EpilepsyNCT05529264
Human Intracranial Electrophysiology
A study testing Memory Tasks, Attention/arousal tasks and Language tasks in people with Epilepsy, run by Dartmouth-Hitchcock Medical Center at 1 site in United States.
Trial summary
This study will enroll patients with epilepsy who are being evaluated for epilepsy surgery and have electrodes implanted in the brain and/or have electrodes on the scalp. Additionally, this study will recruit normal and online controls (participants who do not have epilepsy). Read more about this study
- Who is it for?
- Ages 18 years and olderHealthy volunteers can take part
- Conditions the study is for
- Epilepsy
- What is being tested?
- Memory Tasks, Attention/arousal tasks and Language tasks
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 175 participants
- Where
- 1 siteUnited States
- Study dates
- 17 Jan 2023to 1 Aug 2032
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Patients with Intracranial EEG: Inclusion Criteria
- Patients must be age 18 years or older. There is no upper age limit.
- Patients must have a diagnosis of refractory epilepsy undergoing intracranial EEG recording for clinical purposes.
Patients with Intracranial EEG: Exclusion Criteria
- Patient has additional neurological condition (such as stroke or dementia) or a psychiatric condition (such as active psychosis or suicidal ideation) and are deemed inappropriate for the study
- Patients are not able to provide informed consent for any reason (e.g. encephalopathic, experiencing a seizure)
Patients with Scalp EEG: Inclusion Criteria
- Patients must be age 18 years or older. There is no upper age limit.
- Patients must have a probable diagnosis of epilepsy.
Patients with Scalp EEG: Exclusion Criteria
- Patient has additional neurological condition (such as stroke or dementia) or a psychiatric condition (such as active psychosis or suicidal ideation) and are deemed inappropriate for the study
- Patients are not able to provide informed consent for any reason (e.g. encephalopathic, experiencing a seizure)
Normal Controls: Inclusion Criteria
- Participants must be age 18 years or older. There is no upper age limit.
- Participants must be able to provide informed consent for themselves.
Normal Controls: Exclusion Criteria
- Determined not to be appropriate normal control for the study population
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
United States1 site, 1 recruiting
- Recruiting
Dartmouth-Hitchcock Medical Center
Lebanon, New Hampshire, 03776
Krzysztof A Bujarski, MD, 603 650-5104, krzysztof.a.bujarski@hitchcock.org
Gina Kersey, (603) 650-0260, Gina.E.Kersey@Hitchcock.ORG
About this study
This study will enroll patients with epilepsy who are being evaluated for epilepsy surgery and have electrodes implanted in the brain and/or have electrodes on the scalp. Additionally, this study will recruit normal and online controls (participants who do not have epilepsy). Participants will be asked to participate in 1 to 2 (30-90 minutes) daily sessions designed to test aspects of human cognition such as memory, speech, language, feeling, movement, attention, sound perception, and emotions. Generally, this will involve working on a computer, looking at pictures or watching videos, and answering questions. Additionally, participants may be asked to be hooked up to additional equipment such as eye tracker, electrical stimulator, heart rate monitor, sweat monitor or other non-invasive equipment. The overall aim of this study is to use human intracranial electrophysiology (the recording of the electrical activity of the human brain) to study localization and function of the human brain.
Read the detailed description
This project aims to study the mechanisms of brain function by using Human Intracranial Electrophysiology (HIE) methods and is a continuation of the "Localization of Human Brain Function" study done at Dartmouth-Hitchcock Medical Center (DHMC). HIE refers to the recording of brain signals using electrodes which are surgically inserted into the human brain for the clinical purpose of localizing the origins of epileptic seizures.
Secondary to clinical goals, such patients with intracranial EEG electrodes can be safely recruited to participate in research studies, i.e. the research "piggybacks" on procedures that are performed strictly for a clinical purpose. Brain signals obtained using HIE methods during performance of specific tasks have unique properties rich with insight into the inner workings of the human brain. HIE methods can be used together with electrical brain stimulation (EBS) techniques to better understand relationship between brain and behavior. Furthermore, HIE methods can be recorded together with other non-invasive bio-physiological data streams such as pupillometry, electrodermal activity (EDA), cardiac monitoring, and respiratory monitoring to understand the relationship between the brain and many aspects of human physiology.
