Perception of Things Changing ColorNCT05779228
Visual Mode Switching in Color Perception
A study testing Mode Switching Training in people with Perception of Things Changing Color and Adaptive Behavior, run by University of Minnesota at 1 site in United States.
Trial summary
Participants will be given experience wearing colored lenses that add a tint to the environment. Changes in visual perception and neural processing that arise as a result of this experience will be measured. Read more about this study
- Who is it for?
- Ages 18 to 65 yearsHealthy volunteers can take part
- Conditions the study is for
- Perception of Things Changing Color, Adaptive Behavior
- What is being tested?
- Mode Switching Training
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 0 participants
- Where
- 1 siteUnited States
- Study dates
- 1 Jan 2026to 4 Feb 2032
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 65 years
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- Normal or corrected to normal vision by contact lenses
- No known visual disorders
- Little to no experience in tinted environments (e.g. dark rooms, swimming goggles)
Who cannot join
- Abnormal color vision
Trial locations and contacts
1 site in 1 country.
United States1 site
University of Minnesota
Minneapolis, Minnesota, 55455
About this study
Participants will be given experience wearing colored lenses that add a tint to the environment. Changes in visual perception and neural processing that arise as a result of this experience will be measured. These are expected as participants learn to switch to "colored lenses mode" where the effects of the lenses are discounted and colors appear more normal as soon as the lenses are put on.
Read the detailed description
All participants will wear tinted lenses for 1 hour at a time, 5 times per day. Perception (behavior) and neural function (with functional MRI and EEG) before and after this experience will be measured. In the neural measurements, activity will be recorded while participants view stripes of many different colors both with the lenses on and off. In the perceptual measurements, participants will adjust the color of a small patch to appear neutral, neither red nor green. Behavior will be measured in a variety of conditions to test different hypotheses about the origins of the mode-switching effects. These include: 1) surrounding the patch with different colors, 2) preceding the presentation of the patch with presentation of different colors, 3) presenting the tests in a red-illuminated room, 4) presenting the tests in a completely darkened room, and 5) using a head-mount-display (virtual reality goggles) to present simulated lenses that gradually change in strength.
- Being tested
- Mode Switching Training
- Keywords
- Visual Perception, Visual Adaptation, Color Perception
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Mode Switching TrainingBehavioural
Wear of colored lenses for 1 hr, 5 times per day, for 5 days
| Study group | Role | What they receive |
|---|---|---|
| Color Contrast | Experimental | Test patch is surrounded spatially by different colors Receives: Behavioral: Mode Switching Training |
| Color Adaptation | Experimental | Test patch is surrounded temporally (preceded) by different colors Receives: Behavioral: Mode Switching Training |
| Neuroimaging | Experimental | Functional MRI and Electroencephelography data are acquired for multiple test colors Receives: Behavioral: Mode Switching Training |
| Red Room | Experimental | Participants are tested in a red-illuminated room Receives: Behavioral: Mode Switching Training |
| Dark Room | Experimental | Participants are tested in a completely darkened room Receives: Behavioral: Mode Switching Training |
| Gradual Change | Experimental | Participants view a gradual change in tint, presented on a head-mounted display Receives: Behavioral: Mode Switching Training |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change in unique yellow settings
This is a standard psychophysical measure referenced in 100s of papers. Participants adjust a patch of color until it appears neither red nor green and this color is reported in standard colorimetric coordinates (e.g. CIE).
Measured: Change will be assessed over the entire study, by comparing a pre-test the day before the intevention (which lasts 5 days) to a post-test the day after the intervention.
Change in BOLD functional MRI activity
Neural activation will be measured with functional MRI which will be used to measure BOLD activity with standard methods, and reported as percent change from rest, a standard measure, for each voxel in the brain.
Measured: Change will be assessed over the entire study, by comparing a pre-test the day before the intevention (which lasts 5 days) to a post-test the day after the intervention.
Change in EEG activity
Neural activity will be measured with electroencephelography using standard techniques and will be reported as voltage changes over time for each electrode in a standard configuration.
Measured: Change will be assessed over the entire study, by comparing a pre-test the day before the intevention (which lasts 5 days) to a post-test the day after the intervention.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted22 Mar 2023
- Study start1 Jan 2026 (estimated)
- Primary completion4 Feb 2031 (estimated)
- Study completion4 Feb 2032 (estimated)
Why it stopped: Grant was not funded
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Perception of Things Changing ColorStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- The interventional study type is correct. The investigative team is giving all subjects a treatment- behavioral training in visual mode switching- and measuring effects of that treatment, by comparing measures made before to measures made after the treatment. Thus, this is a within-subjects, repeated measures experimental design. The experimenters have 6 different measurements they are using this design in different groups of subjects run in parallel, all examining different effects of the same treatment. . This is why parallel study model is appropriate. These parallel groups with different measurements, but same treatment, are the arms of the study.
- Masking
- None (open label)
- Enrolment
- 0 participants (actual)
Sponsor and investigators
- Lead sponsor
- University of Minnesota
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05779228
- Sponsor's protocol ID
- STUDY00002354
- Status last verified
- Jan 2026
- First submitted
- 20 Jan 2023
- Last updated
- 14 Jan 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes: Completely deidentified data, meta-data, stimulus presentation code, and analysis code will be shared following an NIH data sharing plan. Data will be shared using the OSF platform, as well as github for code.
Publications
Li Y, Tregillus KE, Luo Q, Engel SA. Visual mode switching learned through repeated adaptation to color. Elife. 2020 Dec 15;9:e61179. doi: 10.7554/eLife.61179.
