COPDNCT05825638
Evolution of Pulsed Oxygen Saturation During Interval Training Compared to Continuous Training in COPD Patients
An observational study of COPD and Exercise, run by Groupe Hospitalier du Havre at 1 site in France.
Trial summary
A problem often observed during exercise training is oxygen desaturation exclusively during exercise in some patients. In the case of exercise-induced desaturation, it may be suggested to train these patients in interval training to limit exercise-induced desaturation. Read more about this study
- Who is it for?
- Any age
- Conditions the study is for
- COPD, Exercise, Pulmonary Rehabilitation
- What is being tested?
- Continuous training session and Interval training session
- How many people
- 12 participants
- Where
- 1 siteFrance
- Study dates
- 10 Jan 2023to 10 Oct 2025
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages Any age
- All sexes
- No healthy volunteers
- Child, Adult, Older adult
Study population: Patients with COPD who meet the inclusion criteria will be offered to participate in this study during a pulmonary rehabilitation programme which will take place in the pneumology rehabilitation department of the Le Havre Hospital. If the patient wishes to participate in the study, he/she will be given an information note containing a declaration of non-opposition which he/she will have to complete and sign.
Who may be able to join
- a diagnosis of COPD
- participating in a pulmonary rehabilitation programme
- with an exercise-induced desaturation less than 90%
- no oxygen supplementation
Who cannot join
- Under 18 years of age
- Pregnant woman
- Person not affiliated to a health insurance regime or not benefiting from a social security regime
- Patient under curatorship, guardianship or safeguard of justice
- Patient speaking a language other than French
- Patient with severe hypoxaemia (SpO2 ≤ 80%) during exercise
Show all 9Show fewer
- Patient having had a moderate or severe exacerbation (hospitalisation for respiratory reasons) in the previous 4 weeks
- Patients with orthopaedic, rheumatic, vascular or neurological pathology limiting their ability to make an effort
- Breastfeeding women
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Evolution of Pulsed Oxygen Saturation Throughout an Interval Training Session Compared to a Continuous Training Session in Patients With Chronic Obstructive Pulmonary Disease With Exercise-induced Oxygen Desaturation.
A problem often observed during exercise training is oxygen desaturation exclusively during exercise in some patients. In the case of exercise-induced desaturation, it may be suggested to train these patients in interval training to limit exercise-induced desaturation. Interval training consists of alternating active phases of short duration (often 30 seconds to 1 minute) followed by a short active or passive recovery phase of equivalent duration to the previous phase. Investigators therefore hypothesise that interval training on a cycloergometer or treadmill can limit exercise-induced desaturation in COPD patients.
The aim of the study is to observe the evolution of pulsed oxygen saturation between a continuous training session and a interval training session.
- Conditions
- COPD, Exercise, Pulmonary Rehabilitation, Desaturation of Blood
- Being tested
- Continuous training session, Interval training session
- Keywords
- COPD, Pulmonary rehabilitation, Interval training
- Medical subject headings
- Pulmonary Disease, Chronic Obstructive, Motor Activity
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Continuous training sessionOther
Continuous training consists of a 5 minute warm up, 5 minute cool down and 20 minutes of moderate intensity work. The workload is set at 60% of the patient's maximum power
Interval training sessionOther
Interval training consists of a 5-minute warm-up, a 5-minute cool-down and 20 minutes of alternating 60 seconds of high-intensity work (100% of the maximum power recorded in the incremental test that was carried out when the patient was admitted to the pulmonary rehabilitation department) and 60 seconds of unloaded pedalling or rest.
| Study group | Role | What they receive |
|---|---|---|
| Continuous training session | Not described Receives: Other: Continuous training session | |
| Interval Training session | Not described Receives: Other: Interval training session |
What is being measured
The primary outcome is the main question the study is designed to answer.
Difference in oxygen pulsed saturation
Difference in minimum saturation during both exercise, the measurement will be performed with a pulse oximeter (Spirodoc, MIR)
Measured: One week
Secondary outcomes (7)
Difference in oxygen pulsed saturation
Difference in mean pulsed oxygen saturation and the time spent with a pulsed oxygen saturation below 90% during the two training sessions. The measurement will be performed with a pulse oximeter (Spirodoc, MIR)
Measured: One week
Difference in peripheral muscle oxygenation
Muscle oxygenation (arbitrary unit) will be evaluated using Near-infrared spectroscopy technology. the measurement will be performed with a Near Infrared spectroscopy (Portamon, Artinis Medical Systems)
Measured: One week
Difference in respiratory rate
Difference in respiratory rate will be measured breath-by-breath using a portable spirometer (Spirodoc, MIR)
Measured: One week
Difference in tidal volume
Difference in tidal volume will be measured breath-by-breath using a portable spirometer (Spirodoc, MIR)
Measured: One week
Difference in inspiratory capacity
Difference in inspiratory capacity will be measured using a portable spirometer (Spirodoc, MIR)
Measured: One week
Difference in Dyspnea
Dyspnea peak during exercise using the modified Borg scale 0-10, 0 no dyspnea, 10 maximal dyspnea
Measured: One week
Difference in muscle discomfort
Muscle discomfort peak during exercise using the modified Borg scale 0-10, 0 no dyspnea, 10 maximal dyspnea
Measured: One week
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted24 Apr 2023
- Study start10 Jan 2023
- Primary completion30 Sep 2025
- Study completion10 Oct 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for COPDStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Case crossover
- Time perspective
- Prospective
- Enrolment
- 12 participants (actual)
Sponsor and investigators
- Lead sponsor
- Groupe Hospitalier du Havre
- Sponsor type
- University, hospital or other
- Collaborators
- Medrinal Clement, Combret Yann, Machefert Margaux
- Responsible party
- Principal investigator, Guillaume Prieur, Groupe Hospitalier du Havre
- Investigators
- Guillaume Prieur, PT, PhD, Principal investigator, Groupe Hospitalier du Havre
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05825638
- Sponsor's protocol ID
- 2022-A02087-36
- Status last verified
- Jan 2026
- First submitted
- 10 Jan 2023
- Last updated
- 21 Jan 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes: deidentified participtant data
Study at a glance
From the registry record, last updated by the sponsor on 21 Jan 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Evolution of Pulsed Oxygen Saturation Throughout an Interval Training Session Compared to a Continuous Training Session in Patients With Chronic Obstructive Pulmonary Disease With Exercise-induced Oxygen Desaturation.
