Clinical trials: Critical Care
Critical Illness
Alternative Substrates in the Critically Ill Subject
The over-arching aim of this study is to investigate the feasibility of administrating alternative substrates to intensive care unit (ICU) patients.
- Trial name
- ASICS (NCT04101071)
- Testing
- Modular ketogenic feed, Standard feed
- Where
- 2 sites in United Kingdom
- Volunteers
- 29 people
- Sponsor
- Barts & The London NHS Trust
Muscle Weakness, Critical Illness
Systematic Team Approach to Guide Early Mobilization in Surgical Intensive Care Unit Patients
The investigators hypothesize that by applying a validated algorithm to accomplish early mobilization in surgical intensive care unit (ICU) patients, these patients will achieve a higher level of mobility which translates to…
- Conditions
- Muscle Weakness, Critical Illness, Respiratory Insufficiency
- Trial name
- mSOMS (NCT01363102)
- Testing
- SOMS
- Where
- 5 sites in United States, Austria and 1 more
- Volunteers
- 200 people
- Sponsor
- Massachusetts General Hospital
Circulatory Shock, Hemodynamic Instability
Peripheral pULSe Assessment and Arterial pRessure (PULSAR)
This prospective multicenter observational study aims to investigate the relationship between palpable peripheral pulses and simultaneously measured arterial blood pressure in adult patients with circulatory shock or impending…
- Conditions
- Circulatory Shock, Hemodynamic Instability, Hypotension, Shock
- Trial name
- PULSAR (NCT07609095)
- Testing
- Peripheral Pulse Palpation
- Where
- Sweden
- Volunteers
- 5,000 people
- Sponsor
- Region Stockholm
Critically Ill, Mechanically Ventilated
Treatment of Invasively Ventilated Adults With Early Activity and Mobilisation
The aim of this study is to evaluate the effect of early activity and mobilisation during prolonged IMV on the composite outcome "days alive and out of hospital to day 180".
- Trial name
- TEAM(III) (NCT03133377)
- Testing
- Early activity and mobilisation
- Where
- 49 sites in Australia, Germany and 3 more
- Volunteers
- 750 people
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Respiratory Insufficiency
VivaSight-SL™ Versus Bronchoscopy for Percutaneous Tracheotomy
Optical guidance for percutaneous tracheotomy in intensive care is usually performed by bronchoscopy. Recently, an endotracheal tube with a camera mounted at its tip (VivaSight-SL) has been introduced that allows for endotracheal…
- Trial name
- VivaPDT (NCT02861001)
- Testing
- conventional bronchoscopy, VivaSight-SL tube
- Where
- Germany
- Volunteers
- 56 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
New Onset Atrial Fibrillation, Sepsis
Rapid Atrial Fibrillation Treatment Strategy
Prospective, randomized, open-label clinical trial studying the treatment of new onset atrial fibrillation in critically ill patients with septic shock.
- Conditions
- New Onset Atrial Fibrillation, Sepsis, Respiratory Failure
- Trial name
- RAFTS (NCT04092621)
- Testing
- Amiodarone in Parenteral Dosage Form, Amiodarone Pill, Direct Current Cardioversion (DCC)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Our Lady of the Lake Hospital
Gastric Residual Volume, Abdominal Distension
Abdominal Massage for Gastric Residual Volume in Surgical Patients
This randomized controlled trial aimed to evaluate the effect of abdominal massage on gastric residual volume (GRV) and abdominal distension in surgical intensive care patients receiving enteral nutrition.
- Conditions
- Gastric Residual Volume, Abdominal Distension, Enteral Nutrition, Massage Therapy
- Trial name
- NCT07018414
- Testing
- Abdominal Massage
- Where
- Turkey (Türkiye)
- Volunteers
- 84 people
- Sponsor
- Marmara University
Critical Care
Validation of the Korean Confusion Assessment Method for the Intensive Care Unit (CAM-ICU)
The purpose of this study is to translate and validate the CAM-ICU for use in the Korean ICU setting.
- Trial name
- NCT00998387
- Where
- South Korea
- Volunteers
- 63 people
- Sponsor
- Seoul National University Hospital
Any Disease Causing Death in the ICU or Within 24 Hours of Discharge From the ICU
Integrating Palliative and Critical Care (IPACC) Study
The purpose of this research study is to evaluate an intervention to improve the care given to patients who are dying in the intensive care unit (ICU) and their families.
- Trial name
- IPACC (NCT00685893)
- Testing
- Education, Local Champions, Institution Feedback
- Where
- 15 sites in United States
- Volunteers
- 3,498 people
- Sponsor
- University of Washington
Cardiopulmonary Arrest, Nurse's Role
Mobile Micro-learning on Nurses' Self-confidence, Motivation, and Stress
Before and after effect of using mobile micro-learning on their self-confidence, motivation, and stress toward cardiopulmonary resuscitation.
