Stress Reaction; AcuteNCT05820659
Racial Discrimination and Stress Response
A study testing peer rejection task, conversation about peer rejection, and impossible puzzle task in people with Stress Reaction; Acute, run by Western Kentucky University at 1 site in United States.
Trial summary
The goal of this study is to learn about whether ethnic minority adolescents' racial discrimination experience is related to dysregulated biological responses to subtle racism, and how the relationship may be attenuated or exacerbated by a set of social and cognitive factors. Read more about this study
- Who is it for?
- Ages 9 to 99 yearsHealthy volunteers can take part
- Conditions the study is for
- Stress Reaction; Acute
- What is being tested?
- peer rejection task, conversation about peer rejection, and impossible puzzle task
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 178 participants
- Where
- 1 siteUnited States
- Study dates
- 29 Jun 2023to 17 Nov 2024
- Phase
- Interventional
- Are there results?
- Yes, posted in the registrySummary in the doctors' view
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 9 to 99 years
- All sexes
- Healthy volunteers accepted
- Child, Adult, Older adult
Who may be able to join
- 9-14 years old
- identified as Latino American or Black/African American
- Living in Warren county of Kentucky
- with parent consent
- parents of adolescent participants
Who cannot join
- Adolescents will not participate in the peer rejection task when they report to have:
- frequent experiences of peer victimization
- frequent experiences of racial discrimination
- severe depression
- severe social anxiety disorder
- severe generalized anxiety disorder
- limited English reading competence to understand the task instruction
Trial locations and contacts
1 site in 1 country.
United States1 site
Western Kentucky University
Bowling Green, Kentucky, 42101
About this study
Official title: Racial Discrimination and Dysregulated Stress Response: Risk/Protective Factors
The goal of this study is to learn about whether ethnic minority adolescents' racial discrimination experience is related to dysregulated biological responses to subtle racism, and how the relationship may be attenuated or exacerbated by a set of social and cognitive factors. The main questions it aims to answer are:
- to reveal the relationship between racial discrimination experiences and ethnic minority adolescents' stress response to subtle racism
- to test parental ethnic-racial socialization, children's attribution to subtle racism and their racial identity as potential risk and protective factors.
Read the detailed description
Racial discrimination experiences constitute significant risks for ethnic minority youth's physical and mental health problems. One explanation poses that chronic stress can lead to altered, dysregulated stress responses, which can make individuals susceptible to health problems. Currently, there is no experimental study that comprehensively measure ethnic minority youth's stress response to subtle racism, or investigate the contributing roles of racial discrimination experience and possible risk and protective factors.
A community sample of 9-14-year-old ethnic minority adolescents (40 Latino American, 40 Black/African American) will be recruited. The study employs an adapted peer rejection task which has been widely used with youth, and carefully designed to elicit the experience of subtle racial discrimination from White peers. Adolescents' cardiovascular activity and saliva samples will be taken at multiple time points before, during, and after the peer rejection task, tapping on response involving hypothalamic-pituitary-adrenal (HPA) axis, autonomic nervous system (ANS), and inflammatory mediator (IM). Adolescents will report their racial discrimination experience, make attribution about the peer rejection experience, report emotional experience, and rate their racial identity. Adolescents will complete an impossible puzzle task to elicit cognitive stress, during which they will be asked to fit all puzzle pieces into a wooden frame with a wrong piece provided. Their cardiovascular activity, attribution, and emotional experience in response to the impossible puzzle task will be measured. Parents will complete a questionnaire to report their ethnic-racial socialization practices. Adolescents will rate on their ethnic-racial identity via a questionnaire.
The goals of this proposal are: 1) Reveal the relationship between racial discrimination experiences and ethnic minority adolescents' stress response to subtle racism as well as to cognitive stress; and 2) Test parental ethnic-racial socialization, children's attribution to subtle racism and their racial identity as potential risk and protective factors.
- Conditions
- Stress Reaction; Acute
- Being tested
- peer rejection task, conversation about peer rejection, and impossible puzzle task
- Keywords
- cardiovascular reactivity, hypothalamic-pituitary-adrenal axis, inflammatory mediator, subtle racism
- Medical subject headings
- Stress Disorders, Traumatic, Acute
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
peer rejection task, conversation about peer rejection, and impossible puzzle taskBehavioural
Peer rejection task: Adolescents will be informed that two peers will take turns to choose who they will chat with for different topics. Participants will not be chosen by virtual White peers 75% of the time. In reality, White peers are computerized avatars and whether or not adolescents are chosen by those peers is programmed with PsychoPy software.
Conversation about peer rejection: parents and adolescents will discuss the peer rejection task guided with suggested question prompts.
