Knee OsteoarthritisNCT05238350
The Effect of Acupressure in Patients With Knee Osteoarthritis
A study testing Acupressure in people with Knee Osteoarthritis, run by TC Erciyes University at 1 site in Turkey (Türkiye).
Trial summary
Abstract Pain is the most common symptom of osteoarthritis and affects people's functional status with quality of life. This study was conducted to determine the effect of acupressure on pain, functional status, and quality of life in patients living with knee osteoarthritis. Read more about this study
- Who is it for?
- Ages 38 years and olderHealthy volunteers can take part
- Conditions the study is for
- Knee Osteoarthritis
- What is being tested?
- Acupressure
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 90 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 7 Mar 2015to 11 Nov 2015
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 38 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- 38 years old and over
- Diagnosed by a doctor with knee OA according to American College of Rheumatology (ACR) criteria
- had three points and over on the VAS pain scale,
- had no communication problems
- did not have any significant knee trauma within the last six months or an intra-articular steroid injection
- did not have any infection in the lower extremities or wounds, surgery or physiotherapy within the last six months
- those who accepted to participate to the study.
Who cannot join
- the patient is not willing to go on the study in any stage of the study and case of any adverse effect of acupressure.
Trial locations and contacts
1 site in 1 country.
Turkey (Türkiye)1 site
Nigde Omer Halisdemir University
Niğde, Ni̇ğde, 51240
About this study
Official title: The Effect of Acupressure on Pain, Functional Status and Quality of Life in Patients With Knee Osteoarthritis
Abstract Pain is the most common symptom of osteoarthritis and affects people's functional status with quality of life. This study was conducted to determine the effect of acupressure on pain, functional status, and quality of life in patients living with knee osteoarthritis. Acupressure application and follow-ups were performed by the researcher in the patient's home environment. The study was performed with 90 patients, 45 in the intervention group and 45 in the control group. Acupressure was performed two days a week for four weeks with a total of eight sessions on the ST34, ST35, ST36, SP9, SP10, GB34 acupuncture points following an acupressure practice guide prepared by the researcher. It was determined that while the Visual Analog Scale (VAS), the Western Ontario and McMaster University Osteoarthritis Index (WOMAC) scores of the intervention group were higher than those of the control group before application, they had decreased after application. It was found that all subscale mean scores of the Short-Form Health Survey (SF-36) quality of life questionnaire increased after application in the intervention group. It was concluded that acupressure has decreased pain severity and increased the functional status and quality of life of patients with knee osteoarthritis.
Keywords: Osteoarthritis, pain, nursing, acupressure.
Read the detailed description
Abstract Background: Pain is the most common symptom of osteoarthritis and affects people's functional status with quality of life.
Objective: This study was conducted to determine the effect of acupressure on pain, functional status, and quality of life in patients living with knee osteoarthritis.
Methods/Design: The study was conducted as an experimental study with a pre-posttest and a control group.
Settings: The study was conducted on patients diagnosed with knee osteoarthritis and attended the Physical Therapy and Rehabilitation Polyclinics of Nevşehir government hospital in the Central Anatolia Region of Turkey. Acupressure application and follow-ups were performed by the researcher in the patient's home environment.
Participants: The study was performed with 90 patients, 45 in the intervention group and 45 in the control group.
Intervention: Acupressure was performed two days a week for four weeks with a total of eight sessions on the ST34, ST35, ST36, SP9, SP10, GB34 acupuncture points following an acupressure practice guide prepared by the researcher.
Measurement of efficacy: Data was collected before and after acupressure application by using a Visual Analogue Scale (VAS), the 36-Item Short-Form Health Survey (SF-36), and the Western Ontario and McMaster University Osteoarthritis Index (WOMAC).
- Conditions
- Knee Osteoarthritis
- Being tested
- Acupressure
- Keywords
- Osteoarthritis, Pain, Nursing, Acupressure.
- Medical subject headings
- Osteoarthritis, Knee, Osteoarthritis, Pain
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
AcupressureProcedure or surgery
Also called Control
Acupressure was performed two days a week for four weeks with a total of eight sessions on the ST34, ST35, ST36, SP9, SP10, GB34 acupuncture points following an acupressure practice guide prepared by the researcher.
| Study group | Role | What they receive |
|---|---|---|
| Acupressure (intervention group) | Experimental | The intervention group was performed with 45 patients. Acupressure was performed two days a week for four weeks with a total of eight sessions on the ST34, ST35, ST36, SP9, SP10, GB34 acupuncture points following an acupressure practice guide prepared by the researcher. Receives: Procedure: Acupressure |
| Control group | No intervention | Thecontrol group was performed with 45 patients. Any application was not performed for the control group. |
What is being measured
The primary outcome is the main question the study is designed to answer.