PubMed 33320093
Study at a glance
From the registry record, last updated by the sponsor on 14 Jan 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Visual Mode Switching in Color Perception
- ClinicalTrials.gov ID
- NCT05779228
- Acronym / sponsor ID
- STUDY00002354
- Keywords
- Visual Perception, Visual Adaptation, Color Perception
- Study type
- Interventional
- Recruitment status
- WithdrawnReason stopped: Grant was not funded
- Enrolment
- 0 participants (actual)
- Lead sponsor
- University of MinnesotaUniversity, hospital or other
- Study start
- 1 Jan 2026 (estimated)
- Primary completion
- 4 Feb 2031 (estimated)
- Study completion
- 4 Feb 2032 (estimated)
- First posted
- 22 Mar 2023 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Participants will be given experience wearing colored lenses that add a tint to the environment. Changes in visual perception and neural processing that arise as a result of this experience will be measured. These are expected as participants learn to switch to "colored lenses mode" where the effects of the lenses are discounted and colors appear more normal as soon as the lenses are put on.
Detailed description
All participants will wear tinted lenses for 1 hour at a time, 5 times per day. Perception (behavior) and neural function (with functional MRI and EEG) before and after this experience will be measured. In the neural measurements, activity will be recorded while participants view stripes of many different colors both with the lenses on and off. In the perceptual measurements, participants will adjust the color of a small patch to appear neutral, neither red nor green. Behavior will be measured in a variety of conditions to test different hypotheses about the origins of the mode-switching effects. These include: 1) surrounding the patch with different colors, 2) preceding the presentation of the patch with presentation of different colors, 3) presenting the tests in a red-illuminated room, 4) presenting the tests in a completely darkened room, and 5) using a head-mount-display (virtual reality goggles) to present simulated lenses that gradually change in strength.
Study design
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 6
- Model description
- The interventional study type is correct. The investigative team is giving all subjects a treatment- behavioral training in visual mode switching- and measuring effects of that treatment, by comparing measures made before to measures made after the treatment. Thus, this is a within-subjects, repeated measures experimental design. The experimenters have 6 different measurements they are using this design in different groups of subjects run in parallel, all examining different effects of the same treatment. . This is why parallel study model is appropriate. These parallel groups with different measurements, but same treatment, are the arms of the study.
| Arm | Type | Receives |
|---|---|---|
| Color Contrast | Experimental | Behavioral: Mode Switching TrainingTest patch is surrounded spatially by different colors |
| Color Adaptation | Experimental | Behavioral: Mode Switching TrainingTest patch is surrounded temporally (preceded) by different colors |
| Neuroimaging | Experimental | Behavioral: Mode Switching TrainingFunctional MRI and Electroencephelography data are acquired for multiple test colors |
| Red Room | Experimental | Behavioral: Mode Switching TrainingParticipants are tested in a red-illuminated room |
| Dark Room | Experimental | Behavioral: Mode Switching TrainingParticipants are tested in a completely darkened room |
| Gradual Change | Experimental | Behavioral: Mode Switching TrainingParticipants view a gradual change in tint, presented on a head-mounted display |
Who may qualify
- Ages
- 18 to 65 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (3 listed)
- Normal or corrected to normal vision by contact lenses
- No known visual disorders
- Little to no experience in tinted environments (e.g. dark rooms, swimming goggles)
Key exclusion criteria (1 listed)
- Abnormal color vision
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Mode Switching TrainingWear of colored lenses for 1 hr, 5 times per day, for 5 days | Behavioural | Color Adaptation, Color Contrast, Dark Room, Gradual Change, Neuroimaging, Red Room |
Primary outcome
Change in unique yellow settings
Time frame: Change will be assessed over the entire study, by comparing a pre-test the day before the intevention (which lasts 5 days) to a post-test the day after the intervention.
This is a standard psychophysical measure referenced in 100s of papers. Participants adjust a patch of color until it appears neither red nor green and this color is reported in standard colorimetric coordinates (e.g. CIE).
Change in BOLD functional MRI activity
Time frame: Change will be assessed over the entire study, by comparing a pre-test the day before the intevention (which lasts 5 days) to a post-test the day after the intervention.
Neural activation will be measured with functional MRI which will be used to measure BOLD activity with standard methods, and reported as percent change from rest, a standard measure, for each voxel in the brain.
Change in EEG activity
Time frame: Change will be assessed over the entire study, by comparing a pre-test the day before the intevention (which lasts 5 days) to a post-test the day after the intervention.
Neural activity will be measured with electroencephelography using standard techniques and will be reported as voltage changes over time for each electrode in a standard configuration.
Results and safety
The study was withdrawn before enrolling participants, so there are no results.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 14 Jan 2026.
- Results publication: PubMed 33320093Li Y, Tregillus KE, Luo Q, Engel SA. Visual mode switching learned through repeated adaptation to color. Elife. 2020 Dec 15;9:e61179. doi: 10.7554/eLife.61179.
- Individual participant dataSharing planned: Yes. Completely deidentified data, meta-data, stimulus presentation code, and analysis code will be shared following an NIH data sharing plan. Data will be shared using the OSF platform, as well as github for code.
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Mode Switching Training in people with Perception of Things Changing Color and Adaptive Behavior, run by University of Minnesota at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: withdrawn, as of the sponsor's last update on 14 Jan 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study was withdrawn before enrolling participants, so there are no results.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change in unique yellow settings (time frame: Change will be assessed over the entire study, by comparing a pre-test the day before the intevention (which lasts 5 days) to a post-test the day after the intervention.). The study lists 3 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT05779228, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 14 Jan 2026.