Clinical trials: Adaptive Behavior
Emotional Regulation, Alcohol Drinking in College
Just-in-Time Coping Prompts for Reactive Digital Behavior in College Students
This study looks at the moments when college students feel a strong emotional swing, and how those moments relate to reacting online when upset, drinking alcohol, and eating in response to emotions.
- Conditions
- Emotional Regulation, Alcohol Drinking in College, Emotional Eating, Aggression
- Trial name
- REACT (NCT07789314)
- Testing
- Momentary coping prompt, Active control message
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Florida
Transplant, Adaptive Immunity
CNTRP POSITIVE Study
Adequate control of immunosuppression is critical in preventing graft failure after solid organ transplantation (SOT) and in avoiding life-threatening viral and malignant complications.
- Conditions
- Transplant, Adaptive Immunity, EBV, Medication Adherence
- Trial name
- NCT02318030
- Where
- Canada
- Volunteers
- 600 people
- Sponsor
- The Hospital for Sick Children
Depression
An Adaptive Intervention for Depression Among Latinos Living With HIV
This study will use a pilot sequential multiple assignment randomized trial (SMART) design to build an adaptive treatment strategy (ATS) for depression and engagement in HIV among Latinos living with HIV.
- Trial name
- Latino-SMART (NCT03668379)
- Testing
- Augment w/mHealth, Maintenance, Switch to CBT & mHealth
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Depression, Anxiety, Engagement, Patient
Mobile Apps to Reduce Distress in Breast Cancer Survivors Using an Adaptive Design
The overarching goals of this project are to provide the first rigorous test of a scalable and publicly accessible mobile health intervention (IntelliCare) to address emotional distress in women with breast cancer, and to test…
- Trial name
- NCT04583891
- Testing
- IntelliCare, Psychoeducation, Coaching
- Where
- United States
- Volunteers
- 313 people
- Sponsor
- University of Virginia
Cardiac Arrest
Therapeutic Hypothermia to Improve Survival After Cardiac Arrest in Pediatric Patients-THAPCA-OH [Out of Hospital] Trial
Cardiac arrest is a sudden, unexpected loss of heart function. Therapeutic hypothermia, in which the body's temperature is lowered and maintained several degrees below normal for a period of time, has been used to successfully…
- Trial name
- THAPCA-OH (NCT00878644)
- Testing
- Therapeutic Hypothermia, Therapeutic Normothermia
- Where
- 34 sites in United States, Canada
- Volunteers
- 295 people
- Sponsor
- University of Michigan
Educational Problems, Work-Related Condition
Intervention Program of a Job Crafting
The implementation of effective intervention programs is crucial in enhancing the overall well-being and performance of healthcare professionals, particularly in demanding environments such as nursing
- Conditions
- Educational Problems, Work-Related Condition, Nurse's Role
- Trial name
- JobCrafting (NCT06200701)
- Testing
- Job Crafting program
- Where
- Egypt
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Overweight and Obesity, Overweight
Precision Public Health: Enhancing Connections to Develop Just-in-Time Adaptive Intervention Strategies
The purpose of this pilot study is to examine the effects of different types of just-in-time intervention messages on daily meeting dietary, activity, and weighing goals in a sample of young adults participating in a mobile-based…
- Conditions
- Overweight and Obesity, Overweight, Obesity
- Trial name
- Nudge (NCT03836391)
- Testing
- Nudge
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Abnormal Uterine Bleeding
Decisionmaking for Abnormal Uterine Bleeding (AUB)
The purpose of this study is to determine if using a computer survey about preferences for treatment of abnormal uterine bleeding (AUB) is useful and if it will improve patient satisfaction with clinical care and decision making.
- Trial name
- NCT01721304
- Testing
- Adaptive Conjoint Analysis
- Where
- 2 sites in United States
- Volunteers
- 380 people
- Sponsor
- Indiana University
FOXP1 Syndrome
Psychiatric Phenotype Characterization of Individuals With FOXP1 Syndrome
FOXP1 syndrome is a rare genetic disorder with a variable phenotype, characterized somatically by facial dysmorphia, dysphagia, hypotonia, relative or real macrocephaly, which may be associated with cerebral, cardiac, urogenital…
- Trial name
- FOXP1-PP (NCT06211673)
- Testing
- Semi-structured interviews, Heteroquestionnaires
- Where
- France
- Volunteers
- 25 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Opioid-use Disorder
Examining an Adaptive Approach to Providing Psychosocial Support to Buprenorphine Patients
The purpose of this study is to address important knowledge gaps regarding the optimal way to provide psychosocial treatment to patients who are receiving buprenorphine for opioid use disorder (OUD) in office-based settings.
