No ConditionNCT05882942
Matcha Green Tea Effects at Rest and During Moderate-intensity Exercise in Females
A study testing Matcha green tea in people with No Condition, run by University of Chichester at 2 sites in United Kingdom.
Trial summary
Intake of the green tea catechin epigallocatechin (EGCG) increased fat oxidation during walking. It is also known to reduce blood pressure and improve body composition. This research will expand the insight on the effects by Matcha green tea supplementation and address the effects on heart rate variability, substrate… Read more about this study
- Who is it for?
- Ages 18 to 30 years, women onlyHealthy volunteers can take part
- Conditions the study is for
- No Condition
- What is being tested?
- Matcha green tea
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 8 participants
- Where
- 2 sitesUnited Kingdom
- Study dates
- 3 Mar 2023to 15 Aug 2023
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 30 years
- Women only
- Healthy volunteers accepted
- Adult
Who may be able to join
- healthy
- non-smokers
- not taking any supplements
- no known allergy to green tea
Who cannot join
- smokers
- known high blood pressure
- on medication
Trial locations and contacts
2 sites in 1 country.
United Kingdom2 sites
Mark Willems
Chichester, West Sussex, PO19 6PE
University of Chichester
Chichester
About this study
Official title: Effects of Matcha Green Tea on Heart Rate Variability, Substrate Oxidation and Cardiovascular Response at Rest and During Moderate-intensity Exercise in Females
Intake of the green tea catechin epigallocatechin (EGCG) increased fat oxidation during walking. It is also known to reduce blood pressure and improve body composition. This research will expand the insight on the effects by Matcha green tea supplementation and address the effects on heart rate variability, substrate oxidation at rest, and cardiovascular responses at rest in addition to metabolic and physiologic responses for a 1-hr walk in healthy females.
Read the detailed description
Intake of the catechin epigallocatechin (EGCG) increased fat oxidation during walking. It is also known to reduce blood pressure and improve body composition. EGCG is the most abundant and potent bioactive compound (50-80% of the total catechin content) found in Matcha green tea (MGT) and is usually consumed as a drink or in a capsulated from unfermented tea leaves. MGT polyphenols have antioxidant and anti-inflammatory properties, providing numerous health benefits, such as the reduced risk of type 2 diabetes and obesity. MGT supplementation (3g over a 24hr period) has been shown to enhance fat oxidation during 30-min brisk walking as well as lower respiratory exchange ratio in females. Understanding the effectiveness of the bioactive compounds found in natural food sources in improving human health is key to informing the general population and the public health policies preceding them; the daily consumption of drinks and food naturally high in EGCG content could be recommended as an essential part of a healthy lifestyle. This research will expand the insight on Matcha green tea supplementation address the effect on heart rate variability, substrate oxidation at rest, and cardiovascular responses at rest in addition to metabolic and physiologic responses for a 1-hr walk in healthy females.
- Conditions
- No Condition
- Being tested
- Matcha green tea, Placebo
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Matcha green teaDietary supplement
This is the condition with the Matcha green tea
PlaceboDietary supplement
This is the condition with the placebo
| Study group | Role | What they receive |
|---|---|---|
| Placebo | Experimental | Participants will be supplemented with a placebo. Receives: Dietary Supplement: Placebo |
| Matcha green tea | Experimental | Participants will be supplemented with Matcha green tea. Receives: Dietary Supplement: Matcha green tea |
What is being measured
The primary outcome is the main question the study is designed to answer.