- Trial name
- NCT06693232
- Testing
- Mobile micro-learning
- Where
- 2 sites in Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Damanhour University
Malnutrition, Critical Illness
Anabolic Steroids for Nutritional Rehabilitation of Critically Ill Patients
This prospective, double-blinded study will determine the feasibility of determining the efficacy of a weekly intramuscular injection of nandrolone (an anabolic steroid) in malnourished ICU patients.The data from this study will…
- Trial name
- NCT00242463
- Testing
- Nandrolone (anabolic steroid)
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Nutritional Support, Intensive Care Unit
Evaluation of Nutritional Practices in the Critical Care
Background: The adequacy of the artificial Nutritional Support (NS) in the critical care patient has implications in morbidity and prognosis.
- Conditions
- Nutritional Support, Intensive Care Unit, Critical Illness
- Trial name
- ENPIC (NCT03634943)
- Testing
- Patients with Nutritional Support
- Where
- 43 sites in Spain
- Volunteers
- 642 people
- Sponsor
- Hospital Universitari de Bellvitge
Central Venous Catheter Thrombosis, Critical Illness
Daily Ultrasound-screening for CVC-related Thrombosis
The central venous catheters (CVC) related thrombosis is an issue of importance to ICU clinicians.This study conducts the daily ultrasound-screening for CVC-related thrombosis (DUCT).Its aim is to evaluate the characteristic and…
- Conditions
- Central Venous Catheter Thrombosis, Critical Illness, Ultrasonography
- Trial name
- DUCT (NCT03327376)
- Testing
- ultrasound-screening
- Where
- China
- Volunteers
- 1,262 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Diabetes Mellitus, Glycemic Control for Diabetes Mellitus
Intermittent vs Continuous Enteral Nutrition in Glycaemic Control of Diabetic ICU Patients
The goal of this clinical trial is to learn if intermittent or continuous enteral nutrition applications can improve glycemic control and affect certain metabolic parameters in adult critically ill patients with diabetes…
- Conditions
- Diabetes Mellitus, Glycemic Control for Diabetes Mellitus, Glycaemia
- Trial name
- NCT07054476
- Testing
- Intermittent Enteral Nutrition, Continuous Enteral Nutrition (CE)
- Where
- Turkey (Türkiye)
- Volunteers
- 25 people
- Sponsor
- Hacettepe University
Critical Care, Intensive Care, Critical Illness
Validation of the Turkish RDOS Using End-Tidal Carbon Dioxide
Dyspnea is a complex and distressing symptom frequently observed in critically ill patients and is associated with increased morbidity, mortality, and prolonged intensive care unit (ICU) stay.
- Trial name
- NCT07383389
- Volunteers
- 64 people
- Sponsor
- Istinye University
Delirium in the Intensive Care Unit
Nurse-Led Implementation of the ABCDEF Bundle
This study evaluated the effectiveness of a nurse-led implementation of the ABCDEF bundle, an evidence-based, interprofessional care framework, in the prevention and management of delirium among Intensive Care Unit (ICU)…
- Trial name
- NCT07054268
- Testing
- Nurse-Led ABCDEF Bundle Implementation
- Where
- Egypt
- Volunteers
- 140 people
- Sponsor
- Helwan University
Acute Respiratory Distress Syndrome Related to SARS-CoV-2
COronaVirus Induced Acute Respiratory Disease Syndrome During PREGnancy
Few data are available on the management of critically ill pregnant women with pneumonia related to SARS-CoV-2. In the absence of clear recommendations for the management of delivery, clinicians are faced with the risk of…
- Trial name
- COVADIS-PREG (NCT05193526)
- Testing
- No intervention
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Intercommunal Creteil
ARDS, ARDS, Human
Efficacy and Safety Evaluation of BZ371B in ARDS Patients
The purpose of this study is to evaluate safety, tolerability and efficacy of BZ371B in intubated patients with severe Acute Respiratory Distress Syndrome.
- Conditions
- ARDS, ARDS, Human, Pulmonary Disease
- Trial name
- NCT05384379
- Testing
- Inhaled BZ371B
- Where
- Brazil
- Volunteers
- 1 people
- Sponsor
- Biozeus Biopharmaceutical S.A.
Sepsis, Sepsis and Septic Shock
Role of Transposable Elements in Septic Immune Aging
The goal of this observational study is to learn about how transposable element levels affect the patient outcomes in sepsis. The main questions it aims to answer is: 1.
- Conditions
- Sepsis, Sepsis and Septic Shock, Sepsis With Multiple Organ Dysfunction (MOD), Sepsis With Acute Organ Dysfunction
- Trial name
- SITE (NCT06809868)
- Testing
- RNA and DNA Sequencing
- Where
- United States
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Ultrasound, Neurosonology
Survey About Practice of Neurosonology in Belgium
Ultrasounds are widely employed in almost all medical specialties. In Neurology, the applications are numerous nowadays. There is constant interest in the traditional use of US as well as a growing attention towards the newest…
- Conditions
- Ultrasound, Neurosonology, NeuroPOCUS
- Trial name
- NCT06536621
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
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