Chronic PainADDICTALGONCT05976178
Study of the Characteristics of Chronic Pain in Patients With Addiction
An observational study of Chronic Pain and Addiction, run by Groupe Hospitalier de Bretagne Sud at 1 site in France.
Trial summary
It is described in the literature a higher prevalence of pain in patients with an addiction but there are few studies describing the pain profile of patients with use disorder. Pain has a very negative impact on the quality of life of opioid substituted patients. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Chronic Pain, Addiction
- How many people
- 300 participants
- Where
- 1 siteFrance
- Study dates
- 10 Dec 2022to 1 Mar 2025
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: Patients hospitalized in the addictology department of LORIENT Hospital, in full hospitalization or in a day hospital
Who may be able to join
- > 18 years old
- Presence of addiction to at least one substance, based on DSM-5 criteria
- Hospitalized in the addiction service of LORIENT Hospital
- Knowing how to read and write French
- Not objecting to their participation in the study after informed information
Who cannot join
- Already included during a precedent hospitalization
- Adults subject to legal protection or deprived of their liberty.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Descriptive, Prospective Study of the Characteristics of Chronic Pain in Patients With Addiction to at Least One Substance
It is described in the literature a higher prevalence of pain in patients with an addiction but there are few studies describing the pain profile of patients with use disorder.
Pain has a very negative impact on the quality of life of opioid substituted patients. Improving knowledge on this point would make it possible to better guide specific care.
The investigator proposes to conduct a single-center descriptive observational study using questionnaires, without changing the management of patients with chronic pain.
The primary objective of the study is to determine the prevalence of chronic pain in patients with substance addiction hospitalized for addiction treatment.
Read the detailed description
It is described in the literature a higher prevalence of pain in patients with an addiction but there are few studies describing the pain profile of patients with use disorder.
Pain has a very negative impact on the quality of life of opioid substituted patients. Improving knowledge on this point would make it possible to better guide specific care.
The investigator proposes to conduct a single-center descriptive observational study using questionnaires, without changing the management of patients with chronic pain. All patients admitted to hospitalization in the addiction department of the LORIENT Hospital will be offered participation in the study.
The primary objective of the study is to determine the prevalence of chronic pain in patients with substance addiction hospitalized for addiction treatment.
The study will also evaluate the impact on daily activities of the presence of two chronic pathologies: chronic pain and addiction, describe the frequency of the two main psychiatric comorbidities of chronic pain: anxiety and depression, describe the different components of chronic pain in patients with substance addiction, and get information on analgesic medications.
- Conditions
- Chronic Pain, Addiction
- Medical subject headings
- Chronic Pain, Behavior, Addictive
What is being measured
The primary outcome is the main question the study is designed to answer.
Prevalence of chronic pain in patients with substance addiction hospitalized for addiction treatment.
Percentage of patients presenting with pain for more than three months among patients hospitalized in an addiction service for the management of an addiction
Measured: During the hospitalization, maximum 1 month
Secondary outcomes (8)
Pain intensity in the last 24 hours
Results of the Brief Pain Inventory : worst and least of pain in the last 24 hours
Measured: During the hospitalization, maximum 1 month
Interference of pain on the quality of life
Result of Brief pain inventory on general activity, mood, walking ability, normal work, relations with other people, sleep, enjoyment of life. On a scale from 0 (does not interfere) to 10 (completely interferes)
Measured: During the hospitalization, maximum 1 month
Localisation of pain
Drawing on a diagram of a human body
Measured: During the hospitalization, maximum 1 month
Describe the frequency of the two main psychiatric comorbidities of chronic pain: anxiety
Results of the anxiety scale of Hospital Anxiety and Depression scale. Positive if > 8. Minimum 0, maximum 21
Measured: During the hospitalization, maximum 1 month
Describe the frequency of the two main psychiatric comorbidities of chronic pain: depression
Results of the depression scale of Hospital Anxiety and Depression scale. Positive if > 8. Minimum 0, maximum 21
Measured: During the hospitalization, maximum 1 month
Describe the prevalence of fibromyalgia among patients with substance addiction
Results of the Fibromyalgia Rapid Screening Tool. Suspicion of fibromyalgia if >5 yes. Maximum 6 yes
Measured: During the hospitalization, maximum 1 month
Information on analgesics medication
Collection of current analgesic medication taken every day
Measured: During the hospitalization, maximum 1 month
Describe the prevalence of neuropathic pain among patients with substance addiction
Results of the DN3 (neuropathic pain 3). Suspicion of neuropathic pain when > 3/7
Measured: During the hospitalization, maximum 1 month
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted4 Aug 2023
- Study start10 Dec 2022
- Primary completion1 Mar 2025
- Study completion1 Mar 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (5)Papers the sponsor has linked to this study.