Pain level in visual analogue scale (VAS)
Pain severity scores were determined by measuring values that were chosen on VAS by patients. The numerical scale ranges from 0 "No pain", to 10 "Worst pain imaginable", and a numerical value is given to every 1 cm range to measure pain severity.
Measured: baseline, change from baseline at 4th week;
Secondary outcomes (2)
The Western Ontario and McMaster University Osteoarthritis Index (WOMAC) Osteoarthritis Index
Their functional status levels were evaluated by using WOMAC Osteoarthritis Index.Every question is scored between 0 and 4 points evaluated with a five-way Likert-type scale. High scores from the index show increased pain and stiffness and dysfunction in physical function.
Measured: baseline, change from baseline at 4th week;
36-Item Short-Form Health Survey (SF-36)
Their changes in quality of life levels were evaluated by using SF-36 scale.The scale gives separate scores for every sub-scale, which varies between 0 and 100 points. High scores on the subscales show good health status, while low scores show a deterioration in health
Measured: baseline, change from baseline at 4th week;
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted14 Feb 2022
- Study start7 Mar 2015
- Primary completion11 Jun 2015
- Study completion11 Nov 2015
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Knee OsteoarthritisStudies of the same condition, open and under way.
- More trials run by TC Erciyes UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Supportive care
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- The study was conducted as an experimental study with a pre-posttest and a control group.
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 90 participants (actual)
Sponsor and investigators
- Lead sponsor
- TC Erciyes University
- Sponsor type
- University, hospital or other
- Collaborators
- Pınar TEKİNSOY KARTIN, Rabiye ÇIRPAN
- Responsible party
- Principal investigator, Tuğba AYDEMİR, TC Erciyes University
- Investigators
- Tuğba AYDEMİR, RN, MSc, Principal investigator, Nigde Omer Halisdemir University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05238350
- Sponsor's protocol ID
- NevsehirU
- Status last verified
- Aug 2022
- First submitted
- 21 Dec 2021
- Last updated
- 17 Aug 2022
- Results posted
- No
Publications
Aydemir T, Cirpan R, Tekinsoy Kartin P. Impact of Acupressure on Pain, Functional Status, and Quality of Life in Individuals With Knee Osteoarthritis. J Manipulative Physiol Ther. 2025 Jan-Jun;48(1-5):204-213. doi: 10.1016/j.jmpt.2025.09.001. Epub 2025 Oct 7.
PubMed 41055613
Study at a glance
From the registry record, last updated by the sponsor on 17 Aug 2022. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Effect of Acupressure on Pain, Functional Status and Quality of Life in Patients With Knee Osteoarthritis
- ClinicalTrials.gov ID
- NCT05238350
- Acronym / sponsor ID
- NevsehirU
- Conditions
- Knee Osteoarthritis
- Keywords
- Osteoarthritis, Pain, Nursing, Acupressure.
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 90 participants (actual)
- Lead sponsor
- TC Erciyes UniversityUniversity, hospital or other
- Collaborators
- Pınar TEKİNSOY KARTIN, Rabiye ÇIRPAN
- Study start
- 7 Mar 2015 (actual)
- Primary completion
- 11 Jun 2015 (actual)
- Study completion
- 11 Nov 2015 (actual)
- First posted
- 14 Feb 2022 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Abstract Pain is the most common symptom of osteoarthritis and affects people's functional status with quality of life. This study was conducted to determine the effect of acupressure on pain, functional status, and quality of life in patients living with knee osteoarthritis. Acupressure application and follow-ups were performed by the researcher in the patient's home environment. The study was performed with 90 patients, 45 in the intervention group and 45 in the control group. Acupressure was performed two days a week for four weeks with a total of eight sessions on the ST34, ST35, ST36, SP9, SP10, GB34 acupuncture points following an acupressure practice guide prepared by the researcher. It was determined that while the Visual Analog Scale (VAS), the Western Ontario and McMaster University Osteoarthritis Index (WOMAC) scores of the intervention group were higher than those of the control group before application, they had decreased after application. It was found that all subscale mean scores of the Short-Form Health Survey (SF-36) quality of life questionnaire increased after application in the intervention group. It was concluded that acupressure has decreased pain severity and increased the functional status and quality of life of patients with knee osteoarthritis.
