Osteoarthritis, KneeLuRu2NCT06173193
Effects of Multicomponent Exercise on Subchondral Bone and Cartilage in Postmenopausal Women With Knee Osteoarthritis
A study testing Multicomponent exercise regimen and Standard rehabilitative management in people with Osteoarthritis, Knee, run by University of Jyvaskyla at 1 site in Finland.
Trial summary
Today, osteoarthritis (OA) is considered a whole-organ disease that is amenable to prevention and treatment in the early stages. Information on the articular cartilage and subchondral bone responses to exercise may help to develop safe and feasible exercise programs which can potentially improve cartilage and bone… Read more about this study
- Who is it for?
- Ages 55 to 75 years, women only
- Conditions the study is for
- Osteoarthritis, Knee
- What is being tested?
- Multicomponent exercise regimen and Standard rehabilitative management
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 103 participants
- Where
- 1 siteFinland
- Study dates
- 1 Jun 2023to 11 Dec 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 55 to 75 years
- Women only
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- voluntary women 55-75 years of age.
- no history of any illness for which exercise is contraindicated or that would limit participation in the exercise program.
- knee pain during the last 12 months.
- willingness and voluntarily signed informed consent to undergo testing and intervention procedures with all of its aspects.
- weight-bearing knee x-rays show radiographic Kellgren-Lawrence grade 1-2 OA in one or both tibiofemoral joints.
Who cannot join
- body-mass index over 35 kg/m2.
- knee instability or trauma that would jeopardize the training.
- inflammatory joint disease.
- intra-articular steroid injections in the preceding 12 months in the knee.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Effects of a Multicomponent Exercise Regimen on Subchondral Bone, Cartilage, and Inflammation Markers in Postmenopausal Women With Knee Osteoarthritis: A Randomized Controlled Study
Today, osteoarthritis (OA) is considered a whole-organ disease that is amenable to prevention and treatment in the early stages. Information on the articular cartilage and subchondral bone responses to exercise may help to develop safe and feasible exercise programs which can potentially improve cartilage and bone properties. Therefore, the goal of this study is to produce the knowledge needed to understand what effects multicomponent exercise regimen have on subchondral bone and articular cartilage of the knee joint in postmenopausal women with knee OA.
Participants will be randomized into either:
Read more
- Intervention group, which conducts multicomponent exercise regimen including alternating step-aerobic and resistance training.
- Reference group, which represents the standard rehabilitative management for knee OA patients with home exercises.
Researchers will compare intervention and reference groups to see if subchondral bone morphology and properties and cartilage biochemical alterations differ between the groups at the end of the 8-month intervention and 12-month follow-up period.
Read the detailed description
The study is an 8-month, randomized controlled intervention study with 12-month follow-up in volunteer postmenopausal (55-75-year-old) women with mild radiographic knee OA according to the Kellgren-Lawrence classification (grade 1-2). The participants will be randomly assigned into the subgroups. The study will be conducted in two phases.
8-month multicomponent exercise regimen will be carried out gradually and progressively three times a week by experienced and recently trained exercise instructors. The instructors will keep an attendance and an adverse event record for each of the intervention group's participants. The home exercises carried out three times a week by the reference group represent the standard rehabilitative management for knee OA patients.
In addition to the above-mentioned treatments, all participants will receive instructions to use paracetamol on an as-needed basis. Participants will be called to end-point measurements at 8 months after baseline and follow-up measurements at 20 months after baseline.
The overall goal of this study is to produce the knowledge needed to understand what effects multicomponent exercise regimen have on subchondral bone and articular cartilage of the knee joint in postmenopausal women with knee OA. In addition, the aim is to develop means to improve functional competence as well as to prevent physical disability among women suffering from knee OA. Specifically, the objectives are to investigate the effects of joint loading exercise regimen on knee joint subchondral bone morphology and properties, and cartilage biochemical alterations and their 12 month maintenance in women with knee OA. Also, training effects on molecular biomarkers related to OA and inflammation, bone traits, physical function, performance, body composition, and clinically important symptoms will be examined.
- Conditions
- Osteoarthritis, Knee
- Being tested
- Multicomponent exercise regimen, Standard rehabilitative management
- Keywords
- Exercise, Subchondral bone, Cartilage, Randomized controlled trial, Postmenopausal women, Osteoarthritis, Physiotherapy, Joint Diseases, Musculoskeletal Diseases, Physical functioning
- Medical subject headings
- Osteoarthritis, Knee, Motor Activity, Osteoarthritis, Joint Diseases, Musculoskeletal Diseases
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Multicomponent exercise regimenBehavioural
A multicomponent exercise regimen applied is comprised of the step-aerobic and resistance training programs alternating every two weeks. The trainees participate in supervised training sessions 3 times a week for 8 months. Each session will include a 10-minutes warm-up, 30-minutes of effective training part and a 10-minutes period for cooling down.
Step-aerobic: The program includes accelerating and decelerating through forwards and sideways movements with stops and turns to music. The degree of difficulty of movements and steps as well as training intensity will be gradually increased by increasing the height of the step benches.
Resistance training: The participants will undergo a progressive resistance training program. Resistance training will emphasize training of following muscle groups: Quadriceps and hamstrings, hip abductors, adductors and extensors, and calf muscles. In addition to lower limb exercises, trunk and upper body exercises will be applied at intervals.
Standard rehabilitative managementBehavioural
The treatments that will be provided to the members of a reference group represent the standard rehabilitative management for knee OA patients. The home exercises focus on functional exercises maintaining lower extremity flexibility and muscle function. The home exercises are instructed to be carried out three times a week, each work-out lasting 30 minutes.
| Study group | Role | What they receive |
|---|---|---|
| multicomponent exercise group | Experimental | 8 months of multicomponent exercise (3 sessions/week). Receives: Behavioral: Multicomponent exercise regimen |
| Reference group | Active comparator | 8 months of standard rehabilitative care based home exercises. Receives: Behavioral: Standard rehabilitative management |
What is being measured
The primary outcome is the main question the study is designed to answer.
Tibiofemoral articular cartilage's glycosaminoglycan content
Assessed by quantitative Magnetic Resonance Imaging (qMRI) techniques at 3Tesla MR-system. Rotating frame of reference contrast adiabatic T1rho (ms) will be measured.
Measured: Baseline, 8 months, 20 months
Tibiofemoral articular cartilage's collagen content and orientation
T2 maps (ms) will be assessed by qMRI techniques at 3Tesla MR-system. In addition, some clinical MRI series will be conducted.
Measured: Baseline, 8 months, 20 months
Tibiofemoral articular cartilage thickness (mm)
Assessed by 3D-texture analysis.
Measured: Baseline, 8 months, 20 months
Tibiofemoral articular cartilage volume (mm^3)
Assessed by 3D-texture analysis.
Measured: Baseline, 8 months, 20 months
Tibiofemoral subchondral bone mineral density (g/cm^3)
Assessed by high-resolution cone beam computed tomography (CBCT).
Measured: Baseline, 8 months, 20 months
Tibiofemoral subchondral bone mineral content (g)
Assessed by high-resolution CBCT.
Measured: Baseline, 8 months, 20 months
Tibiofemoral joint space narrowing (mm)
Assessed by high-resolution CBCT.
Measured: Baseline, 8 months, 20 months
Secondary outcomes (25)
Bone mineral content (BMC, g) of the femoral neck
Assessed by Dual-energy X-ray absorptiometry (DXA).
Measured: Baseline, 8 months, 20 months
Areal bone mineral density (aBMD, g/cm^2) of the femoral neck
Assessed by DXA.
Measured: Baseline, 8 months, 20 months
Cortical thickness (mm) of the femoral neck
Assessed by Advanced Hip Analysis software.
Measured: Baseline, 8 months, 20 months
Femoral neck width (mm)
Assessed by Advanced Hip Analysis software.
Measured: Baseline, 8 months, 20 months
Cross-sectional area (cm^2) of the femoral neck
Assessed by Advanced Hip Analysis software.
Measured: Baseline, 8 months, 20 months
Cross-sectional moment of inertia (cm^4) of the femoral neck
Assessed by Advanced Hip Analysis software.