Heart rate variability
Measurement of root mean square of standard deviation of RR intervals
Measured: Three weeks
Carbohydrate oxidation
Measurement of carbohydrate oxidation in grams/minute
Measured: Three weeks
Fat oxidation
Measurement of fat oxidation in grams/minute
Measured: Three weeks
Cardiac output
Measurement of cardiac output in liters per minute
Measured: Three weeks
Stroke volume
Measurement of stroke volume in milliliters
Measured: Three weeks
Total peripheral resistance
Measurement of total peripheral resistance in (mmHg x min) / mL
Measured: Three weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted31 May 2023
- Study start3 Mar 2023
- Primary completion26 Jul 2023
- Study completion15 Aug 2023
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for No ConditionStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Crossover
- Model description
- Randomized, placebo-controlled, crossover design
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 8 participants (actual)
Sponsor and investigators
- Lead sponsor
- University of Chichester
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Mark Eilisabeth Willems, University of Chichester
- Investigators
- Mark E Willems, Principal investigator, University of Chichester
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05882942
- Sponsor's protocol ID
- 22231905455
- Status last verified
- May 2024
- First submitted
- 17 May 2023
- Last updated
- 8 May 2024
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 8 May 2024. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effects of Matcha Green Tea on Heart Rate Variability, Substrate Oxidation and Cardiovascular Response at Rest and During Moderate-intensity Exercise in Females
- ClinicalTrials.gov ID
- NCT05882942
- Acronym / sponsor ID
- 22231905455
- Conditions
- No Condition
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 8 participants (actual)
- Lead sponsor
- University of ChichesterUniversity, hospital or other
- Study start
- 3 Mar 2023 (actual)
- Primary completion
- 26 Jul 2023 (actual)
- Study completion
- 15 Aug 2023 (actual)
- First posted
- 31 May 2023 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Intake of the green tea catechin epigallocatechin (EGCG) increased fat oxidation during walking. It is also known to reduce blood pressure and improve body composition. This research will expand the insight on the effects by Matcha green tea supplementation and address the effects on heart rate variability, substrate oxidation at rest, and cardiovascular responses at rest in addition to metabolic and physiologic responses for a 1-hr walk in healthy females.
Detailed description
Intake of the catechin epigallocatechin (EGCG) increased fat oxidation during walking. It is also known to reduce blood pressure and improve body composition. EGCG is the most abundant and potent bioactive compound (50-80% of the total catechin content) found in Matcha green tea (MGT) and is usually consumed as a drink or in a capsulated from unfermented tea leaves. MGT polyphenols have antioxidant and anti-inflammatory properties, providing numerous health benefits, such as the reduced risk of type 2 diabetes and obesity. MGT supplementation (3g over a 24hr period) has been shown to enhance fat oxidation during 30-min brisk walking as well as lower respiratory exchange ratio in females. Understanding the effectiveness of the bioactive compounds found in natural food sources in improving human health is key to informing the general population and the public health policies preceding them; the daily consumption of drinks and food naturally high in EGCG content could be recommended as an essential part of a healthy lifestyle. This research will expand the insight on Matcha green tea supplementation address the effect on heart rate variability, substrate oxidation at rest, and cardiovascular responses at rest in addition to metabolic and physiologic responses for a 1-hr walk in healthy females.
Study design
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- Single blind (participant)
- Number of arms
- 2
- Model description
- Randomized, placebo-controlled, crossover design
| Arm | Type | Receives |
|---|---|---|
| Placebo | Experimental | Dietary Supplement: PlaceboParticipants will be supplemented with a placebo. |
| Matcha green tea | Experimental | Dietary Supplement: Matcha green teaParticipants will be supplemented with Matcha green tea. |
Who may qualify
- Ages
- 18 to 30 years
- Sex
- Female only
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (4 listed)
- healthy
- non-smokers
- not taking any supplements
- no known allergy to green tea
Key exclusion criteria (3 listed)
- smokers
- known high blood pressure
- on medication
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Matcha green teaThis is the condition with the Matcha green tea | Dietary supplement | Matcha green tea |
| PlaceboThis is the condition with the placebo | Dietary supplement | Placebo |
Primary outcome
Heart rate variability
Time frame: Three weeks
Measurement of root mean square of standard deviation of RR intervals
Carbohydrate oxidation
Time frame: Three weeks
Measurement of carbohydrate oxidation in grams/minute
Fat oxidation
Time frame: Three weeks
Measurement of fat oxidation in grams/minute
Cardiac output
Time frame: Three weeks
Measurement of cardiac output in liters per minute
Stroke volume
Time frame: Three weeks
Measurement of stroke volume in milliliters
Total peripheral resistance
Time frame: Three weeks
Measurement of total peripheral resistance in (mmHg x min) / mL
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 8 May 2024.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Mark E Willems principal investigator
University of Chichester
2 sites in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Matcha green tea in people with No Condition, run by University of Chichester at 2 sites in United Kingdom.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 8 May 2024. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 2 sites in United Kingdom. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Heart rate variability (time frame: Three weeks). The study lists 6 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 8 May 2024.