EpilepsyNCT05507320
Neural Circuits for Action Perception
An observational study of Epilepsy, run by Boston Children's Hospital at 1 site in United States.
Trial summary
Study the mechanisms underlying action recognition and execution Read more about this study
- Who is it for?
- Ages 14 to 70 years
- Conditions the study is for
- Epilepsy
- What is being tested?
- Mechanisms of action perception and execution
- Type of treatment
- Lifestyle or therapy programme
- How many people
- 30 participants
- Where
- 1 siteUnited States
- Study dates
- 1 Sep 2021to 1 Sep 2025
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 14 to 70 years
- All sexes
- No healthy volunteers
- Child, Adult, Older adult
Study population: Patients with pharmacologically intractable epilepsy undergoing invasive implantation of electrodes
Who may be able to join
- Patients with pharmacologically intractable epilepsy
Who cannot join
- Any situation that may put the patient at risk
Trial locations and contacts
1 site in 1 country.
United States1 site, 1 recruiting
- Recruiting
Boston Children's Hospital
Boston, Massachusetts, 02115
Dominguez Robleinscky, 617-919-2530, domingues.robleinscky@childrens.harvard.edu
Gabriel Kreiman, 6179192242, gabriel.kreiman@tch.harvard.edu
About this study
Study the mechanisms underlying action recognition and execution
Read the detailed description
Subjects will participate in a task where they have to either
- Perform a movement
- Observe an actor performing a movement There are three types of actions including different kinematics and grip types The goal is to compare the neural circuits activated by action execution versus action observation.
- Conditions
- Epilepsy
- Being tested
- Mechanisms of action perception and execution
- Medical subject headings
- Epilepsy
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Mechanisms of action perception and executionBehavioural
Study the mechanisms of action perception and execution
What is being measured
The primary outcome is the main question the study is designed to answer.
Selectivity for kinematics and movement type in neurophysiological responses
Measure intracranial field potentials (in microvolts) in the gamma frequency band through neurophysiological responses comparing neural responses during action perception versus execution.
We will assess selectivity for kinematics for each movement type
Measured: Through study completion, an average of 2 years.
Evoked responses by action execution
Measure intracranial field potentials (in microvolts) in the gamma frequency band through neurophysiological responses comparing neural responses during action perception versus execution.
We will quantify responses evoked by action execution
Measured: Through study completion, an average of 2 years.
Evoked responses by action observation
Measure intracranial field potentials (in microvolts) in the gamma frequency band through neurophysiological responses comparing neural responses during action perception versus execution.
We will quantify responses evoked by action observation
Measured: Through study completion, an average of 2 years.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted18 Aug 2022
- Study start1 Sep 2021
- Primary completion1 Sep 2025 (estimated)
- Study completion1 Sep 2025 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for EpilepsyStudies of the same condition, open and under way.
- More trials run by Boston Children's HospitalThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Other
- Time perspective
- Other
- Enrolment
- 30 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Boston Children's Hospital
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Gabriel Kreiman, Boston Children's Hospital
- Investigators
- Gabriel Kreiman, PhD, Principal investigator, CHB
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05507320
- Sponsor's protocol ID
- IRB_P0405065R
- Status last verified
- Aug 2022
- First submitted
- 9 Aug 2022
- Last updated
- 18 Aug 2022
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 18 Aug 2022. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Neural Circuits for Action Perception
- ClinicalTrials.gov ID
- NCT05507320
- Acronym / sponsor ID
- IRB_P0405065R
- Conditions
- Epilepsy
- Study type
- Observational
- Recruitment status
- Unknown status
- Enrolment
- 30 participants (estimated)
- Lead sponsor
- Boston Children's HospitalUniversity, hospital or other
- Study start
- 1 Sep 2021 (actual)
- Primary completion
- 1 Sep 2025 (estimated)
- Study completion
- 1 Sep 2025 (estimated)
- First posted
- 18 Aug 2022 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Study the mechanisms underlying action recognition and execution
Detailed description
Subjects will participate in a task where they have to either
- Perform a movement
- Observe an actor performing a movement There are three types of actions including different kinematics and grip types The goal is to compare the neural circuits activated by action execution versus action observation.
Study design
- Observational model
- Other
- Time perspective
- Other
Who may qualify
- Ages
- 14 to 70 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Child, Adult, Older adult
- Study population
- Patients with pharmacologically intractable epilepsy undergoing invasive implantation of electrodes
Key inclusion criteria (1 listed)
- Patients with pharmacologically intractable epilepsy
Key exclusion criteria (1 listed)
- Any situation that may put the patient at risk
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Mechanisms of action perception and executionStudy the mechanisms of action perception and execution | Behavioural | – |
Primary outcome
Selectivity for kinematics and movement type in neurophysiological responses
Time frame: Through study completion, an average of 2 years.
Measure intracranial field potentials (in microvolts) in the gamma frequency band through neurophysiological responses comparing neural responses during action perception versus execution. We will assess selectivity for kinematics for each movement type
Evoked responses by action execution
Time frame: Through study completion, an average of 2 years.
Measure intracranial field potentials (in microvolts) in the gamma frequency band through neurophysiological responses comparing neural responses during action perception versus execution. We will quantify responses evoked by action execution
Evoked responses by action observation
Time frame: Through study completion, an average of 2 years.
Measure intracranial field potentials (in microvolts) in the gamma frequency band through neurophysiological responses comparing neural responses during action perception versus execution. We will quantify responses evoked by action observation
Results and safety
Results are not available in the source record.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 18 Aug 2022.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Gabriel Kreiman, PhD principal investigator
CHB
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Epilepsy, run by Boston Children's Hospital at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: status not confirmed, as of the sponsor's last update on 18 Aug 2022. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
Results are not available in the source record.
How can a doctor refer a patient or contact the research team?
Contact Gabriel Kreiman, PhD (6179192530, gabriel.kreiman@tch.harvard.edu), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Selectivity for kinematics and movement type in neurophysiological responses (time frame: Through study completion, an average of 2 years.). The study lists 3 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 18 Aug 2022.