- Other trials for Chronic PainStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 300 participants (actual)
Sponsor and investigators
- Lead sponsor
- Groupe Hospitalier de Bretagne Sud
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Alexandre Cauchie, Groupe Hospitalier de Bretagne Sud
- Investigators
- Alexandre Cauchie, MD, Principal investigator, GH Bretagne Sud
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05976178
- Sponsor's protocol ID
- 56LORC_2021_ADDICTALGO
- Acronym
- ADDICTALGO
- Status last verified
- May 2025
- First submitted
- 11 Jul 2023
- Last updated
- 11 May 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Rosenblum A, Joseph H, Fong C, Kipnis S, Cleland C, Portenoy RK. Prevalence and characteristics of chronic pain among chemically dependent patients in methadone maintenance and residential treatment facilities. JAMA. 2003 May 14;289(18):2370-8. doi: 10.1001/jama.289.18.2370.
PubMed 12746360Lusted A, Roerecke M, Goldner E, Rehm J, Fischer B. Prevalence of pain among nonmedical prescription opioid users in substance use treatment populations: systematic review and meta-analyses. Pain Physician. 2013 Nov-Dec;16(6):E671-84.
PubMed 24284850Breivik H, Collett B, Ventafridda V, Cohen R, Gallacher D. Survey of chronic pain in Europe: prevalence, impact on daily life, and treatment. Eur J Pain. 2006 May;10(4):287-333. doi: 10.1016/j.ejpain.2005.06.009. Epub 2005 Aug 10.
PubMed 16095934Voon P, Greer AM, Amlani A, Newman C, Burmeister C, Buxton JA. Pain as a risk factor for substance use: a qualitative study of people who use drugs in British Columbia, Canada. Harm Reduct J. 2018 Jul 5;15(1):35. doi: 10.1186/s12954-018-0241-y.
PubMed 29976203Larson MJ, Paasche-Orlow M, Cheng DM, Lloyd-Travaglini C, Saitz R, Samet JH. Persistent pain is associated with substance use after detoxification: a prospective cohort analysis. Addiction. 2007 May;102(5):752-60. doi: 10.1111/j.1360-0443.2007.01759.x.
PubMed 17506152
Study at a glance
From the registry record, last updated by the sponsor on 11 May 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Descriptive, Prospective Study of the Characteristics of Chronic Pain in Patients With Addiction to at Least One Substance
- ClinicalTrials.gov ID
- NCT05976178
- Acronym / sponsor ID
- ADDICTALGO / 56LORC_2021_ADDICTALGO
- Conditions
- Chronic Pain, Addiction
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 300 participants (actual)
- Lead sponsor
- Groupe Hospitalier de Bretagne SudUniversity, hospital or other
- Study start
- 10 Dec 2022 (actual)
- Primary completion
- 1 Mar 2025 (actual)
- Study completion
- 1 Mar 2025 (actual)
- First posted
- 4 Aug 2023 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
It is described in the literature a higher prevalence of pain in patients with an addiction but there are few studies describing the pain profile of patients with use disorder.
Pain has a very negative impact on the quality of life of opioid substituted patients. Improving knowledge on this point would make it possible to better guide specific care.
The investigator proposes to conduct a single-center descriptive observational study using questionnaires, without changing the management of patients with chronic pain.
The primary objective of the study is to determine the prevalence of chronic pain in patients with substance addiction hospitalized for addiction treatment.
Detailed description
It is described in the literature a higher prevalence of pain in patients with an addiction but there are few studies describing the pain profile of patients with use disorder.
Pain has a very negative impact on the quality of life of opioid substituted patients. Improving knowledge on this point would make it possible to better guide specific care.
