Clinical trials: Desaturation of Blood
Hypoxia, Desaturation of Blood
SpO2 Accuracy Low Saturation Validation of the OxySoftN Sensor
To compare prototype pulse oximeter saturation measurements, during normal to low saturation, to saturation measurements made by a multi-wavelength CO-oximeter, taken from arterial blood samples from healthy human subjects.
- Trial name
- NCT04811963
- Testing
- Non-Invasive Controlled Hypoxia
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Medtronic - MITG
Cerebral Desaturation, Cerebral Ischemia
Assessment of Cerebral Blood Flow Asymmetry in Cardiac Surgery Patients Undergoing Hypothermic Circulatory Arrest
Cerebral oxygen desaturation during cardiac surgery measured using near infrared spectroscopy (NIRS) derived cerebral oximetry has been associated with significant postoperative morbidity.
- Trial name
- COASTLINE (NCT03215589)
- Where
- Canada
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Apnea, Postanesthetic, Desaturation of Blood
Transnasal Humidified Rapid-Insufflation Ventilatory Exchange (THRIVE) Could Decrease the Incidence of Oxygen Desaturation During Suspension Laryngoscopy: a Randomized Controlled Trial (Optilaryngo)
Suspension laryngoscopy is realised during apnea. In effect, surgeons are in the mouth of the patient and we can't have access at the aiways.
- Conditions
- Apnea, Postanesthetic, Desaturation of Blood, Apnea, Anesthesia
- Trial name
- optilaryngo (NCT03843580)
- Testing
- optiflow
- Where
- 2 sites in France
- Volunteers
- 80 people
- Sponsor
- University Hospital, Caen
Lung Diseases, Desaturation of Blood
Finding the Optimal Location for Saturation Measurement During Flexible Bronchoscopy
An observational comparison of different locations of saturation measurements during Flexible Bronchoscopy
- Trial name
- NCT03062137
- Testing
- blood gas sampling
- Where
- Israel
- Volunteers
- 116 people
- Sponsor
- Rabin Medical Center
Apnea of Prematurity, Desaturation of Blood
Arterial Oxygen Saturation on Ventilatory Stability in Extremely Premature Infants
This is a prospective crossover study to compare the within-subject effect of the two target ranges of arterial oxygen saturation (SpO2), both within the clinically recommended range of 90- 95%.
- Conditions
- Apnea of Prematurity, Desaturation of Blood, Central Apnea, Periodic Breathing
- Trial name
- NCT03695900
- Testing
- Targeting SpO2 at 93-95%, Targeting SpO2 at 90-92%
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- University of Miami
Obstructive Sleep Apnea, Hypertension
Effects of Antihypertensive Drugs in Patients With Hypertension and Obstructive Sleep Apnea (OSA)
The aim of the present study is to compare the effects of different types of antihypertensive drugs (angiotensin II receptor blockers and long-acting calcium channel blockers) in patients with hypertension and obstructive sleep…
- Trial name
- NCT01028534
- Testing
- Olmesartan and Azelnidipine
- Where
- 2 sites in Japan
- Volunteers
- 150 people
- Sponsor
- Kyoto University, Graduate School of Medicine
Gastroesophageal Reflux Disease, Apnea Infants
Gastroesophageal Reflux and Cardiorespiratory Problems
Cardiorespiratory and gastroesophageal reflux events often coexist in infants in Neonatal Intensive Care Unit (NICU) thus leading to drugs over-prescription and delayed discharge.
- Conditions
- Gastroesophageal Reflux Disease, Apnea Infants, Desaturation of Blood, Bradycardia
- Trial name
- CR-GER (NCT03053609)
- Where
- Italy
- Volunteers
- 72 people
- Sponsor
- University of Turin, Italy
Hypoxemia, Desaturation of Blood
Alternate Methodology of Pulse Oximeter Validation
This study will determine if the replacement of the measured arterial blood oxygen saturation with expired (end-tidal) oxygen value is an acceptable method to calculate the accuracy of pulse oximeters.
- Trial name
- NCT03628560
- Testing
- RespirAct Step-Wise Normocapnia desaturation sequence, RespirAct Slope Normocapnia desaturation sequence, RespirAct Step-Wise Hypocapnia desaturation sequence
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Duke University
Hypoxia, Desaturation of Blood
SpO2 Accuracy Validation of the OxySoft Sensor Via Reference CO-Oximetry Motion Study
SpO2 (oxygen saturation) and pulse rate accuracy of pulse oximetry equipment, OxySoft Sensor/N-600x and OxySoft Sensor/N-395, continuous measure of arterial oxygen saturation during hypoxic state throughout motion and non-motion…
- Trial name
- NCT04559763
- Testing
- Non-Invasive Controlled Hypoxia, Introduction of Motion conditions: tapping or rubbing
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Medtronic - MITG
Oxygen Deficiency, Desaturation of Blood
THRIVE Use in Pediatric Populations- Multi Site
THRIVE (Transnasal Humidified Rapid-Insufflation Ventilatory Exchange) refers to the use of high-flow nasal cannula to augment the ability to oxygenate and ventilate a patient under general anesthesia.
