EmergenciesTACCNCT06079099
Time Within the Acute Care Chain: How Long Have Medical Emergency Department Patients Spent
An observational study of Emergencies, run by Maastricht University Medical Center at 6 sites in Netherlands.
Trial summary
This study is part of a research domain focusing on the acute care chain, which includes the patient journey from symptoms to treatment on the Emergency Medical Department (ED). Within hospitals there is much attention for triage and the amount of time patients spent within the chain, especially for the ED. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Emergencies
- How many people
- 583 participants
- Where
- 6 sitesNetherlands
- Study dates
- 20 Apr 2022to 30 Aug 2022
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- Adult, Older adult
Study population: Adult patients who visit the ED in need of acute care
Who may be able to join
- Patients of 18 years and older
- Patient is treated at ED during inclusion period
- Patient is able and willing to sign informed consent or has a legal representative
Who cannot join
- Language barrier
Trial locations and contacts
6 sites in 1 country.
6 sites in 1 country
Netherlands6 sites
Zuyderland MC
Heerlen
MUMC
Maastricht, Limburg, 6202 AZ
Laurentius Ziekenhuis Roermond
Roermond
Zuyderland MC
Sittard
VieCuri
Venlo
St. Jans Gasthuis Weert
Weert
About this study
This study is part of a research domain focusing on the acute care chain, which includes the patient journey from symptoms to treatment on the Emergency Medical Department (ED). Within hospitals there is much attention for triage and the amount of time patients spent within the chain, especially for the ED. However, there is less information available on what occurs before patients visit the ED. Gaining more insight in the patient journey in the acute care chain as a whole, might provide important information to further optimize care at the ED. In the current study, 750 patients will be included at multiple ED's in the Netherlands. The primary goal is to gain insight in the patient journey of adult ED patients.
Read the detailed description
All adult ED patients in the province of Limburg will be included in a 72 hour time frame. Students were present at the EDs 24 hours to include all these patients. Patient data were gathered from medical records (including hospital file, referral letters and EMS notes) using a Case Report Form (CRF) and from a questionnaire filled out by the patient. Data were collected on demographic variables, including sex, age, highest level of education, living situation and the presence of roommates. Furthermore, information regarding the ACC and Time spent in the ACC (TACC) was collected.
The entire ACC was divided into four phases: the pre-referral phase, the referral phase, the ED phase and the post ED phase. In each phase several variables were collected.
Pre-referral phase The pre-referral phase started with the onset of complaints this disease period up to the referring contact. The following variables of this phase were collected: the symptom duration in days calculated from the day of onset of symptoms until ED visit, number of prior contacts with a healthcare provider and prescribed medication this disease period before ED visit. A prior contact with a healthcare provider was defined as a contact within this disease period, regarding the same complaint, and before the contact during which the patient was referred to the ED.
Referral phase The referral phase started with the moment of referral until arrival at the ED. The following variables of this phase were collected: time and date of referral contact, referring health care provider (GP, EMS, medical specialist, nursing home doctor, other or self-referral), prehospital triage urgency (EMS and GCP), and mode of transportation to the ED (own transport or by EMS). Prehospital triage urgency levels (for GPC and EMS) are determined using the Netherlands Triage Standard (NTS), which categorizes patients from U1 (life threatening, immediate action required) up to U5 (advice, a physical examination can wait until the next day) (16). If necessary, an ambulance is subsequently dispatched according to these urgency levels.
ED phase The ED phase started with arrival at the ED until hospital discharge, including 30-day follow-up. The following variables of this phase were collected at the ED: referred specialty (the specialty to which the patient has been referred), treating specialty (the specialty that eventually treated/discharged/admitted the patient), triage urgency level (MTS (17)), presenting symptoms, the number of patients with a presumptive prespecified complex condition, ED work up, and arrival and departure time in the ED to calculate the length of stay (LOS).
The EDs in this study use the Manchester Triage System (MTS) as a triage system, which categorises patients into five levels of urgency (17). Immediate (red) patients are to be evaluated immediately, whereas non-urgent (blue) patients are allowed to wait for 240 minutes prior to evaluation. In this study we combined red and orange triage urgencies as 'highly urgent' (evaluation within 10 minutes maximum), and yellow, green and blue as 'urgent' (evaluation within 60-240 minutes). Presenting symptoms were categorized into 18 groups after discussion with the researchers: minor trauma, abdominal pain, dyspnoea, general malaise, fever, extremity complaints (e.g. arthritis), neurological complaints, syncope/palpitations, skin symptoms, urological complaints, complaints after treatment, allergic reaction, hypertension, minor oncological complaints (e.g. rash), chest pain, ENT problem, intoxication, and other. Prespecified complex conditions were defined as patients presenting with the presumptive diagnosis of a stroke, myocardial infarction, aortic syndrome or major trauma.
