Heart FailureNCT06032780
Eccentric Resistance Training Among Individuals With Chronic Heart Failure
A study testing Eccentric Resistive Training + Aerobic training Group, Resistance Training + Aerobic training Group and Aerobic training Group in people with Heart Failure, run by Riphah International University at 2 sites in Pakistan.
Trial summary
To determine the effects of eccentric resistive training on ventricle functions and aerobic capacity as compared to a resistance and aerobic training among Heart failure (HF) Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Heart Failure
- What is being tested?
- Eccentric Resistive Training + Aerobic training Group, Resistance Training + Aerobic training Group and Aerobic training Group
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 84 participants
- Where
- 2 sitesPakistan
- Study dates
- 20 Sep 2023to May 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Diagnosis of Chronic HF and currently stable with optimal medical therapy
- Chronic Heart failure with ejection fraction > 30 %
- Patient able to safely perform lower limb exercise will be check by six- minute walk test (6 MWT)
Who cannot join
- Those Heart failure patient whose are in acute phase or planed for any immediate medical intervention
- Already participating in cardiac rehabilitation
- New York Heart Association (NYHA) Classification of HF class IV HF symptoms
- Co-existent other disease such as asthma/ COPD/interstitial lung disease.
- Symptomatic Second degree or third degree heart block.
- ECG with uncontrolled ventricular arrhythmia
- Limited Exercise ability due to neurologic or orthopedic impairments of the legs (will cross-check with 6 MWT)
Trial locations and contacts
2 sites in 1 country. Contact the study team or a site near you to ask about taking part.
Pakistan2 sites, 1 recruiting
- Suspended
Pakistan Railway Hospital
Rawalpindi, Punjab Province, 46000
- Recruiting
Rawalpindi Institute of Cardiology
Rawalpindi, Punjab Province, 46000
Muhammad Iqbal Tariq, PhD*, +92 333 8236752, iqbal.tariq@riphah.edu.pk
Muhammad Iqbal Tariq, PhD*
About this study
Official title: Effects of Eccentric Resistance Training on Ventricle Functions and Aerobic Capacity Among Individuals With Chronic Heart Failure
To determine the effects of eccentric resistive training on ventricle functions and aerobic capacity as compared to a resistance and aerobic training among Heart failure (HF)
- Conditions
- Heart Failure
- Being tested
- Eccentric Resistive Training + Aerobic training Group, Resistance Training + Aerobic training Group, Aerobic training Group
- Medical subject headings
- Heart Failure
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Eccentric Resistive Training + Aerobic training GroupOther
Eccentric Resistive training includes upper limb (biceps and triceps) and lower limb large muscle training (quadriceps and hamstrings) 2 sets of 12 repetitions (reps) for each group of muscles in lengthened position for eccentric training in approx. 20 minutes (min). Intensity will be based on 1 repetition maximum (1RM) starting from 20% of (1RM) and its intensity in percentage will be progress by 10% after every two weeks. Stair descending training and squatting position and eccentric hamstring curls with weights at ankle for lower limb eccentric training progressive as per tolerance in response to modified Borg scale (with cut off of showing dyspnea of 4 somewhat hard) and Numeric Pain rating scale (with cut off of showing 7 on scale, crossing moderate pain) . (approx. 20 min).
+ Aerobic training as a control will be given to this group as well for approximately 30 minutes per session.
Resistance Training + Aerobic training GroupOther
Resistive training (concentric) includes Upper limb (biceps and triceps) and lower limb large muscle training (quadriceps and hamstrings), 2 sets of 12 reps for each group of muscles in approx. 30 min. Intensity will be based on 1 repetition maximum (1RM) starting from 20% of (1RM) and its intensity in percentage will be progress by 10% after every two weeks. Stair climbing training and quadriceps training + standing hamstring curls with weight at ankle for lower limb concentric training progressive as per tolerance in response to modified Borg scale (with cut off of showing dyspnea of 4 somewhat hard) and Numeric Pain rating scale (with cut off of showing 7 on scale, crossing moderate pain)
+ Aerobic training as a control will be given to this group as well for approximately 30 minutes per session.
Aerobic training GroupOther
Aerobic training as a control will be given to this group as well for approximately 60 minutes per session. Aerobic training exercise will be completed via a ergometer/stationary cycle; type will be continuous aerobic exercise and intensity of 60% of max HR (or peak VO2) in HF individuals.
| Study group | Role | What they receive |
|---|---|---|
| Eccentric Resistive Training + Aerobic training Group | Experimental | Not described Receives: Other: Eccentric Resistive Training + Aerobic training Group |
| Resistance Training + Aerobic training Group | Active comparator | Not described Receives: Other: Resistance Training + Aerobic training Group |
| Aerobic training Group | Active comparator | Not described Receives: Other: Aerobic training Group |
What is being measured
The primary outcome is the main question the study is designed to answer.
Ventricle Functions
Changes from the baseline will be measured. Doppler resting echocardiography will be performed to measure ventricle functions. Standard views, including the parasternal long-axis, short-axis at the papillary muscle level, and apical 4- and 2-chamber views will be recorded. Left ventricular ejection fraction (LVEF) and end systolic and end-diastolic diameters (LVESD and LVEDD) will be measured using formula (Tiecholz formula i-e spherical volume of the heart multiplied by a correction factor). Any structural changes will also be recorded.
Measured: 12 week
Aerobic Capacity
Changes will be measured at baseline, 4th week, 8th week and 12th week. The 6-min walk test provides an indirect measure of cardiovascular functional/aerobic capacity. Six Minute Walk test (6MWT) will be used to assess the functional capacity of the individuals with HF. The subjects will be instructed to walk for 6 minutes at a given time along a 30-m line at an interval of 1.5 m in an outdoor corridor, and the distance walked will be recorded in meters. The participants will be encouraged to continue walking as fast as possible. Then a generalized equation will be used to predict peak VO2 from 6 minute walk distance (6MWD) with the help of formula. Mean Peak VO2 (ml/kg/Mean) = 4.948 + 0.023 *Mean 6MWD (meters)
Measured: 12 week
Secondary outcomes (9)
Quality of life (Minnesota Living with Heart Failure Questionnaire)
Changes from the baseline will be measured. Quality of life will be measured through Minnesota Living with Heart Failure Questionnaire (MLHFQ). It is one of the most widely used health-related quality of life questionnaires for individuals with HF. It provides scores for two dimensions, physical and emotional, and a total score. The MLHFQ is a self-administered, 21-item disease-specific instrument for individuals with HF. Each item is scored in a 6-point Likert Scale (0 to 5), thus the total score could range from 0 to 105, with higher scores indicating more significant impairment in health-related quality of life. The MLHFQ has two domains; physical domain (eight items, score range from 0 to 40) and emotional domain (five items, score range from 0 to 25).
Measured: 12 week
Strength
Changes will be measured at baseline, 4th week, 8th week and 12th week. Maximum muscle strength of the all major muscles biceps, triceps, quadriceps and hamstring, will be measured in sitting position with (MicroFET2 Digital Handheld Dynamometer muscle tester).
Measured: 12 week
Maximal strength of respiratory muscles
Changes will be measured at baseline, 4th week, 8th week and 12th week. Maximum Inspiratory pressure (MIP) and Maximal Expiratory pressure (MEP) will be assessed through a handheld mouth pressure meter.
Measured: 12 week
Forced Expiratory Volume in 1 second (FEV1)
Changes will be measured at baseline, 4th week, 8th week and 12th week, the digital spirometer is used in clinical setting to analyze Forced Expiratory Volume in 1 second FEV1 in Liters
Measured: 12 week
Forced vital Capacity (FVC)
Changes will be measured at baseline, 4th week, 8th week and 12th week, the digital spirometer is used in clinical setting to analyze Forced vital Capacity in Liters
Measured: 12 week
Peak Expiratory Flow (PEF)
Changes will be measured at baseline, 4th week, 8th week and 12th week, the digital spirometer is used in clinical setting to analyze peak expiratory flow PEF in Liter/second.
Measured: 12 week
Cardiac Risk Factors - Blood Pressure
Changes from the Baseline, Blood pressure (Bp) (both systolic/diastolic) will be measured in mmHg. It will be measured manually through sphygmomanometer by trained assessor in sitting position at baseline and at end of training on each week (for safety check).
