AzTrials
AzTrials

Heart FailurePhase 3HERMESNCT05636176

A Research Study to Look at How Ziltivekimab Works Compared to Placebo in People With Heart Failure and Inflammation

A Phase 3 study testing Ziltivekimab in people with Heart Failure, run by Novo Nordisk A/S at 1,013 sites in 46 countries.

Terminated

Stopped early. The study ended before it was planned to and will not resume.

Official record
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Trial summary

This study will be done to see if ziltivekimab can be used to treat people living with heart failure and inflammation. Participants will either get ziltivekimab or placebo. Participants will get study medicine for once-monthly injections either in a pre-filled syringe to inject the study medicine into a skinfold or a… Read more about this study

Who is it for?
Ages 18 years and older
Conditions the study is for
Heart Failure
What is being tested?
Ziltivekimab
Type of treatment
Injection or infusion
Could I receive a placebo?
Yes, some participants may receive a placebo
How many people
4,874 participants
Where
1,013 sitesin 46 countries
Study dates
8 May 2023to 3 Sep 2026
Phase
Phase 3
Are there results?
None posted in the registry

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 18 years and older
  • All sexes
  • No healthy volunteers
  • Adult, Older adult

Who may be able to join

  • Serum high-sensitivity C-reactive protein (hs-CRP) greater than equal to 2 milligrams per liter (mg/L) at screening (visit 1) Disease specific - cardiovascular
  • At least one of the following:
  • N-terminal-pro-brain natriuretic peptide (NT-proBNP) greater than equal to 300 picograms per milliliter (pg/mL) at screening (Visit 1) for patients without ongoing atrial fibrillation/flutter. If ongoing atrial fibrillation/flutter at screening (visit 1), NTproBNP must be greater than equal to 600 pg/mL. Note that the screening electrocardiogram (ECG) must be obtained the same day as sampling for NT-proBNP.
  • Hospitalisation or urgent/unplanned visit with a primary diagnosis of decompensated heart failure which required intravenous loop diuretic treatment, within the last 9 months prior to screening (visit 1) in combination with NT-proBNP greater than equal to 200 pg/mL at screening (Visit 1) for patients without ongoing atrial fibrillation/flutter. If ongoing atrial fibrillation/flutter at screening (visit 1), NT-proBNP must be greater than equal to 600 pg/mL.
  • Diagnosis of heart failure (New York Heart Association [classification] [NYHA] Class II-IV).
  • Left ventricular ejection fraction (LVEF) greater than 40 percentage (%) documented by echocardiography within 12 months prior to or at screening (visit 1). The LVEF must be documented in medical records and the most recent measurement must be used to determine eligibility with no interim event signalling potential deterioration in ejection fraction (e.g., myocardial infarction [MI] or heart failure [HF] hospitalisation).
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  • Structural heart disease and/or functional heart disease documented by echocardiography within 12 months prior to or at screening (visit 1) showing at least one of the following:
  • Left atrial (LA) volume index greater than 34 milliliters per meter square (mL/m^2).
  • LA diameter greater than equal to 3.8 centimeters (cm).
  • LA length greater than equal to 5.0 cm.
  • LA area greater than equal to 20 cm square.
  • LA volume greater than equal to 55 milliliters (mL).
  • Intraventricular septal thickness greater than equal to 1.1 cm.
  • Posterior wall thickness greater than equal to 1.1 cm.
  • Left ventricular (LV) mass index greater than equal to 115 grams per meter square (g⁄m^2 ) in men or greater than equal to 95 g⁄m^2 in women.
  • E/e' (mean septal and lateral) greater than equal to 10.
  • e' (mean septal and lateral) less than 9 centimeter per second (cm/s).
  • No heart failure hospitalisations or urgent heart failure visits between screening (visit 1) and randomisation (visit 2).

Who cannot join

  • Medical conditions - cardiovascular
  • Myocardial infarction, stroke, unstable angina pectoris, transient ischaemic attack, or heart failure hospitalisation, within 30 days prior to screening (visit 1).
  • Systolic blood pressure greater than equal to 180 millimeters of mercury (mmHg) at screening (visit 1). If the systolic blood pressure is 160-179 mmHg, the patient should be receiving greater than equal to 3 antihypertensive drugs. (Note: Potential participants may be retested for this criterion within the visit window and without rescreening, at the discretion of the investigator).
  • Heart rate above 110 or below 40 beats per minute as evaluated on the electrocardiogram (ECG) performed at screening (visit 1) (Note: Potential participants may be retested for this criterion within the visit window and without rescreening, at the discretion of the investigator).
  • Planned coronary, carotid or peripheral artery revascularisation known during the screening period (visit 1). (Note: Planned coronary angiogram is not exclusionary).
  • Planned cardiac device or atrial flutter/atrial fibrillation ablation procedure known during the screening period (visit 1).
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  • Major cardiac surgical, non-cardiac surgical, or major endoscopic procedure (thoracoscopic or laparoscopic) within the past 60 days prior to randomisation (visit 2) or any major surgical procedure planned at the time of randomisation (visit 2).
  • Heart failure due to infiltrative cardiomyopathy (e.g., sarcoid, amyloid), arrhythmogenic right ventricular cardiomyopathy, Takutsubo cardiomyopathy, genetic hypertrophic cardiomyopathy or obstructive cardiomyopathy, active myocarditis, constrictive pericarditis, cardiac tamponade, uncorrected more than moderate primary valve disease.
  • Primary pulmonary hypertension, chronic pulmonary embolism, severe pulmonary disease including COPD.
  • Any other condition judged by the investigator that could account for heart failure symptoms and signs (e.g., anaemia, hypothyroidism).
  • Medical conditions - infections/immunosuppression
  • Clinical evidence of, or suspicion of, active infection at the discretion of the investigator.

Trial locations and contacts

1,013 sites in 46 countries.

1013 sites in 46 countries

United States172 sites

  • Capital Cardiology Associates_Albany

    Albany, New York, 12211

  • Advanced Cardiovascular, LLC

    Alexander City, Alabama, 35010

  • Cambridge Medical Trials

    Alexandria, Louisiana, 71301

  • InvivoCure -2

    Alhambra, California, 91801

  • Heart MD_Allen TX

    Allen, Texas, 75013

  • PharmaTex Research, LLC

    Amarillo, Texas, 79106

  • University of Michigan Medicine

    Ann Arbor, Michigan, 48109

  • Endeavor Health Clinical Operations-NCH

    Arlington Heights, Illinois, 60005

  • Morehouse School of Medicine

    Atlanta, Georgia, 30310

  • Emory University School of Medicine_Atlanta

    Atlanta, Georgia, 30322

  • Rocky Mountain Regional VAMC

    Aurora, Colorado, 80045

  • Austin Heart

    Austin, Texas, 78756

  • Ascension Saint Agnes Heart Ca

    Baltimore, Maryland, 21229

  • Johns Hopkins University_Baltimore

    Baltimore, Maryland, 21287

  • National Heart Institute Cal

    Beverly Hills, California, 90211

  • LOUISIANA HEART Center

    Bogalusa, Louisiana, 70427

  • Bridgeport Hospital

    Bridgeport, Connecticut, 06610

  • Advanced Heart Care LLC

    Bridgewater, New Jersey, 08807-3064

  • University at Buffalo_Erie County Med Ctr

    Buffalo, New York, 14215

  • University of Vermont Med Ctr

    Burlington, Vermont, 05401

  • University of Vermont Medical Center

    Burlington, Vermont, 05401

  • Capital Area Research LLC

    Camp Hill, Pennsylvania, 17011

  • Penn State Hlth Holy Spirit Med Ctr

    Camp Hill, Pennsylvania, 17011

  • Aultman Hospital

    Canton, Ohio, 44710

  • UNC Cardiology Outpatient Ctr

    Chapel Hill, North Carolina, 27599

  • University of Virginia

    Charlottesville, Virginia, 22908

  • James River Cardiology

    Chesterfield, Virginia, 23832

  • Prisma Health-Midlands

    Columbia, South Carolina, 29203

  • Hawthorne Health NC

    Concord, North Carolina, 28025

  • Pioneer Clinical Studies-Coral Gables

    Coral Gables, Florida, 33134

  • Valley Clinical Trials

    Covina, California, 91723

  • Nature Coast Clin Rsrch_Crystal River

    Crystal River, Florida, 34429

  • UTD SW Medical Center-Dallas

    Dallas, Texas, 75390

  • Geisinger Medical Center

    Danville, Pennsylvania, 17822

  • InvivoCure -2

    Denver, Colorado, 80012

  • Detroit Med Center-Wayne State

    Detroit, Michigan, 48201

  • Henry Ford Hlth System_Detroit

    Detroit, Michigan, 48202

  • Hawthorne Health

    Diamondhead, Mississippi, 39525

  • Advocate Good Samaritan

    Downers Grove, Illinois, 60515

  • Dallas Heart and Vascular

    Duncanville, Texas, 75137

  • Duke University

    Durham, North Carolina, 27710

  • David Turbay, MD, PLLC

    El Paso, Texas, 79905

  • Baptist Health Hardin

    Elizabethtown, Kentucky, 42701

  • Midwest Cardiovascu Rsrch Foundation

    Elkhart, Indiana, 46514

  • Heart House_Elmer

    Elmer, New Jersey, 08318

  • Eastern Shore Rsrch Inst, LLC

    Fairhope, Alabama, 36532

  • Virginia Heart

    Falls Church, Virginia, 22042

  • Elite Research Center

    Flint, Michigan, 48532

  • Integrative Research Assoc Inc

    Fort Lauderdale, Florida, 33312

  • Healthy Heart Cardiology

    Grand Rapids, Michigan, 49546

  • Medication Mgmnt, LLC_Grnsboro

    Greensboro, North Carolina, 27405

  • Asha Clinical Rsch-Munster, LLC

    Hammond, Indiana, 46324

  • Heart Clinic of Hammond

    Hammond, Louisiana, 70403

  • Mass General Community Physicians

    Haverhill, Massachusetts, 01830

  • Chicago Medical Research LLC

    Hazel Crest, Illinois, 60429

  • Penn State Hershey Medical Center

    Hershey, Pennsylvania, 17033

  • New Generation of Medical Research

    Hialeah, Florida, 33016

  • Memorial Region Hosp_Hollywood

    Hollywood, Florida, 33021

  • The Queen's Medical Center

    Honolulu, Hawaii, 96817

  • Biopharma Informatic_Houston

    Houston, Texas, 77025

  • Houston Methodist Hospital

    Houston, Texas, 77030-2703

  • Houston Methodist Hospital

    Houston, Texas, 77030

  • Texas Heart Inst Medical Ctr

    Houston, Texas, 77030

  • UT Physicians - Houston Medical Center

    Houston, Texas, 77030

  • Card Specialists of Willowbrook

    Houston, Texas, 77070

  • Heart Center Rsrch_Hunstville

    Huntsville, Alabama, 35801

  • Franciscan Network-IN Heart PHY

    Indianapolis, Indiana, 46237

  • University Of Iowa Hospitals and Clinics

    Iowa City, Iowa, 52242

  • Apex Research Foundation, LLC

    Jackson, Tennessee, 38301

  • The Jackson Clinic, PA

    Jackson, Tennessee, 38305

  • E Coast Inst for Rsrch LLC_Jacksonville

    Jacksonville, Florida, 32204

  • Jacksonville Ctr for Clin Res

    Jacksonville, Florida, 32216

  • Baptist Health Research Institute

    Jacksonville, Florida, 32258

  • NSC Research, Inc

    Johns Creek, Georgia, 30024

  • Logan Health Research

    Kalispell, Montana, 59901

  • Marian David, MD, PC

    Kew Gardens, New York, 11415

  • Tennova HC Turkey Creek MC

    Knoxville, Tennessee, 37934

  • Scripps Memorial Hospital La Jolla

    La Jolla, California, 90237

  • Purushotham & Akther Kotha MD, inc.

    La Mesa, California, 91942

  • Heart Grp_ Lancaster Gen Hlth

    Lancaster, Pennsylvania, 17603

  • Capitol Cardiology Assoc_Lanham

    Lanham, Maryland, 20706

  • Palm Research Center Inc.

