Post Activation PotentiationNCT05606276
Effects of Eccentric Potentiation Activation on Muscle Function
A study testing Eccentric Exercise and Cycle ergometer in people with Post Activation Potentiation, run by Brennan Thompson at 1 site in United States.
Trial summary
The purpose of this study is to examine the potentiation effects of 2 sets of multi-joint eccentric overload maximal contractions on muscle function. Read more about this study
- Who is it for?
- Ages 18 to 30 yearsHealthy volunteers can take part
- Conditions the study is for
- Post Activation Potentiation
- What is being tested?
- Eccentric Exercise and Cycle ergometer
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 0 participants
- Where
- 1 siteUnited States
- Study dates
- 1 Nov 2022to 1 Mar 2024
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 30 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- 18 - 30 years old
- strength train lower body 1-3 times per week
Who cannot join
- lower body surgery or injury in the last 12 months
- have any neuromuscular disease
- height >76 inches tall
- height <54 inches tall
- eccentric strength greater than 725 pounds
- pregnant or plan to be pregnant in the duration of the protocol
Show all 9Show fewer
- don't do resistance exercise at least once per week
- perform intense cardio or strength training >4 days per week
- Present with any other significant comorbid conditions that would impair the ability to participate in the exercise-based testing
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Effects of Multi-joint Eccentric Potentiation Maximal Contractions on Muscle Function
The purpose of this study is to examine the potentiation effects of 2 sets of multi-joint eccentric overload maximal contractions on muscle function.
- Conditions
- Post Activation Potentiation
- Being tested
- Eccentric Exercise, Cycle ergometer
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Eccentric ExerciseOther
Individuals will do a randomized crossover intervention involving maximal eccentric contractions (2 sets of 6 per leg; experimental condition)
Cycle ergometerOther
Individuals will do a randomized crossover intervention involving cycling (active control) exercise
| Study group | Role | What they receive |
|---|---|---|
| Cycling exercise | Active comparator | Cycling on a cycle ergometer instead of doing the experimental eccentric exercise. Receives: Other: Cycle ergometer |
| Eccentric exercise | Experimental | Perform 2 sets of maximal eccentric contractions as the single session exercise intervention. Receives: Other: Eccentric Exercise |
What is being measured
The primary outcome is the main question the study is designed to answer.
Vertical Jump
3 countermovement vertical jumps, with 30 seconds of rest between attempts
Measured: Baseline (pretest)
Vertical Jump
3 countermovement vertical jumps, with 30 seconds of rest between attempts
Measured: Immediately post intervention
Vertical Jump
3 countermovement vertical jumps, with 30 seconds of rest between attempts
Measured: 12 minutes post intervention
Vertical Jump
3 countermovement vertical jumps, with 30 seconds of rest between attempts
Measured: 20 minutes post intervention
Isokinetic eccentric maximal strength
Maximal eccentric strength on the Eccentron machine. 2 repetitions per time point
Measured: Baseline (pretest)
Isokinetic eccentric maximal strength
Maximal eccentric strength on the Eccentron machine. 2 repetitions per time point
Measured: Immediately post intervention
Isokinetic eccentric maximal strength
Maximal eccentric strength on the Eccentron machine. 2 repetitions per time point
Measured: 12 minutes post intervention
Isokinetic eccentric maximal strength
Maximal eccentric strength on the Eccentron machine. 2 repetitions per time point
Measured: 20 minutes post intervention
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted4 Nov 2022
- Study start1 Nov 2022
- Primary completion1 Mar 2024
- Study completion1 Mar 2024
Why it stopped: Student researcher graduated and study will not be done.
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Post Activation PotentiationStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Crossover
- Model description
- Following a familiarization session, subjects will be assigned to an order for performing both an eccentric and a cycle (sham) session (i.e., crossover design, the order being randomized). These will be performed 3-7 days apart.
