HemodynamicNCT06112769
A Correlation Study of Internal Jugular Vein Variability Under Deep Inhalation and Propofol-induced Hypotension
An observational study of Hemodynamic, run by Affiliated Hospital of Jiaxing University at 1 site in China.
Trial summary
The correlation between internal jugular vein variability during deep inhalation and the decrease in blood pressure during propofol induction. Read more about this study
- Who is it for?
- Ages 60 years and older
- Conditions the study is for
- Hemodynamic
- How many people
- 64 participants
- Where
- 1 siteChina
- Study dates
- 29 Oct 2023to 31 Jan 2024
- How long will I take part?
- 1 Day
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 60 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: Patients undergoing intravenous general anesthesia surgery at Jiaxing First Hospital
Who may be able to join
- age over 60 years
- American Society of Anesthesiology (ASA) status Ⅱ-Ⅲ
- Surgery with radial artery puncture
- Propofol induction
Who cannot join
- BMI≥30kg/m2
- People with short necks;
- Previous hypotension (systolic blood pressure <90mmHg or mean arterial pressure <65mmHg)
- Previous poorly controlled hypertension
- Cardiac insufficiency , EF value<50%
- Upper limb deep vein thrombosis
Show all 11Show fewer
- History of radiotherapy or neck surgery
- Inability to maintain a supine position for necessary measurements
- Mechanical ventilation status or inability to take deep breaths patients
- gastrointestinal surgery
- patients allergic to propofol.
Trial locations and contacts
1 site in 1 country.
About this study
The correlation between internal jugular vein variability during deep inhalation and the decrease in blood pressure during propofol induction.
Read the detailed description
- Ultrasound records at least one quiet breathing cycle and one deep inhalation cycle to calculate IJVV
- Propofol was infused target-controlled at 4 μg/ml, and changes in arterial blood pressure within 3 minutes of propofol induction were observed.
- Aim to conduct a prospective observational study to evaluate the correlation between internal jugular vein variability during deep inhalation and the decrease in blood pressure during propofol induction.
- Conditions
- Hemodynamic
- Keywords
- Internal jugular vein, propofol, hypotension, hemodynamic
- Medical subject headings
- Hypotension
What is being measured
The primary outcome is the main question the study is designed to answer.
IJVV during deep inhalation
IJVV (%) = (diamax - diamin)/[(diamax + diamin)/2] × 100
Measured: 1 year
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted1 Nov 2023
- Study start29 Oct 2023
- Primary completion31 Jan 2024
- Study completion31 Jan 2024
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for HemodynamicStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Case only
- Time perspective
- Prospective
- Enrolment
- 64 participants (actual)
- Target duration
- 1 Day
Sponsor and investigators
- Lead sponsor
- Affiliated Hospital of Jiaxing University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Qing-he Zhou, Affiliated Hospital of Jiaxing University
- Investigators
- Qinghe Zhou, Principal investigator, Affiliated Hospital of Jiaxing University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06112769
- Sponsor's protocol ID
- 2023-KY-603
- Status last verified
- Mar 2025
- First submitted
- 29 Oct 2023
- Last updated
- 12 Mar 2025
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Wei XL, Xi YZ, Xie L, Li ZP, Tang HL, Zhou QH. Effects of liquid resuscitation guided by internal jugular vein variability during deep inhalation on preventing propofol-induced hypotension in elderly patients. BMC Anesthesiol. 2025 Jul 17;25(1):350. doi: 10.1186/s12871-025-03227-3.
PubMed 40676549
Study at a glance
From the registry record, last updated by the sponsor on 12 Mar 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- A Correlation Study of Internal Jugular Vein Variability Under Deep Inhalation and Propofol-induced Hypotension
- ClinicalTrials.gov ID
- NCT06112769
- Acronym / sponsor ID
- 2023-KY-603
- Conditions
- Hemodynamic
- Keywords
- Internal jugular vein, propofol, hypotension, hemodynamic
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 64 participants (actual)
- Lead sponsor
- Affiliated Hospital of Jiaxing UniversityUniversity, hospital or other
- Study start
- 29 Oct 2023 (actual)
- Primary completion
- 31 Jan 2024 (actual)
- Study completion
- 31 Jan 2024 (actual)
- First posted
- 1 Nov 2023 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The correlation between internal jugular vein variability during deep inhalation and the decrease in blood pressure during propofol induction.
Detailed description
- Ultrasound records at least one quiet breathing cycle and one deep inhalation cycle to calculate IJVV
- Propofol was infused target-controlled at 4 μg/ml, and changes in arterial blood pressure within 3 minutes of propofol induction were observed.
- Aim to conduct a prospective observational study to evaluate the correlation between internal jugular vein variability during deep inhalation and the decrease in blood pressure during propofol induction.
Study design
- Observational model
- Case only
- Time perspective
- Prospective
- Target follow-up
- 1 Day
Who may qualify
- Ages
- 60 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- Patients undergoing intravenous general anesthesia surgery at Jiaxing First Hospital
Key inclusion criteria (4 listed)
- age over 60 years
- American Society of Anesthesiology (ASA) status Ⅱ-Ⅲ
- Surgery with radial artery puncture
- Propofol induction
Key exclusion criteria (11 listed)
- BMI≥30kg/m2
- People with short necks;
- Previous hypotension (systolic blood pressure <90mmHg or mean arterial pressure <65mmHg)
- Previous poorly controlled hypertension
- Cardiac insufficiency , EF value<50%
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
IJVV during deep inhalation
Time frame: 1 year
IJVV (%) = (diamax - diamin)/[(diamax + diamin)/2] × 100
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 12 Mar 2025.
- Derived from this study: PubMed 40676549Wei XL, Xi YZ, Xie L, Li ZP, Tang HL, Zhou QH. Effects of liquid resuscitation guided by internal jugular vein variability during deep inhalation on preventing propofol-induced hypotension in elderly patients. BMC Anesthesiol. 2025 Jul 17;25(1):350. doi: 10.1186/s12871-025-03227-3.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Qinghe Zhou principal investigator
Affiliated Hospital of Jiaxing University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Hemodynamic, run by Affiliated Hospital of Jiaxing University at 1 site in China.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 11 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 12 Mar 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in China. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
IJVV during deep inhalation (time frame: 1 year). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT06112769, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 12 Mar 2025.