Critical CareNCT06234709
Long-term Mortality After Intensive Care Considering Comorbidity and Admission Diagnoses
An observational study of Critical Care, run by Anna Aronsson at 1 site in Sweden.
Trial summary
This is a register-based study The aim of this study is to investigate how common comorbidity is in different age groups and which comorbidity that has the greatest impact on mortality considering different admission diagnosis and after the acute phase compared to the general population. Read more about this study
- Who is it for?
- Ages 16 years and older
- Conditions the study is for
- Critical Care
- How many people
- 200,000 participants
- Where
- 1 siteSweden
- Study dates
- 1 Jan 2005to 31 Dec 2016
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 16 years and older
- All sexes
- No healthy volunteers
- Child, Adult, Older adult
Study population: The study population included all patients > 16 years old admitted to an ICU during the years 2006 to 2012 and registered in the Swedish Intensive Care Registry (SIR)
Who may be able to join
- The study population included all patients > 16 years old admitted to an ICU during the years 2006 to 2012 and registered in the Swedish Intensive Care Registry (SIR)
Who cannot join
- -
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Comorbidity With Greatest Impact on Mortality Considering Different Admission Diagnosis and After Landmark Time in an Intensive Care Population Compared to the General Population
This is a register-based study
The aim of this study is to investigate how common comorbidity is in different age groups and which comorbidity that has the greatest impact on mortality considering different admission diagnosis and after the acute phase compared to the general population. Also, how different degrees of comorbidity affect mortality, adjusted for other comorbidities and SAPS 3?
Read the detailed description
The study population included all patients > 16 years old admitted to an ICU during the years 2006 to 2012 and registered in the Swedish Intensive Care Registry (SIR).
Hospital discharge diagnoses from in-patient care five years preceding the index time for the ICU admission were extracted from the National Patient Register (NPR) and linked to ICU admissions using unique person identity numbers. Follow-up for all-cause mortality were extracted from the cause of death register at NPR.
- Conditions
- Critical Care
- Keywords
- Comorbidity, Intensive care, SAPS3
What is being measured
The primary outcome is the main question the study is designed to answer.
All-cause mortality
Extracted from the cause of death register at National Patient Registry in Sweden.
Measured: january 1, 2005 til december 31, 2016
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted31 Jan 2024
- Study start1 Jan 2005
- Primary completion31 Dec 2016
- Study completion31 Dec 2016
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Critical CareStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Retrospective
- Enrolment
- 200,000 participants (actual)
Sponsor and investigators
- Lead sponsor
- Anna Aronsson
- Sponsor type
- University, hospital or other
- Collaborators
- Uppsala University
- Responsible party
- Sponsor-investigator, Anna Aronsson, Uppsala University
- Investigators
- Anna Aronsson Dannewitz, med mag, Principal investigator, Uppsala university department of surgical sciense
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06234709
- Sponsor's protocol ID
- Anna Aronsson Dannewitz
- Status last verified
- Feb 2024
- First submitted
- 22 Jan 2024
- Last updated
- 2 Feb 2024
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Publications
Aronsson Dannewitz A, Svennblad B, Michaelsson K, Lipcsey M, Gedeborg R. The long-term conditional mortality rate in older ICU patients compared to the general population. Crit Care. 2024 Nov 14;28(1):368. doi: 10.1186/s13054-024-05147-z.
PubMed 39543756
Study at a glance
From the registry record, last updated by the sponsor on 2 Feb 2024. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Comorbidity With Greatest Impact on Mortality Considering Different Admission Diagnosis and After Landmark Time in an Intensive Care Population Compared to the General Population
- ClinicalTrials.gov ID
- NCT06234709
- Acronym / sponsor ID
- Anna Aronsson Dannewitz
- Conditions
- Critical Care
- Keywords
- Comorbidity, Intensive care, SAPS3
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 200,000 participants (actual)
- Lead sponsor
- Anna AronssonUniversity, hospital or other
- Collaborators
- Uppsala University
- Study start
- 1 Jan 2005 (actual)
- Primary completion
- 31 Dec 2016 (actual)
- Study completion
- 31 Dec 2016 (actual)
- First posted
- 31 Jan 2024 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This is a register-based study
The aim of this study is to investigate how common comorbidity is in different age groups and which comorbidity that has the greatest impact on mortality considering different admission diagnosis and after the acute phase compared to the general population. Also, how different degrees of comorbidity affect mortality, adjusted for other comorbidities and SAPS 3?
Detailed description
The study population included all patients > 16 years old admitted to an ICU during the years 2006 to 2012 and registered in the Swedish Intensive Care Registry (SIR).
Hospital discharge diagnoses from in-patient care five years preceding the index time for the ICU admission were extracted from the National Patient Register (NPR) and linked to ICU admissions using unique person identity numbers. Follow-up for all-cause mortality were extracted from the cause of death register at NPR.
Study design
- Observational model
- Cohort
- Time perspective
- Retrospective
Who may qualify
- Ages
- 16 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Child, Adult, Older adult
- Study population
- The study population included all patients > 16 years old admitted to an ICU during the years 2006 to 2012 and registered in the Swedish Intensive Care Registry (SIR)
Key inclusion criteria (1 listed)
- The study population included all patients > 16 years old admitted to an ICU during the years 2006 to 2012 and registered in the Swedish Intensive Care Registry (SIR)
Key exclusion criteria (1 listed)
- -
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
All-cause mortality
Time frame: january 1, 2005 til december 31, 2016
Extracted from the cause of death register at National Patient Registry in Sweden.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 2 Feb 2024.
- Derived from this study: PubMed 39543756Aronsson Dannewitz A, Svennblad B, Michaelsson K, Lipcsey M, Gedeborg R. The long-term conditional mortality rate in older ICU patients compared to the general population. Crit Care. 2024 Nov 14;28(1):368. doi: 10.1186/s13054-024-05147-z.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Anna Aronsson Dannewitz, med mag principal investigator
Uppsala university department of surgical sciense
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Critical Care, run by Anna Aronsson at 1 site in Sweden.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 2 Feb 2024. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Sweden. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
All-cause mortality (time frame: january 1, 2005 til december 31, 2016). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT06234709, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 2 Feb 2024.