Age-Related Loss of Skeletal Muscle MassAgilENCT05727254
Agility Training for Older Adults to Improve Fall Risk Factors
A study testing Agility training, Exercise recommendations and Exercise diary in people with Age-Related Loss of Skeletal Muscle Mass and Aging, run by Oliver Faude at 1 site in Switzerland.
Trial summary
In this randomized controlled trial the effect of 4 months of multi-component (strength, balance, cognition, endurance) exercise training intervention on measures of neuromuscular performance, cognition, and endurance as well as neural adaptations on a central and peripheral level is investigated. Read more about this study
- Who is it for?
- Ages 60 to 80 yearsHealthy volunteers can take part
- Conditions the study is for
- Age-Related Loss of Skeletal Muscle Mass, Aging, Sarcopenia
- What is being tested?
- Agility training, Exercise recommendations and Exercise diary
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 48 participants
- Where
- 1 siteSwitzerland
- Study dates
- 13 Jul 2022to 15 Dec 2023
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 60 to 80 years
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- willing to be randomized to either arm
- ability to travel to the sports facility twice a week
- understanding the german language
Who cannot join
- smoking, obesity
- history of cardiovascular, pulmonary or chronic inflammatory disease
- vision impairments
- orthopaedic problems preventing them from participating in an exercise program
- history of osteoporosis or recent low trauma fracture
- less than two weeks during the intervention period
- not have taken part in a structured exercise program more than once a week in the past three months
Trial locations and contacts
1 site in 1 country.
Switzerland1 site
Departement für Sport, Bewegung und Gesundheit
Basel, Canton of Basel-City, 4052
About this study
Official title: Agility Training for Older Adults: A Randomized Controlled Trial
In this randomized controlled trial the effect of 4 months of multi-component (strength, balance, cognition, endurance) exercise training intervention on measures of neuromuscular performance, cognition, and endurance as well as neural adaptations on a central and peripheral level is investigated. 40 subjects are recruited that are generally health and between 60 and 80 years of age. The interventions is based around exercises, where different tasks have to be solved simultaneously rather than serially, as has previously been done.
- Being tested
- Agility training, Exercise recommendations, Exercise diary
- Medical subject headings
- Sarcopenia, Cognitive Dysfunction
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Agility trainingBehavioural
Multi-component (strength, balance, cognition) exercise training.
Exercise recommendationsBehavioural
Participants are being given the standard recommendations how much exercise and what type older adults should do.
Exercise diaryBehavioural
Participants are instructed to write down their physical activity and exercises.
| Study group | Role | What they receive |
|---|---|---|
| Agility Training | Experimental | 16 weeks, two times per week, 1 hour of multi-component exercise training, exercise guidelines and exercise diary. Receives: Behavioral: Agility training; Behavioral: Exercise recommendations; Behavioral: Exercise diary |
| Control | Active comparator | Exercise guidelines and exercise diary. Receives: Behavioral: Exercise recommendations; Behavioral: Exercise diary |
What is being measured
The primary outcome is the main question the study is designed to answer.
Isometric knee-extension strength
Strength in torque (N*m) of the quadriceps femoris muscle. Measured on an isokinetic device in an isometric condition.
Measured: 16 weeks
Secondary outcomes (14)
Isometric knee-flexion strength
Strength in torque (N*m) of the hamstring muscle group measured on an isokinetic device in an isometric condition.
Measured: 16 weeks
Cognitive Processing Speed
Eriksen flanker task performance measured be reaction speed in milliseconds and accuracy in percentage.
Measured: 16 weeks
Cognitive Impulsiveness
Go / No-Go task performance measured by reaction speed in milliseconds and accuracy in percentage.
Measured: 16 weeks
Balance Performance
Staying as stable as possible during ten seconds in tandem stance eyes open condition. Center of pressure sway path length in mm and average sway speed in m/s is calculated.
Measured: 16 weeks
Hand Grip Strength
Using a handheld dynamometer with an extended arm squeezing as hard as possible. Measured in N.
Measured: 16 weeks
Counter movement jump power
Measured on a force plate participants are instructed to jump as high as possible with their hands akimbo. Peak of the time-power curve in Watts.
Measured: 16 weeks
Blood Pressure
Blood pressure cuff on the right arm at the height of the aorta. Measured in mmHG.
Measured: 16 weeks
Pulse Wave Velocity
Estimated from a mobile blood pressure cuff (mobil-O-graph) on the right arm. Measured in m/s.
Measured: 16 weeks
Retinal vessel diameter
A photo is made from the retinal vessels with a static vessel analyzer (camera)through the eye and the vessel diameters are measured in mikrometers.
Measured: 16 weeks
Quality of Life Questionnaire
26 item questionnaire (WHOQOL-Bref). Every answer is rated on a scale from 1 to 5. Aggregate Score from 0 to 100.
Measured: 16 weeks
Fall Efficacy
16 item qestionnaire (Fall Efficacy Scale). Every answer is rated on a scale from 1 to 4.