The ED work up was defined as simple when ED work-up included lab tests, electrocardiogram and X-ray and was defined complex when included CT, ultrasound, lumbar puncture (LP), abdominal paracentesis, gastroscopy, MRI scan and consultations of other specialties.
Post ED phase The post ED phase started after ED discharge until 30-day follow-up. The following variables were collected: post-ED disposition, 7- and 30-day all-cause mortality and 30-day revisit. A combination of 7- and 30-day all-cause mortality and 30-day revisit were called adverse outcome.
- Conditions
- Emergencies
- Keywords
- Acute Care Chain, Emergency Department, Patient Journey
- Medical subject headings
- Emergencies
What is being measured
The primary outcome is the main question the study is designed to answer.
Total time a patient spent in acute care chain.
Patient journey in the acute care chain. From all included patients: We measure the duration in the Acute care chain: From the moment a patient has contact with the referring healthcare provider until ED discharge
Measured: up to hours with a maximum of 48 hours.Time unit: hours.
Secondary outcomes (4)
Number of contacts with a healthcare provider this disease period
Did patients have contact with care provider(s) before visiting the ED? If yes, which type of care providers were they and what was the urgency level? We ask the included patients during the inclusion periode how many healthcare providers the contacted: From first contact with a healthcare provider this disease period until entering the ED. This disease period = start complaints
Measured: Days, maximum 14 days. Time unit: days.
How many investigations were done during the ED visit
Which investigations are carried out: blood test, ultrasound, x-ray? Patients that present in the inclusion period, at the ED. During the ED visit of the patient we look at the amount and which ancillary investigations are done. Timeframe = ED stay. No change is measured.
Measured: During ED stay, that means in a couple of hours. ED stays are no longer that > 1 day. time unit is hours.
Number of participant that are admitted to the hospital.
What happens after ED visit? How many patients will be admitted.
Measured: 30 days after ED visit we check on how many patients are admitted. Time frame 30 days. Unit: number of participants.
Number of participant that are deceased after 30 days. .
What happens after ED visit? How many patients died
Measured: 30 days after ED visit we check on how many patients are deceased. Time frame 30 days. Unit: number of participants.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted12 Oct 2023
- Study start20 Apr 2022
- Primary completion24 Apr 2022
- Study completion30 Aug 2022
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for EmergenciesStudies of the same condition, open and under way.
- More trials run by Maastricht University Medical CenterThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Other
- Time perspective
- Prospective
- Enrolment
- 583 participants (actual)
Sponsor and investigators
- Lead sponsor
- Maastricht University Medical Center
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06079099
- Sponsor's protocol ID
- TACC
- Acronym
- TACC
- Status last verified
- Dec 2021
- First submitted
- 22 Dec 2021
- Last updated
- 12 Oct 2023
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Publications
Claassen L, Stassen PM, Boumans TJT, Barten DG, Kremers MNT, Hermans AME, Zelis N, Cals JWL, Latten GHP. Characteristics of Dutch ED patients and their journey through the acute care chain: A province-wide flash-mob study. PLoS One. 2025 Apr 3;20(4):e0318510. doi: 10.1371/journal.pone.0318510. eCollection 2025.
PubMed 40179077
Study at a glance
From the registry record, last updated by the sponsor on 12 Oct 2023. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Time Within the Acute Care Chain: How Long Have Medical Emergency Department Patients Spent
- ClinicalTrials.gov ID
- NCT06079099
- Acronym / sponsor ID
- TACC / TACC
- Conditions
- Emergencies
- Keywords
- Acute Care Chain, Emergency Department, Patient Journey
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 583 participants (actual)
- Lead sponsor
- Maastricht University Medical CenterUniversity, hospital or other
- Study start
- 20 Apr 2022 (actual)
- Primary completion
- 24 Apr 2022 (actual)
- Study completion
- 30 Aug 2022 (actual)
- First posted
- 12 Oct 2023 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study is part of a research domain focusing on the acute care chain, which includes the patient journey from symptoms to treatment on the Emergency Medical Department (ED). Within hospitals there is much attention for triage and the amount of time patients spent within the chain, especially for the ED. However, there is less information available on what occurs before patients visit the ED. Gaining more insight in the patient journey in the acute care chain as a whole, might provide important information to further optimize care at the ED. In the current study, 750 patients will be included at multiple ED's in the Netherlands. The primary goal is to gain insight in the patient journey of adult ED patients.
Detailed description
All adult ED patients in the province of Limburg will be included in a 72 hour time frame. Students were present at the EDs 24 hours to include all these patients. Patient data were gathered from medical records (including hospital file, referral letters and EMS notes) using a Case Report Form (CRF) and from a questionnaire filled out by the patient. Data were collected on demographic variables, including sex, age, highest level of education, living situation and the presence of roommates. Furthermore, information regarding the ACC and Time spent in the ACC (TACC) was collected.
The entire ACC was divided into four phases: the pre-referral phase, the referral phase, the ED phase and the post ED phase. In each phase several variables were collected.