- Conditions
- Oxygen Deficiency, Desaturation of Blood, Hypoventilation, Anesthesia; Adverse Effect
- Trial name
- NCT04322994
- Testing
- Transnasal Humidified Rapid-Insufflation Ventilatory Echange
- Where
- 5 sites in United States
- Volunteers
- 175 people, healthy volunteers welcome
- Sponsor
- Stanford University
Propofol, Hypoxia
HFNC and Hypoxia/Desaturation During Radiofrequency Ablation Under Moderate Sedation: A Randomized Clinical Trial
Background: Propofol based sedated anesthesia was widely used in percutaneous radiofrequency ablation and hypoxia/desaturation is one of the most frequent adverse events during this procedure.
- Conditions
- Propofol, Hypoxia, Sedation Complication, Desaturation of Blood
- Trial name
- NCT05212064
- Testing
- high-flow oxygen nasal cannula therapy, nasal cannula oxygen therapy
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Zhejiang Cancer Hospital
Desaturation of Blood
HFNC Versus Conventional Nasal Cannula in Oxygen Performance in Patients Receiving Colonoscopy Under IV Sedation
The purpose of this study is to investigate if high flow nasal cannula (HFNC), as compared to conventional nasal cannula, improves oxygenation and prevents desaturation events in obese patients undergoing colonoscopy.
- Trial name
- HFNC (NCT02968706)
- Testing
- High Flow Nasal Cannula, Conventional Nasal Cannula, Patient satisfaction questionnaire
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Aventura Hospital and Medical Center
Respiratory Insufficiency, Pneumonia
Diaphragm Dysfunction and Ultrasound Perioperatively
This study aims at determining whether diaphragm ultrasound examining diaphragm thickening fraction, excursion and density before and after surgery can predict respiratory complications in the postoperative period.
- Conditions
- Respiratory Insufficiency, Pneumonia, Desaturation of Blood, Tachypnea
- Trial name
- DiaphPeriop (NCT05906030)
- Testing
- Diaphragm ultrasound
- Where
- 2 sites in Sweden
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Karolinska University Hospital
Desaturation of Blood, Obesity
High-Flow Nasal Cannula and Desaturation Episodes in the Morbidly Obese Patients
It is standard practice in the United States and many parts of world to perform Gastrointestinal (GI) endoscopy with the patient under deep sedation.
- Conditions
- Desaturation of Blood, Obesity, Colonoscopy, Sleep Apnea
- Trial name
- NCT03148262
- Testing
- The Comfort Flo system, The Salter nasal cannula
- Where
- 2 sites in United States
- Volunteers
- 59 people
- Sponsor
- University of Texas Southwestern Medical Center
Anesthesia, Preoxygenation
Preoxygenation Before General Anesthesia
Rationale of the study: we aim to clarify the question (related to still unclear and not univocal response) about the protective or unnecessary role of preoxygenation in non-critically ill patients (otherwise with no high risk of…
- Trial name
- PREOX2018 (NCT03802643)
- Where
- Italy
- Volunteers
- 1,000 people
- Sponsor
- University of Parma
COPD, Exercise
Evolution of Pulsed Oxygen Saturation During Interval Training Compared to Continuous Training in COPD Patients
A problem often observed during exercise training is oxygen desaturation exclusively during exercise in some patients. In the case of exercise-induced desaturation, it may be suggested to train these patients in interval training…
- Conditions
- COPD, Exercise, Pulmonary Rehabilitation, Desaturation of Blood
- Trial name
- NCT05825638
- Testing
- Continuous training session, Interval training session
- Where
- France
- Volunteers
- 12 people
- Sponsor
- Groupe Hospitalier du Havre
Oxygen Deficiency, Desaturation of Blood
Transnasal Humidified Rapid-Insufflation Ventilatory Exchange (THRIVE) Use in Pediatric Procedures
THRIVE (Transnasal Humidified Rapid-Insufflation Ventilatory Exchange) refers to the use of high-flow nasal cannula to augment the ability to oxygenate and ventilate a patient under general anesthesia.
- Conditions
- Oxygen Deficiency, Desaturation of Blood, Hypoventilation, Anesthesia; Adverse Effect
- Trial name
- NCT03430206
- Testing
- High-flow nasal cannula
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- Stanford University
Low Oxygen Saturation
Clinical Performance Evaluation of Pediatric and Neonatal Low Saturation Oximetry Sensors
The general purpose of this study is to evaluate the feasibility, accuracy and performance of the Nellcor/Covidian 600-x and the Masimo rainbow technologypediatric and neonatal oximetry sensors over clinically relevant ranges of…
- Trial name
- NCT00843401
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Children's National Research Institute
Desaturation of Blood, Colonoscopy
The Use of High Flow Nasal Cannula, Standard Face Mask and Standard Nasal Cannula in Morbidly Obese Patients
It is standard practice in the United States and many parts of world to perform Gastrointestinal endoscopy with the patient under deep intravenous sedation.
- Trial name
- NCT03479905
- Testing
- Salter nasal cannula, Face mask, High Flow Nasal Cannula
- Where
- United States
- Volunteers
- 143 people
- Sponsor
- University of Texas Southwestern Medical Center
Desaturation of Blood
Early Recognition of Hypoxia in Pediatric Patient Sedation
Early recognition of hypoxia through monitoring in sedation practices in pediatric patients
- Trial name
- NCT04622436
- Where
- Turkey (Türkiye)
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital