Clinical trials: Motor Cortex
Basic Physiology, Brain Stimulation
Transcranial Direct Current Stimulation (tDCS) in the Primary Motor Cortex in Healthy Individuals
The main aim of this study is to assess the short-term effects of active-tDCS (a-tDCS) on the M1 regarding sensorimotor variables such as discriminative sensation, pressure pain threshold and electromyographic activity compared…
- Trial name
- NCT04148547
- Testing
- Sooma transcranial direct current stimulation device
- Where
- Spain
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Universidad Autonoma de Madrid
Stroke
Transcranial Direct Current Stimulation to Improve Hand Movement in Stroke Patients
This study will examine whether hand movement in stroke patients can be improved by applying electrical stimulation to the side of the brain affected by the stroke.
- Trial name
- NCT00307385
- Where
- United States
- Volunteers
- 82 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Healthy Young Adult, Neurophysiology
Motor Cortex Plasticity Response to Theta-Burst Stimulation After Ketone Monoester Supplementation
Transcranial magnetic stimulation is a medical device that can alter motor cortical (M1) excitability through the scalp via various protocols.
- Trial name
- KME-TBS (NCT06799260)
- Testing
- Ketone Monoester (KME), iTBS, cTBS
- Where
- Malaysia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universiti Putra Malaysia
Fibromyalgia
Influence of Transcranial Direct Current Stimulation of the Primary Motor Cortex on Pain Sensation in Patients Suffering From Fibromyalgia Syndrome
Fibromyalgia is a common chronic pain syndrome characterized by bad treatable chronic widespread pain present at a similar level for at least 3 months.
- Trial name
- NCT01261650
- Testing
- transcranial direct current stimulation
- Where
- Austria
- Volunteers
- 50 people
- Sponsor
- Karl Landsteiner Institute of Remobilization and Functional Health
Obsessive - Compulsive Disorder
Neural Mechanisms of the Sensorymotor Circuit in Sensory Phenomena in OCD
The goal of this clinical study is to investigate the neural mechanisms of abnormal sensory phenomena in patients with Obsessive-Compulsive Disorder and to evaluate whether modulation of the insula-supplementary motor area…
- Trial name
- NCT07480408
- Testing
- repetitive transcranial magnetic stimulation (rTMS)
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Shanghai Mental Health Center
Healthy
Investigating the Effects of Intensity of Transcranial Direct Current Stimulation on Subjective Appetite
This is a randomized double-blind sham controlled systematic investigation to understand the importance of the brain region that controls the tongue and the submental muscle region on perceived appetite.
- Trial name
- tDCS (NCT04994379)
- Testing
- 1 mA tDCS, 1.5 mA tDCS
- Where
- Italy
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Messina
Healthy
The Effect of Transcranial Direct Current Stimulation of the Primary Motor and Somatosensory Cortex on Pain Thresholds.
The purpose of this study is to investigate the modulatory effect of a novel tDCS configuration on the pain sensitivity in healthy subjects.
- Trial name
- NCT04658485
- Testing
- Active tDCS
- Where
- Denmark
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Aging
Effect of Aging on Cortical Excitability and Motor Learning
The objective of the current proposal is to identify 1) how aging-related changes in GABAergic cortical inhibition affect motor performance, and 2) how aerobic exercise may improve inhibitory function and facilitate motor…
- Trial name
- ACE (NCT03750903)
- Testing
- Aerobic Exercise, Stretching and Balance Training
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Cortical Excitability, Brain Stimulation
Neuroplastic Alterations of the Motor Cortex by Caffeine
Caffeine is a psychostimulant drug. It acts as a competitive antagonist at adenosine receptors, which modulate cortical excitability as well.
- Conditions
- Cortical Excitability, Brain Stimulation, Caffeine
- Trial name
- NCT04011670
- Testing
- 200 mg caffeine tablet, Non-active tablet
- Where
- Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Medical Center Goettingen
Cerebrovascular Accident
Electrical Stimulation to Improve Hand Function in Patients With Chronic Stroke
This study will determine whether an electric shock to the forearm can improve hand function in patients with chronic stroke and, if so, whether the improvement is related to brain reorganization.
- Trial name
- NCT00023569
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Locked-In Syndrome
First Study With a Brain Implant to Help Locked-in Patients Communicate at Home
In this study a new means of communication for people with locked-in syndrome will be tested. The investigators will record brain signals directly from the surface of the brain by means of a completely implantable system.