- Conditions
- Epilepsy
- Being tested
- Memory Tasks, Attention/arousal tasks, Language tasks, Visuospatial tasks, Auditory Tasks
- Medical subject headings
- Epilepsy
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Memory TasksOther
Participants will be asked to view pictures and videos presented on a computer screen and will be asked to recall the details of presented pictures or videos sometime later.
Attention/arousal tasksOther
Participants will be asked to perform a continuous performance task, such as continuous addition of numbers. Additionally, participants may be presented with images and may be asked to rate the significance or arousal values for each image.
Language tasksOther
Participants will be asked to view pictures of actions or things and will be asked to name them. Participants may also be asked to read words or passages.
Visuospatial tasksOther
Participants will be asked to copy 3 dimensional designs or make judgements of angle size.
Auditory TasksOther
Participants will be presented with short, approximately 8-minute clips of music from various genres ( i.e. classical, country, rock, etc.) with an attention task (modified sustained attention to response task) nested within each trial. Participants will receive approximately 8 music stimuli and 1 control stimulus (pink noise) twice over the course of two testing sessions ( 90 mins each). Additionally, participants will be asked to answer questions about their hearing, music preferences/training, and certain demographic information (age, handedness, and language proficiency).
Brain StimulationProcedure or surgery
A brain stimulator will be used to understand new functions of the brain. Participants will be presented with pictures on a computer screen and may be asked to tell researchers what is seen or remembered by participants. As pictures are viewed by the participants, the brain stimulator may be activated, which would not be something that would be felt by an individual participant.
Social Emotional TaskOther
Participants will be asked to view presented pictures and videos of people engaged in social interaction. Additionally, participants will be presented with the standardized tasks that are designed to help the researchers with understanding the nature of emotions. Some of these images may be emotionally disturbing. If participants are not comfortable viewing such images, they will be asked to refrain from participation in this study.
Recording of facial expressionsOther
Some participants may be asked permission to record the video of their facial expressions during performance of a research task. Generally, this will include only research tasks investigating brain representation of social/emotional information. Automated analysis of facial expression may be used in certain experiments to provide information on experience of emotional states such as happiness and sadness related to the images being presented.
Judgement/Impulsivity TaskOther
Certain study participants may be enrolled into research tasks designed to activate regions important for judgment and impulse control. These tasks will present participants with choices of varying monetary rewards and ask them to make judgements to measure one's tendency to prefer immediate over delayed rewards.
| Study group | Role | What they receive |
|---|---|---|
| Invasive EEG (electrodes are implanted in a participant's brain) | Experimental | Patients with intracranial electrodes (electrodes are implanted in a participant's brain) undergoing pre-surgical evaluation for clinical reasons will be asked to participate in various study tasks with the recording of intracranial EEG (recording of brain waves via electrodes implanted in a participant's brain) during these tasks. Receives: Other: Memory Tasks; Other: Attention/arousal tasks; Other: Language tasks; Other: Visuospatial tasks; Other: Auditory Tasks; Procedure: Brain Stimulation; Other: Social Emotional Task; Other: Recording of facial expressions; Other: Judgement/Impulsivity Task |
| Scalp EEG (electrodes are placed on a participant's scalp) | Experimental | Patients with non-invasive scalp electrodes who are admitted to the hospital for clinical reasons will be asked to participate in various study tasks with the recording of their EEG (recording of brain waves via electrodes attached to a participant's scalp) during these tasks. Receives: Other: Memory Tasks; Other: Attention/arousal tasks; Other: Language tasks; Other: Visuospatial tasks; Other: Auditory Tasks; Other: Social Emotional Task; Other: Recording of facial expressions; Other: Judgement/Impulsivity Task |
| Normal Controls | Active comparator | Normal controls will be recruited from family members of patients, from advertisements, or from online tools. There will be no EEG recordings obtained from these participants. Receives: Other: Memory Tasks; Other: Attention/arousal tasks; Other: Language tasks; Other: Visuospatial tasks; Other: Social Emotional Task; Other: Recording of facial expressions; Other: Judgement/Impulsivity Task |
| Online Controls | Active comparator | Certain control subjects will be recruited through Amazon Mechanical Turk. These participants will be given their task on the online platform using Qualtric survey function. The task design will be identical to normal controls who are recruited in-person, with the exception of identifiers. There will be no EEG recordings obtained from these participants. Receives: Other: Memory Tasks; Other: Attention/arousal tasks; Other: Language tasks; Other: Visuospatial tasks; Other: Social Emotional Task; Other: Recording of facial expressions; Other: Judgement/Impulsivity Task |
What is being measured
The primary outcome is the main question the study is designed to answer.