Measured: 12 week
Cardiac Risk Factors - Body mass index
Changes will be measured at baseline, 6th week and at 12th week. Weight in kilograms (kg) and Height in meters (m) will be combined to report BMI in kg/m^2 to measure the Body mass index
Measured: 12 week
Cardiac Risk Factors - Lipid profile
Changes form the baseline, The lipid profile includes total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglyceride (TG). All units are in mmol/L.
Measured: 12 week
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted13 Sep 2023
- Study start20 Sep 2023
- Primary completionMay 2026 (estimated)
- Study completionMay 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Heart FailureStudies of the same condition, open and under way.
- More trials run by Riphah International UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind
- Who is masked
- Care provider, Outcomes assessor
- Enrolment
- 84 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Riphah International University
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Muhammad Iqbal Tariq, PhD*, Principal investigator, Riphah International UniversityArshad Nawaz Malik, PhD, Study chair, Riphah International UniversityShane Patman, PhD, Study chair, University of Notre Dame Australia
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06032780
- Sponsor's protocol ID
- ISB/REC/PhD/01199 Iqbal Tariq
- Status last verified
- Nov 2025
- First submitted
- 5 Sep 2023
- Last updated
- 19 Nov 2025
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 19 Nov 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effects of Eccentric Resistance Training on Ventricle Functions and Aerobic Capacity Among Individuals With Chronic Heart Failure
- ClinicalTrials.gov ID
- NCT06032780
- Acronym / sponsor ID
- ISB/REC/PhD/01199 Iqbal Tariq
- Conditions
- Heart Failure
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 84 participants (estimated)
- Lead sponsor
- Riphah International UniversityUniversity, hospital or other
- Study start
- 20 Sep 2023 (actual)
- Primary completion
- May 2026 (estimated)
- Study completion
- May 2026 (estimated)
- First posted
- 13 Sep 2023 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
To determine the effects of eccentric resistive training on ventricle functions and aerobic capacity as compared to a resistance and aerobic training among Heart failure (HF)
Study design
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind (care provider, outcomes assessor)
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| Eccentric Resistive Training + Aerobic training Group | Experimental | Other: Eccentric Resistive Training + Aerobic training Group |
| Resistance Training + Aerobic training Group | Active comparator | Other: Resistance Training + Aerobic training Group |
| Aerobic training Group | Active comparator | Other: Aerobic training Group |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (3 listed)
- Diagnosis of Chronic HF and currently stable with optimal medical therapy
- Chronic Heart failure with ejection fraction > 30 %
- Patient able to safely perform lower limb exercise will be check by six- minute walk test (6 MWT)
Key exclusion criteria (7 listed)
- Those Heart failure patient whose are in acute phase or planed for any immediate medical intervention
- Already participating in cardiac rehabilitation
- New York Heart Association (NYHA) Classification of HF class IV HF symptoms
- Co-existent other disease such as asthma/ COPD/interstitial lung disease.
