Healthy AgingNCT05550779

What Makes People Better at Retrieving Proper Names?

A study testing Mental Exercise in people with Healthy Aging, run by University of Colorado, Colorado Springs at 1 site in United States.

Completed

Finished. The study has ended and is not enrolling. Results may be posted on the official record.

Official record

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Trial summary

Who is it for?: Ages 18 to 80 years
Conditions the study is for: Healthy Aging
What is being tested?: Mental Exercise
Type of treatment: Lifestyle or therapy programme
Could I receive a placebo?: No, everyone receives an active treatment
How many people: 109 participants
Where: 1 siteUnited States
Study dates: 1 Oct 2022to 26 May 2023
Phase: Interventional
Are there results?: Yes, posted in the registrySummary in the doctors' view

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

Ages 18 to 80 years
All sexes
No healthy volunteers
Adult, Older adult

Who may be able to join

fluent speaker of English
ages 18-35 or 60-80
lived in the United States for at least 5 years

Who cannot join

Trial locations and contacts

1 site in 1 country.

United States1 site

UCCS
Colorado Springs, Colorado, 80918

Other trials in United States

About this study

This study is being conducted to learn more about how various personal and situational characteristics are related to the ability to produce names of pictured people. Participants will perform a brief mental exercise, then see 83 celebrity photographs to produce the names of. Participants will also complete other surveys and measures. Collected data will give researchers a better understanding of how different variables relate to proper name production.

Read the detailed description

This study is being conducted to learn more about how various personal and situational characteristics are related to the ability to produce names of pictured people. Adult participants ages 18-35 and 60-80 will participant in videoconference calls during which they will perform a brief mental exercise, then see 83 celebrity photographs with instructions to name each pictured person. The naming task will be video recorded for later scoring. Participants will also complete other surveys and measures, including some about demographics and other personal characteristics. Participation will take approximately 60-75 minutes. Collected will be de-identified and the aggregate data will give researchers a better understanding about how individual's personality and cognitive traits and the mental exercise performed before the study relate to people's proper name production.

Conditions: Healthy Aging
Being tested: Mental Exercise
Keywords: cognitive aging, name retrieval

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

Mental ExerciseBehavioural
Participant perform a 10-minute mental exercise

Study groups in NCT05550779
Study group	Role	What they receive
Mental Exercise A	Experimental	Participants follow instructions on a 10-minute audio clip Receives: Behavioral: Mental Exercise
Mental Exercise B	Active comparator	Participants follow instructions on a 10-minute audio clip Receives: Behavioral: Mental Exercise

What is being measured

The primary outcome is the main question the study is designed to answer.

Percent of Familiar Faces With TOT Responses
Percent of trials with name retrieval failures were measured on a task created for this purpose. Specifically, participants tried to provide names that fit photographs, indicating when a name got stuck on the "tip of their tongue" by saying "TOT."
Measured: During the 60-75 minute experimental session
Percent of Known Names With TOT Responses
Percent of trials with name retrieval failures were measured on a task created for this purpose. Specifically, participants tried to provide names that fit photographs, indicating when a name got stuck on the "tip of their tongue" by saying "TOT." These percentages are out of correct and TOT responses only.
Measured: During the 60-75 minute experimental session
Percent of Unknown Names With TOT Responses
Percent of trials with name retrieval failures were measured on a task created for this purpose. Specifically, participants tried to provide names that fit photographs, indicating when a name got stuck on the "tip of their tongue" by saying "TOT." These percentages are out of all responses that are not correct or TOTs only.
Measured: During the 60-75 minute experimental session

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

1 Oct 202226 May 2023

First posted22 Sep 2022
Study start1 Oct 2022
Primary completion26 May 2023
Study completion26 May 2023

Resources

Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
Posted resultsParticipant flow, outcome measures and adverse events reported by the sponsor.
Other trials for Healthy AgingStudies of the same condition, open and under way.
What the trial phases meanHow a treatment moves from first tests in people to approval.

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design

Study type: Interventional
Phase: Phase N/A
Primary purpose: Basic science
Allocation: Randomised
Intervention model: Parallel groups
Model description: Participants are randomly assigned to one of two mental exercises before performing a proper name production task and completing other measures.
Masking: Single blind
Who is masked: Participant
Enrolment: 109 participants (actual)

IDs, dates and publications

ClinicalTrials.gov ID: NCT05550779
Sponsor's protocol ID: 2023-023
Other IDs: R15AG063111-01
Status last verified: Sep 2024
First submitted: 19 Sep 2022
Last updated: 19 Sep 2024
Results posted: Yes, on ClinicalTrials.gov
Data monitoring committee: No
FDA-regulated drug: No
FDA-regulated device: No
Individual data sharing: No: De-identified participant data may be posted on a website for open access to other researchers, if the publication outlet requires it. But I do not currently plan to share the data

Want to know more?

The sponsor has not listed a contact. The official record may have more details.

Talk to your doctor first and take this page with you. Only the study team can confirm whether you can join.

Questions to ask the study team

What is the study trying to find out?
What would I need to do, and how often would I visit?
Could I receive a placebo instead of the treatment?
What are the possible risks and benefits for me?
Will it cost me anything? Are travel or time paid for?
Can I keep seeing my own doctor during the study?
What happens when the study ends?

See locations

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Study at a glance

From the registry record, last updated by the sponsor on 19 Sep 2024. Recruitment status is as the sponsor reported it: confirm with the study team.