Measured: Baseline, 8 months, 20 months
Section modulus (cm^3) of the femoral neck
Assessed by Advanced Hip Analysis software.
Measured: Baseline, 8 months, 20 months
Total body fat percentage (%)
Assessed by DXA.
Measured: Baseline, 8 months, 20 months
Fat Free Mass Index (FFMI, kg/m^2)
Assessed by DXA.
Measured: Baseline, 8 months, 20 months
Clinically important OA-symptoms and physical function
Assessed by Knee Injury and Osteoarthritis Outcome Score (KOOS) questionnaire (Score 0-100). Higher scores represent better outcomes.
Measured: Baseline, 8 months, 20 months
Health-related quality of life
Assessed by RAND 36-Item Health Survey questionnaire (Scores 0-100 on different domains). Higher scores represent a more favorable health state.
Measured: Baseline, 8 months, 20 months
Work disablement
Assessed by short form of Örebro musculoskeletal pain screening questionnaire (Score 1-100). Higher scores estimate increased risk for future work disability.
Measured: Baseline, 8 months, 20 months
Self-rated physical activity
Assessed by International Physical Activity Questionnaire (IPAQ, Metabolic equivalent task (MET) -minutes). Also, physical activity diary (MET-minutes) will be filled by the control group through the 8-month study intervention.
Measured: IPAQ: Baseline, 8 months, 20 months. Physical activity diary: through the 8-month study intervention in the control group
Objective daily physical activity
Assessed by a tri-axial accelerometer (minutes \& MET-hours), worn 24 hours a day. A tri-axial accelerometer will be used through the 8-month study intervention in the intervention group and periods of 7 consecutive days every two months during the 8-month study intervention in the control group. During the 12-month follow-up, all the participants will be measured every four months for seven consecutive days.
Measured: See above
Quantity of painkillers consumed
Assessed by diary.
Measured: Through the 8-month study intervention
Systemic inflammation markers
High sensitivity C-reactive protein and serum cytokines including interleukin-6 and tumor-necrosis factor alpha will be assessed from blood.
Measured: Baseline, 8 months, 20 months
Metabolic profile
Circulating metabolomes including resistin, leptin, adiponectin, lipids, lipoproteins, and metabolites will be assessed from blood.
Measured: Baseline, 8 months, 20 months
Cardiorespiratory fitness
Assessed by UKK 2km walk test (minutes and seconds).
Measured: Baseline, 8 months, 20 months
Knee extension and flexion maximal isometric muscle strength
Assessed by an adjustable dynamometer chair (Newtons).
Measured: Baseline, 8 months, 20 months
Static balance
Assessed by a single leg stance test (seconds).
Measured: Baseline, 8 months, 20 months
30 second chair-stand test (seconds)
Measured: Baseline, 8 months, 20 months
Timed up and go (TUG) (seconds)
Measured: Baseline, 8 months, 20 months
40m Fast-paced walk test (seconds)
Measured: Baseline, 8 months, 20 months
Stair climb test (seconds)
Measured: Baseline, 8 months, 20 months
Walking biomechanics
Lower body's segmental acceleration (m/s^2) in 40m Fast-paced walk test, Stair climb test, and 2-minute walk at the subject's preferred pace will be assessed by Inertial Measurement Unit (IMU).
Measured: Baseline, 8 months, 20 months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted15 Dec 2023
- Study start1 Jun 2023
- Primary completion10 Dec 2025
- Study completion11 Dec 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (2)Papers the sponsor has linked to this study.
- Other trials for Osteoarthritis, KneeStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 103 participants (actual)
Sponsor and investigators
- Lead sponsor
- University of Jyvaskyla
- Sponsor type
- University, hospital or other
- Collaborators
- University of Oulu, Wellbeing Services County of Central Finland, UKK Institute, Research Council of Finland
- Responsible party
- Sponsor
- Investigators
- Ari Heinonen, Prof., emeritus, Principal investigator, University of Jyvaskyla
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06173193
- Sponsor's protocol ID
- 21000057531
- Other IDs
- 351483
- Acronym
- LuRu2
- Status last verified
- Apr 2026
- First submitted
- 31 Oct 2023
- Last updated
- 11 May 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: IPD cannot be anonymized and will thus remain restricted due to personal data protection. The basic project-level discovery metadata of the dataset(s) will be made openly available in the University's repository with a DOI for permanent findability and accessibility whenever the metadata are sufficiently complete to be published.
