SarcopeniaNCT05869526
A Comparison of the Effects of Krill Oil and Fish Oil Supplementation on Muscle Function in Older Adults
A study testing Fish oil, Kril oil and Vegetable oil in people with Sarcopenia, run by University of Glasgow at 1 site in United Kingdom.
Trial summary
The aim of the study is to compare the effects of Krill Oil and Fish Oil supplementation on muscle function in older adults. The secondary aim is to investigate the mechanisms underlying the beneficial effects previously observed. Read more about this study
- Who is it for?
- Ages 60 to 90 yearsHealthy volunteers can take part
- Conditions the study is for
- Sarcopenia
- What is being tested?
- Fish oil, Kril oil and Vegetable oil
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 61 participants
- Where
- 1 siteUnited Kingdom
- Study dates
- 1 May 2023to 1 Apr 2024
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 60 to 90 years
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- Older adults (aged 60 years or older). BMI less than 30kg/m2
Who cannot join
- Participants (diagnosed and being treated for a pre-existing medical condition (cancer, kidney disease, liver disease, diabetes mellitus and cardiovascular disease, uncontrolled hypertension, gait disturbances limiting the ability to perform assessments of muscle function, dementia, affecting muscles known to use drugs (e.g., steroids). History of allergy to fish or fish oil and regular consumption of more than1portion of oily fish per week or use of fish oil or krill oil supplements will also be excluded.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: A Comparison of the Effects of Krill Oil and Fish Oil Supplementation on Muscle Function in Older Adults: a Randomised Controlled Pilot Study
The aim of the study is to compare the effects of Krill Oil and Fish Oil supplementation on muscle function in older adults. The secondary aim is to investigate the mechanisms underlying the beneficial effects previously observed.
- Conditions
- Sarcopenia
- Being tested
- Fish oil, Kril oil, Vegetable oil
- Keywords
- muscle mass, strength, omega-3, ageing
- Medical subject headings
- Sarcopenia
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Fish oilDietary supplement
EPA rich fish oil
Kril oilDietary supplement
Superba Krill Oil
Vegetable oilDietary supplement
Mixed vegetable oil
| Study group | Role | What they receive |
|---|---|---|
| Fish oil | Active comparator | Fish oil 4 g/day Receives: Dietary Supplement: Fish oil |
| Krill oil | Active comparator | Krill oil 4g/day Receives: Dietary Supplement: Kril oil |
| Placebo | Placebo comparator | Vegetable oil 4g/day Receives: Dietary Supplement: Vegetable oil |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change in knee extensor maximal isometric torque ( MVC)
Knee extensor maximal isometric torque measured during a maximal voluntary contraction
Measured: Change from baseline to 16 weeks
Secondary outcomes (9)
Change in fat mass
Whole body fat mass measured by measured via bio-electrical impedance
Measured: Change from baseline to 16 weeks
Change in lean mass
Whole body lean mass measured by measured via bio-electrical impedance
Measured: Change from baseline to 16 weeks
Blood sample
Red Blood Cell Omega-3 levels
Measured: Change from baseline to 16 weeks
Change in Grip strength
Grip strength measured with a hand held dynamometer
Measured: Change from baseline to 16 weeks
Change in Muscle thickness
Vastus lateralis muscle thickness measured by ultrasound
Measured: Change from baseline to 16 weeks
Force steadiness during submaximal isometric knee extensor contractions
Measured by using intramuscular iEMG
Measured: Change from baseline to 16 weeks
Neuromuscular Junction (NMJ)
Measured by iEMG
Measured: Change from baseline to 16 weeks
Change in gait speed
Time taken to walk 4 metres at a normal walking pace
Measured: Change from baseline to 16 weeks
Change in Chair rise time
A 30-second sit-to-stand test measured functional abilities
Measured: Change from baseline to 16 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted22 May 2023
- Study start1 May 2023
- Primary completion1 Feb 2024
- Study completion1 Apr 2024
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for SarcopeniaStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- 1:1:1 basis
- Masking
