Abdominal SurgeryNCT06228729
Association Between EEG Changes and Hormonal Response to Tracheal Intubation and Surgical Stimulation
An observational study of Abdominal Surgery and Endotracheal Intubation, run by Seoul National University Hospital at 1 site in South Korea.
Trial summary
This study aims to prospectively evaluate the relationship between changes in EEG and hormonal responses induced by endotracheal intubation and surgical incision following general anesthesia. Read more about this study
- Who is it for?
- Ages 20 to 80 years
- Conditions the study is for
- Abdominal Surgery, Endotracheal Intubation, Surgical Incision
- What is being tested?
- Endotracheal intubation
- Type of treatment
- Surgery or procedure
- How many people
- 52 participants
- Where
- 1 siteSouth Korea
- Study dates
- 1 Apr 2025to 21 Nov 2025
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 20 to 80 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: Adult patients undergoing open abdominal surgery and endotracheal intubation under general anesthesia
Who may be able to join
- 1) Patients scheduled to undergo open abdominal surgery under general anesthesia with endotracheal intubation.
- 2) Patients requiring invasive blood pressure monitoring during surgery
Who cannot join
- 1) Patients transferred to the intensive care unit after surgery
- 2) Surgery duration of less than one hour
- 3) Patients with neurological underlying conditions
- 4) Patients on chronic use of psychotropic medications and opioid drugs
- 5) Emergency surgery
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Evaluation of the Association Between Electroencephalographic Changes and Hormonal Response to Tracheal Intubation and Surgical Stimulation in Abdominal Surgery: a Prospective Observational Study
This study aims to prospectively evaluate the relationship between changes in EEG and hormonal responses induced by endotracheal intubation and surgical incision following general anesthesia.
Read the detailed description
This study aims to investigate the relationship between changes in EEG patterns and stress hormone levels in patients undergoing open abdominal surgery under general anesthesia when subjected to endotracheal intubation and surgical incision stimuli.
Hormone measurements (cortisol, ACTH) are taken at four time points: before endotracheal intubation (T1), one minute after intubation (T2), and one minute after surgical incision (T3). The investigators evaluate the correlation between hormone levels (cortisol, ACTH) and EEG band power changes (alpha, beta, delta) before and after endotracheal intubation and surgical incision.
- Being tested
- Endotracheal intubation
- Medical subject headings
- Surgical Wound
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Endotracheal intubationProcedure or surgery
Inserting endotracheal tube into the trachea
What is being measured
The primary outcome is the main question the study is designed to answer.
Association between band power changes in EEG and hormone respones caused by endotracheal intubation
Measured: from the start of anesthesia induction to one minute after endotracheal intubation
Secondary outcomes (1)
Association between band power changes in EEG and hormone respones caused by surgical incision
Measured: from the start of anesthesia induction to one minute after surgical incision
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted29 Jan 2024
- Study start1 Apr 2025
- Primary completion28 Oct 2025
- Study completion21 Nov 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Abdominal SurgeryStudies of the same condition, open and under way.
- More trials run by Seoul National University HospitalThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 52 participants (actual)
Sponsor and investigators
- Lead sponsor
- Seoul National University Hospital
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Hyun-Kyu Yoon, Seoul National University Hospital
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06228729
- Sponsor's protocol ID
- 2311-093-1484
- Status last verified
- Dec 2025
- First submitted
- 18 Jan 2024
- Last updated
- 6 Jan 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 6 Jan 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Evaluation of the Association Between Electroencephalographic Changes and Hormonal Response to Tracheal Intubation and Surgical Stimulation in Abdominal Surgery: a Prospective Observational Study
- ClinicalTrials.gov ID
- NCT06228729
- Acronym / sponsor ID
- 2311-093-1484
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 52 participants (actual)
- Lead sponsor
- Seoul National University HospitalUniversity, hospital or other
- Study start
- 1 Apr 2025 (actual)
- Primary completion
- 28 Oct 2025 (actual)
- Study completion
- 21 Nov 2025 (actual)
- First posted
- 29 Jan 2024 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study aims to prospectively evaluate the relationship between changes in EEG and hormonal responses induced by endotracheal intubation and surgical incision following general anesthesia.
Detailed description
This study aims to investigate the relationship between changes in EEG patterns and stress hormone levels in patients undergoing open abdominal surgery under general anesthesia when subjected to endotracheal intubation and surgical incision stimuli.
Hormone measurements (cortisol, ACTH) are taken at four time points: before endotracheal intubation (T1), one minute after intubation (T2), and one minute after surgical incision (T3). The investigators evaluate the correlation between hormone levels (cortisol, ACTH) and EEG band power changes (alpha, beta, delta) before and after endotracheal intubation and surgical incision.
Study design
- Observational model
- Cohort
- Time perspective
- Prospective
Who may qualify
- Ages
- 20 to 80 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- Adult patients undergoing open abdominal surgery and endotracheal intubation under general anesthesia
Key inclusion criteria (2 listed)
- 1) Patients scheduled to undergo open abdominal surgery under general anesthesia with endotracheal intubation.
- 2) Patients requiring invasive blood pressure monitoring during surgery
Key exclusion criteria (5 listed)
- 1) Patients transferred to the intensive care unit after surgery
- 2) Surgery duration of less than one hour
- 3) Patients with neurological underlying conditions
- 4) Patients on chronic use of psychotropic medications and opioid drugs
- 5) Emergency surgery
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Endotracheal intubationInserting endotracheal tube into the trachea | Procedure or surgery | – |
Primary outcome
Association between band power changes in EEG and hormone respones caused by endotracheal intubation
Time frame: from the start of anesthesia induction to one minute after endotracheal intubation
1 secondary outcome
Association between band power changes in EEG and hormone respones caused by surgical incision
Time frame: from the start of anesthesia induction to one minute after surgical incision
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 6 Jan 2026.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Abdominal Surgery and Endotracheal Intubation, run by Seoul National University Hospital at 1 site in South Korea.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 6 Jan 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in South Korea. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Association between band power changes in EEG and hormone respones caused by endotracheal intubation (time frame: from the start of anesthesia induction to one minute after endotracheal intubation). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 6 Jan 2026.