    Las Vegas, Nevada, 89128

  • Witham Health Services

    Lebanon, Indiana, 46052

  • The Research Group of Lexington LLC

    Lexington, Kentucky, 40503

  • NJ Heart

    Linden, New Jersey, 07036

  • Cardiology & Medicine Clinic

    Little Rock, Arkansas, 72204

  • S Denver Cardiology Associates

    Littleton, Colorado, 80120

  • Barnabas Health

    Livingston, New Jersey, 07039

  • VA Loma Linda Hlthcr Sys

    Loma Linda, California, 92357

  • Biopharma Clinical Research Services, LLC

    Los Angeles, California, 90035

  • VA Greater Los Angeles Hlthcare System

    Los Angeles, California, 90073

  • VAGrtrLosAngelesHlthcareSystem

    Los Angeles, California, 90073

  • University Of Louisville

    Louisville, Kentucky, 40202

  • Robley Rex VA Medical Center

    Louisville, Kentucky, 40206

  • Baptist Health Louisville

    Louisville, Kentucky, 40207

  • Duke University/Southeastern

    Lumberton, North Carolina, 28358

  • GA Arrhythmia Cons & Rsch Inst

    Macon, Georgia, 31201

  • William S Middleton Mem VA Hosp

    Madison, Wisconsin, 53705

  • Carient Heart and Vascular

    Manassas, Virginia, 20109

  • Fairview Health Services

    Maplewood, Minnesota, 55109

  • K&R Research Llc

    Marion, Ohio, 43302

  • Rama Research LLC

    Marion, Ohio, 43302

  • Texas Institute of Cardiology PA

    McKinney, Texas, 75071

  • St. Luke's Idaho Cardiology Associates

    Meridian, Idaho, 83642

  • Baptist Health South Florida

    Miami, Florida, 33173

  • Pioneer Clinical Studies-Coral Gables

    Miami, Florida, 33176

  • Aurora St. Luke's Medi Ctr

    Milwaukee, Wisconsin, 53215

  • Minneapolis VA Health Care Sys

    Minneapolis, Minnesota, 55417

  • Carteret Medical Group

    Morehead City, North Carolina, 28557

  • WVU Heart & Vascular Institute

    Morgantown, West Virginia, 26506

  • Inspira Health - Cardiology

    Mullica Hill, New Jersey, 08062

  • Cardiovascular Rsrch of NW_IN

    Munster, Indiana, 46321

  • Midwest Cardiovascular Institute

    Naperville, Illinois, 60540

  • NCH Research Institute

    Naples, Florida, 34102

  • University Medical Center New Orleans

    New Orleans, Louisiana, 70112

  • Mount Sinai Hosp at NYC

    New York, New York, 10019

  • NY Presbyt Hosp-W Cornell Med

    New York, New York, 10021

  • Mount Sinai Hosp at NYC

    New York, New York, 10029

  • Harlem Cardiology_Madison ave

    New York, New York, 10035

  • Saint Michael's Med Ctr NJ

    Newark, New Jersey, 07102

  • York Clinical Research LLC

    Norfolk, Virginia, 23504

  • Sentara Health Research Center

    Norfolk, Virginia, 23507

  • Amavita Research Services, LLC

    North Miami Beach, Florida, 33169

  • Valley Clinical Trials, Inc.

    Northridge, California, 91325

  • Ocala Cardiovascular Research

    Ocala, Florida, 34471

  • South Oklahoma Heart Research, LLC

    Oklahoma City, Oklahoma, 73135

  • Univ. of Nebraska Medical Center_Omaha

    Omaha, Nebraska, 68198

  • UCI Health

    Orange, California, 92868

  • Ormond Beach Clinical Research

    Ormond Beach, Florida, 32174

  • Midwest Heart & Vasc Spec

    Overland Park, Kansas, 66211

  • MD Medical Research

    Oxon Hill, Maryland, 20745

  • Stanford Univ School of Med

    Palo Alto, California, 94304

  • OSF HealthCare_Cardiovasc Inst

    Peoria, Illinois, 61614

  • Methodist Medical Center of Illinois

    Peoria, Illinois, 61636

  • Thomas Jefferson University_Philadelphia

    Philadelphia, Pennsylvania, 19114

  • Banner University Medical Ctr

    Phoenix, Arizona, 85006

  • Allegheny Health Network

    Pittsburgh, Pennsylvania, 15212

  • UNC Rex Healthcare

    Raleigh, North Carolina, 27607

  • Monument Health Clinical Rsrch

    Rapid City, South Dakota, 57701

  • Reid Physician Associates

    Richmond, Indiana, 47374

  • Virginia Commonwealth University

    Richmond, Virginia, 23298

  • The Valley Hosptial - Ridgewood

    Ridgewood, New Jersey, 07450

  • The Valley Hosptial

    Ridgewood, New Jersey, 07450

  • Roanoke Heart Institute

    Roanoke, Virginia, 24014

  • Laurelton Heart Specialist PC

    Rosedale, New York, 11422

  • St Johns Ctr Clin Rsch-St. Aug

    Saint Augustine, Florida, 32086

  • VA Medical Center_Salem

    Salem, Virginia, 24153-6404

  • Clinical Advancement Center

    San Antonio, Texas, 78212

  • Audie L. Murphy VA Hospital

    San Antonio, Texas, 78229

  • San Diego Cardiac Center

    San Diego, California, 92123

  • North America Research Institute

    San Dimas, California, 91773

  • Saratoga Clinical Research

    Saratoga Springs, New York, 12866

  • Virginia Mason Medical Center

    Seattle, Washington, 98101

  • Swedish Medical Center_Seattle

    Seattle, Washington, 98122-5789

  • Sherman Clinical Research

    Sherman, Texas, 75092

  • Sanford Health_Sioux Falls

    Sioux Falls, South Dakota, 57117

  • Providence Med Research Ctr

    Spokane, Washington, 99204

  • St Louis Heart & Vascular, P.C.

    St Louis, Missouri, 63136

  • Cardiology Associates of Fairfield County

    Stamford, Connecticut, 06905

  • Manshadi Heart Institute

    Stockton, California, 95204

  • Stony Brook University Hospital

    Stony Brook, New York, 11794

  • Chear Center LLC

    The Bronx, New York, 10455

  • Lundquist Inst-Biomed Innovtn

    Torrance, California, 90502

  • Cardiolg Assoc Rsch LLC_Tupelo

    Tupelo, Mississippi, 38801

  • InvivoCure

    Van Nuys, California, 91405

  • Cardio Partners Clin Res Inst

    Wellington, Florida, 33449

  • Selma Medical Associates

    Winchester, Virginia, 22601-3834

  • Valley Health Link

    Winchester, Virginia, 22601

  • Winter Haven Hospital

    Winter Haven, Florida, 33881

  • Guardian Research Org LLC

    Winter Park, Florida, 32792

  • Penn State Health-Berks Cardiology

    Wyomissing, Pennsylvania, 19610

  • Trinity Health Michigan Heart

    Ypsilanti, Michigan, 48197

Other trials in United States

India59 sites

  • Sardar Vallabhbhai Patel Institute of Medical Sciences and Research

    Ahmedabad, Gujarat, 380006

  • CIMS- Care Institute of Medical Sciences

    Ahmedabad, Gujarat, 380060

  • EPIC Hospital

    Ahmedabad, Gujarat, 380060

  • Marengo Asia Health Care Private Limited

    Ahmedabad, Gujarat, 380060

  • Sardar Vallabhbhai Patel Institute of Medical Sciences and Research

    Ahmedabad, Gujarat, 38006

  • Aligarh Muslim University

    Aligarh, 202002

  • Manipal Hospital, Old Airport Road, Bengaluru

    Bangalore, Karnataka, 560017

  • KLES Dr. Prabhakar Kore Hospital & Medical Research Centre

    Belagavi, Karnataka, 590010

  • Sri Jayadeva Institute of Cardiovascular Sciences & Research

    Bengaluru, Karnataka, 560069

  • Narayana Institute of Cardiac Sciences

    Bengaluru, Karnataka, 560099

  • MS Ramaiah

    Bengaluru, 560054

  • S.P. Medical College and A.G. Hospitals

    Bikaner, Rajasthan, 334003

  • Post Graduate Institute of Medical Education & Research_Chandigarh

    Chandigarh, Punjab, 160012

  • The Madras Medical Mission

    Chennai, Tamil Nadu, 600037

  • Shri Mahant Indiresh Hospital

    Dehradun, Uttarakhand, 248001

  • Lalitha PVS Institute of Medical Sciences

    Guntur, Andhra Pradesh, 522001

  • Lalitha Super Specialities Hospital

    Guntur, Andhra Pradesh, 522001

  • Medanta - The Medicity Multi-Speciality Hospital, Gurugram

    Gurugram, Haryana, 122001

  • GNRC Hospital

    Guwahati, Assam, 781006

  • Osmania General Hospital

    Hyderabad, Telangana, 500 012

  • Osmania General Hospital

    Hyderabad, Telangana, 500012

  • Guru Nanak CARE Hospitals

    Hyderabad, Telangana, 500020

  • AIG Hospitals,Hyderabad

    Hyderabad, Telangana, 500032

  • SMS Medical College & Attached Hospitals

    Jaipur, Rajasthan, 302001

  • SMS Medical College & Attached Hospitals

    Jaipur, Rajasthan, 302004

  • All India Institute of Medical Sciences (AIIMS), Jodhpur

    Jodhpur, Rajasthan, 342005

  • All India Institute of Medical Sciences (AIIMS)

    Jodhpur, Rajasthan, 342005

  • KLE's Dr. Prabhakar Kore Hospital & Medical Research Centre

    Karnataka, 590010

  • Lisie Hospital

    Kochi, Kerala, 682018

  • Amrita Institute of Medical Sciences

    Kochi, Kerala, 682041

  • IPGME&R and SSKM Hospital

    Kolkata, West Bengal, 700020

  • Government Medical College, Kozhikode

    Kozhikode, Kerala, 673008

  • King George's Medical University (KGMU)

    Lucknow, Uttar Pradesh, 226003

  • Dayanand Medical College & Hospital

    Ludhiana, Punjab, 141001

  • Deep Healthcare Private Limited.

    Ludhiana, Punjab, 141002

  • Fortis Hospital, Mohali

    Mohali, Punjab, 160062

  • Seth GS medical college and KEM Hospital

    Mumbai, Maharashtra, 400012

  • Government Medical College and Super Speciality Hospital, Nagpur

    Nagpur, Maharashtra, 440003

  • Arneja Heart & Multispeciality Hospital

    Nagpur, Maharashtra, 440010

  • Shri Krishna Hrudayalaya & Critical Care Centre

    Nagpur, Maharashtra, 440012

  • Sengupta Hospital and Research Institute

    Nagpur, Maharashtra, 440033

  • VMMC & Safdarjung Hospital

    New Dehli, New Delhi, 110029

  • G B Pant Institute of Postgraduate Medical Education and Research

    New Delhi, National Capital Territory of Delhi, 110002

  • Fortis Escorts Heart Institute, New Delhi

    New Delhi, National Capital Territory of Delhi, 110025

  • All India Institute of Medical Sciences (AIIMS)

    New Delhi, National Capital Territory of Delhi, 110029

  • Dr B L Kapur Memorial Hospital

    New Delhi, 110055

  • Sir Ganga Ram Hospital-Cardiology

    New Delhi, 110060

  • Aakash Healthcare Super Speciality Hospital

    New Delhi, 110075

  • Lakshmi Hospital

    Palakkad, 678013

  • JIPMER

    Puducherry, 605006

  • B J Goverment Medical College and Sassoon General Hospital

    Pune, Maharashtra, 411001

  • Jehangir Clinical Development Centre

    Pune, Maharashtra, 411001

  • Sahyadri Clinical Research And Development Center

    Pune, Maharashtra, 411004

  • KEM Hospital

    Pune, Maharashtra, 411011

  • Shri B. D. Mehta Mahavir Heart Institute

    Surat, Gujarat, 395001

  • Nirmal Hospital Pvt. Ltd.

    Surat, Gujarat, 395002

  • Rhythm Heart Institute

    Vadodara, Gujarat, 390022

  • Government Siddhartha Medical College & Government General Hospital, Vijayawada

    Vijayawada, Andhra Pradesh, 520008

  • Ramesh Hospitals

    Vijayawada, Andhra Pradesh, 520008

Other trials in India

China54 sites

  • Beijing Anzhen Hospital, Capital Medical University

    Beijing, Beijing Municipality, 100029

  • China-Japan Friendship Hospital

    Beijing, Beijing Municipality, 100029

  • Chinese Academy of Medical Sciences Fuwai Hospital

    Beijing, Beijing Municipality, 100037

  • Peking University Third Hospital-Cardiology

    Beijing, Beijing Municipality, 100191

  • China-Japan Union Hospital of Jilin University-Cardiology

    Changchun, Jilin, 130033

  • Jilin Province People's Hospital-Cardiology

    Changchun, Jilin, 130499

  • The Third Xiangya Hospital of Central South University

    Changsha, Hunan, 410013

  • Changsha Central Hospital

    Changsha, Hunan, 410028

  • Changzhou No.2 People's Hospital, Yanghu Branch

    Changzhou, Jiangsu, 213003

  • The First People's Hospital of Changzhou

    Changzhou, Jiangsu, 213004

  • The First Affiliated Hospital of Chongqing Medical University-Cardiology

    Chongqing, Chongqing Municipality, 400042

  • The Second Affiliated Hospital of Chongqing Medical University

    Chongqing, Chongqing Municipality, 400060

  • Chongqing University Three Gorges Hospital

    Chongqing, Chongqing Municipality, 404000

  • Chongqing University Three Gorges Hospital

    Chongqing, 404000

  • Sun Yat-sen Memorial Hospital, Sun Yat-sen University

    Guangzhou, Guangdong, 510120

  • Sun Yat-sen Memorial Hospital, Sun Yat-sen Universtiy

    Guangzhou, Guangdong, 510120

  • The First Affiliated Hospital of Jinan University

    Guangzhou, Guangdong, 510630

  • Hainan General Hospital

    Haikou, Hainan, 570311

  • The First Affiliated Hospital, Zhejiang University School of Medicine

    Hangzhou, Zhejiang, 310003

  • Zhejiang Provincial People's Hospital

    Hangzhou, Zhejiang, 310014

  • The First Affiliated Hospital of Harbin Medical University-Cardiovascular

    Harbin, Heilongjiang, 150001

  • Huai'an First People's Hospital, Nanjing Medical University

    Huai'an, Jiangsu, 223300

  • The First Hospital of Anhui University of Science & Technology (Huainan First People's Hospital)-Cardiology