The investigator proposes to conduct a single-center descriptive observational study using questionnaires, without changing the management of patients with chronic pain. All patients admitted to hospitalization in the addiction department of the LORIENT Hospital will be offered participation in the study.
The primary objective of the study is to determine the prevalence of chronic pain in patients with substance addiction hospitalized for addiction treatment.
The study will also evaluate the impact on daily activities of the presence of two chronic pathologies: chronic pain and addiction, describe the frequency of the two main psychiatric comorbidities of chronic pain: anxiety and depression, describe the different components of chronic pain in patients with substance addiction, and get information on analgesic medications.
Study design
- Observational model
- Cohort
- Time perspective
- Prospective
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- Patients hospitalized in the addictology department of LORIENT Hospital, in full hospitalization or in a day hospital
Key inclusion criteria (5 listed)
- > 18 years old
- Presence of addiction to at least one substance, based on DSM-5 criteria
- Hospitalized in the addiction service of LORIENT Hospital
- Knowing how to read and write French
- Not objecting to their participation in the study after informed information
Key exclusion criteria (2 listed)
- Already included during a precedent hospitalization
- Adults subject to legal protection or deprived of their liberty.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Prevalence of chronic pain in patients with substance addiction hospitalized for addiction treatment.
Time frame: During the hospitalization, maximum 1 month
Percentage of patients presenting with pain for more than three months among patients hospitalized in an addiction service for the management of an addiction
8 secondary outcomes
Pain intensity in the last 24 hours
Time frame: During the hospitalization, maximum 1 month
Interference of pain on the quality of life
Time frame: During the hospitalization, maximum 1 month
Localisation of pain
Time frame: During the hospitalization, maximum 1 month
Describe the frequency of the two main psychiatric comorbidities of chronic pain: anxiety
Time frame: During the hospitalization, maximum 1 month
Describe the frequency of the two main psychiatric comorbidities of chronic pain: depression
Time frame: During the hospitalization, maximum 1 month
Describe the prevalence of fibromyalgia among patients with substance addiction
Time frame: During the hospitalization, maximum 1 month
Information on analgesics medication
Time frame: During the hospitalization, maximum 1 month
Describe the prevalence of neuropathic pain among patients with substance addiction
Time frame: During the hospitalization, maximum 1 month
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 11 May 2025.
- Background: PubMed 12746360Rosenblum A, Joseph H, Fong C, Kipnis S, Cleland C, Portenoy RK. Prevalence and characteristics of chronic pain among chemically dependent patients in methadone maintenance and residential treatment facilities. JAMA. 2003 May 14;289(18):2370-8. doi: 10.1001/jama.289.18.2370.
- Background: PubMed 24284850Lusted A, Roerecke M, Goldner E, Rehm J, Fischer B. Prevalence of pain among nonmedical prescription opioid users in substance use treatment populations: systematic review and meta-analyses. Pain Physician. 2013 Nov-Dec;16(6):E671-84.
- Background: PubMed 16095934Breivik H, Collett B, Ventafridda V, Cohen R, Gallacher D. Survey of chronic pain in Europe: prevalence, impact on daily life, and treatment. Eur J Pain. 2006 May;10(4):287-333. doi: 10.1016/j.ejpain.2005.06.009. Epub 2005 Aug 10.
- Background: PubMed 29976203Voon P, Greer AM, Amlani A, Newman C, Burmeister C, Buxton JA. Pain as a risk factor for substance use: a qualitative study of people who use drugs in British Columbia, Canada. Harm Reduct J. 2018 Jul 5;15(1):35. doi: 10.1186/s12954-018-0241-y.
- Background: PubMed 17506152Larson MJ, Paasche-Orlow M, Cheng DM, Lloyd-Travaglini C, Saitz R, Samet JH. Persistent pain is associated with substance use after detoxification: a prospective cohort analysis. Addiction. 2007 May;102(5):752-60. doi: 10.1111/j.1360-0443.2007.01759.x.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Alexandre Cauchie, MD principal investigator
GH Bretagne Sud
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Chronic Pain and Addiction, run by Groupe Hospitalier de Bretagne Sud at 1 site in France.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 2 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 11 May 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in France. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Prevalence of chronic pain in patients with substance addiction hospitalized for addiction treatment. (time frame: During the hospitalization, maximum 1 month). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT05976178, which also lists 5 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 11 May 2025.