Using scalp and intracranial EEG, measure changes in electrical activity of the human brain associated with memory.
Primary objective is to use human intracranial electrophysiology to study localization and function of the human brain. With continuous recording of the electrical activity in participants' brain, study participants will be asked to take part in research tasks involving memory. The researchers will use the information to further the understanding of the exact location of cognitive functions.
Measured: Evaluated for each patient during monitoring period of approximately 2 weeks.
Using scalp and intracranial EEG, measure changes in electrical activity of the human brain associated with language.
Primary objective is to use human intracranial electrophysiology to study localization and function of the human brain. With continuous recording of the electrical activity in participants' brain, study participants will be asked to take part in research tasks involving language. The researchers will use the information to further the understanding of the exact location of cognitive functions.
Measured: Evaluated for each patient during monitoring period of approximately 2 weeks.
Using scalp and intracranial EEG, measure changes in electrical activity of the human brain associated with emotions.
Primary objective is to use human intracranial electrophysiology to study localization and function of the human brain. With continuous recording of the electrical activity in participants' brain, study participants will be asked to take part in research tasks involving emotions. The researchers will use the information to further the understanding of the exact location of cognitive functions.
Measured: Evaluated for each patient during monitoring period of approximately 2 weeks.
Using scalp and intracranial EEG, measure changes in electrical activity of the human brain associated with movement.
Primary objective is to use human intracranial electrophysiology to study localization and function of the human brain. With continuous recording of the electrical activity in participants' brain, study participants will be asked to take part in research tasks involving movement. The researchers will use the information to further the understanding of the exact location of cognitive functions.
Measured: Evaluated for each patient during monitoring period of approximately 2 weeks.
Using scalp and intracranial EEG, measure changes in electrical activity of the human brain associated with attention and executive function.
Primary objective is to use human intracranial electrophysiology to study localization and function of the human brain. With continuous recording of the electrical activity in participants' brain, study participants will be asked to take part in research tasks involving attention and executive function. The researchers will use the information to further the understanding of the exact location of cognitive functions.
Measured: Evaluated for each patient during monitoring period of approximately 2 weeks.
Using scalp and intracranial EEG, measure changes in electrical activity of the human brain associated with sound perception.
Primary objective is to use human intracranial electrophysiology to study localization and function of the human brain. With continuous recording of the electrical activity in participants' brain, study participants will be asked to take part in research tasks involving sound perception. The researchers will use the information to further the understanding of the exact location of cognitive functions.
Measured: Evaluated for each patient during monitoring period of approximately 2 weeks.
Secondary outcomes (4)
The degree of correlation between the brain activation and respiratory activity.
Researchers will investigate the degree of correlation (correlation coefficient or how similar the measurements are) between the human intracranial EEG signals and respiratory activity. The respiratory activity (e.g. breathing rate, oxygen level, etc.) will be measured with non-invasive sensors such as respiratory belt worn around a participant's chest and abdomen as well as a small sensor under their nose.
Measured: Evaluated for each patient during monitoring period of approximately 2 weeks.
The degree of correlation between the brain activation and electrodermal activity.
Researchers will investigate the degree of correlation between the human intracranial EEG signals and electrodermal activity (electrical characteristics of human skin). The electrodermal activity will be measured with non-invasive electrodermal sensors such as wrist or ankle sensors and expressed as a variation in electrical characteristics of participants' skin.
Measured: Evaluated for each patient during monitoring period of approximately 2 weeks.
Measure the degree of correlation between the brain activation and sweat variations.
Researchers will investigate the degree of correlation between the human intracranial EEG signals and sweat volume. The researchers will use use a Q-SWEAT system to noninvasively measure the sweat volume produced during specific study tasks. The Q-SWEAT system has a multicompartmental capsule, which is placed tightly on the skin, often in four standard locations (the dorsal foot, distal leg, proximal leg, and forearm), though any flat, area of skin can be used. Nitrogen gas flows through the inner compartment, and the system detects sweat volume by measuring changes in the relative humidity of returning nitrogen during the recording period.
Measured: Evaluated for each patient during monitoring period of approximately 2 weeks.
Measure the degree of correlation between the brain activation and cardiac physiology.