    Huainan, Anhui, 232007

  • The Affiliated Hospital of Jining Medical University-Cardiology

    Jining, Shandong, 272029

  • The Second Hospital & Clinical Medical School, Lanzhou University-Internal Medicine & Cardiovascular

    Lanzhou, Gansu, 730030

  • Lishui People's Hospital-Cardiology

    Lishui, Zhejiang, 323000

  • Lishui People's Hospital

    Lishui, Zhejiang, 323000

  • Mianyang Central Hospital-Cardiology

    Mianyang, Sichuan, 621000

  • The Second Affiliated Hospital of Nanchang University-Cardiology

    Nanchang, Jiangxi, 330006

  • Zhongda Hospital Southeast University

    Nanjing, Jiangsu, 210009

  • The Second Affiliated Hospital of Nanjing Medical University

    Nanjing, Jiangsu, 210011

  • The People's Hospital of Guangxi Zhuang Autonomous Region

    Nanning, Guangxi, 530021

  • Shanghai Xuhui Central Hospital

    Shanghai, Shanghai Municipality, 200031

  • Huashan Hospital Fudan University

    Shanghai, Shanghai Municipality, 200040

  • Tongji Hospital of Tongji University-Cardiology

    Shanghai, Shanghai Municipality, 200065

  • Shanghai Xuhui Central Hospital

    Shanghai, 20031

  • The Second Affiliated Hospital of Shantou University Medical College-Cardiovascular

    Shantou, Guangdong, 515041

  • The People's Hospital of Liaoning Province-Cardiology

    Shenyang, Liaoning, 110016

  • Shenzhen People's Hospital

    Shenzhen, Guangdong, 518020

  • The First Hospital of Hebei Medical University-Cardiovascular

    Shijiazhuang, Hebei, 050023

  • Hebei General Hospital

    Shijiazhuang, Hebei, 050051

  • Siping City Central People's Hospital-Cardiology

    Siping, Jilin, 136000

  • The First Affiliated Hospital of Soochow University

    Suzhou, Jiangsu, 215000

  • Tianjin Union Medical Center

    Tianjin, Tianjin Municipality, 300121

  • Tianjin Chest Hospital

    Tianjin, Tianjin Municipality, 300222

  • The First Affiliated Hospital of WMU-Cardiology

    Wenzhou, Zhejiang, 325000

  • Wuhan Asia Heart Hospital-Department of Cardiovascular

    Wuhan, Hubei, 430022

  • Renmin Hospital of Wuhan University-Cardiology

    Wuhan, Hubei, 430060

  • The First Affiliated Hospital of Xi'an JiaoTong University-Cardiovascular

    Xi'an, Shaanxi, 710061

  • Shaanxi Provincial People's Hospital-Cardiology

    Xi'an, Shaanxi, 710068

  • The Affiliated Hospital of Xuzhou Medical University-Cardiology

    Xuzhou, Jiangsu, 221002

  • Northern Jiangsu People's Hospital

    Yangzhou, Jiangsu, 225001

  • General Hospital of Ningxia Medical University

    Yinchuan, Ningxia, 750004

  • The Affiliated Hospital of Jiangsu University

    Zhenjiang, Jiangsu, 212001

Other trials in China

Japan53 sites

  • The Univ. of Tokyo Hp., Dept. of Cardiovascular Medicine

    Bunkyo-ku, Tokyo, 113-8655

  • Hamanomachi Hospital_Cardiovascular medicine

    Fukuoka, 810-8539

  • Kyushu University Hospital_Cardiovascular Medicine

    Fukuoka, 812-8582

  • Fukuoka University Hospital_Cardiology

    Fukuoka-shi, Fukuoka, 814-0133

  • Ogaki Municipal Hospital_Cardiology

    Gifu, 503-8502

  • JA Shizuoka Kohseiren Enshu Hospital_Internal Medicine

    Hamamatsu-shi, Shizuoka, 430-0929

  • Hyogo Prefectural HarimaHimeji General Medical Center_Cardiology

    Himeji-shi, Hyogo, 670-8560

  • Asahikawa-Kosei General Hospital_Cardiology

    Hokkaido, 078-8211

  • Veritas Hospital_Cardiology

    Hyōgo, 665-0125

  • National Hospital Organization Mito Medical Center_Cardiovascular medicine

    Ibaraki, 311-3193

  • Saiseikai Imabari Hospital_Cardiology

    Imabari-shi, Ehime, 799-1592

  • Saiseikai Imabari Hospital

    Imabari-shi, Ehime, 799-1592

  • Ishikawa Prefectural Central Hospital_Cardiology

    Ishikawa, 920-8530

  • Mitoyo General Hospital_Cardiovascular medicine

    Kagawa, 769-1695

  • Kagoshima City Hospital_Cardiovascular Medicine

    Kagoshima, 890-8760

  • Yokohama Minami Kyousai Hospital_Cardiology

    Kanagawa, 236-0037

  • Kanagawa Prefectural Hospital Organization Kanagawa Cardiovascular and Respiratory Center_Cardiology

    Kanagawa, 236-0051

  • Tokai University Hospital_Cardiology

    Kanagawa, 259-1193

  • Kishiwada Tokushukai Hospital_Cardiology

    Kishiwada-shi, Osaka, 596-0042

  • Japan Community Health care Organization Kyushu Hospital_Cardiology

    Kitakyushu-shi, Fukuoka, 806-8501

  • JCHO Kyushu Hospital_Cardiology

    Kitakyushu-shi, Fukuoka, 806-8501

  • Rakuwakai Marutamachi Hospital_Cardiology

    Kyoto, 604-8401

  • Kyoto University Hospital_Cardiovascular Medicine

    Kyoto, 606-8507

  • Mie Prefectural General Medical Center_Cardiology

    Mie, 510-8561

  • KKR Tohoku Kosai Hospital_Cardiology

    Miyagi, 980-0803

  • Tohoku Medical and Pharmaceutical University Hospital_Division of Cardiology

    Miyagi, 983-8512

  • National Hospital Organization Sendai Medical Center_Cardiovascular medicine

    Miyagi, 983-8520

  • Iwate Prefectural Central Hospital_Cardiology

    Morioka-shi, Iwate, 020-0066

  • Iwate Prefectural Central Hospital

    Morioka-shi, Iwate, 020-0066

  • Nagasaki Harbor Medical Center_Cardiovascular medicine

    Nagasaki, 850-8555

  • Okayama City General Medical Center Okayama City Hospital_Cardiovascular Medicine

    Okayama, 700-8557

  • Okayama Medical Center_Cardiology

    Okayama, 701-1154

  • Okayama University Hospital_Cardiovascular Medicine

    Okayama-shi, Okayama, 700-8558

  • National Hospital Organization Osaka National Hospital_Cardiovascular Division

    Osaka, 540-0006

  • Saiseikai Suita Hospital_Cardiovascular Medicine

    Osaka, 564-0013

  • National Cerebral and Cardiovascular Center Hospital_Department of Heart Failure

    Osaka, 564-8565

  • Osaka University Hospital_Cardiovascular medicine

    Osaka, 565-0871

  • The University of Osaka Hospital_Cardiovascular medicine

    Osaka, 565-0871

  • Yao Tokushukai General Hospital_Cardiovascular division

    Osaka, 581-0011

  • Saga-ken Medical Centre Koseikan_Cardiology

    Saga, 840-8571

  • Chutoen General Medical Center_Cardiology

    Shizuoka, 436-8555

  • Kagawa Prefectural Central Hospital_Cardiovascular Medicine

    Takamatsu-shi, Kagawa, 760-8557

  • Tokyo-Eki Center-building Clinic_Internal Medicine

    Tokyo, 103-0027

  • Juntendo University Hospital_Cardiology

    Tokyo, 113-8431

  • Tokyo Shinagawa Hospital_Cardiovascular Medicine

    Tokyo, 140-8522

  • Keio University Hospital_Cardiology

    Tokyo, 160-8582

  • Tottori University Hospital_Cardiovascular Medicine

    Tottori, 683-8504

  • Toyama University Hospital_Internal Medicine 2

    Toyama, 930-0194

  • Uwajima City Hospital_Cardiology

    Uwajima-shi, Ehime, 798-8510

  • National Hospital Organization Iwakuni Clinical Center_Cardiovascular Medicine

    Yamaguchi, 740-8510

  • JCHO Tokuyama Community Health Center_Department of Cardiology

    Yamaguchi, 745-8522

  • Showa University Fujigaoka Hospital_Cardiology

    Yokohama, Kanagawa, 227-8501

  • Saiseikai Yokohamashi Nanbu Hospital_Cardiology

    Yokohama-shi, Kanagawa, 234-0054

Other trials in Japan

Poland51 sites

  • American Heart of Poland S.A.

    Bełchatów, 97-400

  • American Heart of Poland S.A.

    Bełchatów, Łódź Voivodeship, 97-400

  • Panek Med Centrum Leczenia Chorob Naczyn

    Bialystok, Podlaskie Voivodeship, 15-111

  • Uniwersytecki Szpital Kliniczny w Bialymstoku K. Kardio

    Bialystok, Podlaskie Voivodeship, 15-540

  • American Heart of Poland S.A.

    Chrzanów, Lesser Poland Voivodeship, 32-500

  • MediNess Sp. z o.o.

    Cracow, Lesser Poland Voivodeship, 30-701

  • American Heart of Poland S.A.

    Dąbrowa Górnicza, Silesian Voivodeship, 41-300

  • Ind. Spec. Prak. Lek. w dziedz. Kardiologii lek. med. K. Cymerman

    Gdynia, Pomeranian Voivodeship, 81-157

  • Szpital Miejski w Gliwicach Sp. z o.o.

    Gliwice, 44-100

  • Samodzielny Publiczny Specjalistyczny Szpital Zachodni Im.Sw.Jana Pawla II

    Grodzisk Mazowiecki, Masovian Voivodeship, 05-825

  • Gornoslaskie Centrum Medyczne Im Prof. Leszka Gieca Sląskiego Uniwersytetu Medycznego W Katowicach

    Katowice, Silesian Voivodeship, 40-635

  • Pro Familia Altera Sp. z o.o.

    Katowice, Silesian Voivodeship, 40-648

  • Kardio Brynow Sp. z o. o.

    Katowice, 40-555

  • Care Clinic Sp. z o. o.

    Katowice, 40-568

  • Gyncentrum Sp. z o. o.

    Katowice, 40-600

  • Vita Longa Sp. z o. o.

    Katowice, 40-748

  • SCANMED Spółka Akcyjna

    Kluczbork, 46-200

  • MediNess Sp. z o.o.

    Krakow, Lesser Poland Voivodeship, 30-701

  • Specjalistyczna Praktyka Lekarska L. Bryniarski

    Krakow, 30-082

  • UniCardia & UniMedica & UniEstetica

    Krakow, 31-271

  • Intercard Spolka z ograniczona odpowiedzialnoscia

    Krosno, 38-400

  • Szpitale Powiatowe Sp. z o.o.

    Łask, 98-100

  • Santa Sp. z o.o.

    Lodz, 90-302

  • Wojewódzki Specjalistyczny Szpital im.Wl. Bieganskiego,

    Lodz, 91-347

  • Instytut Centrum Zdrowia Matki Polki

    Lodz, 93-338

  • Uniwersytecki Szpital Kliniczny nr 2 Uniwersytetu Medycznego w Lodzi

    Lodz, Łódź Voivodeship, 90-549

  • Clinical Best Solutions Sp. z o.o., Sp. k

    Lublin, 20-011

  • Szpital Sw. Anny w Miechowie

    Miechów, 32-200

  • Jantar Sp. z o.o.

    Ostrów Wielkopolski, 63-400

  • Wojewodzki Szpital Im. Sw.Ojca Pio W Przemyslu

    Przemyśl, 37-700

  • Poradnia Aka-Med Centrum Sp. z o.o.

    Ruda Śląska, Silesian Voivodeship, 41-710

  • Samodzielny Publiczny Zaklad Opieki Zdrowotnej Ministerstwa Spraw Wewnetrznych i Administracji w Rzeszowie

    Rzeszów, 35-111

  • EMED Centrum Usług Medycznych Ewa Smialek

    Rzeszów, 35-205

  • Korczowski Bartosz Gabinet Lekarski

    Rzeszów, 35-302

  • Balticmed Świnoujście Sp. z o. o.

    Świnoujście, 72-600

  • American Heart of Poland S.A.

    Sztum, 82-400

  • Wojewodzki Szpital Zespolony Im.L.Rydygiera W Toruniu

    Torun, Kuyavian-Pomeranian Voivodeship, 87-100

  • American Heart of Poland S.A.

    Tychy, Silesian Voivodeship, 43-100

  • American Heart of Poland S.A.

    Tychy, 43-100

  • Samodzielny Publiczny Szpital Kliniczny Im. Prof. W. Orlowskiego Centrum Medycznego Ksztalcenia Podyplomowego

    Warsaw, Masovian Voivodeship, 00-416

  • Polimedica Centrum Badan, Profilaktyki i Leczenia Sp. z o. o.

    Warsaw, 02-777

  • Polimedica Centrum Badań, Profilaktyki i Leczenia Sp. z o. o.