Pre-referral phase The pre-referral phase started with the onset of complaints this disease period up to the referring contact. The following variables of this phase were collected: the symptom duration in days calculated from the day of onset of symptoms until ED visit, number of prior contacts with a healthcare provider and prescribed medication this disease period before ED visit. A prior contact with a healthcare provider was defined as a contact within this disease period, regarding the same complaint, and before the contact during which the patient was referred to the ED.
Referral phase The referral phase started with the moment of referral until arrival at the ED. The following variables of this phase were collected: time and date of referral contact, referring health care provider (GP, EMS, medical specialist, nursing home doctor, other or self-referral), prehospital triage urgency (EMS and GCP), and mode of transportation to the ED (own transport or by EMS). Prehospital triage urgency levels (for GPC and EMS) are determined using the Netherlands Triage Standard (NTS), which categorizes patients from U1 (life threatening, immediate action required) up to U5 (advice, a physical examination can wait until the next day) (16). If necessary, an ambulance is subsequently dispatched according to these urgency levels.
ED phase The ED phase started with arrival at the ED until hospital discharge, including 30-day follow-up. The following variables of this phase were collected at the ED: referred specialty (the specialty to which the patient has been referred), treating specialty (the specialty that eventually treated/discharged/admitted the patient), triage urgency level (MTS (17)), presenting symptoms, the number of patients with a presumptive prespecified complex condition, ED work up, and arrival and departure time in the ED to calculate the length of stay (LOS).
The EDs in this study use the Manchester Triage System (MTS) as a triage system, which categorises patients into five levels of urgency (17). Immediate (red) patients are to be evaluated immediately, whereas non-urgent (blue) patients are allowed to wait for 240 minutes prior to evaluation. In this study we combined red and orange triage urgencies as 'highly urgent' (evaluation within 10 minutes maximum), and yellow, green and blue as 'urgent' (evaluation within 60-240 minutes). Presenting symptoms were categorized into 18 groups after discussion with the researchers: minor trauma, abdominal pain, dyspnoea, general malaise, fever, extremity complaints (e.g. arthritis), neurological complaints, syncope/palpitations, skin symptoms, urological complaints, complaints after treatment, allergic reaction, hypertension, minor oncological complaints (e.g. rash), chest pain, ENT problem, intoxication, and other. Prespecified complex conditions were defined as patients presenting with the presumptive diagnosis of a stroke, myocardial infarction, aortic syndrome or major trauma.
The ED work up was defined as simple when ED work-up included lab tests, electrocardiogram and X-ray and was defined complex when included CT, ultrasound, lumbar puncture (LP), abdominal paracentesis, gastroscopy, MRI scan and consultations of other specialties.
Post ED phase The post ED phase started after ED discharge until 30-day follow-up. The following variables were collected: post-ED disposition, 7- and 30-day all-cause mortality and 30-day revisit. A combination of 7- and 30-day all-cause mortality and 30-day revisit were called adverse outcome.
Study design
- Observational model
- Other
- Time perspective
- Prospective
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Age groups
- Adult, Older adult
- Study population
- Adult patients who visit the ED in need of acute care
Key inclusion criteria (3 listed)
- Patients of 18 years and older
- Patient is treated at ED during inclusion period
- Patient is able and willing to sign informed consent or has a legal representative
Key exclusion criteria (1 listed)
- Language barrier
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Total time a patient spent in acute care chain.
Time frame: up to hours with a maximum of 48 hours.Time unit: hours.
Patient journey in the acute care chain. From all included patients: We measure the duration in the Acute care chain: From the moment a patient has contact with the referring healthcare provider until ED discharge
4 secondary outcomes
Number of contacts with a healthcare provider this disease period
Time frame: Days, maximum 14 days. Time unit: days.
How many investigations were done during the ED visit
Time frame: During ED stay, that means in a couple of hours. ED stays are no longer that > 1 day. time unit is hours.
Number of participant that are admitted to the hospital.
Time frame: 30 days after ED visit we check on how many patients are admitted. Time frame 30 days. Unit: number of participants.
Number of participant that are deceased after 30 days. .
Time frame: 30 days after ED visit we check on how many patients are deceased. Time frame 30 days. Unit: number of participants.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 12 Oct 2023.
- Derived from this study: PubMed 40179077Claassen L, Stassen PM, Boumans TJT, Barten DG, Kremers MNT, Hermans AME, Zelis N, Cals JWL, Latten GHP. Characteristics of Dutch ED patients and their journey through the acute care chain: A province-wide flash-mob study. PLoS One. 2025 Apr 3;20(4):e0318510. doi: 10.1371/journal.pone.0318510. eCollection 2025.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
6 sites in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Emergencies, run by Maastricht University Medical Center at 6 sites in Netherlands.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 12 Oct 2023. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 6 sites in Netherlands. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Total time a patient spent in acute care chain. (time frame: up to hours with a maximum of 48 hours.Time unit: hours.). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT06079099, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 12 Oct 2023.