Multifocal Motor NeuropathyiMMersioNNCT05988073
A Prospective Longitudinal Study in Adults With Multifocal Motor Neuropathy
An observational study of Multifocal Motor Neuropathy, run by argenx at 114 sites in 20 countries.
Trial summary
This prospective longitudinal study will follow participants with Multifocal Motor Neuropathy over time and collect data on their clinical outcomes, quality of life, and use of health care resources. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Multifocal Motor Neuropathy
- How many people
- 413 participants
- Where
- 114 sitesin 20 countries
- Study dates
- 29 Nov 2023to 31 Dec 2028
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: Patients with MMN receiving standard of care at their treating physician.
Who may be able to join
- Is at least the local legal age of consent for clinical studies when signing the ICF
- Is capable of providing signed informed consent and complying with protocol requirements
- Has an existing or new diagnosis of MMN made by a neuromuscular specialist or neurologist
Who cannot join
- Is currently participating in any clinical study with an IMP
- Has other medical conditions that could affect the assessment of MMN
Trial locations and contacts
114 sites in 20 countries.
114 sites in 20 countries
United States25 sites
University of Colorado - Anschutz Medical Campus
Aurora, Colorado, 80045
University of North Carolina - Chapel Hill
Chapel Hill, North Carolina, 27599-7025
MedStar Georgetown University Hospital
Chevy Chase, Maryland, 20815-6902
Ohio State University Wexner Medical Center - Ohio State Martha Morehouse Outpatient Care
Columbus, Ohio, 43221-3502
Northwest Houston Neurology - Cypress
Cypress, Texas, 77429
The University of Kansas Health System - Landon Center on Aging
Kansas City, Kansas, 66103
Rutgers University - Robert Wood Johnson Medical School
New Brunswick, New Jersey, 08901
YaleNewHavenHealth - Yale New Haven Hospital
New Haven, Connecticut, 06520
Columbia University Irving Medical Center - Neurological Institute of New York
New York, New York, 10032
Hospital Sisters Health System (HSHS) - St Elizabeth's Hospital
O'Fallon, Illinois, 62269
UCI Health - ALS and Neuromuscular Center
Orange, California, 92868
Stanford Medicine Health Care - Stanford Neuroscience Health Center
Palo Alto, California, 94304
Penn Medicine - Penn Medicine University City
Philadelphia, Pennsylvania, 19104
Penn Medicine - Perelman Center for Advanced Medicine
Philadelphia, Pennsylvania, 19104
Neuromuscular Clinical and Research Center
Phoenix, Arizona, 85028
University of Pittsburgh Medical Center
Pittsburgh, Pennsylvania, 15213
The Neurology Group
Pomona, California, 91767-2009
Medsol Clinical Research Center Inc
Port Charlotte, Florida, 33952
Oregon Health and Science University (OHSU) Hospital - Marquam Hill Campus
Portland, Oregon, 97239
Eisenhower Health - Rancho Mirage Medical Center
Rancho Mirage, California, 92270
UC Davis Health - Lawrence J. Ellison Ambulatory Care Center
Sacramento, California, 95817-2307
UCSF Health - UCSF Medical Center
San Francisco, California, 94143-2204
HonorHealth Neurology - Bob Bove Neuroscience Institute
Scottsdale, Arizona, 85251
D&H National Research Centers - Tamarac Research Center
Tamarac, Florida, 33321
MedStar Georgetown University Hospital
Washington D.C., District of Columbia, 20007
France11 sites
CHU Angers
Angers, 49933
CHU de Bordeaux - Hôpital Pellegrin
Bordeaux, 33000
CHU Brest - Hopital La Cavale Blanche
Brest, 29200
Hospices Civils de Lyon (HCL) - Hopital Pierre Wertheimer
Bron, 69500
Assistance Publique Hopitaux de Paris (AP-HP) - Hopital Bicetre
Le Kremlin-Bicêtre, 94270
CHU Lille - Hopital Salengro
Lille, 59037
CHU de Limoges - CHU Dupuytren 1
Limoges, 87042
AP-HM - CHU Timone
Marseille, 13385
CHU de Nantes - Hotel Dieu
Nantes, 44093
CHU de Nice - Hopital Pasteur
Nice, 06001
Assistance Publique Hopitaux de Paris (AP-HP) - Hopital Pitie-Salpetriere
Paris, 75013
Italy10 sites
Azienda Ospedaliero Universitaria Careggi
Florence, 50134
Fondazione Serena Onlus - NeMO Brescia
Gussago, 25064
Azienda Ospedaliera Universitaria Gaetano Martino
Messina, 98125
Universita degli Studi del Piemonte Orientale Amedeo Avogadro - Scuola di Medicina
Novara, 28100
Azienda Ospedaliero-Universitaria San Luigi Gonzaga
Orbassano, 10043
Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone
Palermo, 90129
Istituto Neurologico Nazionale a Carattere Scientifico IRCCS
Pavia, 27100
Azienda Ospedaliero Universitaria Pisana - Ospedale Santa Chiara
Pisa, 56126
Azienda Ospedaliero Universitaria Sant'Andrea
Roma, 00189
Fondazione PTV Policlinico Tor Vergata
Roma, 133
Poland9 sites
Medicover Integrated Clinical Services (MICS) - Centrum Medyczne Bydgoszcz
Bydgoszcz, 85-065
Wielospecjalistyczna Poradnia Lekarska Synapsis
Katowice, 40-123
Specjalistyczne Gabinety Sp. z o.o.