- ClinicalTrials.gov ID
- NCT05825638
- Acronym / sponsor ID
- 2022-A02087-36
- Conditions
- COPD, Exercise, Pulmonary Rehabilitation, Desaturation of Blood
- Keywords
- COPD, Pulmonary rehabilitation, Interval training
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 12 participants (actual)
- Lead sponsor
- Groupe Hospitalier du HavreUniversity, hospital or other
- Collaborators
- Medrinal Clement, Combret Yann, Machefert Margaux
- Study start
- 10 Jan 2023 (actual)
- Primary completion
- 30 Sep 2025 (actual)
- Study completion
- 10 Oct 2025 (actual)
- First posted
- 24 Apr 2023 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
A problem often observed during exercise training is oxygen desaturation exclusively during exercise in some patients. In the case of exercise-induced desaturation, it may be suggested to train these patients in interval training to limit exercise-induced desaturation. Interval training consists of alternating active phases of short duration (often 30 seconds to 1 minute) followed by a short active or passive recovery phase of equivalent duration to the previous phase. Investigators therefore hypothesise that interval training on a cycloergometer or treadmill can limit exercise-induced desaturation in COPD patients.
The aim of the study is to observe the evolution of pulsed oxygen saturation between a continuous training session and a interval training session.
Study design
- Observational model
- Case crossover
- Time perspective
- Prospective
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Continuous training session | – | Other: Continuous training session |
| Interval Training session | – | Other: Interval training session |
Who may qualify
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Child, Adult, Older adult
- Study population
- Patients with COPD who meet the inclusion criteria will be offered to participate in this study during a pulmonary rehabilitation programme which will take place in the pneumology rehabilitation department of the Le Havre Hospital. If the patient wishes to participate in the study, he/she will be given an information note containing a declaration of non-opposition which he/she will have to complete and sign.
Key inclusion criteria (4 listed)
- a diagnosis of COPD
- participating in a pulmonary rehabilitation programme
- with an exercise-induced desaturation less than 90%
- no oxygen supplementation
Key exclusion criteria (9 listed)
- Under 18 years of age
- Pregnant woman
- Person not affiliated to a health insurance regime or not benefiting from a social security regime
- Patient under curatorship, guardianship or safeguard of justice
- Patient speaking a language other than French
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Continuous training sessionContinuous training consists of a 5 minute warm up, 5 minute cool down and 20 minutes of moderate intensity work. The workload is set at 60% of the patient's maximum power | Other | Continuous training session |
| Interval training sessionInterval training consists of a 5-minute warm-up, a 5-minute cool-down and 20 minutes of alternating 60 seconds of high-intensity work (100% of the maximum power recorded in the incremental test that was carried out when the patient was admitted to the pulmonary rehabilitation department) and 60 seconds of unloaded pedalling or rest. | Other | Interval Training session |
Primary outcome
Difference in oxygen pulsed saturation
Time frame: One week
Difference in minimum saturation during both exercise, the measurement will be performed with a pulse oximeter (Spirodoc, MIR)
7 secondary outcomes
Difference in oxygen pulsed saturation
Time frame: One week
Difference in peripheral muscle oxygenation
Time frame: One week
Difference in respiratory rate
Time frame: One week
Difference in tidal volume
Time frame: One week
Difference in inspiratory capacity
Time frame: One week
Difference in Dyspnea
Time frame: One week
Difference in muscle discomfort
Time frame: One week
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 21 Jan 2026.
- Individual participant dataSharing planned: Yes. deidentified participtant data
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Guillaume Prieur, PT, PhD principal investigator
Groupe Hospitalier du Havre
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of COPD and Exercise, run by Groupe Hospitalier du Havre at 1 site in France.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 9 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 21 Jan 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in France. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Difference in oxygen pulsed saturation (time frame: One week). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 21 Jan 2026.