Motor CortexNCT05861284
Developing and Optimizing Transcranial Magnetic Stimulation for Motor Rehabilitation
A study testing Transcranial Magnetic Stimulation (TMS) in people with Motor Cortex and Motor Skills, run by Elisa Kallioniemi.
Trial summary
This study aims to evaluate three different transcranial magnetic stimulation protocols and their impact on motor system neurophysiology and skill learning. Read more about this study
- Who is it for?
- Ages 18 to 40 yearsHealthy volunteers can take part
- Conditions the study is for
- Motor Cortex, Motor Skills
- What is being tested?
- Transcranial Magnetic Stimulation (TMS)
- Type of treatment
- Medical device
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 0 participants
- Where
- No sites listed yet
- Study dates
- 1 Jul 2026to 1 Dec 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 40 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- 18-40 years old
- Able to read, understand, and sign the informed consent in English
- Right-handed
Who cannot join
- A sensory or physical impairment
- History of epilepsy or seizures in the family
- Non-removable metal or electronics (e.g., a cochlear implant, cardiac pacemaker, or implanted electronic devices) in your head or body
- A head injury with loss of consciousness
- Diagnosis of psychiatric or neurological disorder
- Skin defects or active infections on the scalp or hands
- Pregnancy or breastfeeding
About this study
This study aims to evaluate three different transcranial magnetic stimulation protocols and their impact on motor system neurophysiology and skill learning.
Read the detailed description
Transcranial magnetic stimulation (TMS) is a non-invasive brain stimulation method that induces long-term changes in connections between neuronal networks. This and the ability to activate the whole motor system allows the use of TMS to facilitate motor recovery. The motor system has different excitatory states associated with ongoing mu oscillation. Here, the investigators will monitor brain mu oscillations in real-time non-invasively using electroencephalography and modulate the function of the motor system. The investigators will test the impact of three different TMS protocols on motor system neurophysiology and skill learning. These data will provide novel understanding needed to improve TMS approaches for individuals requiring motor rehabilitation.
- Conditions
- Motor Cortex, Motor Skills
- Being tested
- Transcranial Magnetic Stimulation (TMS)
- Keywords
- TMS, Motor system, Healthy
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Transcranial Magnetic Stimulation (TMS)Device
Transcranial magnetic stimulation (TMS) is a non-invasive brain stimulation method that can induce long-term changes in connections between neuronal networks.
| Study group | Role | What they receive |
|---|---|---|
| Single-pulse TMS over the primary motor cortex | Experimental | We will administer single-pulse TMS to the primary motor cortex while measuring motor responses and just before a skill-learning task. Receives: Device: Transcranial Magnetic Stimulation (TMS) |
| Paired-pulse TMS over the primary motor cortex | Experimental | We will administer paired-pulse TMS to the primary motor cortex while measuring motor responses and just before a skill-learning task. Receives: Device: Transcranial Magnetic Stimulation (TMS) |
| Sham TMS over the primary motor cortex | Sham comparator | We will administer sham TMS to the primary motor cortex while measuring motor responses and before a skill-learning task. Receives: Device: Transcranial Magnetic Stimulation (TMS) |
What is being measured
The primary outcome is the main question the study is designed to answer.
Effect of TMS on motor evoked potentials
Amplitude of the motor evoked potentials in millivolts.
Measured: Up to 1 second after TMS
Skill learning accuracy
Skill learning accuracy as the total number of correct responses.
Measured: Up to 12 minutes
Skill learning speed
Skill learning speed in seconds.
Measured: Up to 12 minutes
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted16 May 2023
- Study start1 Jul 2026 (estimated)
- Primary completion1 Dec 2026 (estimated)
- Study completion1 Dec 2026 (estimated)
Why it stopped: Study withdrawn before enrollment due to resource constraints. No participants were enrolled.
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Motor CortexStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 0 participants (actual)
Sponsor and investigators
- Lead sponsor
- Elisa Kallioniemi
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor-investigator, Elisa Kallioniemi, New Jersey Institute of Technology
- Investigators
- Elisa Kallioniemi, Ph.D., Principal investigator, New Jersey Institute of Technology
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05861284
- Sponsor's protocol ID
- IRB_2303032088
- Status last verified
- Jun 2026
- First submitted
- 27 Apr 2023
- Last updated
- 4 Jun 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes: Preprocessed and anonymized data will be provided upon request to the faculty / research staff of recognized research, medical, and educational institutions for educational and scientific purposes.
Study at a glance
From the registry record, last updated by the sponsor on 4 Jun 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Developing and Optimizing Transcranial Magnetic Stimulation for Motor Rehabilitation
- ClinicalTrials.gov ID
- NCT05861284
- Acronym / sponsor ID
- IRB_2303032088
- Conditions
- Motor Cortex, Motor Skills
- Keywords
- TMS, Motor system, Healthy
- Study type
- Interventional
- Recruitment status
- WithdrawnReason stopped: Study withdrawn before enrollment due to resource constraints. No participants were enrolled.