Researchers will use a CNAP machine (finger sensor) to record heart-rate variability. The CNAP machine will measure the waveform and pressure continuously, which will allow for detection of changes in blood pressure without using an arterial line or other invasive methods. Researchers will investigate the degree of correlation between the human intracranial EEG signals and heart-rate variability, including changes in blood pressure during the performance of study tasks.
Measured: Evaluated for each patient during monitoring period of approximately 2 weeks.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted7 Sep 2022
- Study start17 Jan 2023
- Primary completion1 Aug 2027 (estimated)
- Study completion1 Aug 2032 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for EpilepsyStudies of the same condition, open and under way.
- More trials run by Dartmouth-Hitchcock Medical CenterThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 175 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Dartmouth-Hitchcock Medical Center
- Sponsor type
- University, hospital or other
- Collaborators
- Dartmouth College
- Responsible party
- Principal investigator, Krzysztof Bujarski, Dartmouth-Hitchcock Medical Center
- Investigators
- Krzysztof A Bujarski, MD, Principal investigator, Dartmouth-Hitchcock Medical Center
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05529264
- Sponsor's protocol ID
- STUDY02001606
- Status last verified
- Jan 2026
- First submitted
- 22 Aug 2022
- Last updated
- 15 Jan 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 15 Jan 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Human Intracranial Electrophysiology
- ClinicalTrials.gov ID
- NCT05529264
- Acronym / sponsor ID
- STUDY02001606
- Conditions
- Epilepsy
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 175 participants (estimated)
- Lead sponsor
- Dartmouth-Hitchcock Medical CenterUniversity, hospital or other
- Collaborators
- Dartmouth College
- Study start
- 17 Jan 2023 (actual)
- Primary completion
- 1 Aug 2027 (estimated)
- Study completion
- 1 Aug 2032 (estimated)
- First posted
- 7 Sep 2022 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study will enroll patients with epilepsy who are being evaluated for epilepsy surgery and have electrodes implanted in the brain and/or have electrodes on the scalp. Additionally, this study will recruit normal and online controls (participants who do not have epilepsy). Participants will be asked to participate in 1 to 2 (30-90 minutes) daily sessions designed to test aspects of human cognition such as memory, speech, language, feeling, movement, attention, sound perception, and emotions. Generally, this will involve working on a computer, looking at pictures or watching videos, and answering questions. Additionally, participants may be asked to be hooked up to additional equipment such as eye tracker, electrical stimulator, heart rate monitor, sweat monitor or other non-invasive equipment. The overall aim of this study is to use human intracranial electrophysiology (the recording of the electrical activity of the human brain) to study localization and function of the human brain.
Detailed description
This project aims to study the mechanisms of brain function by using Human Intracranial Electrophysiology (HIE) methods and is a continuation of the "Localization of Human Brain Function" study done at Dartmouth-Hitchcock Medical Center (DHMC). HIE refers to the recording of brain signals using electrodes which are surgically inserted into the human brain for the clinical purpose of localizing the origins of epileptic seizures.
Secondary to clinical goals, such patients with intracranial EEG electrodes can be safely recruited to participate in research studies, i.e. the research "piggybacks" on procedures that are performed strictly for a clinical purpose. Brain signals obtained using HIE methods during performance of specific tasks have unique properties rich with insight into the inner workings of the human brain. HIE methods can be used together with electrical brain stimulation (EBS) techniques to better understand relationship between brain and behavior. Furthermore, HIE methods can be recorded together with other non-invasive bio-physiological data streams such as pupillometry, electrodermal activity (EDA), cardiac monitoring, and respiratory monitoring to understand the relationship between the brain and many aspects of human physiology.