- Trial name
- NCT04650386
- Testing
- Psychosocial support determined by adaptive treatment algorithm
- Where
- 2 sites in United States
- Volunteers
- 125 people
- Sponsor
- Public Health Management Corporation
Depression, Anxiety
Improving Student Mental Health: Adaptive School-based Implementation of CBT
The overarching goal of this study is to improve the delivery of an established, evidence-based intervention (cognitive-behavioral therapy-CBT) in Michigan schools through different implementation strategies designed to better…
- Trial name
- NCT03541317
- Testing
- Stage 1 Strategy: REP, Stage 1 Strategy: REP + Coaching, Stage 2 Strategy: Augment with Facilitation
- Where
- United States
- Volunteers
- 1,329 people
- Sponsor
- University of Michigan
Attention-Deficit Hyperactivity Disorder
Pharmacokinetics of HLD200 in Children and Adolescents With ADHD
This study was designed to assess the pharmacokinetic effects of a single dose of HLD200 (methylphenidate hydrochloride) in children and adolescents with ADHD.
- Trial name
- NCT01907360
- Testing
- HLD200 (methylphenidate hydrochloride)
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Ironshore Pharmaceuticals and Development, Inc
Alzheimer's Disease, Dementia
Safety and Efficacy Study of Ladostigil in Mild to Moderate Probable Alzheimer's Disease
For many, Alzheimer's disease is the number one medical issue facing our aging society. It is a late onset neurodegenerative disease, frequently under diagnosed, that impairs memory and cognitive performance.
- Conditions
- Alzheimer's Disease, Dementia, Memory Loss, Cognitive Impairment
- Trial name
- NCT01354691
- Testing
- ladostigil hemitartrate
- Where
- 19 sites in Austria, Croatia and 3 more
- Volunteers
- 200 people
- Sponsor
- Avraham Pharmaceuticals Ltd
Spinal Cord Injuries
Feasibility of the First Known Adaptive Intervention for People With SCI
The overall goal of the proposed research is to conduct a pilot study to test the feasibility and acceptability of a home-based exercise intervention (SMART-HEALTH).
- Trial name
- SMART-HEALTH (NCT04726891)
- Testing
- Movement-2-Music + Social Networking Support
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Accident, Traffic
Tiny Cargo, Big Deal! An ED-Based Study of Child Passenger Safety Behaviors
This study involves an emergency department (ED)-based intervention utilizing Motivational Interviewing (MI) techniques and patient-centered eHealth materials (e.g., a tailored, mobile-friendly website and text messages) to…
- Trial name
- NCT04238247
- Testing
- Tiny Cargo, Big Deal/Abróchame Bien, Cuídame Bien (TCBD/ABCB) Basic Intervention, Tiny Cargo, Big Deal/Abróchame Bien, Cuídame Bien (TCBD/ABCB) Enhanced Intervention
- Where
- United States
- Volunteers
- 513 people
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Exercise Training
Exercise-Induced Metabolic Compensation; a Physiological Adaptive Response to Exercise Training
The primary aim of this proposal is to identify changes in the volume of highly metabolic organs (liver, kidneys, and brain) that occur as a physiological adaptation to exercise training and lower the resting energy expenditure.
- Trial name
- NCT04460040
- Testing
- Exercise training
- Where
- Israel
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Tel Aviv University
Loneliness, Social Support
Activating Social Resources in Psychotherapy-Seeking Individuals: Effectiveness and Timing of a Social Support Just-in-Time Adaptive Intervention
This study evaluates a Just-In-Time Adaptive Intervention (JITAI) aiming to foster social support processes for adults with elevated depressive symptoms awaiting outpatient psychotherapy.
- Conditions
- Loneliness, Social Support, Depressive Symptoms
- Trial name
- NCT07471529
- Testing
- Social Support Just-in-Time Adaptive Intervention
- Where
- Switzerland
- Volunteers
- 120 people
- Sponsor
- University of Zurich
Obesity
Effects of Diet Changes on Metabolism
This study, conducted at the NIH Clinical Research Unit at the Phoenix Indian Medical Center, will examine how the body s metabolism (energy expenditure) changes when people overeat and when they fast and how different diets…
- Trial name
- NCT00523627
- Where
- United States
- Volunteers
- 203 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Alcohol Drinking, Violence
SafERteens M-Coach
This study will use a SMART (Sequential, Multiple Assignment Randomized Trial) design to optimize adaptive interventions (AIs) for adolescents reporting alcohol misuse and violent behaviors.
- Trial name
- NCT03344666
- Testing
- Step 1 Treatment BI+HC, Step 1 Treatment BI+TM, Step 2 Treatment Responders
- Where
- 4 sites in United States
- Volunteers
- 400 people
- Sponsor
- University of Michigan
Low Vision
Wearable Echolocation Aids Using Parametric Sound
The objective of this study is to study a novel device designed to aid patients with impaired vision to safely navigate their environment.
- Trial name
- NCT07218991
- Testing
- Wearable Echolocation Device
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston