SarcopeniaMASKNCT06005064
Middle Age muScle Krill Study
A study testing Krill oil and Vegetable oil in people with Sarcopenia, run by University of Glasgow at 1 site in United Kingdom.
Trial summary
This study will determine the effect of 6 months of supplementation with krill oil on muscle strength and mass in middle-aged adults. The study hypothesis is that krill oil supplementation will increase muscle strength and mass in middle-aged adults. Read more about this study
- Who is it for?
- Ages 35 to 60 yearsHealthy volunteers can take part
- Conditions the study is for
- Sarcopenia
- What is being tested?
- Krill oil and Vegetable oil
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 54 participants
- Where
- 1 siteUnited Kingdom
- Study dates
- 1 Nov 2023to 1 Oct 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 35 to 60 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Be 35-60 years old
- Have a BMI of less than 35kg/m2
Who cannot join
- People with diabetes, severe cardiovascular disease, seizure disorders, uncontrolled hypertension (>150/90mmHg at baseline measurement), cancer or cancer that has been in remission <5 years, ambulatory impairments which would limit the ability to perform assessments of muscle function, dementia, on anticoagulant therapy, and/or taking medication known to affect muscle (e.g., steroids).
- People who have allergies to seafood, and/or regular consumption of more than 1 portion of oily fish per week.
- People who perform regular (>1 day/week) resistance exercise training.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: The Effect of Krill Oil Supplementation on Muscle Function and Mass in Middle-aged Adults: A Randomised Controlled Trial
This study will determine the effect of 6 months of supplementation with krill oil on muscle strength and mass in middle-aged adults. The study hypothesis is that krill oil supplementation will increase muscle strength and mass in middle-aged adults.
- Conditions
- Sarcopenia
- Being tested
- Krill oil, Vegetable oil
- Keywords
- Krill oil, Muscle strength, Muscle mass, Middle-aged
- Medical subject headings
- Sarcopenia
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Krill oilDietary supplement
Superba krill oil
Vegetable oilDietary supplement
Mixed vegetable oil
| Study group | Role | What they receive |
|---|---|---|
| Intervention | Experimental | Krill oil 4g/day for 24 weeks Receives: Dietary Supplement: Krill oil |
| Placebo | Placebo comparator | Vegetable oil 4g/day for 24 weeks Receives: Dietary Supplement: Vegetable oil |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change in knee extensor maximal isometric torque ( MVC)
Knee extensor maximal isometric torque measured during a maximal voluntary contraction
Measured: Change from baseline to 24 weeks
Secondary outcomes (5)
Change in fat mass
Whole body fat mass measured by measured via bio-electrical impedance
Measured: Change from baseline to 24 weeks
Change in lean mass
Whole body lean mass measured by measured via bio-electrical impedance
Measured: Change from baseline to 24 weeks
Change in omega-3 levels
Red blood cell omega-3 levels
Measured: Change from baseline to 24 weeks
Change in Grip strength
Grip strength measured with a hand held dynamometer
Measured: Change from baseline to 24 weeks
Change in Muscle thickness
Vastus lateralis muscle thickness measured by ultrasound
Measured: Change from baseline to 24 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted22 Aug 2023
- Study start1 Nov 2023
- Primary completion1 Oct 2025
- Study completion1 Oct 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for SarcopeniaStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- 1:1 basis
- Masking
- Triple blind
- Who is masked
- Participant, Investigator, Outcomes assessor
- Enrolment
- 54 participants (actual)
Sponsor and investigators
- Lead sponsor
- University of Glasgow
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Stuart Gray, University of Glasgow
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06005064
- Sponsor's protocol ID
- MASK
- Acronym
- MASK
- Status last verified
- Apr 2026
- First submitted
- 16 Aug 2023
- Last updated
- 29 Apr 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 29 Apr 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Effect of Krill Oil Supplementation on Muscle Function and Mass in Middle-aged Adults: A Randomised Controlled Trial
- ClinicalTrials.gov ID
- NCT06005064
- Acronym / sponsor ID
- MASK / MASK
- Conditions
- Sarcopenia
- Keywords
- Krill oil, Muscle strength, Muscle mass, Middle-aged
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 54 participants (actual)
- Lead sponsor
- University of GlasgowUniversity, hospital or other
- Study start
- 1 Nov 2023 (actual)
- Primary completion
- 1 Oct 2025 (actual)
- Study completion
- 1 Oct 2025 (actual)
- First posted
- 22 Aug 2023 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study will determine the effect of 6 months of supplementation with krill oil on muscle strength and mass in middle-aged adults. The study hypothesis is that krill oil supplementation will increase muscle strength and mass in middle-aged adults.
Study design
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Triple blind (participant, investigator, outcomes assessor)
- Number of arms
- 2
- Model description
- 1:1 basis
| Arm | Type | Receives |
|---|---|---|
| Intervention | Experimental | Dietary Supplement: Krill oilKrill oil 4g/day for 24 weeks |
| Placebo | Placebo comparator | Dietary Supplement: Vegetable oilVegetable oil 4g/day for 24 weeks |
Who may qualify
- Ages
- 35 to 60 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (2 listed)
- Be 35-60 years old
- Have a BMI of less than 35kg/m2
Key exclusion criteria (3 listed)
- People with diabetes, severe cardiovascular disease, seizure disorders, uncontrolled hypertension (>150/90mmHg at baseline measurement), cancer or cancer that has been in remission <5 years, ambulatory impairments which would limit the ability to perform assessments of muscle function, dementia, on anticoagulant therapy, and/or taking medication known to affect muscle (e.g., steroids).
- People who have allergies to seafood, and/or regular consumption of more than 1 portion of oily fish per week.
- People who perform regular (>1 day/week) resistance exercise training.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Krill oilSuperba krill oil | Dietary supplement | Intervention |
| Vegetable oilMixed vegetable oil | Dietary supplement | Placebo |
Primary outcome
Change in knee extensor maximal isometric torque ( MVC)
Time frame: Change from baseline to 24 weeks
Knee extensor maximal isometric torque measured during a maximal voluntary contraction
5 secondary outcomes
Change in fat mass
Time frame: Change from baseline to 24 weeks
Change in lean mass
Time frame: Change from baseline to 24 weeks
Change in omega-3 levels
Time frame: Change from baseline to 24 weeks
Change in Grip strength
Time frame: Change from baseline to 24 weeks
Change in Muscle thickness
Time frame: Change from baseline to 24 weeks
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 29 Apr 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Krill oil and Vegetable oil in people with Sarcopenia, run by University of Glasgow at 1 site in United Kingdom.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 29 Apr 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United Kingdom. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change in knee extensor maximal isometric torque ( MVC) (time frame: Change from baseline to 24 weeks). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 29 Apr 2026.