Study design
- Primary purpose
- Basic science
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 4
| Arm | Type | Receives |
|---|---|---|
| Invasive EEG (electrodes are implanted in a participant's brain) | Experimental | Other: Memory Tasks, Other: Attention/arousal tasks, Other: Language tasks, Other: Visuospatial tasks, Other: Auditory Tasks, Procedure: Brain Stimulation, Other: Social Emotional Task, Other: Recording of facial expressions, Other: Judgement/Impulsivity TaskPatients with intracranial electrodes (electrodes are implanted in a participant's brain) undergoing pre-surgical evaluation for clinical reasons will be asked to participate in various study tasks with the recording of intracranial EEG (recording of brain waves via electrodes implanted in a participant's brain) during these tasks. |
| Scalp EEG (electrodes are placed on a participant's scalp) | Experimental | Other: Memory Tasks, Other: Attention/arousal tasks, Other: Language tasks, Other: Visuospatial tasks, Other: Auditory Tasks, Other: Social Emotional Task, Other: Recording of facial expressions, Other: Judgement/Impulsivity TaskPatients with non-invasive scalp electrodes who are admitted to the hospital for clinical reasons will be asked to participate in various study tasks with the recording of their EEG (recording of brain waves via electrodes attached to a participant's scalp) during these tasks. |
| Normal Controls | Active comparator | Other: Memory Tasks, Other: Attention/arousal tasks, Other: Language tasks, Other: Visuospatial tasks, Other: Social Emotional Task, Other: Recording of facial expressions, Other: Judgement/Impulsivity TaskNormal controls will be recruited from family members of patients, from advertisements, or from online tools. There will be no EEG recordings obtained from these participants. |
| Online Controls | Active comparator | Other: Memory Tasks, Other: Attention/arousal tasks, Other: Language tasks, Other: Visuospatial tasks, Other: Social Emotional Task, Other: Recording of facial expressions, Other: Judgement/Impulsivity TaskCertain control subjects will be recruited through Amazon Mechanical Turk. These participants will be given their task on the online platform using Qualtric survey function. The task design will be identical to normal controls who are recruited in-person, with the exception of identifiers. There will be no EEG recordings obtained from these participants. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Memory TasksParticipants will be asked to view pictures and videos presented on a computer screen and will be asked to recall the details of presented pictures or videos sometime later. | Other | Invasive EEG (electrodes are implanted in a participant's brain), Normal Controls, Online Controls, Scalp EEG (electrodes are placed on a participant's scalp) |
| Attention/arousal tasksParticipants will be asked to perform a continuous performance task, such as continuous addition of numbers. Additionally, participants may be presented with images and may be asked to rate the significance or arousal values for each image. | Other | Invasive EEG (electrodes are implanted in a participant's brain), Normal Controls, Online Controls, Scalp EEG (electrodes are placed on a participant's scalp) |
| Language tasksParticipants will be asked to view pictures of actions or things and will be asked to name them. Participants may also be asked to read words or passages. | Other | Invasive EEG (electrodes are implanted in a participant's brain), Normal Controls, Online Controls, Scalp EEG (electrodes are placed on a participant's scalp) |
| Visuospatial tasksParticipants will be asked to copy 3 dimensional designs or make judgements of angle size. | Other | Invasive EEG (electrodes are implanted in a participant's brain), Normal Controls, Online Controls, Scalp EEG (electrodes are placed on a participant's scalp) |
| Auditory TasksParticipants will be presented with short, approximately 8-minute clips of music from various genres ( i.e. classical, country, rock, etc.) with an attention task (modified sustained attention to response task) nested within each trial. Participants will receive approximately 8 music stimuli and 1 control stimulus (pink noise) twice over the course of two testing sessions ( 90 mins each). Additionally, participants will be asked to answer questions about their hearing, music preferences/training, and certain demographic information (age, handedness, and language proficiency). | Other | Invasive EEG (electrodes are implanted in a participant's brain), Scalp EEG (electrodes are placed on a participant's scalp) |
| Brain StimulationA brain stimulator will be used to understand new functions of the brain. Participants will be presented with pictures on a computer screen and may be asked to tell researchers what is seen or remembered by participants. As pictures are viewed by the participants, the brain stimulator may be activated, which would not be something that would be felt by an individual participant. | Procedure or surgery | Invasive EEG (electrodes are implanted in a participant's brain) |
| Social Emotional TaskParticipants will be asked to view presented pictures and videos of people engaged in social interaction. Additionally, participants will be presented with the standardized tasks that are designed to help the researchers with understanding the nature of emotions. Some of these images may be emotionally disturbing. If participants are not comfortable viewing such images, they will be asked to refrain from participation in this study. | Other | Invasive EEG (electrodes are implanted in a participant's brain), Normal Controls, Online Controls, Scalp EEG (electrodes are placed on a participant's scalp) |
| Recording of facial expressionsSome participants may be asked permission to record the video of their facial expressions during performance of a research task. Generally, this will include only research tasks investigating brain representation of social/emotional information. Automated analysis of facial expression may be used in certain experiments to provide information on experience of emotional states such as happiness and sadness related to the images being presented. | Other | Invasive EEG (electrodes are implanted in a participant's brain), Normal Controls, Online Controls, Scalp EEG (electrodes are placed on a participant's scalp) |
| Judgement/Impulsivity TaskCertain study participants may be enrolled into research tasks designed to activate regions important for judgment and impulse control. These tasks will present participants with choices of varying monetary rewards and ask them to make judgements to measure one's tendency to prefer immediate over delayed rewards. | Other | Invasive EEG (electrodes are implanted in a participant's brain), Normal Controls, Online Controls, Scalp EEG (electrodes are placed on a participant's scalp) |
Primary outcome
Using scalp and intracranial EEG, measure changes in electrical activity of the human brain associated with memory.