- Symptomatic Second degree or third degree heart block.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Eccentric Resistive Training + Aerobic training GroupEccentric Resistive training includes upper limb (biceps and triceps) and lower limb large muscle training (quadriceps and hamstrings) 2 sets of 12 repetitions (reps) for each group of muscles in lengthened position for eccentric training in approx. 20 minutes (min). Intensity will be based on 1 repetition maximum (1RM) starting from 20% of (1RM) and its intensity in percentage will be progress by 10% after every two weeks. Stair descending training and squatting position and eccentric hamstring curls with weights at ankle for lower limb eccentric training progressive as per tolerance in response to modified Borg scale (with cut off of showing dyspnea of 4 somewhat hard) and Numeric Pain rating scale (with cut off of showing 7 on scale, crossing moderate pain) . (approx. 20 min). + Aerobic training as a control will be given to this group as well for approximately 30 minutes per session. | Other | Eccentric Resistive Training + Aerobic training Group |
| Resistance Training + Aerobic training GroupResistive training (concentric) includes Upper limb (biceps and triceps) and lower limb large muscle training (quadriceps and hamstrings), 2 sets of 12 reps for each group of muscles in approx. 30 min. Intensity will be based on 1 repetition maximum (1RM) starting from 20% of (1RM) and its intensity in percentage will be progress by 10% after every two weeks. Stair climbing training and quadriceps training + standing hamstring curls with weight at ankle for lower limb concentric training progressive as per tolerance in response to modified Borg scale (with cut off of showing dyspnea of 4 somewhat hard) and Numeric Pain rating scale (with cut off of showing 7 on scale, crossing moderate pain) + Aerobic training as a control will be given to this group as well for approximately 30 minutes per session. | Other | Resistance Training + Aerobic training Group |
| Aerobic training GroupAerobic training as a control will be given to this group as well for approximately 60 minutes per session. Aerobic training exercise will be completed via a ergometer/stationary cycle; type will be continuous aerobic exercise and intensity of 60% of max HR (or peak VO2) in HF individuals. | Other | Aerobic training Group |
Primary outcome
Ventricle Functions
Time frame: 12 week
Changes from the baseline will be measured. Doppler resting echocardiography will be performed to measure ventricle functions. Standard views, including the parasternal long-axis, short-axis at the papillary muscle level, and apical 4- and 2-chamber views will be recorded. Left ventricular ejection fraction (LVEF) and end systolic and end-diastolic diameters (LVESD and LVEDD) will be measured using formula (Tiecholz formula i-e spherical volume of the heart multiplied by a correction factor). Any structural changes will also be recorded.
Aerobic Capacity
Time frame: 12 week
Changes will be measured at baseline, 4th week, 8th week and 12th week. The 6-min walk test provides an indirect measure of cardiovascular functional/aerobic capacity. Six Minute Walk test (6MWT) will be used to assess the functional capacity of the individuals with HF. The subjects will be instructed to walk for 6 minutes at a given time along a 30-m line at an interval of 1.5 m in an outdoor corridor, and the distance walked will be recorded in meters. The participants will be encouraged to continue walking as fast as possible. Then a generalized equation will be used to predict peak VO2 from 6 minute walk distance (6MWD) with the help of formula. Mean Peak VO2 (ml/kg/Mean) = 4.948 + 0.023 *Mean 6MWD (meters)
9 secondary outcomes
Quality of life (Minnesota Living with Heart Failure Questionnaire)
Time frame: 12 week
Strength
Time frame: 12 week
Maximal strength of respiratory muscles
Time frame: 12 week
Forced Expiratory Volume in 1 second (FEV1)
Time frame: 12 week
Forced vital Capacity (FVC)
Time frame: 12 week
Peak Expiratory Flow (PEF)
Time frame: 12 week
Cardiac Risk Factors - Blood Pressure
Time frame: 12 week
Cardiac Risk Factors - Body mass index
Time frame: 12 week
Cardiac Risk Factors - Lipid profile
Time frame: 12 week
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 19 Nov 2025.
- Individual participant dataSharing planned: No
Related trials for Heart Failure
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Enrolling by invitationObservational study
Multi-Scale Analysis of Phenotypes in Heart Failure (MAP-HEART)
Heart Failure
Recruiting
ELEVATE-HFpEF Clinical Study
Heart Failure With Preserved Ejection Fraction (HFpEF)
Recruiting
Safety and Effectiveness of Left Bundle Branch Area Pacing Versus Conventional Cardiac Resynchronization Therapy in Heart Failure
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Muhammad Iqbal Tariq, PhD* principal investigator
Riphah International University
Arshad Nawaz Malik, PhD study chair
Riphah International University
Shane Patman, PhD study chair
University of Notre Dame Australia
2 sites in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Eccentric Resistive Training + Aerobic training Group, Resistance Training + Aerobic training Group and Aerobic training Group in people with Heart Failure, run by Riphah International University at 2 sites in Pakistan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 19 Nov 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 2 sites in Pakistan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Muhammad Iqbal Tariq, PhD* (+923338236752, iqbal.tariq@riphah.edu.pk), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Ventricle Functions (time frame: 12 week). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 19 Nov 2025; AzTrials last refreshed its copy on 4 Nov 2026.