Krakow, 30-539
Michalski i Partnerzy Lekarze Spolka Partnerska
Krakow, 31-426
SP ZOZ Szpital Uniwersytecki w Krakowie
Krakow, 31-503
CLINIREM Sp z o.o.
Lublin, 20-093
Rejdak Konrad Indywidualna Praktyka Lekarska
Lublin, 20-605
Centrum Medyczne Hope Clinic
Lublin, 20-701
ETG Network - ETG Neuroscience
Warsaw, 02-677
United Kingdom9 sites
North Bristol NHS Trust - Southmead Hospital Bristol
Bristol, BS10 5NB
Lancashire Teaching Hospitals NHS Foundation Trust - Royal Preston Hospital
Fulwood, PR2 9HT
NHS Great Glasgow and Clyde - Queen Elizabeth University Hospital
Glasgow, G51 4TF
Nottingham University Hospitals NHS Trust - Queen's Medical Centre
Nottingham, NG7 2UH
Oxford University Hospitals NHS Foundation Trust - John Radcliffe Hospital
Oxford, OX3 9DU
Northern Care Allicance NHS Foundation Trust - Salford Royal
Salford, M6 8HD
Sheffield Teaching Hospitals NHS Foundation Trust - Royal Hallamshire Hospital
Sheffield, S10 2JF
Somerset NHS Foundation Trust - Musgrove Park Hospital
Taunton, TA1 5DA
Royal Cornwall Hospitals NHS Trust - Royal Cornwall Hospital
Truro, TR1 3LJ
Spain8 sites
Hospital General Universitario Dr. Balmis
Alicante, 03010
Hospital Universitari Germans Trias i Pujol (HUGTP)
Badalona, 08916
Hospital de la Santa Creu i Sant Pau
Barcelona, 08041
Hospital Universitario de Basurto
Bilbao, 48013
Hospital Universitari de Bellvitge
L'Hospitalet de Llobregat, 08907
Hospital Universitario Central de Asturias
Oviedo, 33011
Hospital Universitario de Navarra
Pamplona, 31008
Hospital Universitario de Donostia
San Sebastián, 20014
Belgium7 sites
Hopital Erasme
Brussels, 1070
Universitair Ziekenhuis Antwerpen
Edegem, 2650
Universitair Ziekenhuis Gent
Ghent, 9000
Universitair Ziekenhuis Brussel
Jette, 1090
Universitair Ziekenhuis Leuven - Campus Gasthuisberg
Leuven, 3000
L'hopital de la Citadelle - Site Citadelle
Liège, 4000
Cliniques Universitaires Saint-Luc
Woluwe-Saint-Lambert, 1200
Canada5 sites
London Health Sciences Centre - University Hospital
London, N6A 5A5
Centre Hospitalier de l'Universite de Montreal
Montreal, H2X 0C1
McGill University Health Centre - The Neuro (Montreal Neurological Institute-Hospital)
Montreal, H3A 2B4
CHU de Quebec - Hopital de L'enfant Jesus
Québec, G1J 1Z4
University of Saskatchewan - University of Saskatchewan College of Medicine
Saskatoon, S7H 0G9
Germany5 sites
Universitatsklinikum Essen
Essen, 45147
Universitatsklinikum Giessen und Marburg - Campus Giessen
Giessen, 35385
Medizinische Hochschule Hannover
Hanover, 30625
St. Josefs- Krankenhaus Potsdam- Sanssouci
Potsdam, 14471
Universitatsklinikum Wurzburg
Würzburg, 97080
Bulgaria4 sites
Multiprofile Hospital for Active Treatment - Uni Hospital OOD
Panagyurishte, 4500
Medical Center Medconsult Pleven OOD
Pleven, 5800
Military Medical Academy - Military Hospital for Active Treatment Pleven
Pleven, 5800
University Multiprofile Hospital for Active Treatment and Emergency Medicine N. I. Pirogov
Sofia, 1606
Australia3 sites
Royal Melbourne Hospital
Parkville, 3050
Gold Coast University Hospital
Southport, 4215
Princess Alexandra Hospital
Woolloongabba, 4102
China3 sites
Xiangya Hospital of Central South University
Changsha, 410008
The First Affiliated Hospital of Nanchang University
Nanchang, 330006
Huashan Hospital of Fudan University
Shanghai
Japan3 sites
National Center of Neurology and Psychiatry
Kodaira-shi, 187-8551
Dokkyo Medical University Hospital
Mibu, 321-0293
Teikyo University Hospital
tabashi City, 173-8606
Czechia2 sites
Fakultni nemocnice Brno - Areal Bohunice
Brno, 62500
Fakultni nemocnice Hradec Kralove
Hradec Králové, 500 05
Denmark2 sites
Aarhus Universitetshospital
Aarhus, 8200
Rigshospitalet - Blegdamsvej
Copenhagen, 2100
Latvia2 sites
Riga East Clinical University Hospital
Riga, 1038
Pauls Stradins Clinical University Hospital
Riga, LV-1002
Serbia2 sites
Univerzitetski klinicki centar Srbije
Belgrade, 11000
Univerzitetski klinicki centar Kragujevac
Kragujevac, 34000
Sweden2 sites
Sahlgrenska Universitetssjukhuset - MS - mottagning Sahlgrenska
Gothenburg, 413 45
Karolinska Universitetssjukhuset - Huddinge
Huddinge, 141 57
Romania1 site
Spitalul Clinic Judetean de Urgenta Sf. Apostol Andrei
Constanța, 900591
About this study
Official title: A Multicenter Prospective Longitudinal Study of Clinical Outcomes, Disease Course, Health-Related Quality of Life, and Health Care Resource Utilization in Adult Patients With Multifocal Motor Neuropathy
This prospective longitudinal study will follow participants with Multifocal Motor Neuropathy over time and collect data on their clinical outcomes, quality of life, and use of health care resources. Participants will follow their regular visit schedule with their treating physician, except for an optional second visit occurring 7 to 14 days after the start of the study to collect biomarker data. No IMP will be administered.
