Muscle StrengthNCT05932875
Peanut Consumption to Augment Adaptations to Concurrent Resistance and Aerobic Exercise Training
A study testing Exercise Training in people with Muscle Strength and Cardiorespiratory Fitness, run by Southwestern University at 1 site in United States.
Trial summary
The primary objective of this proposal is to determine the effects of post-exercise peanut consumption on long-term aerobic and resistance exercise training adaptations in middle-aged men and women. Read more about this study
- Who is it for?
- Ages 30 to 55 yearsHealthy volunteers can take part
- Conditions the study is for
- Muscle Strength, Cardiorespiratory Fitness, Body Composition
- What is being tested?
- Exercise Training
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 34 participants
- Where
- 1 siteUnited States
- Study dates
- 30 May 2023to 1 Jul 2024
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 30 to 55 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Men and women 30- 55 years old
- healthy
- non-smoking
- no exercise training in the previous 6 months
- not currently attempting to gain or lose weight
- body mass index < 35
- no need for physician clearance prior to beginning an exercise program as determined by American College of Sports Medicine guidelines.
Who cannot join
- neurological or musculoskeletal disorders
- uncontrolled hypertension (resting systolic blood pressure > 180 mmHg or diastolic > 120 mmHg
- unstable or exercise-induced angina pectoris
- diabetes mellitus; any other medical condition that would interfere with testing or training
- androgen (e.g., testosterone), anabolic (e.g., GH, IGF-I), or catabolic (e.g. GLP-1 agonists) therapy
- food allergy to peanuts or dairy products
- pregnant people or people actively trying to get pregnant
- on a special diet that restricts protein/carbs/sugar/fat.
Trial locations and contacts
1 site in 1 country.
About this study
The primary objective of this proposal is to determine the effects of post-exercise peanut consumption on long-term aerobic and resistance exercise training adaptations in middle-aged men and women. The investigators will determine the impact of peanuts on exercise training-induced improvements in muscle strength, gains in muscle mass, and improvements in cardiorespiratory fitness and metabolic capacity.
Read the detailed description
Positive health benefits of peanut consumption are well-known, but potential benefits have yet to be discovered, especially in regard to fitness. This project will directly determine the benefits of peanut consumption as part of a long-term aerobic and resistance exercise training program in middle-aged adults.
Proper nutrition is necessary for the body to properly recover and adapt to an exercise bout and thereby realize the health benefits of the exercise. The period of time immediately after exercise is even more important in realizing these adaptations. With relatively higher amounts of fats, peanuts are often overlooked as a nutritious, post-exercise snack, because they might not be optimal for athletic performance. However, for a middle-aged adult performing the recommended amount of weekly physical activity, the protein and carbohydrate content of peanuts is sufficient to provide the macronutrients necessary to achieve the beneficial health adaptations associated with exercise training. Other micronutrients and healthy fats in peanuts, might confer further benefits beyond those of other post-exercise supplements, however, this has yet to be elucidated.
The randomized, placebo-controlled, clinical trial will provide valuable information on the health benefits of peanut consumption and determine if peanuts can augment beneficial exercise training adaptations in middle-aged adults. The investigators will recruit a group of 48 adults (30-55 years) who do not regularly exercise to undertake a 4-month exercise training program. The program, proven to increase muscle mass and improve cardiorespiratory fitness, will consist of 4 days per week of structured workouts (2/week resistance, 2/week aerobic). Participants will be randomly assigned to consume either a peanut-based snack or an isocaloric, non-peanut carbohydrate-based snack immediately after each exercise session. A comprehensive health and fitness assessment will be conducted before training, after 2-months of training, and after 4-months of training. Measures of cardiorespiratory fitness, muscular fitness, and body composition will be assessed.