- Enrolment
- 0 participants (actual)
- Lead sponsor
- Elisa KallioniemiUniversity, hospital or other
- Study start
- 1 Jul 2026 (estimated)
- Primary completion
- 1 Dec 2026 (estimated)
- Study completion
- 1 Dec 2026 (estimated)
- First posted
- 16 May 2023 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study aims to evaluate three different transcranial magnetic stimulation protocols and their impact on motor system neurophysiology and skill learning.
Detailed description
Transcranial magnetic stimulation (TMS) is a non-invasive brain stimulation method that induces long-term changes in connections between neuronal networks. This and the ability to activate the whole motor system allows the use of TMS to facilitate motor recovery. The motor system has different excitatory states associated with ongoing mu oscillation. Here, the investigators will monitor brain mu oscillations in real-time non-invasively using electroencephalography and modulate the function of the motor system. The investigators will test the impact of three different TMS protocols on motor system neurophysiology and skill learning. These data will provide novel understanding needed to improve TMS approaches for individuals requiring motor rehabilitation.
Study design
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (participant)
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| Single-pulse TMS over the primary motor cortex | Experimental | Device: Transcranial Magnetic Stimulation (TMS)We will administer single-pulse TMS to the primary motor cortex while measuring motor responses and just before a skill-learning task. |
| Paired-pulse TMS over the primary motor cortex | Experimental | Device: Transcranial Magnetic Stimulation (TMS)We will administer paired-pulse TMS to the primary motor cortex while measuring motor responses and just before a skill-learning task. |
| Sham TMS over the primary motor cortex | Sham comparator | Device: Transcranial Magnetic Stimulation (TMS)We will administer sham TMS to the primary motor cortex while measuring motor responses and before a skill-learning task. |
Who may qualify
- Ages
- 18 to 40 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (3 listed)
- 18-40 years old
- Able to read, understand, and sign the informed consent in English
- Right-handed
Key exclusion criteria (7 listed)
- A sensory or physical impairment
- History of epilepsy or seizures in the family
- Non-removable metal or electronics (e.g., a cochlear implant, cardiac pacemaker, or implanted electronic devices) in your head or body
- A head injury with loss of consciousness
- Diagnosis of psychiatric or neurological disorder
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Transcranial Magnetic Stimulation (TMS)Transcranial magnetic stimulation (TMS) is a non-invasive brain stimulation method that can induce long-term changes in connections between neuronal networks. | Device | Paired-pulse TMS over the primary motor cortex, Sham TMS over the primary motor cortex, Single-pulse TMS over the primary motor cortex |
Primary outcome
Effect of TMS on motor evoked potentials
Time frame: Up to 1 second after TMS
Amplitude of the motor evoked potentials in millivolts.
Skill learning accuracy
Time frame: Up to 12 minutes
Skill learning accuracy as the total number of correct responses.
Skill learning speed
Time frame: Up to 12 minutes
Skill learning speed in seconds.
Results and safety
The study was withdrawn before enrolling participants, so there are no results.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 4 Jun 2026.
- Individual participant dataSharing planned: Yes. Preprocessed and anonymized data will be provided upon request to the faculty / research staff of recognized research, medical, and educational institutions for educational and scientific purposes.
Related trials for Motor Cortex
Enrolling by invitation
Efficacy of Repetitive Transcranial Magnetic Stimulation for Improving Depressive Symptoms in Patients With Parkinson's Disease
Parkinson's Disease, Depression
Recruiting
Efficacy of rTMS Treatment After Spinal Cord Injury
Spinal Cord Injuries, Myelopathy
Not yet recruiting
Cerebello-Cortical Connectivity and Balance Adaptation in Younger and Older Adults
Aging, Postural Balance
Active, not recruiting
Sensory Motor Transformations in Human Cortex
Quadriplegia
Recruiting
aiTBS and rTMS in Neuropathic Pain and Prediction of Response
Chronic Neuropathic Pain
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Elisa Kallioniemi, Ph.D. principal investigator
New Jersey Institute of Technology
Questions about this trial
What is this clinical trial studying?
A study testing Transcranial Magnetic Stimulation (TMS) in people with Motor Cortex and Motor Skills, run by Elisa Kallioniemi.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: withdrawn, as of the sponsor's last update on 4 Jun 2026. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study was withdrawn before enrolling participants, so there are no results.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Effect of TMS on motor evoked potentials (time frame: Up to 1 second after TMS). The study lists 3 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 4 Jun 2026.