    Warsaw, 02-777

  • Wojskowy Instytut Medyczny Panstwowy Instytut Badawczy

    Warsaw, 04-141

  • Medical Network Sp. z o. o.

    Warsaw, 04-501

  • Kardio Life - Tomasz Borkowski

    Włocławek, Kuyavian-Pomeranian Voivodeship, 87-800

  • Uniwersytecki Szpital Kliniczny im. J.Mikulicza-Radeckiego

    Wroclaw, Lower Silesian Voivodeship, 50-556

  • 4 Wojskowy Szpital Kliniczny Z Poliklinika Samodzielny Publiczny Zaklad Opieki Zdrowotnej We Wroclawiu

    Wroclaw, Lower Silesian Voivodeship, 50-981

  • Zdrowie S.C. Agnieszka I Donald Drozdz

    Wroclaw, Lower Silesian Voivodeship, 51-134

  • Slaskie Centrum Chorob Serca W Zabrzu

    Zabrze, Silesian Voivodeship, 41-800

  • NZOZ Centrum Medyczne SERAFIN-MED Halina Serafin

    Żarów, 58-130

  • American Heart of Poland S.A.

    Zgierz, Łódź Voivodeship, 95-100

Other trials in Poland

Canada36 sites

  • University of Calgary_Calgary

    Calgary, Alberta, T2N 4Z6

  • Cambridge Cardiac Care Centre

    Cambridge, Ontario, N1R 6V6

  • Saul Vizel Pro. Med. Corp

    Cambridge, Ontario, N1R 7R1

  • Alta Clinical Research

    Edmonton, Alberta, T5A 4L8

  • Health Sciences North Rsrch Inst

    Greater Sudbury, Ontario, P3E 5J1

  • Dawson Clinical Research

    Guelph, Ontario, N1H 1B1

  • Nova Scotia Health

    Halifax, Nova Scotia, B3H 3A7

  • Hamilton Hlth Sc. - General Site

    Hamilton, Ontario, L8L 2X2

  • St. Joseph's Hospital

    London, Ontario, N6A 4V2

  • Viacar Recherche Clinique Inc.

    Longueuil, Quebec, J4H4B9

  • G.A. Research Associates Ltd.

    Moncton, New Brunswick, E1G 1A7

  • Institut de Cardiologie de Montreal

    Montreal, Quebec, H1T 1C8

  • CHU de Montréal

    Montreal, Quebec, H2X 0C1

  • Royal Columbian Hospital

    New Westminster, British Columbia, V3L 3W4

  • Partnrs Adv Cardio Eval (PACE)

    Newmarket, Ontario, L3Y 2P6

  • North Shore Heart Centre

    North Vancouver, British Columbia, V7M 2H4

  • North York Diagn & Cardiac Ctr

    North York, Ontario, M6B 3H7

  • Centricity Research Oshawa

    Oshawa, Ontario, L1J 2K9

  • Kawartha Cardiology Clinical Trials

    Peterborough, Ontario, K9J 0B2

  • CardioVasc HR Inc

    Saint-Jean-sur-Richelieu, Quebec, J3A 1J2

  • Royal University Hospital

    Saskatoon, Saskatchewan, S7N 0W8

  • CIUSSS de l'E CHUS_Sherbrooke

    Sherbrooke, Quebec, J1G 2E8

  • SMH Cardiology Clinical Trials Inc.

    Surrey, British Columbia, V3V 0C6

  • CISSSL Hôsp Pierre-Le Gardeur

    Terrebonne, Quebec, J6V 2H2

  • Ctr de méd métab de Lanaudière

    Terrebonne, Quebec, J6X 4P7

  • St. Michael's - Division of Cardiology

    Toronto, Ontario, M5B 1W8

  • Women's College Hospital

    Toronto, Ontario, M5S 1B1

  • Diabetes Heart Research Centre

    Toronto, Ontario, M6G 1M2

  • Diex Recherche Trois-Rivieres

    Trois-Rivières, Quebec, G9A 4P3

  • Ctr for Cardiovascular Innovation

    Vancouver, British Columbia, V5Z 1M9

  • St Pauls Hospital

    Vancouver, British Columbia, V6Z1Y6

  • Victoria Heart Institute Foundation

    Victoria, British Columbia, V8R 1B2

  • Clinical Research Solutions Inc.

    Waterloo, Ontario, N2T 0C1

  • CPS Research

    Waterloo, Ontario, N2T 0C1

  • Winchester Dist Memorial Hosp

    Winchester, Ontario, K0C 2K0

  • St. Boniface Hospital

    Winnipeg, Manitoba, R2H 2HA6

Other trials in Canada

Romania34 sites

  • Cabinet Medical de Cardiologie Dr. Calin Pop

    Baia Mare, 430222

  • Spitalul Județean de Urgență Brăila

    Brăila, 810325

  • S.C. Centrul Medical Unirea S.R.L.

    Brasov, 500091

  • Centrul Medical de Diagnostic si Tratament Ambulatoriu Neomed

    Brasov, 500283

  • Spitalul Clinic Judetean De Urgenta Brasov

    Brasov, 500326

  • "Carol Davila" Military Emergency Hospital

    Bucharest, 010825

  • Hightech Medical Services S.R.L.

    Bucharest, 011053

  • Spitalul Universitar de Urgență Elias

    Bucharest, 011461

  • Lotus Med SRL

    Bucharest, 012292

  • Centrul Medical Emerald

    Bucharest, 014146

  • Donna Medplus S.R.L.

    Bucharest, 020339

  • Ecocard Srl

    Bucharest, 021337

  • Davius Clinicmed Srl

    Bucharest, 021875

  • Institutul De Urgenta Pentru Boli Cardiovasculare Prof. Dr. C. C. Iliescu

    Bucharest, 022328

  • Spitalul Clinic de Urgenta "Sf. Ioan" Bucuresti

    Bucharest, 042122

  • Spitalul Universitar de Urgenta Bucuresti

    Bucharest, 050098

  • Mat Cord Biomedica S.R.L.

    Buzău, 120133

  • Spitalul Clinic Judetean De Urgenta Sfantul Apostol Andrei Constanta

    Constanța, 900591

  • Neurocord Medical SRL

    Craiova, 200383

  • Cardiomed SRL

    Craiova, 200513

  • SC Diamed Obesity SRL

    Galati, 800291

  • Institutul de Boli Cardiovasculare "Prof. Dr. George I.M. Georgescu"

    Iași, 700503

  • SC Consultmed SRL

    Iași, 700547

  • SC Cardiomed SRL

    Iași, 700732

  • Spitalul Clinic Judetean De Urgenta Bihor

    Oradea, 410469

  • Bella Praxis S.R.L.

    Paşcani, 705200

  • Sc Sal Med Srl

    Piteşti, 110424

  • Spital Judetean De Urgenta Satu Mare

    Satu Mare, 440055

  • CMI Dr. Cristian Podoleanu

    Târgu Mureş, Targu Mures, 540143

  • Emergency Institute For Cardiovascular Diseases And Transplant

    Târgu Mureş, 540136

  • Spitalul Clinic Judetean De Urgenta Targu Mures

    Târgu Mureş, 540136

  • Spitalul Clinic Municipal de Urgenta Timisoara

    Timișoara, 300254

  • Institutul de Boli Cardiovasculare Timisoara

    Timișoara, 300310

  • Echipa Medical.33 S.R.L

    Timișoara, 300366

Other trials in Romania

Italy32 sites

  • Fondazione Salvatore Maugeri I.R.C.C.S. - Bari

    Bari, 70124

  • AORN "San Pio"- Benevento - UOC Cardiologia Interventistica ed UTIC

    Benevento, Bn, 82100

  • AORN "San Pio"- Benevento

    Benevento, Bn, 82100

  • ASST Papa Giovanni XXIII

    Bergamo, Bg, 24127

  • Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII

    Bergamo, Lombardy, 24127

  • Spedali Civili Brescia

    Brescia, Bs, 25123

  • ASL Al Di Alessandria - Ospedale Santo Spirito - Casale Monferrato - Cardiologia

    Casale Monferrato, Al, 15033

  • Ospedale Santo Spirito

    Casale Monferrato, Al, 15033

  • AORN "Sant'Anna e San Sebastiano"

    Caserta, Ce, 81100

  • Azienda Ospedaliero-Universitaria Renato Dulbecco

    Catanzaro, Cz, 88100

  • A.O.U. Ferrara, Sant'Anna

    Cona (Ferrara), Fe, 44124

  • Azienda Ospedaliero Universitaria Ospedali Riuniti - Foggia

    Foggia, 71122

  • Ospedali riuniti di Foggia

    Foggia, 71122

  • IRCCS Ospedale Policlinico San Martino

    Genova, Ge, 16132

  • AUSL Toscana Sud Est - Ospedale Misericordia Grosseto

    Grosseto, 58100

  • ASST Fatebenefratelli Ospedale Luigi Sacco Medicina Interna

    Milan, 20157

  • Azienda Ospedaliera San Gerardo

    Monza, 20900

  • Azienda Ospedaliera Dei Colli - Monaldi - Centro ricerche cardiologiche

    Naples, 80131

  • Azienda Ospedaliera di Rilievo Nazionale AORN Dei Colli, "V.Monaldi",

    Naples, 80131

  • AOU Maggiore della Carità di Novara - Dipartimento Toraco-Cardio-Vascolare - SCDU Cardiologia

    Novara, 28100

  • Fondazione IRCCS Policlinico San Matteo

    Pavia, 27100

  • Azienda Ospedaliera di Perugia;Ospedale S. Maria della Misericordia

    Perugia, Pg, 06129

  • Fondazione Toscana Gabriele Monasterio - Dipartimento Cardiotoracico - UOC Cardiologia e Medicina Cardiovascolare

    Pisa, Pi, 56124

  • Fondazione CNR-Regione Toscana Gabriele Monasterio

    Pisa, Pi, 56126

  • Presidio Ospedaliero di Rivoli

    Rivoli, To, 10098

  • Azienda Sanitaria Locale Roma 1 - Ospedale San Filippo Neri - Cardiologia Clinica

    Roma, Rm, 00135

  • Azienda Ospedaliera Universitaria Senese

    Siena, Si, 53100

  • Azienda Sanitaria Ospedaliera Ordine Mauriziano SC Cardiologia

    Torino, To, 10128

  • Ospedale Ca' Foncello

    Treviso, Veneto, 31100

  • Azienda Sanitaria Univ Giuliano Isontina - SC Cardiologia

    Trieste, 34128

  • Azienda Sanitaria Univ Giuliano Isontina

    Trieste, 34128

  • AOUI Verona

    Verona, Vr, 37126

Other trials in Italy

Germany31 sites

  • Uniklinik Aachen - Med. Klinik I

    Aachen, 52074

  • Velocity - Clinical Research Germany GmbH Berlin

    Berlin, 10787

  • Charite Universitatsmedizin Berlin KöR

    Berlin, 13353

  • Charité - Campus Virchow-Klinikum - Kardiologie, Angiologie und Intensivmedizin (CRU)

    Berlin, 13353

  • Uniklinik Klinikum Bielefeld - Kardiologie und Internist. Intensivmedizin

    Bielefeld, 33604

  • Kath. Klinikum Bochum gGmbH - St. Josef-Hospital Kardiologie

    Bochum, 44791

  • Kardiologisch-Angiologische Praxis Herzzentrum Bremen

    Bremen, 28277

  • Kath. St. Paulus GmbH - St Johannes Hospital Dortmund - Kardiologie

    Dortmund, 44137

  • Facharztzentrum Dresden Betriebsgesellschaft mbH

    Dresden, 01099

  • Cardiologicum Dresden und Pirna - MVZ "Am Felsenkeller" (Dresden)

    Dresden, 01277

  • Uniklinik TU Dresden - Herzzentrum Dresden GmbH

    Dresden, 01307

  • Zentrum für klinische Studien Südbrandenburg GmbH

    Elsterwerda, 04910

  • MVZ CCB Frankfurt und Main-Taunus GbR

    Frankfurt, 60389

  • Universitätsklinikum Frankfurt aM - Kardiologie

    Frankfurt am Main, 60596

  • Universitätsklinikum Freiburg - Medical Center

    Freiburg im Breisgau, 79106

  • Justus-Liebig-Universität Gießen - Kardiologie

    Giessen, 35392

  • Uni-Med. Göttingen - Kardiologie, Pneumologie

    Göttingen, 37075

  • Universitätsklinikum Hamburg-Eppendorf - University Medical Center Hamburg-Eppendorf

    Hamburg, 20246

  • University Medical Center Hamburg-Eppendorf

    Hamburg, 20251

  • Kardiologie Hassloch

    Haßloch, 67454

  • Universität des Saarlandes - Innere Med. III

    Homburg, 66421

  • Uniklinik Jena - Kardiologie

    Jena, 07747

  • Kardiopraxis Schirmer

    Kaiserslautern, 67655

  • Universitätsklinikum Leipzig - Klinik und Poliklinik für Kardiologie

    Leipzig, 04103

  • Gesundheitscentrum Mainz (Regner / Schmitt)