Keywords: Osteoarthritis, pain, nursing, acupressure.
Detailed description
Abstract Background: Pain is the most common symptom of osteoarthritis and affects people's functional status with quality of life.
Objective: This study was conducted to determine the effect of acupressure on pain, functional status, and quality of life in patients living with knee osteoarthritis.
Methods/Design: The study was conducted as an experimental study with a pre-posttest and a control group.
Settings: The study was conducted on patients diagnosed with knee osteoarthritis and attended the Physical Therapy and Rehabilitation Polyclinics of Nevşehir government hospital in the Central Anatolia Region of Turkey. Acupressure application and follow-ups were performed by the researcher in the patient's home environment.
Participants: The study was performed with 90 patients, 45 in the intervention group and 45 in the control group.
Intervention: Acupressure was performed two days a week for four weeks with a total of eight sessions on the ST34, ST35, ST36, SP9, SP10, GB34 acupuncture points following an acupressure practice guide prepared by the researcher.
Measurement of efficacy: Data was collected before and after acupressure application by using a Visual Analogue Scale (VAS), the 36-Item Short-Form Health Survey (SF-36), and the Western Ontario and McMaster University Osteoarthritis Index (WOMAC).
Study design
- Primary purpose
- Supportive care
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (participant)
- Number of arms
- 2
- Model description
- The study was conducted as an experimental study with a pre-posttest and a control group.
| Arm | Type | Receives |
|---|---|---|
| Acupressure (intervention group) | Experimental | Procedure: AcupressureThe intervention group was performed with 45 patients. Acupressure was performed two days a week for four weeks with a total of eight sessions on the ST34, ST35, ST36, SP9, SP10, GB34 acupuncture points following an acupressure practice guide prepared by the researcher. |
| Control group | No intervention | –Thecontrol group was performed with 45 patients. Any application was not performed for the control group. |
Who may qualify
- Ages
- 38 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (7 listed)
- 38 years old and over
- Diagnosed by a doctor with knee OA according to American College of Rheumatology (ACR) criteria
- had three points and over on the VAS pain scale,
- had no communication problems
- did not have any significant knee trauma within the last six months or an intra-articular steroid injection
Key exclusion criteria (1 listed)
- the patient is not willing to go on the study in any stage of the study and case of any adverse effect of acupressure.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| AcupressureAlso: ControlAcupressure was performed two days a week for four weeks with a total of eight sessions on the ST34, ST35, ST36, SP9, SP10, GB34 acupuncture points following an acupressure practice guide prepared by the researcher. | Procedure or surgery | Acupressure (intervention group) |
Primary outcome
Pain level in visual analogue scale (VAS)
Time frame: baseline, change from baseline at 4th week;
Pain severity scores were determined by measuring values that were chosen on VAS by patients. The numerical scale ranges from 0 "No pain", to 10 "Worst pain imaginable", and a numerical value is given to every 1 cm range to measure pain severity.
2 secondary outcomes
The Western Ontario and McMaster University Osteoarthritis Index (WOMAC) Osteoarthritis Index
Time frame: baseline, change from baseline at 4th week;
36-Item Short-Form Health Survey (SF-36)
Time frame: baseline, change from baseline at 4th week;
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 17 Aug 2022.
- Derived from this study: PubMed 41055613Aydemir T, Cirpan R, Tekinsoy Kartin P. Impact of Acupressure on Pain, Functional Status, and Quality of Life in Individuals With Knee Osteoarthritis. J Manipulative Physiol Ther. 2025 Jan-Jun;48(1-5):204-213. doi: 10.1016/j.jmpt.2025.09.001. Epub 2025 Oct 7.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Tuğba AYDEMİR, RN, MSc principal investigator
Nigde Omer Halisdemir University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Acupressure in people with Knee Osteoarthritis, run by TC Erciyes University at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 7 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 17 Aug 2022. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Pain level in visual analogue scale (VAS) (time frame: baseline, change from baseline at 4th week;). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT05238350, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 17 Aug 2022.