Patellofemoral PainNCT05285007
Limited Ankle Dorsiflexion and Effect on Single Limb Squats in Individuals With Patellofemoral Pain
A study testing Mobilization with Movement and No mobilization with movement and education in people with Patellofemoral Pain, run by Loma Linda University at 1 site in United States.
Trial summary
The purpose of this graduate student research study is to investigate the relationship between limited ankle dorsiflexion and the potential effects on a single limb squat task in the Patellofemoral/Knee Pain population. Read more about this study
- Who is it for?
- Ages 18 to 59 years, women onlyHealthy volunteers can take part
- Conditions the study is for
- Patellofemoral Pain
- What is being tested?
- Mobilization with Movement and No mobilization with movement and education
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 60 participants
- Where
- 1 siteUnited States
- Study dates
- 2 Mar 2022to May 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 59 years
- Women only
- Healthy volunteers accepted
- Adult
Who may be able to join
- History of active Patellofemoral Pain for at least 6 months
- No clinic based therapeutic interventions for a 6-month period prior to testing
- Females aged 18-59 years' old
- Limited ankle dorsiflexion as noted by <45degs using the weight bearing lunge test
Who cannot join
- History of musculoskeletal surgery or fractures on the tested leg or lumbar spine that could affect their biomechanics during the study
- History of soft tissue or skeletal abnormalities in the tested limb
- Current knee effusion
- Resting pain greater than 5/10
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
United States1 site, 1 recruiting
- Recruiting
Loma Linda University
Loma Linda, California, 92350
Everett Lohman, DSc, 909-558-4632 ext. 83171, elohman@llu.edu
About this study
Official title: Limited Ankle Dorsiflexion and Effect on Single Limb Squats in Individuals With Patellofemoral Pain: Interventions and Outcomes in a Randomized Clinical Trial
The purpose of this graduate student research study is to investigate the relationship between limited ankle dorsiflexion and the potential effects on a single limb squat task in the Patellofemoral/Knee Pain population.
Read the detailed description
- Participants will undergo Covid screening prior to filling out consent form and PHI. Randomization will occur to create an experimental group and a minimal intervention group.
- Participants will complete two self-reported questionnaires on how their diagnosis affects functional activities.
- Dorsiflexion range of motion in a weight bearing position will be taken.
- Hip abductor strength on tested limb will be measure on isokinetic device.
- The Lateral Step Down test will be conducted for 6 trials on each participant, 3 with a heel wedge and 3 without, movement recorded, and graded using two motion capture devices.
- The experimental group will receive two interventions to increase dorsiflexion range of motion. The minimal intervention group will read and infographic and complete 5 minutes of treadmill walking.
- Each participant will then have their dorsiflexion measured again prior to completing another 3 trials of the Lateral Step Down test.
- Conditions
- Patellofemoral Pain
- Being tested
- Mobilization with Movement, No mobilization with movement and education
- Medical subject headings
- Patellofemoral Pain Syndrome
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Mobilization with MovementOther
Participants will be lunging on a box with posterior ankle glide of 10 seconds times 5 sets. They will have 30 seconds rest between trials. Participant will have their ankle taped and then walk on a treadmill at a self-selected pace for 5 minutes.
No mobilization with movement and educationOther
Participants ankle will not be taped and they will walk on the treadmill for 5 minutes and receive education.
| Study group | Role | What they receive |
|---|---|---|
| Primary Intervention Group | Experimental | The experimental group will receive two interventions to increase dorsiflexion range of motion. Receives: Other: Mobilization with Movement |
| Minimal Intervention Group | Active comparator | The minimal intervention group will read and infographic and complete 5 minutes of treadmill walking. Receives: Other: No mobilization with movement and education |
What is being measured
The primary outcome is the main question the study is designed to answer.
Weight bearing lunge test
This test is used to assess a participant's available dorsiflexion range of motion in a weight bearing position. Furthermore, this places the participants hip, knee, and ankle into a flexed position which correlates with the squat tests we will be using.
Measured: change between baseline and post intervention on Day 1
Secondary outcomes (1)
Patellofemoral Disability Index
The Index is a self-reported questionnaire that addresses the amount of pain a person may have during tasks such as running, jumping, and stair climbing.