    Mainz, 55116

  • zero PRAXEN Mannheim-Schwetzingerstadt

    Mannheim, 68165

  • LMU Klinikum München Klinik und Poliklinik 1

    München, 81377

  • Kardiologische Gemeinschaftspraxis Papenburg

    Papenburg, 26871

  • Herz-Kreislauf-Zentrum Klinikum Hersfeld-Rotenburg GmbH

    Rotenburg A.d. Fulda, 36199

  • Al-Zoebi

    Wermsdorf, 04779

  • Universitatsklinikum Würzburg - Zentrum für Herzinsuffizienz

    Würzburg, 97078

Other trials in Germany

Bulgaria29 sites

  • MHAT Heart and Brain EAD - Burgas, Cardiology

    Burgas, 8000

  • Medical Centre - Avitsena EOOD

    Kardzhali, 6600

  • Medical centre "Zdrave 1" OOD

    Kozloduy, 3320

  • Medical centre Zdrave 1 OOD

    Kozloduy, 3320

  • Medical Centre Hera - Kyustendil EOOD

    Kyustendil, 2500

  • DCC 1 - Lom EOOD

    Lom, 3600

  • Diagnostic Consulting Center 1- Lom EOOD

    Lom, 3600

  • "MHAT - UniHospital" OOD

    Panagyurishte, 4500

  • Medical Center TONUS 2013 OOD

    Pazardzhik, Panagyurishte, 4400

  • Medical center Medconsult Pleven OOD

    Pleven, 5800

  • UMHAT - Dr. Georgi Stranski EAD

    Pleven, 5800

  • MHAT Heart and Brain EAD - Pleven, Cardiology

    Pleven, 5804

  • UMHAT - Plovdiv AD

    Plovdiv, 4002

  • UMHAT Sveti Georgi EAD, Plovdiv, Clinic of Cardiology

    Plovdiv, 4002

  • MHAT Sveta Karidad EAD

    Plovdiv, 4004

  • MC Health Care OOD, Sandanski

    Sandanski, 2800

  • 'Medical Center Hipokrena' EOOD

    Sevlievo, 5400

  • Medical Center Hipokrena EOOD

    Sevlievo, 5400

  • Medical Centre Cardiomed 2020 EOOD

    Sliven, 8801

  • DCC Ascendent OOD

    Sofia, 1202

  • MHAT Knyaginya Klementina - Sofia EAD

    Sofia, 1233

  • NMTH Tsar Boris III

    Sofia, 1233

  • MHAT Sveta Sofia EOOD

    Sofia, 1404

  • DCC Aleksandrovska EOOD

    Sofia, 1431

  • Medical center ISUL - Tsaritsa Yoanna EOOD

    Sofia, 1527

  • Medical Centre Intermedica OOD

    Sofia, 1680

  • Medical center Zara-Med EOOD

    Stara Zagora, 6000

  • MDHAT Dr. Stephen Cherkezov AD

    Veliko Tarnovo, 5000

  • MC Nevromedics EOOD, Cardiology

    Veliko Tarnovo, 5006

Other trials in Bulgaria

Greece29 sites

  • General Hospital of Athens "Elpis" - Cardiology Department

    Ampelokipoi/Athens, 11522

  • Alexandra General Hospital, Therapeutic Clinic

    Athens, Attica, 11528

  • Alexandra General Hospital, Therapeutic Clinic

    Athens, Attica, GR11528

  • 'G. Gennimatas' General Hospital of Athens - Cardiology Department

    Athens, 11527

  • Hippokration Hospital

    Athens, 11527

  • Thoracic General Hospital Of Athens I Sotiria - Cardiology Department

    Athens, 11527

  • Konstantopouleio G.H. of Athens, "Agia Olga"

    Athens, 14233

  • "Hygeia" General Hospital of Athens

    Athens, 15123

  • Iatriko Athinon (Athens Medical Canter)

    Athens, 15125

  • Genl Hospital of Athens Ippokrateio,A' Cardiology Univ dpt

    Athens, GR-11527

  • "Hygeia" General Hospital of Athens

    Athens, GR-15123

  • U.G.H of Athens "Attikon"

    Chaidari, Athens, 12462

  • General Hospital of Kalamata - Cardiology Department

    Chalcis, 34100

  • General Hospital of Chios "Skilitsio" - Cardiology Clinic

    Chios, 82100

  • University General Hospital Of Heraklion - Cardiology Department

    Heraklion, Crete, 71500

  • General Hospital Venizeleio-Pananeio - Cardiology department

    Heraklion, 71409

  • Venizeleio Pananeio

    Heraklion, 71409

  • General Hospital of Kalamata - Cardiology Department

    Kalamata, 24100

  • General Hospital of Kalamata

    Kalamata, 24100

  • General Oncological Hospital of Kifissia Agioi Anargyroi - Cardiology Clinic

    Kifissia, 14564

  • Univ Gen Hospital Larisa, Cardiology Medicine Clinic

    Larissa, 41110

  • General Hospital Of Mytilene Vostanio - Cardiology Department

    Mytilene, 81132

  • Geniko Nosokomeio Peiraia Tzaneio - Cardiology department

    Piraeus, 18536

  • Iatriko Athinon (Athens Medical Canter)

    Pylea, Thessaloniki, 57001

  • General University Hospital of Patras

    Rio Patras, 26504

  • General University Hospital of Patras

    Rio Patras, GR26504

  • General Hospital of Thessaloniki 'G. Gennimatas - Cardiology Department

    Thessaloniki, 54635

  • "AHEPA" University General Hospital of Thessaloniki

    Thessaloniki, 54636

  • 'Ippokrateio' General Hospital of Thessaloniki

    Thessaloniki, 54642

Other trials in Greece

South Africa26 sites

  • East Rand Physicians Clinical Research Division (Pty) Ltd

    Benoni, Gauteng, 1501

  • Cardiology Research_Bloemfontein

    Bloemfontein, Free State, 9301

  • IATROS International

    Bloemfontein, Free State, 9301

  • Josha Research

    Bloemfontein, Free State, 9301

  • Synexus Helderberg Clinical Research Centre

    Cape Town, Western Cape, 7130

  • Dr Corbett

    Cape Town, Western Cape, 7500

  • Tread Research (Pty)Ltd

    Cape Town, Western Cape, 7500

  • Tiervlei Trial Centre

    Cape Town, Western Cape, 7530

  • Cardiac Clinical Research Unit, University of Cape Town

    Cape Town, Western Cape, 7935

  • Johese Clinical Research

    Centurion, Gauteng, 0157

  • KwaPhila Health Solutions

    Durban, KwwaZulu Natal, 4300

  • Excellentis Clinical Trial Consultants

    George, Eastern Cape, 6529

  • Wits Bara Clinical Trial Site

    Johannesburg, Gauteng, 2013

  • Dr Garda Cardiology Practice

    Johannesburg, Gauteng, 2192

  • WITS Clinical Research

    Johannesburg, Gauteng, 2193

  • Clinical Research Institute of South Africa

    KwaDukuza, KwaZulu-Natal, 4449

  • Lenasia Clinical Trial Centre

    Lenasia, Gauteng, 1827

  • Shop#1 Health Emporium

    Midrand, Gauteng, 1685

  • Dr Hendrik Snyman's Practice

    Mossel Bay, Western Cape, 6500

  • RYEXO Clinical Research

    Pretoria, Gauteng, 0002

  • Dr Mpe's Practice

    Pretoria, Gauteng, 0083

  • Dr IO Ebrahim Inc

    Pretoria, Gauteng, 0157

  • Raslouw Private Hospital

    Pretoria, Gauteng, 0157

  • Synexus Watermeyer Clinical Research Centre

    Pretoria, Gauteng, 0184

  • Synexus Helderberg Clinical Research Centre

    Somerset West, Western Cape, 7130

  • Clinical Projects Research

    Worcester, Western Cape, 6850

Other trials in South Africa

Brazil23 sites

  • Jmf Clínica Do Coração Ltda

    Aracaju, 49055-530

  • CCIH-Consultoria em Controle de Infecção Hospitalar Ltda

    Belo Horizonte, Minas Gerais, 30150-320

  • NUPEC Cardio

    Belo Horizonte, Minas Gerais, 30220-140

  • Associação Lar São Francisco de Assis na Providência de Deus - Bragança Paulista

    Bragança Paulista, São Paulo, 12916-542

  • Sociedade Hospitalar Angelina Caron, Brazil

    Campina Grande do Sul, Paraná, 83430-000

  • Instituto de Pesquisa Clínica de Campinas

    Campinas, São Paulo, 13060-080

  • PUCCAMP - Hospital e Maternidade Celso Pierro

    Campinas, São Paulo, 13060-803

  • i9 Pesquisas Clínicas

    Campinas, São Paulo, 13092-133

  • PUCPR - Pontificia Universidade Catolica do Parana

    Curitiba, Paraná, 80230-130

  • Hospital de Clínicas da Universidade Federal de Goiânia

    Goiânia/GO, 74605-020

  • ICM - Instituto do Coração de Marília

    Marília/SP, 17515-000

  • Hospital de Clínicas de Porto Alegre

    Porto Alegre, Rio Grande do Sul, 90035-003

  • Hospital Mãe de Deus - Porto Alegre

    Porto Alegre/RS, 90840-440

  • PROCAPE

    Recife/PE, 56517-630

  • Unidade de Pesquisa Clínica do Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo

    Ribeirão Preto, São Paulo, 14051-140

  • Hospital São Lucas Copacabana

    Rio de Janeiro, 22061-080

  • Instituto D'or de Pesquisa e Ensino

    Rio de Janeiro, 22281-100

  • CIP Centro Integrado de Pesquisas do Hospital de Base

    São José do Rio Preto, São Paulo, 15090-000

  • Universidade Federal de São Paulo - UNIFESP

    São Paulo/SP, 04026-090

  • Instituto de Moléstias Cardiovasculares de Tatuí Ltda

    Tatuí, São Paulo, 18270-170

  • Eurolatino Medical Research Center

    Uberlândia, Minas Gerais, 38400-500

  • Centro de Diag. e Pesquisa da Osteoporose do Espírito Santo

    Vitória, Espírito Santo, 29055-450

  • Integral Pesquisa e Ensino

    Votuporanga, São Paulo, 15500-269

Other trials in Brazil

United Kingdom22 sites

  • Aberdeen Royal Infirmary

    Aberdeen, AB25 2ZN

  • University Hospital Monklands - Cardiology Research

    Airdrie, Lanarkshire, ML6 0JS

  • Basildon University Hospital

    Basildon, Essex, SS16 5NL

  • Royal Bournemouth Hospital

    Bournemouth, Dorset, BH7 7DW

  • Southmead Hospital

    Bristol, BS10 5NB

  • St. Richard's Hospital_Cardiology

    Chichester, West Sussex, PO19 6SE

  • St. Richards Hospital

    Chichester, West Sussex, PO19 6SE

  • Craigavon Area Hospital - Cardiovascular Research Unit

    Craigavon, BT63 5QQ

  • Royal Bournemouth Hospital

    Dorest, BH7 7DW

  • University Hospital Hairmyres - Cardiology

    East Kilbride, South Lanarkshire, G75 8RG

  • Royal Devon and Exeter Hospital

    Exeter, EX2 5DW

  • Royal Devon University Healthcare NHS Foundation Trust

    Exeter, EX2 5DW

  • Glasgow Royal Infirmary

    Glasgow, G31 2ER

  • Wycombe General Hospital

    High Wycombe, HP11 2TT

  • Aintree University Hospital

    Liverpool, L9 7AL

  • Manchester Royal Infirmary - Manchester Heart Centre

    Manchester, M13 9WL

  • North Tyneside General Hospital

    North Shields, NE29 8NH

  • The Royal Oldham Hospital_Cardiology Outpatients Dept.

    Oldham, OL1 2JH

  • John Radcliffe Hospital

    Oxford, OX3 9DU

  • University of North Tees Hospital

    Stockton-on-Tees, TS19 8PE

  • St George's Hospital - Cardiology

    Tooting, London, SW17 0RE

  • St George's Hospital

    Tooting, London, SW17 0RE

Other trials in United Kingdom

Hungary21 sites

  • Lausmed Kft.

    Baja, Bács-Kiskun county, 6500

  • EURÉKA-CENTER Orvosi és Szolgáltató Betéti Társaság

    Baja, 6500

  • DRC Kft.

    Balatonfüred, 8230

  • Tagore Medical Center

    Balatonfüred, 8230

  • Dr. Lakatos Ferenc Kardiológus ,Belgyógyász Magán szakrendelés

    Békéscsaba, Bekes County, 5600

  • Betegápoló Irgalmasrend, Budai Irgalmasrendi Kórház

    Budapest, 1023

  • Gottsegen György Országos Kardiológiai Intézet

    Budapest, 1096

  • Semmelweis Egyetem Városmajori Szív- és Érgyógyászat

    Budapest, 1122

  • Észak-Pesti Centrumkórház Honvédkórház

    Budapest, 1134

  • Jahn Ferenc Dél-pesti Kórház és Rendelőintézet

    Budapest, 1204

  • Békés Vármegyei Központi Kórház

    Gyula, Bekes County, 5700

  • Békés Vármegyei Központi Kórház

    Gyula, 5700

  • Somogy Megyei Kaposi Mór Oktató Kórház

    Kaposvár, Somogy County, 7400

  • Selye János Kórház

    Komárom, Komárom-Esztergom, 2921

  • Borsod-Abaúj-Zemplén Vármegyei Központi Kórház És Egyetemi Oktatókórház

    Miskolc, 3526

  • Arina Trial Research Kft.

