item rated from 1 (very unlikely) to 7 (very likely), with higher scores indicating stronger intention to donate. The same item is administered at Time 1 and Time 2 to assess changes over time and to examine potential effects of the intervention on future donation motivation.
Measured: Immediately after donation
Score of Blood Donation Intention Score at Time 2
Intention to donate blood again in the future at Time 2 is measured using a single self-report intention item rated from 1 (very unlikely) to 7 (very likely), with higher scores indicating stronger intention to donate. The same item is administered at Time 1 and Time 2 to assess changes over time and to examine potential effects of the intervention on future donation motivation.
Measured: 4-22 days after donation
Re-Donation Rate within One Year
Actual re-donation rate is obtained from the Guangzhou Blood Centre's donation records. The variable indicates whether the participant returned for another whole-blood or component donation within one year.
Measured: Up to 12 months after the initial donation
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted28 Jan 2022
- Study start18 Jan 2022
- Primary completion12 Mar 2022
- Study completion16 Mar 2022
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Blood DonationStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 601 participants (actual)
Sponsor and investigators
- Lead sponsor
- Guangzhou Blood Center
- Sponsor type
- Other government
- Responsible party
- Principal investigator, OUYANG Jian, Guangzhou Blood Center
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05213130
- Sponsor's protocol ID
- Blood donation and well-being
- Status last verified
- Jan 2026
- First submitted
- 15 Jan 2022
- Last updated
- 13 Jan 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Ou-Yang J, Feng FF, Ke RR, Huang XY, Liang HQ, Chen JY. Blood donation and subjective wellbeing: a cross-sectional survey and a randomized trial. Front Psychol. 2026 Mar 27;17:1795243. doi: 10.3389/fpsyg.2026.1795243. eCollection 2026.
PubMed 41969898
Study at a glance
From the registry record, last updated by the sponsor on 13 Jan 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Relationship Between Blood Donation and Subjective Well-being
- ClinicalTrials.gov ID
- NCT05213130
- Acronym / sponsor ID
- Blood donation and well-being
- Conditions
- Blood Donation, Happiness
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 601 participants (actual)
- Lead sponsor
- Guangzhou Blood CenterOther government
- Study start
- 18 Jan 2022 (actual)
- Primary completion
- 12 Mar 2022 (actual)
- Study completion
- 16 Mar 2022 (actual)
- First posted
- 28 Jan 2022 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study investigates the psychological effects of blood donation among adult donors at the Guangzhou Blood Center. The primary objective is to examine whether a brief gratitude-based intervention delivered after donation enhances donors' subjective well-being (SWB) and basic psychological need (BPN) satisfaction. Participants who complete a whole-blood donation are randomly assigned to either an Intervention group, receiving a standardized gratitude reinforcement message accompanied by a vignette emphasizing the life-saving impact of donation, or a Control group that receives no additional message. All participants complete questionnaires at Time 1 (immediately after donation) and at Time 2 (4-22 days later), assessing SWB and related psychosocial variables.
Study design
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (participant)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Gratitude-based intervention | Experimental | Other: InformationParticipants in this group receive a standardized gratitude-based intervention immediately after completing whole-blood donation. The intervention consists of (1) a written gratitude reinforcement message acknowledging the donor's contribution and emphasizing the life-saving impact of their donation, and (2) a brief vignette illustrating how donated blood benefits patients in need. The purpose of this intervention is to enhance donors' subjective well-being and psychological need satisfaction by reinforcing their sense of autonomy, competence, and relatedness. Participants complete questionnaires at Time 1 (post-donation) and Time 2 (4-22 days later). |
| No Message | No intervention | –Participants in this group complete the standard post-donation procedure and receive no additional message or vignette. They complete the same questionnaires at Time 1 (post-donation) and Time 2 (4-22 days later) as the Intervention group. This arm serves as the comparison condition for evaluating the effect of the gratitude-based intervention on subjective well-being and related psychosocial outcomes. |
Who may qualify
- Ages
- 18 to 60 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (5 listed)
- Successfully completed a whole-blood donation at the Guangzhou Blood Center during the study period.
- Able to read and understand the study materials and provide informed consent.
- Provided the correct answer to a control question in the questionnaire
- Provided their phone number.
- Donated blood was successfully supplied to the hospitals.
Key exclusion criteria (1 listed)
- Whole blood donors with positive or suspicious serological results.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| InformationA reminder to inform donors that their blood has saved patient's life in a questionnaire. | Other | Gratitude-based intervention |
Primary outcome
Score of Subjective Well-Being at Time 2
Time frame: 4-22 days after donation
Subjective well-being (SWB) is assessed at follow-up using a validated multi-item measure capturing life satisfaction and affective well-being. Affect-Adjective Scale (validated Chinese version): 9 items, each scored 1-7. Satisfaction with Life Scale (validated Chinese version): 5 items scored 1-7. An aggregate SWB score was calculated by standardizing and summing life satisfaction scores with positive affect scores and subtracting the negative affect score from them. Scores range from low to high levels of well-being. The primary objective is to evaluate whether exposure to the gratitude-based intervention leads to higher SWB relative to the control condition.
6 secondary outcomes
Score of Subjective Well-being at Time 1
Time frame: Immediately after donation
Score of Basic Psychological Needs Satisfaction at Time 1
Time frame: Immediately after donation
Score of Basic Psychological Needs Satisfaction at Time 2
Time frame: 4-22 days after donation
Score of Blood Donation Intention at Time 1
Time frame: Immediately after donation
Score of Blood Donation Intention Score at Time 2
Time frame: 4-22 days after donation
Re-Donation Rate within One Year
Time frame: Up to 12 months after the initial donation
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 13 Jan 2026.
- Derived from this study: PubMed 41969898Ou-Yang J, Feng FF, Ke RR, Huang XY, Liang HQ, Chen JY. Blood donation and subjective wellbeing: a cross-sectional survey and a randomized trial. Front Psychol. 2026 Mar 27;17:1795243. doi: 10.3389/fpsyg.2026.1795243. eCollection 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Information in people with Blood Donation and Happiness, run by Guangzhou Blood Center at 1 site in China.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 13 Jan 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in China. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Score of Subjective Well-Being at Time 2 (time frame: 4-22 days after donation). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT05213130, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 13 Jan 2026.