Headache, MigraineNCT05452330
The Effect of Two Different Massages on Migraine
A study testing Connective tissue massage and Classical massage in people with Headache, Migraine and Manuel Therapy, run by Biruni University at 1 site in Turkey (Türkiye).
Trial summary
The study aims to compare the effects of connective tissue massage on pain severity, attack frequency and duration, migraine-related disability, and quality of life in patients diagnosed with migraine, by comparing them with the classical massage. Read more about this study
- Who is it for?
- Ages 18 to 64 years
- Conditions the study is for
- Headache, Migraine, Manuel Therapy
- What is being tested?
- Connective tissue massage and Classical massage
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 30 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 18 Jul 2022to 16 Dec 2022
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 64 years
- All sexes
- No healthy volunteers
- Adult
Who may be able to join
- Volunteers with a migraine diagnosis
- Taking only analgesics for migraine treatment and continuing their routines
- No problem in reading, writing and understanding Turkish
Who cannot join
- Having any other neurological problems
- Who had been injected with botulinum toxin in the last 3 months
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Comparison of the Effectiveness of Connective Tissue Massage and Classical Massage in Patients With Migraine
The study aims to compare the effects of connective tissue massage on pain severity, attack frequency and duration, migraine-related disability, and quality of life in patients diagnosed with migraine, by comparing them with the classical massage.
- Conditions
- Headache, Migraine, Manuel Therapy
- Being tested
- Connective tissue massage, Classical massage
- Medical subject headings
- Migraine Disorders
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Connective tissue massageOther
Connective tissue massage will be applied with short and long pulling strokes to create a reflex effect for 2 days a week, a total of 8 weeks.
Classical massageOther
Classical massage will be applied with the techniques of stroking, kneading, and friction for 2 days a week, a total of 8 weeks.
| Study group | Role | What they receive |
|---|---|---|
| Group 1 | Experimental | Connective tissue massage Receives: Other: Connective tissue massage |
| Group 2 | Experimental | Classical massage Receives: Other: Classical massage |
What is being measured
The primary outcome is the main question the study is designed to answer.
Pain Intensity
The intensity of pain perceived by the subjects will be evaluated with a valid method, the Visual Analogue Scale (VAS). The higher numbers show higher pain intensities.
Measured: 8 weeks
Secondary outcomes (4)
Migraine Related Disability
The Migraine Disability Assessment Scale (MIDAS), which is considered valid and reliable, will be used to evaluate the migraine-related disability. The higher scores indicate an increase in the severity of the disability.
Measured: 8 weeks
The Quality of Life
The patients' quality of life will be evaluated with the 24-hours Quality of Life in Migraine Scale (24-Hr-MQoLQ), which is valid and reliable. The increase in the score obtained from the scale indicates an increase in the quality of life.
Measured: 8 weeks
Perceived Patient-Reported Change
The change perceived by the patients after the intervention will be evaluated with the Global Rating of Change Scale (GROC). According to the scale, it is expressed as "-2: I am much worse, -1: I am worse, 0: No change, 1: I am better, 2: I am much better".
Measured: 8th week (one week)
The general descriptive demographic information
The general descriptive demographic information of the participants such as age and gender; migraine family history, duration of the complaints, attack frequency and duration will be questioned with a form prepared by the researchers.
Measured: 8 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted11 Jul 2022
- Study start18 Jul 2022
- Primary completion9 Dec 2022
- Study completion16 Dec 2022
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Headache, MigraineStudies of the same condition, open and under way.
- More trials run by Biruni UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 30 participants (actual)
Sponsor and investigators
- Lead sponsor
- Biruni University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Begum Kara Kaya, Biruni University
- Investigators
- Arzu Özdinçler, PhD, Study chair, Biruni University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05452330
- Sponsor's protocol ID
- Migren
- Status last verified
- Aug 2026
- First submitted
- 6 Jul 2022
- Last updated
- 13 Aug 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 13 Aug 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Comparison of the Effectiveness of Connective Tissue Massage and Classical Massage in Patients With Migraine
- ClinicalTrials.gov ID
- NCT05452330
- Acronym / sponsor ID
- Migren
- Conditions
- Headache, Migraine, Manuel Therapy
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 30 participants (actual)
- Lead sponsor
- Biruni UniversityUniversity, hospital or other
- Study start
- 18 Jul 2022 (actual)
- Primary completion
- 9 Dec 2022 (actual)
- Study completion
- 16 Dec 2022 (actual)
- First posted
- 11 Jul 2022 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The study aims to compare the effects of connective tissue massage on pain severity, attack frequency and duration, migraine-related disability, and quality of life in patients diagnosed with migraine, by comparing them with the classical massage.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Group 1 | Experimental | Other: Connective tissue massageConnective tissue massage |
| Group 2 | Experimental | Other: Classical massageClassical massage |
Who may qualify
- Ages
- 18 to 64 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (3 listed)
- Volunteers with a migraine diagnosis
- Taking only analgesics for migraine treatment and continuing their routines
- No problem in reading, writing and understanding Turkish
Key exclusion criteria (2 listed)
- Having any other neurological problems
- Who had been injected with botulinum toxin in the last 3 months
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Connective tissue massageConnective tissue massage will be applied with short and long pulling strokes to create a reflex effect for 2 days a week, a total of 8 weeks. | Other | Group 1 |
| Classical massageClassical massage will be applied with the techniques of stroking, kneading, and friction for 2 days a week, a total of 8 weeks. | Other | Group 2 |
Primary outcome
Pain Intensity
Time frame: 8 weeks
The intensity of pain perceived by the subjects will be evaluated with a valid method, the Visual Analogue Scale (VAS). The higher numbers show higher pain intensities.
4 secondary outcomes
Migraine Related Disability
Time frame: 8 weeks
The Quality of Life
Time frame: 8 weeks
Perceived Patient-Reported Change
Time frame: 8th week (one week)
The general descriptive demographic information
Time frame: 8 weeks
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 13 Aug 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Arzu Özdinçler, PhD study chair
Biruni University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Connective tissue massage and Classical massage in people with Headache, Migraine and Manuel Therapy, run by Biruni University at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 2 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 13 Aug 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Pain Intensity (time frame: 8 weeks). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 13 Aug 2026.