Anticipated Products \& Potential Outcomes When completed, this study will provide the first evidence of the effect of post-exercise peanut consumption on long-term exercise training adaptations to both aerobic and resistance training in middle-aged adults. This will be the first study to determine the effects of peanut consumption with aerobic exercise training, and the longest study on resistance exercise training and peanut consumption. With the mid-training 2-month timepoint, the investigators will be able to compare our results to those of similar resistance training peanut studies, but importantly follow them for longer, when resistance training adaptations are likely to be more apparent. The investigators hypothesize that the peanut group will experience greater gains in muscle strength and hypertrophy than the placebo group. The investigatorshypothesize that the peanut and placebo group will have similar improvements in cardiorespiratory fitness and body composition (higher total body lean mass leading to relatively lower body fat). This would be an important finding to prove that, despite their higher fat content, peanut consumption does not lead to negative effects on body composition nor prevent cardiorespiratory adaptions due to exercise training. Overall, the results are likely to demonstrate that peanuts are a simple, inexpensive, and effective post-exercise health food capable of further enhancing the beneficial effects of exercise training.
- Being tested
- Exercise Training
- Keywords
- peanut, muscle health, concurrent training, cardiorespiratory fitness
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Exercise TrainingOther
4 day per week concurrent exercise training program
| Study group | Role | What they receive |
|---|---|---|
| Peanut/Carbohydrate Consumption Exercise Training | Active comparator | Participants in this group will undergo 16 weeks of concurrent exercise training (4 sessions/week) consuming a peanut-based rice/oatmilk smoothie after each workout Receives: Other: Exercise Training |
| Carbohydrate Consumption Exercise Training | Placebo comparator | Participants in this group will undergo 16 weeks of concurrent exercise training (4 sessions/week) consuming a rice/oatmilk smoothie after each workout Receives: Other: Exercise Training |
What is being measured
The primary outcome is the main question the study is designed to answer.
Total Lean Mass
Amount of lean mass as determined by dual energy x-ray absorptiometry scan
Measured: From baseline to the end of the training program at 16 weeks.
Muscle strength
Isometric grip and knee extension strength, as well as dynamic 1-repitition maximum strength of bench press, leg press, overhead press, knee extension
Measured: From baseline to the end of the training program at 16 weeks.
Cardiorespiratory fitness
Maximal oxygen consumption as determined by graded treadmill test
Measured: From baseline to the end of the training program at 16 weeks.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted6 Jul 2023
- Study start30 May 2023
- Primary completion15 Jun 2024
- Study completion1 Jul 2024
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Muscle StrengthStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 34 participants (actual)
Sponsor and investigators
- Lead sponsor
- Southwestern University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Edward Merritt, Southwestern University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05932875
- Sponsor's protocol ID
- SP23_20
- Status last verified
- Apr 2025
- First submitted
- 27 Jun 2023
- Last updated
- 24 Apr 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: IRB approval does not allow for IPD to be shared.
Study at a glance
From the registry record, last updated by the sponsor on 24 Apr 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Peanut Consumption to Augment Adaptations to Concurrent Resistance and Aerobic Exercise Training
- ClinicalTrials.gov ID
- NCT05932875
- Acronym / sponsor ID
- SP23_20
- Keywords
- peanut, muscle health, concurrent training, cardiorespiratory fitness
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 34 participants (actual)
- Lead sponsor
- Southwestern UniversityUniversity, hospital or other
- Study start
- 30 May 2023 (actual)
- Primary completion
- 15 Jun 2024 (actual)
- Study completion
- 1 Jul 2024 (actual)
- First posted
- 6 Jul 2023 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The primary objective of this proposal is to determine the effects of post-exercise peanut consumption on long-term aerobic and resistance exercise training adaptations in middle-aged men and women. The investigators will determine the impact of peanuts on exercise training-induced improvements in muscle strength, gains in muscle mass, and improvements in cardiorespiratory fitness and metabolic capacity.
Detailed description
Positive health benefits of peanut consumption are well-known, but potential benefits have yet to be discovered, especially in regard to fitness. This project will directly determine the benefits of peanut consumption as part of a long-term aerobic and resistance exercise training program in middle-aged adults.
Proper nutrition is necessary for the body to properly recover and adapt to an exercise bout and thereby realize the health benefits of the exercise. The period of time immediately after exercise is even more important in realizing these adaptations. With relatively higher amounts of fats, peanuts are often overlooked as a nutritious, post-exercise snack, because they might not be optimal for athletic performance. However, for a middle-aged adult performing the recommended amount of weekly physical activity, the protein and carbohydrate content of peanuts is sufficient to provide the macronutrients necessary to achieve the beneficial health adaptations associated with exercise training. Other micronutrients and healthy fats in peanuts, might confer further benefits beyond those of other post-exercise supplements, however, this has yet to be elucidated.