- Triple blind
- Who is masked
- Participant, Investigator, Outcomes assessor
- Enrolment
- 61 participants (actual)
Sponsor and investigators
- Lead sponsor
- University of Glasgow
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Stuart Gray, University of Glasgow
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05869526
- Sponsor's protocol ID
- FISHKRILL
- Status last verified
- Mar 2025
- First submitted
- 11 May 2023
- Last updated
- 30 Mar 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 30 Mar 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- A Comparison of the Effects of Krill Oil and Fish Oil Supplementation on Muscle Function in Older Adults: a Randomised Controlled Pilot Study
- ClinicalTrials.gov ID
- NCT05869526
- Acronym / sponsor ID
- FISHKRILL
- Conditions
- Sarcopenia
- Keywords
- muscle mass, strength, omega-3, ageing
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 61 participants (actual)
- Lead sponsor
- University of GlasgowUniversity, hospital or other
- Study start
- 1 May 2023 (actual)
- Primary completion
- 1 Feb 2024 (actual)
- Study completion
- 1 Apr 2024 (actual)
- First posted
- 22 May 2023 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The aim of the study is to compare the effects of Krill Oil and Fish Oil supplementation on muscle function in older adults. The secondary aim is to investigate the mechanisms underlying the beneficial effects previously observed.
Study design
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Triple blind (participant, investigator, outcomes assessor)
- Number of arms
- 3
- Model description
- 1:1:1 basis
| Arm | Type | Receives |
|---|---|---|
| Fish oil | Active comparator | Dietary Supplement: Fish oilFish oil 4 g/day |
| Krill oil | Active comparator | Dietary Supplement: Kril oilKrill oil 4g/day |
| Placebo | Placebo comparator | Dietary Supplement: Vegetable oilVegetable oil 4g/day |
Who may qualify
- Ages
- 60 to 90 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (1 listed)
- Older adults (aged 60 years or older). BMI less than 30kg/m2
Key exclusion criteria (1 listed)
- Participants (diagnosed and being treated for a pre-existing medical condition (cancer, kidney disease, liver disease, diabetes mellitus and cardiovascular disease, uncontrolled hypertension, gait disturbances limiting the ability to perform assessments of muscle function, dementia, affecting muscles known to use drugs (e.g., steroids). History of allergy to fish or fish oil and regular consumption of more than1portion of oily fish per week or use of fish oil or krill oil supplements will also be excluded.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Fish oilEPA rich fish oil | Dietary supplement | Fish oil |
| Kril oilSuperba Krill Oil | Dietary supplement | Krill oil |
| Vegetable oilMixed vegetable oil | Dietary supplement | Placebo |
Primary outcome
Change in knee extensor maximal isometric torque ( MVC)
Time frame: Change from baseline to 16 weeks
Knee extensor maximal isometric torque measured during a maximal voluntary contraction
9 secondary outcomes
Change in fat mass
Time frame: Change from baseline to 16 weeks
Change in lean mass
Time frame: Change from baseline to 16 weeks
Blood sample
Time frame: Change from baseline to 16 weeks
Change in Grip strength
Time frame: Change from baseline to 16 weeks
Change in Muscle thickness
Time frame: Change from baseline to 16 weeks
Force steadiness during submaximal isometric knee extensor contractions
Time frame: Change from baseline to 16 weeks
Neuromuscular Junction (NMJ)
Time frame: Change from baseline to 16 weeks
Change in gait speed
Time frame: Change from baseline to 16 weeks
Change in Chair rise time
Time frame: Change from baseline to 16 weeks
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 30 Mar 2025.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Fish oil, Kril oil and Vegetable oil in people with Sarcopenia, run by University of Glasgow at 1 site in United Kingdom.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 30 Mar 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United Kingdom. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change in knee extensor maximal isometric torque ( MVC) (time frame: Change from baseline to 16 weeks). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 30 Mar 2025.