- Trial name
- UNP (NCT02224469)
- Testing
- ECoG (electrocorticography) sensing
- Where
- Netherlands
- Volunteers
- 6 people
- Sponsor
- UMC Utrecht
Stroke, Neurologic Disorder
Manual Dexterity Modifications After Application of tSMS Over the Primary Motor Cortex (M1)
Transcranial static magnetic field stimulation (tSMS) is a novel brain stimulation technique that has been shown to be safe and effective in modifying biological parameters when applied to the cerebral cortex.
- Conditions
- Stroke, Neurologic Disorder, Manual Dexterity
- Trial name
- NCT05260190
- Testing
- tSMS
- Where
- Spain
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Universidad Rey Juan Carlos
Neuropathic Pain
Cyclization of Motor Cortex Stimulation
Motor cortex stimulation (MCS) is a form of brain stimulation for patients with neuropathic pain not responsive to medication. An electrode is placed on the surface of the brain and connected to a programmable battery in the…
- Trial name
- NCT02465918
- Testing
- motor cortex stimulation (Change of Stimulation Timing)
- Where
- Canada
- Volunteers
- 6 people
- Sponsor
- University of British Columbia
Ischemic Stroke
Focal Cortical Atrophy After Myocardial Internal Capsule
Primary purpose of the trial is to demonstrate the arisen of focal cortical atrophy, localized in the ipsilateral primary motor area, measured in mm, three months after infarction of internal capsule.
- Trial name
- ACFI (NCT01862172)
- Testing
- Additional MRI
- Where
- France
- Volunteers
- 21 people
- Sponsor
- University Hospital, Toulouse
Obsessive-compulsive Disorder
Study of Sequentially Applied Repetitive Transcranial Magnetic Stimulation in Obsessive- Compulsive Disorders
The purpose of study was to investigate possible therapeutic effects and safety of sequentially combined low-frequency repetitive transcranial magnetic stimulation (rTMS) to the right dorsolateral prefrontal cortex (DLPFC) and…
- Trial name
- NCT00932204
- Testing
- repetitive transcranial magnetic stimulation (Magstim rapid magnetic stimulator)
- Where
- South Korea
- Volunteers
- 21 people
- Sponsor
- Severance Hospital
Brain Diseases, Central Nervous System Diseases
Investigating the Feasibility of Combining Virtual Reality and Bilateral Transcranial Direct Stimulation to Improve Upper Limb Recovery in Patients With Stroke
Following a stroke, the function of the distal upper limb, especially hand and finger movements, is often severely compromised, significantly restricting the ability to carry out daily activities.
- Conditions
- Brain Diseases, Central Nervous System Diseases, Nervous System Diseases, Stroke
- Trial name
- bi-tDCS+VR (NCT07288385)
- Testing
- Transcranial Direct Current Stimulation combined with virtual reality
- Where
- Saudi Arabia
- Volunteers
- 100 people
- Sponsor
- King Saud University
Stroke, Hemiparesis
Efficacy Basics of Bihemispheric Motorcortex Stimulation After Stroke
The aim of the study is to investigate whether the combination of bihemispheric ("dual") transcranial direct current stimulation (tDCS) and motor training on 5 consecutive days facilitates motor recovery in chronic stroke.
- Trial name
- NCT01969097
- Testing
- tDCS, Motor training
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Charite University, Berlin, Germany
COVID-19 Respiratory Infection
Cardiopulmonary Rehabilitation in Long COVID-19 Patients With Persistent Breathlessness and Fatigue
The objective of this project is to assess the effects of a 2-month cardiopulmonary rehabilitation program on cardiorespiratory fitness in long COVID19 patients.
- Trial name
- COVID-Rehab (NCT05035628)
- Testing
- Cardiopulmonary exercise training
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Louis Bherer
Ischemic Stroke
Study of the Therapeutic Effects of Cortical Autograft Implantation in Patients With Cerebral Ischemia
Brain lesions in the adult have dramatic consequences, because the spontaneous capacity of the brain to functionally recover is limited. Besides existing rehabilitative therapeutic approaches (e.g.
- Trial name
- AVCell (NCT04488965)
- Testing
- Autologous transplant
- Where
- Switzerland
- Volunteers
- 10 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Migraine Disorders
Transcranial Direct Current Simulation in Chronic Migraine
This study is a pilot, double-blind, placebo-controlled, randomized trial aiming to compare the effects of transcranial direct current stimulation in Chronic Migraine.
- Trial name
- NCT02817139
- Testing
- TDCS
- Where
- Brazil
- Volunteers
- 15 people
- Sponsor
- Federal University of Paraíba