Impossible puzzle task: Adolescents will be asked to fit all puzzle pieces into a wooden frame with a wrong piece provided.
| Study group | Role | What they receive |
|---|---|---|
| stress inducing task | Experimental | Adolescents will complete an adapted peer rejection task on the computer to elicit the experience of subtle racial discrimination from White peers, then discuss the peer rejection task with parents, as well as an impossible puzzle task to elicit cognitive stress. Receives: Behavioral: peer rejection task, conversation about peer rejection, and impossible puzzle task |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change in Mean Arterial Pressure for Peer Rejection
adolescents' diastolic and systolic blood pressure will be continuously monitored.
Measured: baseline (5 minute before to right before the task), during (start to the end of the task), and post-task (right after to 45 minutes after the peer rejection task)
Change in Stress Hormones for Peer Rejection
adolescents' salivary samples will be collected, frozen, and assayed for cortisol.
Measured: five time points (right before, 5 minutes after, 15 minutes after, 30 minutes after, and 45 minutes after the peer rejection task)
Change in Inflammatory Biomarker of Interleukin 6 for Peer Rejection
adolescents' salivary samples will be collected, frozen, and assayed for inflammatory biomarker of Interleukin-6
Measured: five time points (right before, 5 minutes after, 15 minutes after, 30 minutes after, and 45 minutes after the peer rejection task)
Change in Inflammatory Biomarker of C-reactive Protein for Peer Rejection
adolescents' salivary samples will be collected, frozen, and assayed for inflammatory biomarker of C-reactive protein
Measured: adolescents' salivary samples will be collected at five time points (right before, 5 minutes after, 15 minutes after, 30 minutes after, and 45 minutes after the peer rejection task)
Attribution About the Peer Rejection for Peer Rejection
participants will complete the questionnaire, Attribution About The Peer Rejection (AATPR) to rate the likelihood of various reasons for the experience of peer rejection using a 7-point scale. The higher total score for the 4 racial reasons (possible range: 4-28) indicates the higher tendency of making racial attribution about the peer rejection.
Measured: immediately after the 5-minute peer rejection task ends
Emotional Experience for Peer Rejection
adolescents will complete the questionnaire, Emotions In The Peer Rejection (EITPR) to rate the emotional experiences in the peer rejection task using a 7-point scale. The higher total score for 5 sets of emotion terms (possible range: 5-35) indicates the higher levels of negative emotions in the peer rejection task.
Measured: immediately after the 5-minute peer rejection task ends
Change in Skin Conductance Activity for Peer Rejection
adolescents' skin conductance will be continuously monitored for the peer rejection task.
Measured: baseline (5 minutes before to right before the task), during (start to end of the task), first post-task (right after to 15 minutes after) and second post-task (15 to 45 minutes after) the peer rejection task
Change in Respiratory Sinus Arrhythmia for Peer Rejection
adolescents' electrocardiogram data that can be used to extract respiratory sinus arrhythmia, heart rate variability in synchrony with respiration, will be continuously monitored for the peer rejection task.
Measured: baseline (5 minutes before to right before the task), during (start to the end of the task), first post-task (right after to 15 minutes after the task) and second post-task (15 to 45 minutes after the task)
Secondary outcomes (8)
Change in Mean Arterial Pressure for Impossible Puzzle
adolescents' systolic and diastolic blood pressure will be continuously monitored for the impossible puzzle task
Measured: baseline (5 minutes before to right before the task), during (start to end of the task), and post-task (right after to 15 minutes after the task)
Emotional Experience for Impossible Puzzle
adolescents will complete the questionnaire, Emotions In The Impossible Puzzle (EITIP) to rate the emotional experiences in the impossible puzzle task using a 7-point scale. The higher total score for 5 sets of emotion terms (possible range: 5-35) indicates the higher levels of negative emotions in the impossible puzzle task
Measured: immediately after the 5-minute impossible puzzle task ends
Attribution for Impossible Puzzle
adolescents will complete the questionnaire, Attribution About The Impossible Puzzle (AATIP) to rate the likelihood of various reasons for the experience of not being able to complete the puzzle using a 7-point scale. The higher total score for the 3 intrinsic reasons (possible range: 3-21) indicates the higher tendency of making intrinsic attribution about performance in the impossible puzzle task.
