Stroke, IschemicNCT06001736
Utility of CC7 Transfer in Stroke Subtypes
A study testing Contralateral C7 root transfer for the treatment of spastic hemiparesis. in people with Stroke, Ischemic and Stroke Hemorrhagic, run by Dartmouth-Hitchcock Medical Center at 1 site in United States.
Trial summary
The purpose of this study is to evaluate the limb functional improvement after contralateral C7 root transfer in stroke patients. Read more about this study
- Who is it for?
- Ages 18 to 65 years
- Conditions the study is for
- Stroke, Ischemic, Stroke Hemorrhagic, Spastic Hemiparesis
- What is being tested?
- Contralateral C7 root transfer for the treatment of spastic hemiparesis.
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 95 participants
- Where
- 1 siteUnited States
- Study dates
- 13 Mar 2022to 1 Mar 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 65 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- History of ischemic or hemorrhagic stroke with resultant arm paresis that has ceased to improve within 1-5 years of rehabilitation.
- baseline Fugl-Meyer score below 33
Who cannot join
- pregnancy
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
United States1 site, 1 recruiting
- Recruiting
Dartmouth-Health
Lebanon, New Hampshire, 03677
Lauren Sinks, MPH, 603-653-9021, Lauren.J.Sinks@Hitchcock.org
Jennifer Hong, MD
About this study
Official title: Seventh Cervical Nerve Transfer for Spastic Arm Paresis: A Prospective Analysis of Efficacy in Ischemic vs. Hemorrhagic Stroke
The purpose of this study is to evaluate the limb functional improvement after contralateral C7 root transfer in stroke patients.
Read the detailed description
Spastic limb paresis after stroke is a cause of long-term disability and reduction is quality of life, with loss of hand dexterity being especially prohibitive. In the recovery phase after initial injury, neural reorganization occurs and has been observed in both ipsilateral and contralateral hemispheres. Previous studies have identified contralesional (opposite to the side of the injury), in other words, ipsilateral, activation in the recovery of paretic hand function. However, this pathway of recovery is limited due to sparse connections between the ipsilateral hemisphere and the affected arm/hand. By establishing an anatomic connection between the ipsilateral hemisphere and the paretic arm with contralateral nerve transfer, compensatory capacity of the ipsilateral hemisphere is facilitated. This cross neck C7-C7 root transfer is an established procedure for the treatment of brachial plexus injuries and recently, for the treatment of spastic arm paresis in those with cerebral injury.
- Conditions
- Stroke, Ischemic, Stroke Hemorrhagic, Spastic Hemiparesis
- Being tested
- Contralateral C7 root transfer for the treatment of spastic hemiparesis.
- Keywords
- Ischemic stroke, Hemorrhagic stroke, Spastic hemiparesis
- Medical subject headings
- Ischemic Stroke, Hemorrhagic Stroke, Hemiplegia
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Contralateral C7 root transfer for the treatment of spastic hemiparesis.Procedure or surgery
Performing surgery to transfer the C7 nerve to treat stroke patients experiencing spastic hemiparesis.
| Study group | Role | What they receive |
|---|---|---|
| Contralateral C7 root transfer for the treatment of spastic hemiparesis. | Experimental | The C7 nerve root transfer will occur to the patients on this arm. Receives: Procedure: Contralateral C7 root transfer for the treatment of spastic hemiparesis. |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change from baseline in arm function, as measured by the Fugl-Meyer upper-extremity scale.
The Fugl-Meyer is a widely used and highly recommended stroke-specific, performance-based measure of impairment with 5 domains and a possible 226 points.
Measured: 12 months with visits at baseline and months 2, 4, 8, and 12 months after surgery.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted21 Aug 2023
- Study start13 Mar 2022
- Primary completion1 Mar 2027 (estimated)
- Study completion1 Mar 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Stroke, IschemicStudies of the same condition, open and under way.