Publications
Dobson F, Hinman RS, Roos EM, Abbott JH, Stratford P, Davis AM, Buchbinder R, Snyder-Mackler L, Henrotin Y, Thumboo J, Hansen P, Bennell KL. OARSI recommended performance-based tests to assess physical function in people diagnosed with hip or knee osteoarthritis. Osteoarthritis Cartilage. 2013 Aug;21(8):1042-52. doi: 10.1016/j.joca.2013.05.002. Epub 2013 May 13.
PubMed 23680877Konola VM, Parkkari J, Multanen J, Nikander R, Rantalainen T, Vesanto J, Pekkala S, Kalaja M, Ihalainen JK, Waller B, Munukka M, Sievanen H, Nevalainen M, Kautiainen H, Casula V, Paloneva J, Vasankari T, Peuna A, Saarakkala S, Nieminen MT, Heinonen A. Effects of a multicomponent exercise regimen on subchondral bone and cartilage in postmenopausal women with knee osteoarthritis: protocol for a randomized controlled trial. Trials. 2025 Jun 23;26(1):222. doi: 10.1186/s13063-025-08928-1.
PubMed 40551179
Study at a glance
From the registry record, last updated by the sponsor on 11 May 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effects of a Multicomponent Exercise Regimen on Subchondral Bone, Cartilage, and Inflammation Markers in Postmenopausal Women With Knee Osteoarthritis: A Randomized Controlled Study
- ClinicalTrials.gov ID
- NCT06173193
- Acronym / sponsor ID
- LuRu2 / 21000057531
- Conditions
- Osteoarthritis, Knee
- Keywords
- Exercise, Subchondral bone, Cartilage, Randomized controlled trial, Postmenopausal women, Osteoarthritis, Physiotherapy, Joint Diseases
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 103 participants (actual)
- Lead sponsor
- University of JyvaskylaUniversity, hospital or other
- Collaborators
- University of Oulu, Wellbeing Services County of Central Finland, UKK Institute, Research Council of Finland
- Study start
- 1 Jun 2023 (actual)
- Primary completion
- 10 Dec 2025 (actual)
- Study completion
- 11 Dec 2025 (actual)
- First posted
- 15 Dec 2023 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Today, osteoarthritis (OA) is considered a whole-organ disease that is amenable to prevention and treatment in the early stages. Information on the articular cartilage and subchondral bone responses to exercise may help to develop safe and feasible exercise programs which can potentially improve cartilage and bone properties. Therefore, the goal of this study is to produce the knowledge needed to understand what effects multicomponent exercise regimen have on subchondral bone and articular cartilage of the knee joint in postmenopausal women with knee OA.
Participants will be randomized into either:
- Intervention group, which conducts multicomponent exercise regimen including alternating step-aerobic and resistance training.
- Reference group, which represents the standard rehabilitative management for knee OA patients with home exercises.
Researchers will compare intervention and reference groups to see if subchondral bone morphology and properties and cartilage biochemical alterations differ between the groups at the end of the 8-month intervention and 12-month follow-up period.
Detailed description
The study is an 8-month, randomized controlled intervention study with 12-month follow-up in volunteer postmenopausal (55-75-year-old) women with mild radiographic knee OA according to the Kellgren-Lawrence classification (grade 1-2). The participants will be randomly assigned into the subgroups. The study will be conducted in two phases.
8-month multicomponent exercise regimen will be carried out gradually and progressively three times a week by experienced and recently trained exercise instructors. The instructors will keep an attendance and an adverse event record for each of the intervention group's participants. The home exercises carried out three times a week by the reference group represent the standard rehabilitative management for knee OA patients.
In addition to the above-mentioned treatments, all participants will receive instructions to use paracetamol on an as-needed basis. Participants will be called to end-point measurements at 8 months after baseline and follow-up measurements at 20 months after baseline.