Measured: immediately after the 5-minute impossible puzzle task ends
Change in Skin Conductance for Impossible Puzzle
adolescents' skin conductance will be continuously monitored for the impossible puzzle task
Measured: baseline (5 minutes before to right before the task), during (start to end of the task), and post (right after to 15 minutes after the task)
Change in Respiratory Sinus Arrhythmia for Impossible Puzzle
adolescents' electrocardiogram data that can be used to extract respiratory sinus arrhythmia, heart rate variability in synchrony with respiration, will be continuously monitored for the impossible puzzle task
Measured: baseline (5 minutes before to right before the task), during (start to end of the task), and post-task (right after to 15 minutes after the task)
Change in Mean Arterial Pressure for Conversation About Peer Rejection
adolescents' diastolic and systolic blood pressure will be continuously monitored.
Measured: baseline (2.5 minute of discussion about last night's dinner before the conversation about peer rejection), during (5 minutes about the peer rejection task)
Change in Skin Conductance Activity in Conversation About Peer Rejection
adolescents' skin conductance level will be continuously monitored before and during the conversation about peer rejection.
Measured: baseline (2.5 minutes about last night's dinner before the conversation about peer rejection), during (5 minutes discussion about peer rejection)
Change in Respiratory Sinus Arrhythmia for Conversation About Peer Rejection
adolescents' electrocardiogram data that can be used to extract respiratory sinus arrhythmia, heart rate variability in synchrony with respiration, will be continuously monitored for the conversation about peer rejection
Measured: Baseline (2.5 minutes of discussion on last night's dinner before the conversation about peer rejection), during the task (5 minutes of discussion on peer rejection task)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted20 Apr 2023
- Study start29 Jun 2023
- Primary completion17 Nov 2024
- Study completion17 Nov 2024
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Posted resultsParticipant flow, outcome measures and adverse events reported by the sponsor.
- Publications (3)Papers the sponsor has linked to this study.
- Other trials for Stress Reaction; AcuteStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Enrolment
- 178 participants (actual)
Sponsor and investigators
- Lead sponsor
- Western Kentucky University
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Qingfang Song, Ph.D, Principal investigator, Western Kentucky University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05820659
- Sponsor's protocol ID
- U5GMACGETKJ1
- Status last verified
- Aug 2026
- First submitted
- 29 Mar 2023
- Last updated
- 17 Aug 2026
- Results posted
- Yes, on ClinicalTrials.gov
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes: The research resources from the project will include the study protocol and associated data, which will be provided upon request.
Publications
Lucas T, Wegner R, Pierce J, Lumley MA, Laurent HK, Granger DA. Perceived Discrimination, Racial Identity, and Multisystem Stress Response to Social Evaluative Threat Among African American Men and Women. Psychosom Med. 2017 Apr;79(3):293-305. doi: 10.1097/PSY.0000000000000406.
PubMed 27806018Silk JS, Stroud LR, Siegle GJ, Dahl RE, Lee KH, Nelson EE. Peer acceptance and rejection through the eyes of youth: pupillary, eyetracking and ecological data from the Chatroom Interact task. Soc Cogn Affect Neurosci. 2012 Jan;7(1):93-105. doi: 10.1093/scan/nsr044. Epub 2011 Jul 20.
PubMed 21775386Sladek MR, Castro SA, Doane LD. Ethnic-Racial discrimination experiences predict Latinx adolescents' physiological stress processes across college transition. Psychoneuroendocrinology. 2021 Jun;128:105212. doi: 10.1016/j.psyneuen.2021.105212. Epub 2021 Apr 1.
PubMed 33933893
Study at a glance
From the registry record, last updated by the sponsor on 17 Aug 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Racial Discrimination and Dysregulated Stress Response: Risk/Protective Factors
- ClinicalTrials.gov ID
- NCT05820659
- Acronym / sponsor ID
- U5GMACGETKJ1
- Conditions
- Stress Reaction; Acute
- Keywords
- cardiovascular reactivity, hypothalamic-pituitary-adrenal axis, inflammatory mediator, subtle racism
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 178 participants (actual)
- Lead sponsor
- Western Kentucky UniversityUniversity, hospital or other
- Study start
- 29 Jun 2023 (actual)
- Primary completion
- 17 Nov 2024 (actual)
- Study completion
- 17 Nov 2024 (actual)
- First posted
- 20 Apr 2023 (actual)
- Results
- Posted 17 Aug 2026
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this study is to learn about whether ethnic minority adolescents' racial discrimination experience is related to dysregulated biological responses to subtle racism, and how the relationship may be attenuated or exacerbated by a set of social and cognitive factors. The main questions it aims to answer are:
- to reveal the relationship between racial discrimination experiences and ethnic minority adolescents' stress response to subtle racism
- to test parental ethnic-racial socialization, children's attribution to subtle racism and their racial identity as potential risk and protective factors.