Measured: change between baseline and post intervention on Day 1
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted17 Mar 2022
- Study start2 Mar 2022
- Primary completionMay 2027 (estimated)
- Study completionMay 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Patellofemoral PainStudies of the same condition, open and under way.
- More trials run by Loma Linda UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 60 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Loma Linda University
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Everett Lohman, Dsc, Principal investigator, Loma Linda University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05285007
- Sponsor's protocol ID
- 5220026
- Status last verified
- Aug 2026
- First submitted
- 8 Mar 2022
- Last updated
- 20 Aug 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 20 Aug 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Limited Ankle Dorsiflexion and Effect on Single Limb Squats in Individuals With Patellofemoral Pain: Interventions and Outcomes in a Randomized Clinical Trial
- ClinicalTrials.gov ID
- NCT05285007
- Acronym / sponsor ID
- 5220026
- Conditions
- Patellofemoral Pain
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 60 participants (estimated)
- Lead sponsor
- Loma Linda UniversityUniversity, hospital or other
- Study start
- 2 Mar 2022 (actual)
- Primary completion
- May 2027 (estimated)
- Study completion
- May 2027 (estimated)
- First posted
- 17 Mar 2022 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The purpose of this graduate student research study is to investigate the relationship between limited ankle dorsiflexion and the potential effects on a single limb squat task in the Patellofemoral/Knee Pain population.
Detailed description
- Participants will undergo Covid screening prior to filling out consent form and PHI. Randomization will occur to create an experimental group and a minimal intervention group.
- Participants will complete two self-reported questionnaires on how their diagnosis affects functional activities.
- Dorsiflexion range of motion in a weight bearing position will be taken.
- Hip abductor strength on tested limb will be measure on isokinetic device.
- The Lateral Step Down test will be conducted for 6 trials on each participant, 3 with a heel wedge and 3 without, movement recorded, and graded using two motion capture devices.
- The experimental group will receive two interventions to increase dorsiflexion range of motion. The minimal intervention group will read and infographic and complete 5 minutes of treadmill walking.
- Each participant will then have their dorsiflexion measured again prior to completing another 3 trials of the Lateral Step Down test.
Study design
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (participant)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Primary Intervention Group | Experimental | Other: Mobilization with MovementThe experimental group will receive two interventions to increase dorsiflexion range of motion. |
| Minimal Intervention Group | Active comparator | Other: No mobilization with movement and educationThe minimal intervention group will read and infographic and complete 5 minutes of treadmill walking. |
Who may qualify
- Ages
- 18 to 59 years
- Sex
- Female only
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (4 listed)
- History of active Patellofemoral Pain for at least 6 months
- No clinic based therapeutic interventions for a 6-month period prior to testing
- Females aged 18-59 years' old
- Limited ankle dorsiflexion as noted by <45degs using the weight bearing lunge test
Key exclusion criteria (4 listed)
- History of musculoskeletal surgery or fractures on the tested leg or lumbar spine that could affect their biomechanics during the study
- History of soft tissue or skeletal abnormalities in the tested limb
- Current knee effusion
- Resting pain greater than 5/10
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Mobilization with MovementParticipants will be lunging on a box with posterior ankle glide of 10 seconds times 5 sets. They will have 30 seconds rest between trials. Participant will have their ankle taped and then walk on a treadmill at a self-selected pace for 5 minutes. | Other | Primary Intervention Group |
| No mobilization with movement and educationParticipants ankle will not be taped and they will walk on the treadmill for 5 minutes and receive education. | Other | Minimal Intervention Group |
Primary outcome
Weight bearing lunge test
Time frame: change between baseline and post intervention on Day 1
This test is used to assess a participant's available dorsiflexion range of motion in a weight bearing position. Furthermore, this places the participants hip, knee, and ankle into a flexed position which correlates with the squat tests we will be using.
1 secondary outcome
Patellofemoral Disability Index
Time frame: change between baseline and post intervention on Day 1
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 20 Aug 2026.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Everett Lohman, Dsc principal investigator
Loma Linda University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Mobilization with Movement and No mobilization with movement and education in people with Patellofemoral Pain, run by Loma Linda University at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 20 Aug 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Everett Lohman, DSc (909-558-4632 ext. 83171, elohman@llu.edu), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Weight bearing lunge test (time frame: change between baseline and post intervention on Day 1). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 20 Aug 2026.