EpilepsyIMPLICITNCT05285059
Implicit Learning in Epileptic Children
An observational study of Epilepsy, run by Hospices Civils de Lyon at 3 sites in France.
Trial summary
Epileptic children suffer from impairments in various learning and memory tasks. Yet, no study investigated implicit learning in epileptic children. Implicit learning is not only underlying motor skills acquisition, but also social and cognitive ones. Read more about this study
- Who is it for?
- Ages 8 to 14 yearsHealthy volunteers can take part
- Conditions the study is for
- Epilepsy
- What is being tested?
- ASRT task
- Type of treatment
- Lifestyle or therapy programme
- How many people
- 40 participants
- Where
- 3 sitesFrance
- Study dates
- 21 Mar 2023to 21 Mar 2027
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 8 to 14 years
- All sexes
- Healthy volunteers accepted
- Child
Study population: This study focuses on children with epilepsy.
Who may be able to join
- For Patient group only: Children with epilepsy
- For Control group only: Children without neurological, psychiatric or developmental impairments
- For both groups: Parent or tutors agreement
- For both groups: Affiliated to French social security
Who cannot join
- Neurological impairments unrelated to epilepsy
- Psychiatric impairments unrelated to epilepsy
- Developmental impairments unrelated to epilepsy
Trial locations and contacts
3 sites in 1 country. Contact the study team or a site near you to ask about taking part.
France3 sites, 3 recruiting
- Recruiting
Agathe Marcastel, PhD
Bron, Bron, 69675
Marcastel Agathe, PhD, +33 4 27 85 60 40, Agathe.marcastel@chu-lyon.fr
- Not yet recruiting
Dezso Nemeth
Bron, Bron, 69675
Nemeth Dezso, Pr, +33 4 81 10 66 04, dezso.nemeth@univ-lyon1.fr
- Recruiting
Service d'Epileptologie Clinique, des Troubles du sommeil et de Neurologie fonctionnelle de l'enfant, à Hôpital Femme Mère et Enfant,
Bron
MARCASTEL Agathe
About this study
Epileptic children suffer from impairments in various learning and memory tasks. Yet, no study investigated implicit learning in epileptic children. Implicit learning is not only underlying motor skills acquisition, but also social and cognitive ones. Because acquisition of new skills is optimal during childhood, the study of implicit learning mechanism in children is of major importance. The present study will be the first to explore implicit learning mechanisms in children with epilepsy. Implicit learning mechanisms can be preserved or altered.
- Conditions
- Epilepsy
- Being tested
- ASRT task
- Keywords
- Epilepsy,, children,, implicit learning
- Medical subject headings
- Epilepsy
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
ASRT taskBehavioural
The ASRT (Alternating Serial Reaction Time) task is a computerized behavioral task measuring implicit learning. This task consists of 20 series of trials lasting 2 minutes each.
In each trial, a stimulus is displayed on the screen in one of the four possible predefined locations. The participant must press a button to indicate the position of the stimulus on the screen. Response content and response time are recorded.
At the end of every trial, the participant can take a break and resume the task whenever ready. The task lasts about 45 to 50 minutes.
| Study group | Role | What they receive |
|---|---|---|
| Patients | 8- to 14-years-old children with epilepsy Receives: Behavioral: ASRT task | |
| Control | 8- to 14-years-old children without neurological, psychiatric, or developmental impairments Receives: Behavioral: ASRT task |
What is being measured
The primary outcome is the main question the study is designed to answer.
Response time
Response time (in milliseconds) recorded during the ASRT task
Measured: The day of the inclusion
Response accuracy recorded during the ASRT task
Response accuracy (percentage of correct answers)
Measured: The day of the inclusion
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted17 Mar 2022
- Study start21 Mar 2023
- Primary completion21 Mar 2027 (estimated)
- Study completion21 Mar 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for EpilepsyStudies of the same condition, open and under way.
- More trials run by Hospices Civils de LyonThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 40 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Hospices Civils de Lyon
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Marcastel Agathe, PhD, Principal investigator, Service d'Epileptologie Clinique, des Troubles du sommeil et de Neurologie fonctionnelle de l'enfant - Hôpital Femme Mère Enfant
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05285059
- Sponsor's protocol ID
- 69HCL21_1190
- Acronym
- IMPLICIT
- Status last verified
- May 2026
- First submitted
- 7 Mar 2022
- Last updated
- 7 May 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 7 May 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Implicit Learning in Epileptic Children
- ClinicalTrials.gov ID
- NCT05285059
- Acronym / sponsor ID
- IMPLICIT / 69HCL21_1190
- Conditions
- Epilepsy
- Keywords
- Epilepsy,, children,, implicit learning
- Study type
- Observational
- Recruitment status
- Recruiting
- Enrolment
- 40 participants (estimated)
- Lead sponsor
- Hospices Civils de LyonUniversity, hospital or other
- Study start
- 21 Mar 2023 (actual)
- Primary completion
- 21 Mar 2027 (estimated)
- Study completion
- 21 Mar 2027 (estimated)
- First posted
- 17 Mar 2022 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Epileptic children suffer from impairments in various learning and memory tasks. Yet, no study investigated implicit learning in epileptic children. Implicit learning is not only underlying motor skills acquisition, but also social and cognitive ones. Because acquisition of new skills is optimal during childhood, the study of implicit learning mechanism in children is of major importance. The present study will be the first to explore implicit learning mechanisms in children with epilepsy. Implicit learning mechanisms can be preserved or altered.
Study design
- Observational model
- Cohort
- Time perspective
- Prospective
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Patients | – | Behavioral: ASRT task8- to 14-years-old children with epilepsy |
| Control | – | Behavioral: ASRT task8- to 14-years-old children without neurological, psychiatric, or developmental impairments |
Who may qualify
- Ages
- 8 to 14 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Child
- Study population
- This study focuses on children with epilepsy.
Key inclusion criteria (4 listed)
- For Patient group only: Children with epilepsy
- For Control group only: Children without neurological, psychiatric or developmental impairments
- For both groups: Parent or tutors agreement
- For both groups: Affiliated to French social security
Key exclusion criteria (3 listed)
- Neurological impairments unrelated to epilepsy
- Psychiatric impairments unrelated to epilepsy
- Developmental impairments unrelated to epilepsy
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| ASRT taskThe ASRT (Alternating Serial Reaction Time) task is a computerized behavioral task measuring implicit learning. This task consists of 20 series of trials lasting 2 minutes each. In each trial, a stimulus is displayed on the screen in one of the four possible predefined locations. The participant must press a button to indicate the position of the stimulus on the screen. Response content and response time are recorded. At the end of every trial, the participant can take a break and resume the task whenever ready. The task lasts about 45 to 50 minutes. | Behavioural | Control, Patients |
Primary outcome
Response time
Time frame: The day of the inclusion
Response time (in milliseconds) recorded during the ASRT task
Response accuracy recorded during the ASRT task
Time frame: The day of the inclusion
Response accuracy (percentage of correct answers)
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 7 May 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Marcastel Agathe, PhD principal investigator
Service d'Epileptologie Clinique, des Troubles du sommeil et de Neurologie fonctionnelle de l'enfant - Hôpital Femme Mère Enfant
3 sites in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Epilepsy, run by Hospices Civils de Lyon at 3 sites in France.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 7 May 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 3 sites in France. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Marcastel Agathe, PhD (+33 4 27 85 60 40, Agathe.marcastel@chu-lyon.fr), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Response time (time frame: The day of the inclusion). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 7 May 2026.