    Orosháza, Bekes County, 5900

  • PTE ÁOK I. sz. Belgyógyászati Klinika

    Pécs, Baranya, 7624

  • Coromed SMO Kft.

    Pécs, 7623

  • Szegedi Tudományegyetem II. sz Belgyógyászati és Kardiológia

    Szeged, Csongrád-Csanád, 6725

  • Szegedi Tudományegyetem

    Szeged, 6725

  • Léda Platán Magánklinika

    Zalaegerszeg, Zala County, 8900

Other trials in Hungary

Thailand20 sites

  • Chulabhorn hospital_Cardiovascular

    Bangkok, 10210

  • Chulabhorn hospital

    Bangkok, 10210

  • Cardio-Vajira

    Bangkok, 10300

  • Vajira Hospital - Cardio

    Bangkok, 10300

  • King Chulalongkorn Memorial Hospital

    Bangkok, 10330

  • Ramathibodi Hospital-Cardiovascular metabolic Center

    Bangkok, 10400

  • Ramathibodi Hospital_Cardiovascular metabolic Center

    Bangkok, 10400

  • Siriraj Hospital

    Bangkok, 10700

  • Maharaj Nakorn Chiang Mai Hospital_Cardiology

    Chiang Mai, 50200

  • Maharaj Nakorn Chiang Mai Hospital

    Chiang Mai, 50200

  • Chiang Rai Prachanukroh Hospital

    Chiang Rai, 57000

  • Songklanagarind Hospital

    Hat Yai, Changwat Songkhla, 90110

  • Srinagarind Hospital

    Khon Kaen, 40002

  • Thammasat University Hospital

    Klong Luang, Pathumthani, Changwat Pathum Thani, 12120

  • Maharat Nakhon Ratchasima Hospital

    Nakhon Ratchasima, 30000

  • Thammasat Hospital_Cardiology

    Pathum Thani, 12120

  • Buddhachinaraj Hospital_Cardiology

    Phitsanulok, 65000

  • Banphaeo General Hospital

    Samutsakhon, 74120

  • Songklanagarind Hospital

    Songkhla, 90110

  • Sunpasitthiprasong Hospital_Pediatrics Department

    Ubon Ratchathani, 34000

Other trials in Thailand

Argentina19 sites

  • DIM Clinica Privada

    Buenos Aires, B1704ETD

  • Hospital Italiano

    Buenos Aires, C1181ACH

  • Fundación Respirar

    Buenos Aires, C1426ABP

  • Mautalen Salud e investigación

    CABA, Buenos Aires, C1128 AAF

  • CEMEDIC

    CABA, Buenos Aires, C1440CFD

  • Fundacion Favaloro

    CABA, Buenos Aires, Argentina, C1093AAS

  • Fundacion Favaloro

    CABA, C1093AAS

  • CEMEDIC

    CABA, C1440CFD

  • Instituto de Cardiología de Corrientes

    Corrientes, W3400AMZ

  • Centro de Investigaciones Clinica Baigorria

    Granadero Baigorria, Santa Fe Province, 2152

  • Instituto de Investigaciones Clinicas Mar Del Plata

    Mar del Plata, Buenos Aires, B7600FZN

  • Centro de Investigaciones Médicas Clínica de Fracturas y Or

    Mar del Plata, Buenos Aires, B7600GNY

  • Centro de Investigaciones Médicas Mar del Plata

    Mar del Plata, Buenos Aires, B7600GNY

  • Instituto de Investigaciones Clinicas

    Mar del Plata, B7600FZN

  • Centro de Investigaciones Médicas Clínica de Fracturas y Or

    Mar del Plata, B7600GNY

  • Instituto de Investigaciones Clinicas San Nicolás

    San Nicolás, B2900

  • Centro de Investigaciones Clinica Baigorria

    Santa Fe, Santa Fe Province, S2152BOF

  • Centro de investigaciones Clinicas del Litoral

    Santa Fe, 3000

  • CEDIR - Centro de diagnóstico y rehabilitación Santa Fe

    Santa Fe, S3000FSO

Other trials in Argentina

South Korea19 sites

  • Bucheon Sejong Hospital

    Bucheon-si, Gyeonggi-do, 14754

  • Pusan National University Hospital

    Busan, 49241

  • Chungbuk National University Hospital

    Cheongju-si, 28644

  • Keimyung University Dongsan Hospital

    Daegu, 42601

  • Chungnam National University Hospital

    Daejeon, 35015

  • Chonnam National University Hospital

    Gwangju, 61469

  • Hallym University Sacred Heart Hospital

    Gyeonggi-do, 14068

  • Gachon University Gil Medical Center

    Incheon, 21565

  • Inha University Hospital

    Incheon, 22332

  • Seoul National University Bundang Hospital

    Seongnam-si, Gyeonggi-do, 13620

  • Korea University Anam Hospital

    Seoul, 02841

  • Seoul National University Hospital

    Seoul, 03080

  • Severance Hospital, Yonsei University Health System

    Seoul, 03722

  • Asan Medical Center

    Seoul, 05505

  • Samsung Medical Center

    Seoul, 06351

  • The Catholic University of Korea, Seoul ST. Mary's Hospital

    Seoul, 06591

  • Korea University Guro Hospital

    Seoul, 08308

  • Wonju Severance Christian Hospital

    Wŏnju, 26426

  • Pusan National University Yangsan Hospital

    Yangsan, Gyeongsangnam-do, 50612

Other trials in South Korea

Australia18 sites

  • Nightingale Research Adelaide

    Adelaide, South Australia, 5000

  • Royal Adelaide Hospital - Cardiology Department

    Adelaide, South Australia, 5000

  • Flinders Medical Centre

    Bedford Park, South Australia, 5042

  • Royal Brisbane and Women's Hospital

    Brisbane, Queensland, 4029

  • Heart of Australia

    Chelmer, Queensland, 4068

  • Concord Repatriation General Hospital - Cardiology Department

    Concord, New South Wales, 2139

  • Townsville University Hospital

    Douglas, Queensland, 4814

  • Frankston Hospital

    Frankston, Victoria, 3199

  • Peninsula University Hospital - Cardiology Department

    Frankston, Victoria, 3199

  • Canberra Hospital

    Garran, Australian Capital Territory, 2605

  • Adrian Costa Clinical Trials Centre

    Geelong, Victoria, 3220

  • Barwon Health (The Geelong Hospital)

    Geelong, Victoria, 3220

  • Gosford Hospital

    Gosford, New South Wales, 2250

  • Royal Hobart Hospital

    Hobart, Tasmania, 7000

  • Baker-HeartWest - Hoppers Crossing

    Hoppers Crossing, Victoria, 3029

  • Sydney Cardiometabolic Centre

    Liverpool, New South Wales, 2170

  • Epworth HealthCare

    Richmond, Victoria, 3121

  • Clinitrials

    West Perth, Western Australia, 6005

Other trials in Australia

Turkey (Türkiye)18 sites

  • Afyonkarahisar Health Sciences University

    Afyonkarahisar, 03200

  • Afyonkarahisar Sağlık Bilimleri Üniversitesi Sağlık Uygulama Ve Araştırma Merkezi- Kardiyoloji

    Afyonkarahisar, 03200

  • Hacettepe Üniversitesi Hastanesi- Kardiyoloji

    Ankara, 06230

  • Ankara Bilkent Şehir Hastanesi-Kardiyoloji

    Ankara, 06800

  • Ankara Sehir Hastanesi Cardiology

    Ankara, 06800

  • Akdeniz University Medical Faculty

    Antalya, 07059

  • Akdeniz Üniversitesi Hastanesi-Kardiyoloji

    Antalya, 07059

  • Trakya Üniversitesi Tıp Fakültesi Hastanesi- Kardiyoloji

    Edirne, 22030

  • Eskişehir Osmangazi Üniversitesi Hastanesi- Kardiyoloji

    Eskişehir, 26040

  • İstanbul Üniversitesi-Cerrahpaşa Kardiyoloji Enstitüsü

    Istanbul, 34098

  • Mehmet Akif Ersoy Göğüs Kalp ve Damar Cerrahisi EAH

    Istanbul, 34303

  • Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training Research Hospital_Istanbul

    Istanbul, 34303

  • Dr. Siyami Ersek Göğüs Kalp ve Damar Cerrahisi EAH- Kardiyoloji

    Istanbul, 34668

  • Ege Üniversitesi Hastanesi- Kardiyoloji

    Izmir, 35100

  • Dokuz Eylül Üniversitesi Araştırma Uygulama Hastanesi-Kardiyoloji

    Izmir, 35340

  • Erciyes Üniversitesi Hastanesi- Kardiyoloji

    Kayseri, 38039

  • Kocaeli Üniversitesi Hastanesi- Kardiyoloji

    Kocaeli, 41380

  • Mersin Üniversitesi Hastanesi- Kardiyoloji

    Mersin, 33343

Other trials in Turkey (Türkiye)

Czechia17 sites

  • Kardiologie MUDr. Libor Nechvátal s.r.o.

    Brno, 602 00

  • Amkardia s.r.o.

    Brno, 639 00

  • FN Hradec Kralove

    Hradec Králové, 50005

  • KARDIOLOGIE - LIBEREC s.r.o.

    Liberec, 460 01

  • KARDIOLOGIE - LIBEREC s.r.o.

    Liberec, 460 02

  • Fakultni nemocnice Plzen - Lochotin

    Plzen - Lochotín, 323 00

  • Policska nemocnice

    Polička, 572 01

  • Poličská nemocnice s.r.o.

    Polička, 572 01

  • Kardiologická a interní ambulance

    Prague, 110 00

  • Kardiologie Vinohrady s.r.o.

    Prague, 110 00

  • Fakultní poliklinika VFN ambulance Srdecniho selhani

    Prague, 120 00

  • Nemocnice Slany Kardiologie

    Slaný, 274 01

  • Nemocnice Slany

    Slaný, 274 01

  • Vseobecna kardiologicka ambulance

    Tábor, 39003

  • Všeobecná kardiologická ambulance s.r.o.

    Tábor, 39003

  • Kardiologická ambulance MUDr. Ferkl s.r.o.

    Trutnov, 541 01

  • Clinical Trials Service s.r.o.

    Uherské Hradiště, 68601

Other trials in Czechia

Spain17 sites

  • Complejo Hospitalario Universitario A Coruña

    A Coruña, 15006

  • Hospital Germans Trias i Pujol

    Badalona, Barcelona, 08916

  • Hospital del Mar

    Barcelona, 08003

  • Hospital Clinic i Provincial

    Barcelona, 08036

  • Hospital Vithas Sevilla

    Castilleja de la Cuesta, 41950

  • Hospital de Bellvitge

    L'Hospitalet de Llobregat, Barcelona, 08907

  • Hospital Univ. de Gran Canaria Doctor Negrín

    Las Palmas de Gran Canaria, 35010

  • Hospital Universitario de Gran Canaria Doctor Negrín

    Las Palmas de Gran Canaria, 35010

  • Hospital Univ. La Luz_Cardiología

    Madrid, 28003

  • Hospital Ramón y Cajal

    Madrid, 28034

  • Hospital Clínico San Carlos

    Madrid, 28040

  • Hospital Universitario La Paz

    Madrid, 28046

  • Hospital Universitario Puerta de Hierro Majadahonda

    Madrid, 28222

  • Hospital Universitario Puerta de Hierro Majadahonda

    Majadahonda, Madrid, 28222

  • Clínica Nuevas Tecnologías en Diabetes y Endocrinología

    Seville, 41003

  • Fundación para la Investigación del Hospital Clínico de Valencia (INCLIVA)

    Valencia, 46010

  • Hospital General de Valencia

    Valencia, 46014

Other trials in Spain

Croatia16 sites

  • Poliklinika Medikol_Cakovec_Cardiology

    Čakovec, 40000

  • Zupanijska bolnica Cakovec

    Čakovec, 40000

  • Internacionalni medicinski centar PRIORA

    Čepin, 31431

  • Opca bolnica Karlovac_Cardiology

    Karlovac, 47000

  • Opca bolnica Karlovac

    Karlovac, 47000

  • Specijalna bolnica za medicinsku rehabilitaciju Krapinske Toplice_Cardiology

    Krapinske Toplice, Krapinsko Zagorska County, 49217

  • Klinicki Bolnicki Centar Osijek_Cardiology

    Osijek, 31 000

  • Clinical Hospital Centre Rijeka_Cardiology

    Rijeka, 51000

  • Specijalna bolnica Medico

    Rijeka, 51000

  • KBC Split_Cardiology

    Split, 21 000

  • Poliklinika Aritmija

    Zagreb, City of Zagreb, 10 000

  • University Hospital Centre Zagreb

    Zagreb, City of Zagreb, 10 000

  • KB Dubrava, Zavod za bolesti srca i krvnih zila

    Zagreb, City of Zagreb, 10000

  • Poliklinika Solmed

    Zagreb, City of Zagreb, 10000

  • University Hospital Sveti Duh

    Zagreb, 10 000

  • Poliklinika Magnolija d.o.o.

    Zagreb, 10000

Other trials in Croatia

Mexico16 sites

  • Hospital Cardiológica Aguascalientes

    Aguascalientes, Aguascalientes, 20230

  • Centro para el Desarrollo de la Medicina y de Asistencia Médica Especializada, S.C.

    Culiacán, Sinaloa, 80230

  • Centro para el Desarrollo de la Medicina y la Asistencia

    Culiacán, Sinaloa, 80230

  • Diseño y Planeacion en Investigacion Medica S.C.

