Low Flow AnesthesiaNCT05517551
Comparison of Low and Normal Flow Anesthesia in Robotic Assisted Radical Prostatectomy
An observational study of Low Flow Anesthesia and Normal Flow Anesthesia, run by Ankara City Hospital Bilkent at 1 site in Turkey (Türkiye).
Trial summary
Robot-assisted laparoscopic radical prostatectomy has gained increasing popularity compared to open radical prostatectomy with its advantages such as low blood loss, reduced blood transfusion rate, low complication rate, and shortened hospital stay. Read more about this study
- Who is it for?
- Ages 18 to 80 years, men onlyHealthy volunteers can take part
- Conditions the study is for
- Low Flow Anesthesia, Normal Flow Anesthesia, Robotic Surgery
- What is being tested?
- robotic assisted radical prostatectomy
- Type of treatment
- Surgery or procedure
- How many people
- 68 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 24 Aug 2022to 30 Nov 2023
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 80 years
- Men only
- Healthy volunteers accepted
- Adult, Older adult
Study population: Patients who will undergo robotic-assisted laparoscopic prostatectomy surgery
Who may be able to join
- ASA I-II-III risk group
Who cannot join
- ASA IV, V,
- concomitant serious cardiac, respiratory, hepatic, renal disturbance,
- mental status disorder and hearing problem,
- anxiety and depression and/or other psychiatric disorders,
- patient's refusal
Trial locations and contacts
1 site in 1 country.
About this study
Official title: The Effect of Low-flow and Normal-flow Desflurane Anesthesia on Respiratory Parameters in Robotic-assisted Radical Prostatectomy
Robot-assisted laparoscopic radical prostatectomy has gained increasing popularity compared to open radical prostatectomy with its advantages such as low blood loss, reduced blood transfusion rate, low complication rate, and shortened hospital stay. Since robot-assisted laparoscopic radical prostatectomy should be performed in the limited retroperitoneal area, insufflation of the abdomen with carbon dioxide (CO2) (pneumoperitoneum) and steep Trendelenburg position are required to provide better surgical vision.
Low-flow anesthesia warms and moistens the inhaled gases, creating a more physiological breathing atmosphere during anesthesia. In addition, it provides cost advantage by reducing inhalation agent consumption and reduces atmospheric pollution. Studies show that long-term minimal flow anesthesia is safe and advantageous for non-laparoscopic surgery.
Read more
The aim of this study is to compare low-flow (1L/min) with normal flow (3lt/min) desflurane anesthesia in terms of hemodynamic and respiratory parameters, inhalation agent consumption and soda lime consumption for robotic assisted laparoscopic radical prostatectomy surgery.
The secondary aim of the study is to compare the effects of low-flow and normal-flow anesthesia in the steep trendelenburg position (45°) used for robotically assisted laparoscopic radical prostatectomy.
- Conditions
- Low Flow Anesthesia, Normal Flow Anesthesia, Robotic Surgery
- Being tested
- robotic assisted radical prostatectomy
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
robotic assisted radical prostatectomyProcedure or surgery
Patients who will undergo robotic-assisted laparoscopic prostatectomy surgery
| Study group | Role | What they receive |
|---|---|---|
| normal flow anesthesia | A fresh gas flow of 3 L/min will be applied continuously Receives: Procedure: robotic assisted radical prostatectomy | |
| low flow anesthesia | A fresh gas flow of 3 L/min will be applied for the first 20 minutes after intubation , and then it will be reduced to 1 L/min. Receives: Procedure: robotic assisted radical prostatectomy |
What is being measured
The primary outcome is the main question the study is designed to answer.
inspiratory O₂ concentration
inspiratory O₂ concentration is measured from anesthesia machine monitor
Measured: from beginning of anesthesia induction to the end of anesthesia (during periopertaive period)
partial oxygen pressure
PO2 from blood gas analysis
Measured: from beginning of anesthesia induction to the end of anesthesia (during periopertaive period)
Secondary outcomes (2)
desflurane consumption
desflurane consumption at the end of anesthesia is measured from anesthesia machine monitor
Measured: perioperative
changes in liver and kidney function tests from the preoperative values to 48 hours postoperative
to determine the changes in serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), blood urea nitrogen (BUN), and creatinine from the preoperative values to 48 hours postoperative
Measured: during operation and 48 hours postoperative
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted26 Aug 2022
- Study start24 Aug 2022
- Primary completion30 Aug 2022
- Study completion30 Nov 2023
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Low Flow AnesthesiaStudies of the same condition, open and under way.