- More trials run by Dartmouth-Hitchcock Medical CenterThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Enrolment
- 95 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Dartmouth-Hitchcock Medical Center
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Jennifer Hong, Dartmouth-Hitchcock Medical Center
- Investigators
- Jennifer Hong, Dr., Principal investigator, Dartmouth-Hitchcock Medical Center
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06001736
- Sponsor's protocol ID
- STUDY02000586
- Status last verified
- Feb 2026
- First submitted
- 14 Aug 2023
- Last updated
- 27 Feb 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 27 Feb 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Seventh Cervical Nerve Transfer for Spastic Arm Paresis: A Prospective Analysis of Efficacy in Ischemic vs. Hemorrhagic Stroke
- ClinicalTrials.gov ID
- NCT06001736
- Acronym / sponsor ID
- STUDY02000586
- Conditions
- Stroke, Ischemic, Stroke Hemorrhagic, Spastic Hemiparesis
- Keywords
- Ischemic stroke, Hemorrhagic stroke, Spastic hemiparesis
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 95 participants (estimated)
- Lead sponsor
- Dartmouth-Hitchcock Medical CenterUniversity, hospital or other
- Study start
- 13 Mar 2022 (actual)
- Primary completion
- 1 Mar 2027 (estimated)
- Study completion
- 1 Mar 2027 (estimated)
- First posted
- 21 Aug 2023 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The purpose of this study is to evaluate the limb functional improvement after contralateral C7 root transfer in stroke patients.
Detailed description
Spastic limb paresis after stroke is a cause of long-term disability and reduction is quality of life, with loss of hand dexterity being especially prohibitive. In the recovery phase after initial injury, neural reorganization occurs and has been observed in both ipsilateral and contralateral hemispheres. Previous studies have identified contralesional (opposite to the side of the injury), in other words, ipsilateral, activation in the recovery of paretic hand function. However, this pathway of recovery is limited due to sparse connections between the ipsilateral hemisphere and the affected arm/hand. By establishing an anatomic connection between the ipsilateral hemisphere and the paretic arm with contralateral nerve transfer, compensatory capacity of the ipsilateral hemisphere is facilitated. This cross neck C7-C7 root transfer is an established procedure for the treatment of brachial plexus injuries and recently, for the treatment of spastic arm paresis in those with cerebral injury.
Study design
- Primary purpose
- Treatment
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Contralateral C7 root transfer for the treatment of spastic hemiparesis. | Experimental | Procedure: Contralateral C7 root transfer for the treatment of spastic hemiparesis.The C7 nerve root transfer will occur to the patients on this arm. |
Who may qualify
- Ages
- 18 to 65 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (2 listed)
- History of ischemic or hemorrhagic stroke with resultant arm paresis that has ceased to improve within 1-5 years of rehabilitation.
- baseline Fugl-Meyer score below 33
Key exclusion criteria (1 listed)
- pregnancy
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Contralateral C7 root transfer for the treatment of spastic hemiparesis.Performing surgery to transfer the C7 nerve to treat stroke patients experiencing spastic hemiparesis. | Procedure or surgery | Contralateral C7 root transfer for the treatment of spastic hemiparesis. |
Primary outcome
Change from baseline in arm function, as measured by the Fugl-Meyer upper-extremity scale.
Time frame: 12 months with visits at baseline and months 2, 4, 8, and 12 months after surgery.
The Fugl-Meyer is a widely used and highly recommended stroke-specific, performance-based measure of impairment with 5 domains and a possible 226 points.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 27 Feb 2026.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Jennifer Hong, Dr. principal investigator
Dartmouth-Hitchcock Medical Center
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Contralateral C7 root transfer for the treatment of spastic hemiparesis. in people with Stroke, Ischemic and Stroke Hemorrhagic, run by Dartmouth-Hitchcock Medical Center at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 27 Feb 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Lauren Sinks ((603) 653-9021, Lauren.J.Sinks@hitchcock.org), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change from baseline in arm function, as measured by the Fugl-Meyer upper-extremity scale. (time frame: 12 months with visits at baseline and months 2, 4, 8, and 12 months after surgery.). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 27 Feb 2026; AzTrials last refreshed its copy on 3 Nov 2026.