Detailed description
Racial discrimination experiences constitute significant risks for ethnic minority youth's physical and mental health problems. One explanation poses that chronic stress can lead to altered, dysregulated stress responses, which can make individuals susceptible to health problems. Currently, there is no experimental study that comprehensively measure ethnic minority youth's stress response to subtle racism, or investigate the contributing roles of racial discrimination experience and possible risk and protective factors.
A community sample of 9-14-year-old ethnic minority adolescents (40 Latino American, 40 Black/African American) will be recruited. The study employs an adapted peer rejection task which has been widely used with youth, and carefully designed to elicit the experience of subtle racial discrimination from White peers. Adolescents' cardiovascular activity and saliva samples will be taken at multiple time points before, during, and after the peer rejection task, tapping on response involving hypothalamic-pituitary-adrenal (HPA) axis, autonomic nervous system (ANS), and inflammatory mediator (IM). Adolescents will report their racial discrimination experience, make attribution about the peer rejection experience, report emotional experience, and rate their racial identity. Adolescents will complete an impossible puzzle task to elicit cognitive stress, during which they will be asked to fit all puzzle pieces into a wooden frame with a wrong piece provided. Their cardiovascular activity, attribution, and emotional experience in response to the impossible puzzle task will be measured. Parents will complete a questionnaire to report their ethnic-racial socialization practices. Adolescents will rate on their ethnic-racial identity via a questionnaire.
The goals of this proposal are: 1) Reveal the relationship between racial discrimination experiences and ethnic minority adolescents' stress response to subtle racism as well as to cognitive stress; and 2) Test parental ethnic-racial socialization, children's attribution to subtle racism and their racial identity as potential risk and protective factors.
Study design
- Primary purpose
- Basic science
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| stress inducing task | Experimental | Behavioral: peer rejection task, conversation about peer rejection, and impossible puzzle taskAdolescents will complete an adapted peer rejection task on the computer to elicit the experience of subtle racial discrimination from White peers, then discuss the peer rejection task with parents, as well as an impossible puzzle task to elicit cognitive stress. |
Who may qualify
- Ages
- 9 to 99 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Child, Adult, Older adult
Key inclusion criteria (5 listed)
- 9-14 years old
- identified as Latino American or Black/African American
- Living in Warren county of Kentucky
- with parent consent
- parents of adolescent participants
Key exclusion criteria (7 listed)
- frequent experiences of peer victimization
- frequent experiences of racial discrimination
- severe depression
- severe social anxiety disorder
- severe generalized anxiety disorder
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| peer rejection task, conversation about peer rejection, and impossible puzzle taskPeer rejection task: Adolescents will be informed that two peers will take turns to choose who they will chat with for different topics. Participants will not be chosen by virtual White peers 75% of the time. In reality, White peers are computerized avatars and whether or not adolescents are chosen by those peers is programmed with PsychoPy software. Conversation about peer rejection: parents and adolescents will discuss the peer rejection task guided with suggested question prompts. Impossible puzzle task: Adolescents will be asked to fit all puzzle pieces into a wooden frame with a wrong piece provided. | Behavioural | stress inducing task |
Primary outcome
Change in Mean Arterial Pressure for Peer Rejection
Time frame: baseline (5 minute before to right before the task), during (start to the end of the task), and post-task (right after to 45 minutes after the peer rejection task)
adolescents' diastolic and systolic blood pressure will be continuously monitored.
Change in Stress Hormones for Peer Rejection
Time frame: five time points (right before, 5 minutes after, 15 minutes after, 30 minutes after, and 45 minutes after the peer rejection task)
adolescents' salivary samples will be collected, frozen, and assayed for cortisol.
Change in Inflammatory Biomarker of Interleukin 6 for Peer Rejection
Time frame: five time points (right before, 5 minutes after, 15 minutes after, 30 minutes after, and 45 minutes after the peer rejection task)
adolescents' salivary samples will be collected, frozen, and assayed for inflammatory biomarker of Interleukin-6
Change in Inflammatory Biomarker of C-reactive Protein for Peer Rejection
Time frame: adolescents' salivary samples will be collected at five time points (right before, 5 minutes after, 15 minutes after, 30 minutes after, and 45 minutes after the peer rejection task)
adolescents' salivary samples will be collected, frozen, and assayed for inflammatory biomarker of C-reactive protein
Attribution About the Peer Rejection for Peer Rejection
Time frame: immediately after the 5-minute peer rejection task ends
participants will complete the questionnaire, Attribution About The Peer Rejection (AATPR) to rate the likelihood of various reasons for the experience of peer rejection using a 7-point scale. The higher total score for the 4 racial reasons (possible range: 4-28) indicates the higher tendency of making racial attribution about the peer rejection.