Measured: 16 weeks
Sleep Disturbances
7 item questionnaire (Insomnia Severity Index). Every answer is rated on a scale from 1 to 5.
Measured: 16 weeks
Stress
10 item qestionnaire (Perceived Stress Scale). Every answer is rated on a scale from 1 to 5.
Measured: 16 weeks
Depression
15 item questionnaire (Center for Epidemiological Studies Depression Scale). Every answer is rated on a scale from 1 to 4.
Measured: 16 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted14 Feb 2023
- Study start13 Jul 2022
- Primary completion15 Dec 2023
- Study completion15 Dec 2023
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Age-Related Loss of Skeletal Muscle MassStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- Randomized controlled trial with an intervention and a control arm.
- Masking
- None (open label)
- Enrolment
- 48 participants (actual)
Sponsor and investigators
- Lead sponsor
- Oliver Faude
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor-investigator, Oliver Faude, University of Basel
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05727254
- Sponsor's protocol ID
- 2222-00145
- Acronym
- AgilE
- Status last verified
- Mar 2025
- First submitted
- 13 Jan 2023
- Last updated
- 3 Apr 2025
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes: Publication of the raw data along the publication of the results. Data is anonymized. Outcome results of the individual tests are shared.
Study at a glance
From the registry record, last updated by the sponsor on 3 Apr 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Agility Training for Older Adults: A Randomized Controlled Trial
- ClinicalTrials.gov ID
- NCT05727254
- Acronym / sponsor ID
- AgilE / 2222-00145
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 48 participants (actual)
- Lead sponsor
- Oliver FaudeUniversity, hospital or other
- Study start
- 13 Jul 2022 (actual)
- Primary completion
- 15 Dec 2023 (actual)
- Study completion
- 15 Dec 2023 (actual)
- First posted
- 14 Feb 2023 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
In this randomized controlled trial the effect of 4 months of multi-component (strength, balance, cognition, endurance) exercise training intervention on measures of neuromuscular performance, cognition, and endurance as well as neural adaptations on a central and peripheral level is investigated. 40 subjects are recruited that are generally health and between 60 and 80 years of age. The interventions is based around exercises, where different tasks have to be solved simultaneously rather than serially, as has previously been done.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
- Model description
- Randomized controlled trial with an intervention and a control arm.
| Arm | Type | Receives |
|---|---|---|
| Agility Training | Experimental | Behavioral: Agility training, Behavioral: Exercise recommendations, Behavioral: Exercise diary16 weeks, two times per week, 1 hour of multi-component exercise training, exercise guidelines and exercise diary. |
| Control | Active comparator | Behavioral: Exercise recommendations, Behavioral: Exercise diaryExercise guidelines and exercise diary. |
Who may qualify
- Ages
- 60 to 80 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (3 listed)
- willing to be randomized to either arm
- ability to travel to the sports facility twice a week
- understanding the german language
Key exclusion criteria (7 listed)
- smoking, obesity
- history of cardiovascular, pulmonary or chronic inflammatory disease
- vision impairments
- orthopaedic problems preventing them from participating in an exercise program
- history of osteoporosis or recent low trauma fracture
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Agility trainingMulti-component (strength, balance, cognition) exercise training. | Behavioural | Agility Training |
| Exercise recommendationsParticipants are being given the standard recommendations how much exercise and what type older adults should do. | Behavioural | Agility Training, Control |
| Exercise diaryParticipants are instructed to write down their physical activity and exercises. | Behavioural | Agility Training, Control |
Primary outcome
Isometric knee-extension strength
Time frame: 16 weeks
Strength in torque (N*m) of the quadriceps femoris muscle. Measured on an isokinetic device in an isometric condition.
14 secondary outcomes
Isometric knee-flexion strength
Time frame: 16 weeks
Cognitive Processing Speed
Time frame: 16 weeks
Cognitive Impulsiveness
Time frame: 16 weeks
Balance Performance
Time frame: 16 weeks
Hand Grip Strength
Time frame: 16 weeks
Counter movement jump power
Time frame: 16 weeks
Blood Pressure
Time frame: 16 weeks
Pulse Wave Velocity
Time frame: 16 weeks
Retinal vessel diameter
Time frame: 16 weeks
Quality of Life Questionnaire
Time frame: 16 weeks
Fall Efficacy
Time frame: 16 weeks
Sleep Disturbances
Time frame: 16 weeks
Stress
Time frame: 16 weeks
Depression
Time frame: 16 weeks
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 3 Apr 2025.
- Individual participant dataSharing planned: Yes. Publication of the raw data along the publication of the results. Data is anonymized. Outcome results of the individual tests are shared.
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Agility training, Exercise recommendations and Exercise diary in people with Age-Related Loss of Skeletal Muscle Mass and Aging, run by Oliver Faude at 1 site in Switzerland.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 3 Apr 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Switzerland. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Isometric knee-extension strength (time frame: 16 weeks). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 3 Apr 2025; AzTrials last refreshed its copy on 6 Nov 2026.