    Guadalajara, Jalisco, 44130

  • Diseño y Planeación en Investigación Médica S.C.

    Guadalajara, Jalisco, 44130

  • Centro de Imagen y Tecnologia en Intervención Cardiovascular

    México, 10700

  • Instituto Nacional de Cardiología Ignacio Chavez

    Mexico City, México, D.F., 14080

  • Centro de Investigación Biomédica y Farmacéutica S.C.

    Mexico City, 03100

  • Internal Medicine Clin Trials

    Monterrey, Nuevo León, 64020

  • Cardiolink Clin Trials S.C.

    Monterrey, Nuevo León, 64060

  • Eukarya Pharmasite S.C.

    Monterrey, Nuevo León, 64718

  • Centro de atención e investigación cardiovascular del Potosí

    San Luis Potosí City, San Luis Potosí, 78200

  • Centro de Investigación y Control Metabólico S. C.

    San Nicolás de los Garza, Nuevo León, 66465

  • Centro de Estudios Clinicos de Querétaro S.C.

    Santiago de Querétaro, Qro., Querétaro, 76000

  • CINCAME

    Tijuana, Estado de Baja California, 22500

  • Hospital Angeles de Xalapa

    Xalapa, Veracruz, 91193

Other trials in Mexico

Portugal16 sites

  • Hospital de Cascais

    Alcabideche, 2755-009

  • ULS De Braga, E.P.E. - Hospital de Braga

    Braga, 4710-243

  • ULS Do Baixo Mondego, E.P.E. - Hospital Distrital Figueira Da Foz

    Figueira da Foz Municipality, 3094-001

  • ULS Da Guarda E.P.E. - Hospital Sousa Martins

    Guarda, 6301-858

  • ULS De Tâmega e Sousa E.P.E. - Hospital Padre Américo

    Guilhufe - Penafiel, 4560-136

  • ULS Da Região De Leiria E.P.E.- Hospital de Santo André

    Leiria, 2410-197

  • ULS Lisboa Ocidental, E.P.E_Hospital São Francisco Xavier_Hospital de Dia de Especialidades Médicas

    Lisbon, 1449-005

  • Hospital da Luz Lisboa, S.A._Serviço de Medicina Interna

    Lisbon, 1500-650

  • Hospital da Luz

    Lisbon, 1500-650

  • Centro Hospitalar Lisboa Norte

    Lisbon, 1649-035

  • Unidade De Santa Maria E.P.E. - Hospital de Santa Maria

    Lisbon, 1649-035

  • Hospital CUF Descobertas S.A.

    Lisbon, 1998-018

  • ULS De Santo António, E.P.E. - Hospital de Santo António

    Porto, 4099-001

  • ULS Entre Douro e Vouga E.P.E. - Hospital São Sebastião

    Santa Maria da Feira, 4520-211

  • Hospital da Luz Setúbal, S.A.

    Setúbal, 2900-722

  • ULS Da Arrábida, E.P.E._Hospital de São Bernardo

    Setúbal, 2910-446

Other trials in Portugal

Colombia14 sites

  • IPS Centro Cientifico Asistencial Jose Luis Accini SAS

    Barranquilla, Atlántico, 080001

  • Clinica de la Costa

    Barranquilla, Atlántico, 80020

  • Corazón IPS S.A.S

    Barranquilla, 080020

  • Fundacion del Caribe para la Investigacion Biomedica-BIOS

    Barranquilla, 080020

  • Fundación Santa Fe de Bogotá

    Bogotá, 110111

  • Unidad de Estudios Clínicos de la Fundación Cardiovascular de Colombia

    Bucaramanga-piedecuesta, Valle Del Menzuli - Santander, Santander Department, 681012

  • Clinica Imbanaco SAS

    Cali, Valle del Cauca Department, 760036

  • Centro de Atención e Investigación Médica S.A.S. (CAIMED SAS)

    Chía, Cundinamarca, 250001

  • IPS médicos Internistas de Caldas S.A.S.

    Manizales, Caldas Department, 170003

  • Hospital General de Medellin

    Medellín, Antioquia, 050015

  • Rodrigo Botero S.A.S

    Medellín, Antioquia, 050021

  • Promotora Medica Las Americas S.A.

    Medellín, 050021

  • CardiovidCentro Cardiovascular Colombiano ClinicaSantaMaria

    Medellín, 050034

  • Fundación Hospital Universidad del Norte

    Soledad, Barranquilla, 83001

Other trials in Colombia

Malaysia12 sites

  • Hospital Sultanah Bahiyah

    Alor Star, Kedah, 05460

  • Hospital Canselor Tuanku Muhriz UKM

    Cheras, Kuala Lumpur, 56000

  • Hospital Universiti Kebangsaan Malaysia

    Cheras, Kuala Lumpur, 56000

  • Hospital Sultanah Aminah

    Johor Bahru, Johor, 80100

  • Hospital Serdang

    Kajang, Selangor, 43000

  • Hospital Serdang

    Kajang, 43000

  • Hospital Universiti Sains Malaysia

    Kota Bharu, Kelantan, 16150

  • Sarawak Heart Centre

    Kota Samarahan, Sarawak, 94300

  • Hospital Kuala Lumpur

    Kuala Lumpur, 50586

  • Hospital Tengku Ampuan Afzan

    Kuantan, Pahang, 25100

  • University Malaya Medical Centre

    Lembah Pantai, Kuala Lumpur, 59100

  • Universiti Teknologi MARA, Sungai Buloh Campus

    Sungai Buloh, Selangor, 47000

Other trials in Malaysia

Serbia12 sites

  • Clinical centre of Serbia, Clinic for cardiology

    Belgrade, 11000

  • Clinical Centre of Serbia, Emergency Centre, Department of Cardiology

    Belgrade, 11000

  • Emergency Internal Medicine Clinic

    Belgrade, 11000

  • General Hospital "Euromedik 2"

    Belgrade, 11000

  • Institute for Cardiovascular Diseases ''Dedinje''

    Belgrade, 11000

  • Clinical Hospital Center Bezanijska Kosa

    Belgrade, 11080

  • Clinical Hospital Centre Zemun

    Belgrade, 11080

  • Institute for Cardiovascular Diseases of Vojvodina - Sremska Kamenica

    Kamenitz, 21204

  • University Clinical Centre Kragujevac

    Kragujevac, 34000

  • Medical center Leskovac

    Leskovac, 16000

  • University Clinical Centre Nis, Clinic for Cardiology

    Niš, 18108

  • Medical center Uzice

    Užice, 31000

Other trials in Serbia

Austria11 sites

  • Krankenhaus St. Josef Braunau

    Braunau am Inn, 5280

  • Krankenhaus St. Josef Braunau

    Braunau am Inn, A 5280

  • Medizinische Universität Graz

    Graz, 8036

  • Medizinische Universität Graz

    Graz, A 8036

  • Fließer-Görzer [Ordination]

    Saint Stefan, 8511

  • Uniklinikum Salzburg Kardiologie

    Salzburg, 5020

  • Medizinische Universität Wien

    Vienna, 1090

  • Klinik Favoriten

    Vienna, 1100

  • Klinik Ottakring

    Vienna, 1160

  • Imed 19- privat

    Vienna, 1190

  • Imed 19- privat

    Vienna, A 1190

Other trials in Austria

Netherlands11 sites

  • OLVG

    Amsterdam, 1091 AC

  • Deventer Ziekenhuis

    Deventer, 7416 SE

  • Albert Schweitzer Zkh, Dordwijk

    Dordrecht, 3318 AT

  • Treant, Scheper - Cardiologie

    Emmen, 7824 AA

  • Medisch Spectrum Twente - Cardiologie

    Enschede, 7512 KZ

  • UMC Groningen

    Groningen, 9713 GZ

  • Zuyderland ziekenhuis - Cardiologie

    Heerlen, 6419 PC

  • Maastricht Universitair Medisch Centrum

    Maastricht, 6229 HX

  • RadboudUMC

    Nijmegen, 6525 GA

  • Erasmus MC

    Rotterdam, 3015 GD

  • HagaZiekenhuis

    The Hague, 2545AA

Other trials in Netherlands

Slovakia11 sites

  • Narodny ustav srdcovych a cievnych chorob, a.s.

    Bratislava, 833 48

  • KARDIO-SANUS, spol. s r.o.

    Bratislava, 84108

  • Nemocnica S Poliklinikou Brezno N.O.

    Brezno, Banská Bystrica Region, 977 01

  • CARDIO D&R, s.r.o.

    Košice, 040 22

  • Nemocnicna a.s.

    Malacky, 901 22

  • MED-CENTRUM, s.r.o.

    Martin, 036 01

  • Intradia s.r.o.

    Nitra, 949 01

  • BENIMED, s.r.o.

    Piešťany, 92101

  • Interna SK s.r.o.

    Svidník, Presov, 089 01

  • Fakultna Nemocnica Trnava

    Trnava, 917 02

  • MEDIVASA, s.r.o., Kardiologicka ambulancia 1, 2

    Žilina, 010 01

Other trials in Slovakia

France10 sites

  • Centre Hospitalier Universitaire Grenoble Alpes-Site Nord Michallon

    La Tronche, 38700

  • Hôpital Arnaud de Villeneuve_Service de Cardiologie

    Montpellier, 34295

  • Aphp-Hopital Lariboisiere

    Paris, 75010

  • APHP-HOPITAL LA PITIE SALPETRIERE_Institut de Cardiologie

    Paris, 75013

  • Centre Hospitalier de Pau - Hopital Francois Mitterrand

    Pau, 64000

  • CENTRE HOSPITALIER UNIVERSITAIRE DE POITIERS - Centre Cardio Vasculaire

    Poitiers, 86000

  • Centre Hospitalier Universitaire de Poitiers

    Poitiers, 86000

  • Centre Hospitalier Intercommunal Toulon La Seine-Sur-Mer - Hopital Sainte Musse

    Toulon, 83100

  • CENTRE HOSPITALIER UNIVERSITAIRE DE TOULOUSE-HOPITAL RANGUEIL_Service de Cardiologie

    Toulouse, 31059

  • Chru de Nancy - Hopital Brabois

    Vandœuvre-lès-Nancy, 54500

Other trials in France

Lithuania10 sites

  • Kaunas Hospital of the Lithuanian University of Health Sciences

    Kaunas, 45130

  • Klinikiniai sprendimai, Kaunas

    Kaunas, 49387

  • JSC "Saules seimos medicinos centras"

    Kaunas, 49449

  • Hospital of Lithuanian University of Health Sciences Kauno klinikos

    Kaunas, 50161

  • Cardiology and Rehabilitation Clinic

    Klaipėda, 91131

  • Klaipeda university hospital

    Klaipėda, 92288

  • Klaipeda university hospital

    Klaipėda, LT-92288

  • Republican Siauliai Hospital Consulting Outpatient Clinic

    Šiauliai, 76206

  • JSC Inlita Santaros

    Vilnius, 08406

  • Vilnius University hospital Santaros klinikos

    Vilnius, 08661

Other trials in Lithuania

Latvia9 sites

  • Zane Lucane GP Practice

    Grobiņa, South Kurzeme Municipality, 3430

  • Zemgales diabetes centre

    Jelgava, 3001

  • Riga 1st Hospital

    Riga, 1001

  • P. Stradins Clinical University Hospital

    Riga, 1002

  • Adoria

    Riga, 1011

  • Professor Skride Heart Clinic

    Riga, 1013

  • GK Neiroklinika

    Riga, 1023

  • Veselibas centru apvieniba

    Riga, 1039

  • Riga East Clinical University Hospital - Clinic "Gailezers"