Time frame: Evaluated for each patient during monitoring period of approximately 2 weeks.
Primary objective is to use human intracranial electrophysiology to study localization and function of the human brain. With continuous recording of the electrical activity in participants' brain, study participants will be asked to take part in research tasks involving memory. The researchers will use the information to further the understanding of the exact location of cognitive functions.
Using scalp and intracranial EEG, measure changes in electrical activity of the human brain associated with language.
Time frame: Evaluated for each patient during monitoring period of approximately 2 weeks.
Primary objective is to use human intracranial electrophysiology to study localization and function of the human brain. With continuous recording of the electrical activity in participants' brain, study participants will be asked to take part in research tasks involving language. The researchers will use the information to further the understanding of the exact location of cognitive functions.
Using scalp and intracranial EEG, measure changes in electrical activity of the human brain associated with emotions.
Time frame: Evaluated for each patient during monitoring period of approximately 2 weeks.
Primary objective is to use human intracranial electrophysiology to study localization and function of the human brain. With continuous recording of the electrical activity in participants' brain, study participants will be asked to take part in research tasks involving emotions. The researchers will use the information to further the understanding of the exact location of cognitive functions.
Using scalp and intracranial EEG, measure changes in electrical activity of the human brain associated with movement.
Time frame: Evaluated for each patient during monitoring period of approximately 2 weeks.
Primary objective is to use human intracranial electrophysiology to study localization and function of the human brain. With continuous recording of the electrical activity in participants' brain, study participants will be asked to take part in research tasks involving movement. The researchers will use the information to further the understanding of the exact location of cognitive functions.
Using scalp and intracranial EEG, measure changes in electrical activity of the human brain associated with attention and executive function.
Time frame: Evaluated for each patient during monitoring period of approximately 2 weeks.
Primary objective is to use human intracranial electrophysiology to study localization and function of the human brain. With continuous recording of the electrical activity in participants' brain, study participants will be asked to take part in research tasks involving attention and executive function. The researchers will use the information to further the understanding of the exact location of cognitive functions.
Using scalp and intracranial EEG, measure changes in electrical activity of the human brain associated with sound perception.
Time frame: Evaluated for each patient during monitoring period of approximately 2 weeks.
Primary objective is to use human intracranial electrophysiology to study localization and function of the human brain. With continuous recording of the electrical activity in participants' brain, study participants will be asked to take part in research tasks involving sound perception. The researchers will use the information to further the understanding of the exact location of cognitive functions.
4 secondary outcomes
The degree of correlation between the brain activation and respiratory activity.
Time frame: Evaluated for each patient during monitoring period of approximately 2 weeks.
The degree of correlation between the brain activation and electrodermal activity.
Time frame: Evaluated for each patient during monitoring period of approximately 2 weeks.
Measure the degree of correlation between the brain activation and sweat variations.
Time frame: Evaluated for each patient during monitoring period of approximately 2 weeks.
Measure the degree of correlation between the brain activation and cardiac physiology.
Time frame: Evaluated for each patient during monitoring period of approximately 2 weeks.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 15 Jan 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Krzysztof A Bujarski, MD principal investigator
Dartmouth-Hitchcock Medical Center
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Memory Tasks, Attention/arousal tasks and Language tasks in people with Epilepsy, run by Dartmouth-Hitchcock Medical Center at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 15 Jan 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Krzysztof A Bujarski, MD (603-650-5104, krzysztof.a.bujarski@hitchcock.org), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Using scalp and intracranial EEG, measure changes in electrical activity of the human brain associated with memory. (time frame: Evaluated for each patient during monitoring period of approximately 2 weeks.). The study lists 6 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 15 Jan 2026.