The overall goal of this study is to produce the knowledge needed to understand what effects multicomponent exercise regimen have on subchondral bone and articular cartilage of the knee joint in postmenopausal women with knee OA. In addition, the aim is to develop means to improve functional competence as well as to prevent physical disability among women suffering from knee OA. Specifically, the objectives are to investigate the effects of joint loading exercise regimen on knee joint subchondral bone morphology and properties, and cartilage biochemical alterations and their 12 month maintenance in women with knee OA. Also, training effects on molecular biomarkers related to OA and inflammation, bone traits, physical function, performance, body composition, and clinically important symptoms will be examined.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| multicomponent exercise group | Experimental | Behavioral: Multicomponent exercise regimen8 months of multicomponent exercise (3 sessions/week). |
| Reference group | Active comparator | Behavioral: Standard rehabilitative management8 months of standard rehabilitative care based home exercises. |
Who may qualify
- Ages
- 55 to 75 years
- Sex
- Female only
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (5 listed)
- voluntary women 55-75 years of age.
- no history of any illness for which exercise is contraindicated or that would limit participation in the exercise program.
- knee pain during the last 12 months.
- willingness and voluntarily signed informed consent to undergo testing and intervention procedures with all of its aspects.
- weight-bearing knee x-rays show radiographic Kellgren-Lawrence grade 1-2 OA in one or both tibiofemoral joints.
Key exclusion criteria (4 listed)
- body-mass index over 35 kg/m2.
- knee instability or trauma that would jeopardize the training.
- inflammatory joint disease.
- intra-articular steroid injections in the preceding 12 months in the knee.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Multicomponent exercise regimenA multicomponent exercise regimen applied is comprised of the step-aerobic and resistance training programs alternating every two weeks. The trainees participate in supervised training sessions 3 times a week for 8 months. Each session will include a 10-minutes warm-up, 30-minutes of effective training part and a 10-minutes period for cooling down. Step-aerobic: The program includes accelerating and decelerating through forwards and sideways movements with stops and turns to music. The degree of difficulty of movements and steps as well as training intensity will be gradually increased by increasing the height of the step benches. Resistance training: The participants will undergo a progressive resistance training program. Resistance training will emphasize training of following muscle groups: Quadriceps and hamstrings, hip abductors, adductors and extensors, and calf muscles. In addition to lower limb exercises, trunk and upper body exercises will be applied at intervals. | Behavioural | multicomponent exercise group |
| Standard rehabilitative managementThe treatments that will be provided to the members of a reference group represent the standard rehabilitative management for knee OA patients. The home exercises focus on functional exercises maintaining lower extremity flexibility and muscle function. The home exercises are instructed to be carried out three times a week, each work-out lasting 30 minutes. | Behavioural | Reference group |
Primary outcome
Tibiofemoral articular cartilage's glycosaminoglycan content
Time frame: Baseline, 8 months, 20 months
Assessed by quantitative Magnetic Resonance Imaging (qMRI) techniques at 3Tesla MR-system. Rotating frame of reference contrast adiabatic T1rho (ms) will be measured.
Tibiofemoral articular cartilage's collagen content and orientation
Time frame: Baseline, 8 months, 20 months
T2 maps (ms) will be assessed by qMRI techniques at 3Tesla MR-system. In addition, some clinical MRI series will be conducted.
Tibiofemoral articular cartilage thickness (mm)
Time frame: Baseline, 8 months, 20 months
Assessed by 3D-texture analysis.
Tibiofemoral articular cartilage volume (mm^3)
Time frame: Baseline, 8 months, 20 months
Assessed by 3D-texture analysis.
Tibiofemoral subchondral bone mineral density (g/cm^3)
Time frame: Baseline, 8 months, 20 months
Assessed by high-resolution cone beam computed tomography (CBCT).
Tibiofemoral subchondral bone mineral content (g)
Time frame: Baseline, 8 months, 20 months
Assessed by high-resolution CBCT.
Tibiofemoral joint space narrowing (mm)
Time frame: Baseline, 8 months, 20 months
Assessed by high-resolution CBCT.