Emotional Experience for Peer Rejection
Time frame: immediately after the 5-minute peer rejection task ends
adolescents will complete the questionnaire, Emotions In The Peer Rejection (EITPR) to rate the emotional experiences in the peer rejection task using a 7-point scale. The higher total score for 5 sets of emotion terms (possible range: 5-35) indicates the higher levels of negative emotions in the peer rejection task.
Change in Skin Conductance Activity for Peer Rejection
Time frame: baseline (5 minutes before to right before the task), during (start to end of the task), first post-task (right after to 15 minutes after) and second post-task (15 to 45 minutes after) the peer rejection task
adolescents' skin conductance will be continuously monitored for the peer rejection task.
Change in Respiratory Sinus Arrhythmia for Peer Rejection
Time frame: baseline (5 minutes before to right before the task), during (start to the end of the task), first post-task (right after to 15 minutes after the task) and second post-task (15 to 45 minutes after the task)
adolescents' electrocardiogram data that can be used to extract respiratory sinus arrhythmia, heart rate variability in synchrony with respiration, will be continuously monitored for the peer rejection task.
8 secondary outcomes
Change in Mean Arterial Pressure for Impossible Puzzle
Time frame: baseline (5 minutes before to right before the task), during (start to end of the task), and post-task (right after to 15 minutes after the task)
Emotional Experience for Impossible Puzzle
Time frame: immediately after the 5-minute impossible puzzle task ends
Attribution for Impossible Puzzle
Time frame: immediately after the 5-minute impossible puzzle task ends
Change in Skin Conductance for Impossible Puzzle
Time frame: baseline (5 minutes before to right before the task), during (start to end of the task), and post (right after to 15 minutes after the task)
Change in Respiratory Sinus Arrhythmia for Impossible Puzzle
Time frame: baseline (5 minutes before to right before the task), during (start to end of the task), and post-task (right after to 15 minutes after the task)
Change in Mean Arterial Pressure for Conversation About Peer Rejection
Time frame: baseline (2.5 minute of discussion about last night's dinner before the conversation about peer rejection), during (5 minutes about the peer rejection task)
Change in Skin Conductance Activity in Conversation About Peer Rejection
Time frame: baseline (2.5 minutes about last night's dinner before the conversation about peer rejection), during (5 minutes discussion about peer rejection)
Change in Respiratory Sinus Arrhythmia for Conversation About Peer Rejection
Time frame: Baseline (2.5 minutes of discussion on last night's dinner before the conversation about peer rejection), during the task (5 minutes of discussion on peer rejection task)
Results and safety
Loading the posted results from ClinicalTrials.gov…
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 17 Aug 2026.
- Posted resultsParticipant flow, baseline, all outcome measures and adverse events.
- Background: PubMed 27806018Lucas T, Wegner R, Pierce J, Lumley MA, Laurent HK, Granger DA. Perceived Discrimination, Racial Identity, and Multisystem Stress Response to Social Evaluative Threat Among African American Men and Women. Psychosom Med. 2017 Apr;79(3):293-305. doi: 10.1097/PSY.0000000000000406.
- Background: PubMed 21775386Silk JS, Stroud LR, Siegle GJ, Dahl RE, Lee KH, Nelson EE. Peer acceptance and rejection through the eyes of youth: pupillary, eyetracking and ecological data from the Chatroom Interact task. Soc Cogn Affect Neurosci. 2012 Jan;7(1):93-105. doi: 10.1093/scan/nsr044. Epub 2011 Jul 20.
- Background: PubMed 33933893Sladek MR, Castro SA, Doane LD. Ethnic-Racial discrimination experiences predict Latinx adolescents' physiological stress processes across college transition. Psychoneuroendocrinology. 2021 Jun;128:105212. doi: 10.1016/j.psyneuen.2021.105212. Epub 2021 Apr 1.
- Individual participant dataSharing planned: Yes. The research resources from the project will include the study protocol and associated data, which will be provided upon request.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Qingfang Song, Ph.D principal investigator
Western Kentucky University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing peer rejection task, conversation about peer rejection, and impossible puzzle task in people with Stress Reaction; Acute, run by Western Kentucky University at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 17 Aug 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
Yes. Results are posted in the registry (first posted 17 Aug 2026). A summary is in the For doctors view, and the full results are on ClinicalTrials.gov.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change in Mean Arterial Pressure for Peer Rejection (time frame: baseline (5 minute before to right before the task), during (start to the end of the task), and post-task (right after to 45 minutes after the peer rejection task)). The study lists 8 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT05820659, which also lists 3 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 17 Aug 2026.