    Riga, 1079

Other trials in Latvia

Israel8 sites

  • Shamir MC - Cardiology Department

    Beer Yaakov, 7033001

  • Hillel Yaffe MC - Cardiology Department

    Hadera, 3810101

  • Rambam MC - Heart Failure Unit

    Haifa, 3109601

  • Hadassah Ein Karam MC - Cardio Department

    Jerusalem, 91120

  • Rabin MC Beilinson - Heart Failure Unit

    Petah Tikva, 49100

  • Kaplan MC - Heart Failure Unit

    Rehovot, 76100

  • Sourasky MC - Cardio Vascular Research Center

    Tel Aviv, 6423906

  • Sheba MC - Cardiology Clinical Research Unit

    Tel Litwinsky, 5265601

Other trials in Israel

Denmark7 sites

  • Aarhus Universitetshospital, Hjertesygdomme

    Aarhus N, 8200

  • Aarhus Universitetshospital, Skejby Hjertesygdomme

    Aarhus N, 8200

  • Bispebjerg og Frederiksberg Hospital

    Frederiksberg, 2000

  • Herlev Hospital - Afdeling for Hjertesygdomme, Forskning 1

    Herlev, Capital Region, 2730

  • Sjællands Universitetshospital, Roskilde - Kardiologisk Afdeling

    Roskilde, 4000

  • Kardiologisk Odense & Svendborg

    Svendborg, Region South, 5700

  • Svendborg Sygehus - Kardiologisk

    Svendborg, Region South, 5700

Other trials in Denmark

Ireland7 sites

  • Cork University Hospital

    Cork, T12 DC4A

  • St James's CRF

    Dublin, Leinster, D08 A978

  • The Heartbeat Trust

    Dublin, A96 D628

  • Mater Miscericordiae Hospital

    Dublin, D07 KX5K

  • Mater Private Network - Dublin

    Dublin, D07KWR1

  • St James's CRF

    Dublin, D08 A978

  • Mater Private Network Cork

    Mahon, Cork, T12 K199

Other trials in Ireland

Taiwan7 sites

  • Kaohsiung Medical University Chung-Ho Memorial Hospital

    Kaohsiung City, 807

  • Chang Gung Memorial Hospital - Kaohsiung Branch

    Kaohsiung City, 833

  • Taichung Veterans General Hospital

    Taichung, 407

  • Kuang Tien General Hospital

    Taichung, 433

  • Taipei Medical University Hospital

    Taipei, 110

  • Taipei Veterans General Hospital

    Taipei, 112

  • Chang Gung Medical Foundation - Linkou Branch

    Taoyuan, 333

Other trials in Taiwan

Belgium6 sites

  • AZORG Aalst - Moorselbaan

    Aalst, 9300

  • UZ Brussel

    Brussels, 1090

  • UZA - UZ Antwerpen - Cardiology Department

    Edegem, 2650

  • Ziekenhuis Oost-Limburg

    Genk, 3600

  • AZ Groeninge - Kortrijk - Cardiology

    Kortrijk, 8500

  • CHR de la Citadelle

    Liège, 4000

Other trials in Belgium

Finland6 sites

  • HUS Cardiac and Lung Unit CRC

    Helsinki, 00290

  • StudyCor

    Jyväskylä, 40620

  • Health Step Finland Oy

    Kuopio, 70600

  • Seinäjoen keskussairaala

    Seinäjoki, 60220

  • TAYS Sydänsairaala

    Tampere, 33520

  • TYKS Cardiac Unit

    Turku, 20520

Other trials in Finland

Norway6 sites

  • Haukeland Universitetssykehus

    Bergen, 5021

  • Akershus universitetssykehus HF

    Lørenskog, 1478

  • Colosseumklinikken Medisinske Senter AS

    Oslo, 0369

  • Rikshospitalet - Kardiologisk forskning

    Oslo, 0372

  • Oslo universitetssykehus HF - Ullevål

    Oslo, 0450

  • Stavanger Universitetssykehus, Helse Stavanger HF

    Stavanger, NO-4011

Other trials in Norway

Singapore6 sites

  • National University Hospital Singapore

    Singapore, 119074

  • National Heart Centre Singapore

    Singapore, 169609

  • Tan Tock Seng Hospital

    Singapore, 308433

  • Changi General Hospital

    Singapore, 529889

  • Sengkang General Hospital

    Singapore, 544886

  • Khoo Teck Puat Hospital

    Singapore, 768828

Other trials in Singapore

Bosnia and Herzegovina3 sites

  • University Clinical Centre of the Republic Srpska

    Banja Luka, 78000

  • Dr. Abdulah Nakas General Hospital

    Sarajevo, 71000

  • University Clinical Centre Sarajevo

    Sarajevo, 71000

Other trials in Bosnia and Herzegovina

Estonia3 sites

  • East Tallinn Central Hospital

    Tallinn, 10138

  • North Estonia Medical Centre Foundation

    Tallinn, 13419

  • Tartu University Hospital

    Tartu, 50406

Other trials in Estonia

North Macedonia3 sites

  • PHI City General Hospital 8th September

    Skopje, 1000

  • PHI University Clinic for Cardiology

    Skopje, 1000

  • Private Healthcare Institution - Acibadem Sistina Hospital Skopje

    Skopje, 1000

Other trials in North Macedonia

Slovenia3 sites

  • General hospital Celje - cardiology

    Celje, 3000

  • UKC Ljubljana, Cardiology department

    Ljubljana, 1000

  • UKC Maribor - cardiology

    Maribor, 2000

Other trials in Slovenia

About this study

Official title: Effects of Ziltivekimab Versus Placebo on Morbidity and Mortality in Patients With Heart Failure With Mildly Reduced or Preserved Ejection Fraction and Systemic Inflammation

This study will be done to see if ziltivekimab can be used to treat people living with heart failure and inflammation. Participants will either get ziltivekimab or placebo. Participants will get study medicine for once-monthly injections either in a pre-filled syringe to inject the study medicine into a skinfold or a pen-injector to inject the study medicine into flat skin. The study is expected to last for up to 4 years. Participants will have up to 20 clinic visits. Participants will have to use a study app on their phone to record and share information about all their injections of study medicine and to fill in questionnaires.

Conditions
Heart Failure
Being tested
Ziltivekimab, Placebo
Medical subject headings
Heart Failure

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • ZiltivekimabDrug

    Ziltivekimab subcutaneous (s.c.) injection in a pre-filled syringe or a pen-injector once-monthly for up to 4 years.

  • PlaceboDrug

    Ziltivekimab placebo s.c. injection in a pre-filled syringe or a pen-injector once-monthly for up to 4 years.

Study groups in NCT05636176
Study groupRoleWhat they receive
ZiltivekimabExperimentalParticipants will receive ziltivekimab subcutaneous (s.c.) injection once-monthly and added standard of care for up to 4 years.
Receives: Drug: Ziltivekimab
PlaceboPlacebo comparatorParticipants will receive ziltivekimab placebo s.c. injection once-monthly and added standard of care for up to 4 years.
Receives: Drug: Placebo

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Time to First Occurrence of a Composite Heart Failure Endpoint Consisting of: Cardiovascular (CV) Death, Heart Failure (HF) Hospitalisation or Urgent HF Visit

    Measured in months.

    Measured: From randomisation (month 0) to end of study (up to 48 months)

Secondary outcomes (18)

  1. Time to First Occurrence of 4-point Expanded Composite HF Endpoint, a Composite Endpoint Consisting of: CV Death, HF Hospitalisation or Urgent HF Visit, Non-fatal Myocardial Infarction (MI), Non-fatal Stroke

    Measured in months.

    Measured: From randomisation (month 0) to end of study (up to 48 months)

  2. Number of CV Deaths, HF Hospitalisations or Urgent HF Visits (First and Recurrent)

    Measured as count of event.

    Measured: From randomisation (month 0) to end of study (up to 48 months)

  3. Time to Occurrence of CV Death

    Measured in months.

    Measured: From randomisation (month 0) to end of study (up to 48 months)

  4. Time to Occurrence of all-cause Death

    Measured in months.

    Measured: From randomisation (month 0) to end of study (up to 48 months)

  5. Time to First Occurrence of 4-point Expanded Composite HF Endpoint, a Composite Endpoint Consisting of: All-cause Death, HF Hospitalisation or Urgent HF Visit, Non-fatal MI, Non-fatal stroke

    Measured in months.

    Measured: From randomisation (month 0) to end of study (up to 48 months)

  6. Hierarchical Composite of: Time to All-cause Death, Number of HF Hospitalisations or Urgent HF Visits, Time to First HF Hospitalisation or Urgent HF Visit, difference of at least 5 in KCCQ clinical summary score change from baseline to 12 months

    Kansas City Cardiomyopathy Questionnaire (KCCQ) measures Health-Related Quality of Life (HRQOL) and is a disease-specific health status instrument for HF. Score ranges from 0 to 100, with 0 as the lowest score and 100 as the highest score. Higher scores indicate better health status, fewer symptoms, and greater disease-specific health related quality of life, respectively. Measured as total wins for each treatment group.

    Measured: From randomisation (month 0) to end of study (up to 48 months)

  7. Time to First Occurrence of HF Hospitalisation or Urgent HF Visit

    Measured in months.

    Measured: From randomisation (month 0) to end of study (up to 48 months)

  8. Number of Events of Atrial Fibrillation

    Measured as count of event.

    Measured: From randomisation (month 0) to end of study (up to 48 months)

  9. Change in KCCQ Clinical Summary Score

    KCCQ measures Health-Related Quality of Life (HRQOL) and is a disease-specific health status instrument for HF. Score ranges from 0 to 100, with 0 as the lowest score and 100 as the highest score. Higher scores indicate better health status, fewer symptoms, and greater disease-specific health related quality of life, respectively. Measured as score.

    Measured: From randomisation (month 0) to 12 months

  10. Improvement of 5 Points or More in KCCQ Clinical Summary Score (Yes/No)

    Kansas City Cardiomyopathy Questionnaire (KCCQ) measures Health-Related Quality of Life (HRQOL) and is a disease-specific health status instrument for HF. Score ranges from 0 to 100, with 0 as the lowest score and 100 as the highest score. Higher scores indicate better health status, fewer symptoms, and greater disease-specific health related quality of life, respectively. Measured as count of participant.

    Measured: From randomisation (month 0) to 12 months

  11. Improvement of 10 Points or More in KCCQ Clinical Summary Score (Yes/No)

    Kansas City Cardiomyopathy Questionnaire (KCCQ) measures Health-Related Quality of Life (HRQOL) and is a disease-specific health status instrument for HF. Score ranges from 0 to 100, with 0 as the lowest score and 100 as the highest score. Higher scores indicate better health status, fewer symptoms, and greater disease-specific health related quality of life, respectively. Measured as count of participant.

    Measured: From randomisation (month 0) to 12 months

  12. Improvement in New York Heart Association (Classification) [NYHA Class] (Yes/No)

    NEW YORK HEART ASSOCIATION CLASSIFICATION (NYHA) Class I: Participant with cardiac disease but without resulting limitations of physical activity.

    Class II: Participants with cardiac disease resulting in slight limitation of physical activity.

    Class III: Participants with cardiac disease resulting in marked limitation of physical activity.

    Class IV: Participants with cardiac disease resulting in inability to carry on any physical activity without discomfort.

    Measured as count of participant.

    Measured: From randomisation (month 0) to 12 months

  13. Time to First Occurrence of a Composite Chronic Kidney Disease (CKD) Endpoint Consisting of: CV death, Onset of Persistent Greater Than Equal To 40 Percentage Reduction in eGFR (CKD- EPI) compared with baseline; Kidney failure

    eGFR = estimated glomerular filtration rate; CKD-EPI = chronic kidney disease - epidemiology collaboration. Kidney failure defined as: death from kidney failure, onset of persistent eGFR less than 15 milliliters per minute (mL/min)/1.73 meter square (m^2) (CKD-EPI), initiation of chronic kidney replacement therapy (maintenance dialysis or kidney transplantation). Measured in months.

    Measured: From randomisation (month 0) to end of study (up to 48 months)

  14. Change in Estimated Glomerular Filtration Rate (eGFR) (Chronic Kidney Disease - Epidemiology Collaboration [CKD-EPI])

    Measured as mL/min/1.73 m^2.

    Measured: From randomisation (month 0) to 12 months

  15. Annual Rate of Change in eGFR (CKD-EPI) (Total eGFR Slope)

    Measured as mL/min/1.73 m^2/year.

    Measured: From randomisation (month 0) to end of study (up to 48 months)

  16. Number of Hospitalisations With Infection as Primary Cause or Death Due to Infection

    Measured as count of event.

    Measured: From randomisation (month 0) to end of study (up to 48 months)

  17. Change in High-sensitivity C-reactive Protein (hs-CRP)

    Measured as ratio to baseline.

    Measured: From randomisation (month 0) to 12 months

  18. Change in N-terminal-pro-brain Natriuretic Peptide (NT-proBNP)

    Measured as ratio to baseline.

    Measured: From randomisation (month 0) to 12 months

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted5 Dec 2022
  2. Study start8 May 2023
  3. Primary completion3 Sep 2026
  4. Study completion3 Sep 2026

Why it stopped: No longer looking for participants.

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase 3
Primary purpose
Treatment
Allocation
Randomised
Intervention model
Parallel groups
Masking
Quadruple blind
Who is masked
Participant, Care provider, Investigator, Outcomes assessor
Enrolment
4,874 participants (actual)
IDs, dates and publications
ClinicalTrials.gov ID
NCT05636176
Sponsor's protocol ID
EX6018-4915
Other IDs
U1111-1280-0810, 2022-501939-16-00, jRCT2031230085
Acronym
HERMES
Status last verified
Sep 2026
First submitted
23 Nov 2022
Last updated
1 Oct 2026
Results posted
No
Data monitoring committee
Yes
FDA-regulated drug
Yes
FDA-regulated device
No
Individual data sharing
Yes: According to the Novo Nordisk disclosure commitment on novonordisk-trials.com

Questions about this trial

What is this clinical trial studying?

A Phase 3 study testing Ziltivekimab in people with Heart Failure, run by Novo Nordisk A/S at 1,013 sites in 46 countries.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 18 inclusion and 12 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: stopped early, as of the sponsor's last update on 1 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 1,013 sites in United States, India, China, Japan, Poland and 41 more countries. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

What does this phase mean?

Phase 3 studies compare the treatment with the current standard treatment or a placebo in a large group, to confirm how well it works and watch for side effects.

Not every study follows the same path, and some studies (observational studies, device studies) have no phase.

Are results available for this study?

The study was stopped early (reason given: No longer looking for participants.). Results are not available in the source record.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Time to First Occurrence of a Composite Heart Failure Endpoint Consisting of: Cardiovascular (CV) Death, Heart Failure (HF) Hospitalisation or Urgent HF Visit (time frame: From randomisation (month 0) to end of study (up to 48 months)). It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT05636176.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 1 Oct 2026.

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HERMES Clinical Trial NCT05636176 | AzTrials