- More trials run by Ankara City Hospital BilkentThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 68 participants (actual)
Sponsor and investigators
- Lead sponsor
- Ankara City Hospital Bilkent
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Betül Güven, Ankara City Hospital Bilkent
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05517551
- Sponsor's protocol ID
- E1-22-2755
- Status last verified
- Dec 2022
- First submitted
- 23 Aug 2022
- Last updated
- 28 May 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Study at a glance
From the registry record, last updated by the sponsor on 28 May 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Effect of Low-flow and Normal-flow Desflurane Anesthesia on Respiratory Parameters in Robotic-assisted Radical Prostatectomy
- ClinicalTrials.gov ID
- NCT05517551
- Acronym / sponsor ID
- E1-22-2755
- Conditions
- Low Flow Anesthesia, Normal Flow Anesthesia, Robotic Surgery
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 68 participants (actual)
- Lead sponsor
- Ankara City Hospital BilkentUniversity, hospital or other
- Study start
- 24 Aug 2022 (actual)
- Primary completion
- 30 Aug 2022 (actual)
- Study completion
- 30 Nov 2023 (actual)
- First posted
- 26 Aug 2022 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Robot-assisted laparoscopic radical prostatectomy has gained increasing popularity compared to open radical prostatectomy with its advantages such as low blood loss, reduced blood transfusion rate, low complication rate, and shortened hospital stay. Since robot-assisted laparoscopic radical prostatectomy should be performed in the limited retroperitoneal area, insufflation of the abdomen with carbon dioxide (CO2) (pneumoperitoneum) and steep Trendelenburg position are required to provide better surgical vision.
Low-flow anesthesia warms and moistens the inhaled gases, creating a more physiological breathing atmosphere during anesthesia. In addition, it provides cost advantage by reducing inhalation agent consumption and reduces atmospheric pollution. Studies show that long-term minimal flow anesthesia is safe and advantageous for non-laparoscopic surgery.
The aim of this study is to compare low-flow (1L/min) with normal flow (3lt/min) desflurane anesthesia in terms of hemodynamic and respiratory parameters, inhalation agent consumption and soda lime consumption for robotic assisted laparoscopic radical prostatectomy surgery.
The secondary aim of the study is to compare the effects of low-flow and normal-flow anesthesia in the steep trendelenburg position (45°) used for robotically assisted laparoscopic radical prostatectomy.
Study design
- Observational model
- Cohort
- Time perspective
- Prospective
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| normal flow anesthesia | – | Procedure: robotic assisted radical prostatectomyA fresh gas flow of 3 L/min will be applied continuously |
| low flow anesthesia | – | Procedure: robotic assisted radical prostatectomyA fresh gas flow of 3 L/min will be applied for the first 20 minutes after intubation , and then it will be reduced to 1 L/min. |
Who may qualify
- Ages
- 18 to 80 years
- Sex
- Male only
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
- Study population
- Patients who will undergo robotic-assisted laparoscopic prostatectomy surgery
Key inclusion criteria (1 listed)
- ASA I-II-III risk group
Key exclusion criteria (5 listed)
- ASA IV, V,
- concomitant serious cardiac, respiratory, hepatic, renal disturbance,
- mental status disorder and hearing problem,
- anxiety and depression and/or other psychiatric disorders,
- patient's refusal
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| robotic assisted radical prostatectomyPatients who will undergo robotic-assisted laparoscopic prostatectomy surgery | Procedure or surgery | low flow anesthesia, normal flow anesthesia |
Primary outcome
inspiratory O₂ concentration
Time frame: from beginning of anesthesia induction to the end of anesthesia (during periopertaive period)
inspiratory O₂ concentration is measured from anesthesia machine monitor
partial oxygen pressure
Time frame: from beginning of anesthesia induction to the end of anesthesia (during periopertaive period)
PO2 from blood gas analysis
2 secondary outcomes
desflurane consumption
Time frame: perioperative
changes in liver and kidney function tests from the preoperative values to 48 hours postoperative
Time frame: during operation and 48 hours postoperative
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 28 May 2026.
- Individual participant dataSharing planned: Undecided
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Anesthesia
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Low Flow Anesthesia and Normal Flow Anesthesia, run by Ankara City Hospital Bilkent at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 28 May 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
inspiratory O₂ concentration (time frame: from beginning of anesthesia induction to the end of anesthesia (during periopertaive period)). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 28 May 2026.