- Conditions
- Multifocal Motor Neuropathy
What is being measured
The primary outcome is the main question the study is designed to answer.
To characterize MMN patient profiles for participants
Measured: up to 61 months
To assess the MMN disease management and disease course
Measured: up to 61 months
To assess outcome measures specific to MMN disease and their evolution over time
Measured: up to 61 months
To estimate the burden of MMN on participants' quality of life
Measured: up to 61 months
To estimate the economic burden for participants with MMN
Measured: up to 61 months
To collect data on relevant disease biomarkers
Measured: up to 61 months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted14 Aug 2023
- Study start29 Nov 2023
- Primary completion31 Dec 2028 (estimated)
- Study completion31 Dec 2028 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Multifocal Motor NeuropathyStudies of the same condition, open and under way.
- More trials run by argenxThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 413 participants (actual)
Sponsor and investigators
- Lead sponsor
- argenx
- Sponsor type
- Industry (pharma, biotech, devices)
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05988073
- Sponsor's protocol ID
- ARGX-117-2202
- Acronym
- iMMersioN
- Status last verified
- Mar 2026
- First submitted
- 4 Aug 2023
- Last updated
- 4 Nov 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 4 Nov 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- A Multicenter Prospective Longitudinal Study of Clinical Outcomes, Disease Course, Health-Related Quality of Life, and Health Care Resource Utilization in Adult Patients With Multifocal Motor Neuropathy
- ClinicalTrials.gov ID
- NCT05988073
- Acronym / sponsor ID
- iMMersioN / ARGX-117-2202
- Conditions
- Multifocal Motor Neuropathy
- Study type
- Observational
- Recruitment status
- Active, not recruiting
- Enrolment
- 413 participants (actual)
- Lead sponsor
- argenxIndustry (pharma, biotech, devices)
- Study start
- 29 Nov 2023 (actual)
- Primary completion
- 31 Dec 2028 (estimated)
- Study completion
- 31 Dec 2028 (estimated)
- First posted
- 14 Aug 2023 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This prospective longitudinal study will follow participants with Multifocal Motor Neuropathy over time and collect data on their clinical outcomes, quality of life, and use of health care resources. Participants will follow their regular visit schedule with their treating physician, except for an optional second visit occurring 7 to 14 days after the start of the study to collect biomarker data. No IMP will be administered.
Study design
- Observational model
- Cohort
- Time perspective
- Prospective
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- Patients with MMN receiving standard of care at their treating physician.
Key inclusion criteria (3 listed)
- Is at least the local legal age of consent for clinical studies when signing the ICF
- Is capable of providing signed informed consent and complying with protocol requirements
- Has an existing or new diagnosis of MMN made by a neuromuscular specialist or neurologist
Key exclusion criteria (2 listed)
- Is currently participating in any clinical study with an IMP
- Has other medical conditions that could affect the assessment of MMN
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
To characterize MMN patient profiles for participants
Time frame: up to 61 months
To assess the MMN disease management and disease course
Time frame: up to 61 months
To assess outcome measures specific to MMN disease and their evolution over time
Time frame: up to 61 months
To estimate the burden of MMN on participants' quality of life
Time frame: up to 61 months
To estimate the economic burden for participants with MMN
Time frame: up to 61 months
To collect data on relevant disease biomarkers
Time frame: up to 61 months
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 4 Nov 2026.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
114 sites in 20 countries: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Multifocal Motor Neuropathy, run by argenx at 114 sites in 20 countries.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 2 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: under way, not looking for participants, as of the sponsor's last update on 4 Nov 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 114 sites in United States, France, Italy, Poland, United Kingdom and 15 more countries. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
To characterize MMN patient profiles for participants (time frame: up to 61 months). The study lists 6 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 4 Nov 2026.