Official title: What Makes People Better at Retrieving Proper Names?
ClinicalTrials.gov ID: NCT05550779
Acronym / sponsor ID: 2023-023
Conditions: Healthy Aging
Keywords: cognitive aging, name retrieval
Study type: Interventional
Recruitment status: Completed
Enrolment: 109 participants (actual)
Lead sponsor: University of Colorado, Colorado SpringsUniversity, hospital or other
Collaborators: National Institute on Aging (NIA)
Study start: 1 Oct 2022 (actual)
Primary completion: 26 May 2023 (actual)
Study completion: 26 May 2023 (actual)
First posted: 22 Sep 2022 (actual)
Results: Posted 19 Sep 2024

Clinical summary

The research question as the sponsor registered it. This describes what the study plans to test, not what it found.

Detailed description

Study design

Primary purpose: Basic science
Allocation: Randomised
Intervention model: Parallel groups
Masking: Single blind (participant)
Number of arms: 2
Model description: Participants are randomly assigned to one of two mental exercises before performing a proper name production task and completing other measures.

Arm	Type	Receives
Mental Exercise A	Experimental	Behavioral: Mental ExerciseParticipants follow instructions on a 10-minute audio clip
Mental Exercise B	Active comparator	Behavioral: Mental ExerciseParticipants follow instructions on a 10-minute audio clip

Who may qualify

Ages: 18 to 80 years
Sex: All
Healthy volunteers: Not accepted
Age groups: Adult, Older adult

Key inclusion criteria (3 listed)

fluent speaker of English
ages 18-35 or 60-80
lived in the United States for at least 5 years

Key exclusion criteria (1 listed)

Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.

Interventions

Intervention	Type	Arms
Mental ExerciseParticipant perform a 10-minute mental exercise	Behavioural	Mental Exercise A, Mental Exercise B

Primary outcome

Percent of Familiar Faces With TOT Responses
Time frame: During the 60-75 minute experimental session
Percent of trials with name retrieval failures were measured on a task created for this purpose. Specifically, participants tried to provide names that fit photographs, indicating when a name got stuck on the "tip of their tongue" by saying "TOT."
Percent of Known Names With TOT Responses
Time frame: During the 60-75 minute experimental session
Percent of trials with name retrieval failures were measured on a task created for this purpose. Specifically, participants tried to provide names that fit photographs, indicating when a name got stuck on the "tip of their tongue" by saying "TOT." These percentages are out of correct and TOT responses only.
Percent of Unknown Names With TOT Responses
Time frame: During the 60-75 minute experimental session
Percent of trials with name retrieval failures were measured on a task created for this purpose. Specifically, participants tried to provide names that fit photographs, indicating when a name got stuck on the "tip of their tongue" by saying "TOT." These percentages are out of all responses that are not correct or TOTs only.

Results and safety

Results posted to the registry on 19 Sep 2024, as reported by the sponsor. Figures are copied from the record, not re-analysed. Full results on ClinicalTrials.gov.

Participant flow

Group	Started	Completed
Mental Exercise: Intervention	54	54
Mental Exercise: Control	55	55

Primary outcome: Percent of Familiar Faces With TOT Responses

Time frame: During the 60-75 minute experimental session. Mean (Standard Deviation). Unit: Percent of familiar faces with TOTs

Measure	Mental Exercise: Intervention n = 51	Mental Exercise: Control n = 51
Young Adults	16 (14)	15 (9)
Older Adults	18 (14)	15 (12)

Population analysed: Some participants completed the experiment but their data were not included due to having distractions present during testing (e.g., another individual interrupting the participant), experiencing a terrible internet connection during testing, being uncomfortable with turning on their video during testing, and not meeting the age inclusion criteria after initially claiming that they did.

Primary outcome: Percent of Known Names With TOT Responses

Time frame: During the 60-75 minute experimental session. Mean (Standard Deviation). Unit: Percent of known names with TOTs

Measure	Mental Exercise: Intervention n = 51	Mental Exercise: Control n = 51
Young Adults	15 (9)	16 (14)
Older Adults	15 (12)	18 (14)

Primary outcome: Percent of Unknown Names With TOT Responses

Time frame: During the 60-75 minute experimental session. Mean (Standard Deviation). Unit: Percent of unknown names with TOTs

Measure	Mental Exercise: Intervention n = 51	Mental Exercise: Control n = 51
Young Adults	41 (22)	37 (25)
Older Adults	39 (25)	34 (20)

Adverse events

Time frame: 1.25 hour experimental session. Other adverse events reported at 0% frequency or more

Group	Serious adverse events	Other adverse events	Deaths
Mental Exercise: Intervention	0 of 54 (0%)	0 of 54 (0%)	0 of 54
Mental Exercise: Control	0 of 55 (0%)	0 of 55 (0%)	0 of 55

Loading the posted results from ClinicalTrials.gov…

Research links

Official record on ClinicalTrials.govLast updated by the sponsor 19 Sep 2024.
Posted resultsParticipant flow, baseline, all outcome measures and adverse events.
Individual participant dataSharing planned: No. De-identified participant data may be posted on a website for open access to other researchers, if the publication outlet requires it. But I do not currently plan to share the data

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Referral and contact

AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.

Lori James, PhD principal investigator

University of Colorado, Colorado Springs

1 site in 1 country: see every site and its status.

Questions about this trial

What is this clinical trial studying?

A study testing Mental Exercise in people with Healthy Aging, run by University of Colorado, Colorado Springs at 1 site in United States.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 3 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: finished, as of the sponsor's last update on 19 Sep 2024. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

Yes. Results are posted in the registry (first posted 19 Sep 2024). A summary is in the For doctors view, and the full results are on ClinicalTrials.gov.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Percent of Familiar Faces With TOT Responses (time frame: During the 60-75 minute experimental session). The study lists 3 primary outcomes in all. It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT05550779.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 19 Sep 2024.