- Masking
- Single blind
- Who is masked
- Investigator
- Enrolment
- 0 participants (actual)
Sponsor and investigators
- Lead sponsor
- Brennan Thompson
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor-investigator, Brennan Thompson, Utah State University
- Investigators
- Brennan J Thompson, PhD, Principal investigator, Utah State University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05606276
- Sponsor's protocol ID
- 12042c
- Status last verified
- Apr 2024
- First submitted
- 24 Oct 2022
- Last updated
- 23 Apr 2024
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Study at a glance
From the registry record, last updated by the sponsor on 23 Apr 2024. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effects of Multi-joint Eccentric Potentiation Maximal Contractions on Muscle Function
- ClinicalTrials.gov ID
- NCT05606276
- Acronym / sponsor ID
- 12042c
- Conditions
- Post Activation Potentiation
- Study type
- Interventional
- Recruitment status
- WithdrawnReason stopped: Student researcher graduated and study will not be done.
- Enrolment
- 0 participants (actual)
- Lead sponsor
- Brennan ThompsonUniversity, hospital or other
- Study start
- 1 Nov 2022 (actual)
- Primary completion
- 1 Mar 2024 (actual)
- Study completion
- 1 Mar 2024 (actual)
- First posted
- 4 Nov 2022 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The purpose of this study is to examine the potentiation effects of 2 sets of multi-joint eccentric overload maximal contractions on muscle function.
Study design
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- Single blind (investigator)
- Number of arms
- 2
- Model description
- Following a familiarization session, subjects will be assigned to an order for performing both an eccentric and a cycle (sham) session (i.e., crossover design, the order being randomized). These will be performed 3-7 days apart.
| Arm | Type | Receives |
|---|---|---|
| Cycling exercise | Active comparator | Other: Cycle ergometerCycling on a cycle ergometer instead of doing the experimental eccentric exercise. |
| Eccentric exercise | Experimental | Other: Eccentric ExercisePerform 2 sets of maximal eccentric contractions as the single session exercise intervention. |
Who may qualify
- Ages
- 18 to 30 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (2 listed)
- 18 - 30 years old
- strength train lower body 1-3 times per week
Key exclusion criteria (9 listed)
- lower body surgery or injury in the last 12 months
- have any neuromuscular disease
- height >76 inches tall
- height <54 inches tall
- eccentric strength greater than 725 pounds
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Eccentric ExerciseIndividuals will do a randomized crossover intervention involving maximal eccentric contractions (2 sets of 6 per leg; experimental condition) | Other | Eccentric exercise |
| Cycle ergometerIndividuals will do a randomized crossover intervention involving cycling (active control) exercise | Other | Cycling exercise |
Primary outcome
Vertical Jump
Time frame: Baseline (pretest)
3 countermovement vertical jumps, with 30 seconds of rest between attempts
Vertical Jump
Time frame: Immediately post intervention
3 countermovement vertical jumps, with 30 seconds of rest between attempts
Vertical Jump
Time frame: 12 minutes post intervention
3 countermovement vertical jumps, with 30 seconds of rest between attempts
Vertical Jump
Time frame: 20 minutes post intervention
3 countermovement vertical jumps, with 30 seconds of rest between attempts
Isokinetic eccentric maximal strength
Time frame: Baseline (pretest)
Maximal eccentric strength on the Eccentron machine. 2 repetitions per time point
Isokinetic eccentric maximal strength
Time frame: Immediately post intervention
Maximal eccentric strength on the Eccentron machine. 2 repetitions per time point
Isokinetic eccentric maximal strength
Time frame: 12 minutes post intervention
Maximal eccentric strength on the Eccentron machine. 2 repetitions per time point
Isokinetic eccentric maximal strength
Time frame: 20 minutes post intervention
Maximal eccentric strength on the Eccentron machine. 2 repetitions per time point
Results and safety
The study was withdrawn before enrolling participants, so there are no results.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 23 Apr 2024.
- Individual participant dataSharing planned: Undecided
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Athletes, Post Activation Potentiation
Active, not recruiting
Post-activation Performance Enhancement in Soccer Players:
Performance, Post Activation Potentiation
Active, not recruiting
Post-Activation Performance Enhancement in Single and Multi-Joint Exercises With BFR and EMS in Male Volleyball Players
Volleyball Players, Post Activation Potentiation
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Brennan J Thompson, PhD principal investigator
Utah State University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Eccentric Exercise and Cycle ergometer in people with Post Activation Potentiation, run by Brennan Thompson at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 9 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: withdrawn, as of the sponsor's last update on 23 Apr 2024. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study was withdrawn before enrolling participants, so there are no results.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Vertical Jump (time frame: Baseline (pretest)). The study lists 8 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 23 Apr 2024.