25 secondary outcomes
Bone mineral content (BMC, g) of the femoral neck
Time frame: Baseline, 8 months, 20 months
Areal bone mineral density (aBMD, g/cm^2) of the femoral neck
Time frame: Baseline, 8 months, 20 months
Cortical thickness (mm) of the femoral neck
Time frame: Baseline, 8 months, 20 months
Femoral neck width (mm)
Time frame: Baseline, 8 months, 20 months
Cross-sectional area (cm^2) of the femoral neck
Time frame: Baseline, 8 months, 20 months
Cross-sectional moment of inertia (cm^4) of the femoral neck
Time frame: Baseline, 8 months, 20 months
Section modulus (cm^3) of the femoral neck
Time frame: Baseline, 8 months, 20 months
Total body fat percentage (%)
Time frame: Baseline, 8 months, 20 months
Fat Free Mass Index (FFMI, kg/m^2)
Time frame: Baseline, 8 months, 20 months
Clinically important OA-symptoms and physical function
Time frame: Baseline, 8 months, 20 months
Health-related quality of life
Time frame: Baseline, 8 months, 20 months
Work disablement
Time frame: Baseline, 8 months, 20 months
Self-rated physical activity
Time frame: IPAQ: Baseline, 8 months, 20 months. Physical activity diary: through the 8-month study intervention in the control group
Objective daily physical activity
Time frame: See above
Quantity of painkillers consumed
Time frame: Through the 8-month study intervention
Systemic inflammation markers
Time frame: Baseline, 8 months, 20 months
Metabolic profile
Time frame: Baseline, 8 months, 20 months
Cardiorespiratory fitness
Time frame: Baseline, 8 months, 20 months
Knee extension and flexion maximal isometric muscle strength
Time frame: Baseline, 8 months, 20 months
Static balance
Time frame: Baseline, 8 months, 20 months
30 second chair-stand test (seconds)
Time frame: Baseline, 8 months, 20 months
Timed up and go (TUG) (seconds)
Time frame: Baseline, 8 months, 20 months
40m Fast-paced walk test (seconds)
Time frame: Baseline, 8 months, 20 months
Stair climb test (seconds)
Time frame: Baseline, 8 months, 20 months
Walking biomechanics
Time frame: Baseline, 8 months, 20 months
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 11 May 2026.
- Background: PubMed 23680877Dobson F, Hinman RS, Roos EM, Abbott JH, Stratford P, Davis AM, Buchbinder R, Snyder-Mackler L, Henrotin Y, Thumboo J, Hansen P, Bennell KL. OARSI recommended performance-based tests to assess physical function in people diagnosed with hip or knee osteoarthritis. Osteoarthritis Cartilage. 2013 Aug;21(8):1042-52. doi: 10.1016/j.joca.2013.05.002. Epub 2013 May 13.
- Derived from this study: PubMed 40551179Konola VM, Parkkari J, Multanen J, Nikander R, Rantalainen T, Vesanto J, Pekkala S, Kalaja M, Ihalainen JK, Waller B, Munukka M, Sievanen H, Nevalainen M, Kautiainen H, Casula V, Paloneva J, Vasankari T, Peuna A, Saarakkala S, Nieminen MT, Heinonen A. Effects of a multicomponent exercise regimen on subchondral bone and cartilage in postmenopausal women with knee osteoarthritis: protocol for a randomized controlled trial. Trials. 2025 Jun 23;26(1):222. doi: 10.1186/s13063-025-08928-1.
- Individual participant dataSharing planned: No. IPD cannot be anonymized and will thus remain restricted due to personal data protection. The basic project-level discovery metadata of the dataset(s) will be made openly available in the University's repository with a DOI for permanent findability and accessibility whenever the metadata are sufficiently complete to be published.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Ari Heinonen, Prof., emeritus principal investigator
University of Jyvaskyla
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Multicomponent exercise regimen and Standard rehabilitative management in people with Osteoarthritis, Knee, run by University of Jyvaskyla at 1 site in Finland.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 11 May 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Finland. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Tibiofemoral articular cartilage's glycosaminoglycan content (time frame: Baseline, 8 months, 20 months). The study lists 7 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT06173193, which also lists 2 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 11 May 2026.