The randomized, placebo-controlled, clinical trial will provide valuable information on the health benefits of peanut consumption and determine if peanuts can augment beneficial exercise training adaptations in middle-aged adults. The investigators will recruit a group of 48 adults (30-55 years) who do not regularly exercise to undertake a 4-month exercise training program. The program, proven to increase muscle mass and improve cardiorespiratory fitness, will consist of 4 days per week of structured workouts (2/week resistance, 2/week aerobic). Participants will be randomly assigned to consume either a peanut-based snack or an isocaloric, non-peanut carbohydrate-based snack immediately after each exercise session. A comprehensive health and fitness assessment will be conducted before training, after 2-months of training, and after 4-months of training. Measures of cardiorespiratory fitness, muscular fitness, and body composition will be assessed.
Anticipated Products \& Potential Outcomes When completed, this study will provide the first evidence of the effect of post-exercise peanut consumption on long-term exercise training adaptations to both aerobic and resistance training in middle-aged adults. This will be the first study to determine the effects of peanut consumption with aerobic exercise training, and the longest study on resistance exercise training and peanut consumption. With the mid-training 2-month timepoint, the investigators will be able to compare our results to those of similar resistance training peanut studies, but importantly follow them for longer, when resistance training adaptations are likely to be more apparent. The investigators hypothesize that the peanut group will experience greater gains in muscle strength and hypertrophy than the placebo group. The investigatorshypothesize that the peanut and placebo group will have similar improvements in cardiorespiratory fitness and body composition (higher total body lean mass leading to relatively lower body fat). This would be an important finding to prove that, despite their higher fat content, peanut consumption does not lead to negative effects on body composition nor prevent cardiorespiratory adaptions due to exercise training. Overall, the results are likely to demonstrate that peanuts are a simple, inexpensive, and effective post-exercise health food capable of further enhancing the beneficial effects of exercise training.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (participant)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Peanut/Carbohydrate Consumption Exercise Training | Active comparator | Other: Exercise TrainingParticipants in this group will undergo 16 weeks of concurrent exercise training (4 sessions/week) consuming a peanut-based rice/oatmilk smoothie after each workout |
| Carbohydrate Consumption Exercise Training | Placebo comparator | Other: Exercise TrainingParticipants in this group will undergo 16 weeks of concurrent exercise training (4 sessions/week) consuming a rice/oatmilk smoothie after each workout |
Who may qualify
- Ages
- 30 to 55 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (7 listed)
- Men and women 30- 55 years old
- healthy
- non-smoking
- no exercise training in the previous 6 months
- not currently attempting to gain or lose weight
Key exclusion criteria (8 listed)
- neurological or musculoskeletal disorders
- uncontrolled hypertension (resting systolic blood pressure > 180 mmHg or diastolic > 120 mmHg
- unstable or exercise-induced angina pectoris
- diabetes mellitus; any other medical condition that would interfere with testing or training
- androgen (e.g., testosterone), anabolic (e.g., GH, IGF-I), or catabolic (e.g. GLP-1 agonists) therapy
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Exercise Training4 day per week concurrent exercise training program | Other | Carbohydrate Consumption Exercise Training, Peanut/Carbohydrate Consumption Exercise Training |
Primary outcome
Total Lean Mass
Time frame: From baseline to the end of the training program at 16 weeks.
Amount of lean mass as determined by dual energy x-ray absorptiometry scan
Muscle strength
Time frame: From baseline to the end of the training program at 16 weeks.
Isometric grip and knee extension strength, as well as dynamic 1-repitition maximum strength of bench press, leg press, overhead press, knee extension
Cardiorespiratory fitness
Time frame: From baseline to the end of the training program at 16 weeks.
Maximal oxygen consumption as determined by graded treadmill test
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 24 Apr 2025.
- Individual participant dataSharing planned: No. IRB approval does not allow for IPD to be shared.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Exercise Training in people with Muscle Strength and Cardiorespiratory Fitness, run by Southwestern University at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 7 inclusion and 8 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 24 Apr 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Total Lean Mass (time frame: From baseline to the end of the training program at 16 weeks.). The study lists 3 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 24 Apr 2025; AzTrials last refreshed its copy on 6 Nov 2026.