HealthyNCT06240286
Comparing Manual and Neurocognitive Skills-While Sitting, Standing, Walking on a Treadmill and Using a Stepper.
A study testing Sitting workstation, Standing workstation and Stepping workstation in people with Healthy, run by Mayo Clinic at 1 site in United States.
Trial summary
This study is being performed to evaluate the effect of different active workstations (e.g., standing, stepping, or walking stations) on work performance through the evaluation of neurocognitive function using reasoning, memory, concentration, and fine motor skills evaluation tools. Read more about this study
- Who is it for?
- Ages 18 years and olderHealthy volunteers can take part
- Conditions the study is for
- Healthy
- What is being tested?
- Sitting workstation, Standing workstation and Stepping workstation
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 44 participants
- Where
- 1 siteUnited States
- Study dates
- Oct 2015to Nov 2015
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- Dan Abraham Healthy Living Center (DAHLC) members and non-members that have provided informed consent to participate in this study.
Who cannot join
- Unable to stand up, walk on a treadmill or use a stepper.
- Alzheimer, dementia or any memory impairment.
- Cannot attempt fine motor skills.
- Not willing to use a treadmill, stepper or standing desk.
- Not a present user of an active office.
Trial locations and contacts
1 site in 1 country.
United States1 site
Mayo Clinic in Rochester
Rochester, Minnesota, 55905
About this study
This study is being performed to evaluate the effect of different active workstations (e.g., standing, stepping, or walking stations) on work performance through the evaluation of neurocognitive function using reasoning, memory, concentration, and fine motor skills evaluation tools.
- Conditions
- Healthy
- Being tested
- Sitting workstation, Standing workstation, Stepping workstation, Walking workstation
- Keywords
- Neurocognitive function
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Sitting workstationBehavioural
Subjects will conduct reasoning, memory, concentration, and fine motor skills (neurocognitive function) assessments on a computer station in a seated position.
Standing workstationBehavioural
Subjects will conduct reasoning, memory, concentration, and fine motor skills (neurocognitive function) assessments on a computer station while standing.
Stepping workstationBehavioural
Subjects will conduct reasoning, memory, concentration, and fine motor skills (neurocognitive function) assessments on a computer station while utilizing a stepper.
Walking workstationBehavioural
Subjects will conduct reasoning, memory, concentration, and fine motor skills (neurocognitive function) assessments on a computer station while walking on a treadmill.
| Study group | Role | What they receive |
|---|---|---|
| Healthy Subjects | Experimental | Healthy subjects will attend the the Active Wellness Office at the Dan Abraham Healthy Living Center (DAHLC) at Mayo Clinic in Rochester, Minnesota, for four consecutive days. On day one, individuals will use a sitting workstation (control); based on randomization, three active workstations (standing, stepping, or walking stations) will be randomly assigned on the following days (2-4). Receives: Behavioral: Sitting workstation; Behavioral: Standing workstation; Behavioral: Stepping workstation; Behavioral: Walking workstation |
What is being measured
The primary outcome is the main question the study is designed to answer.
Double Trouble Task Score
The Double Trouble Task is a computer based reasoning assessment that evaluates the Stroop effect which relates to the increased difficulty a person has in naming the print color of a word when the text of that word refers to an 'incongruent' color. It evaluates the capacity to inhibit automatic word recognition by selectively focusing the attention to impede the automated access of distracting word information. In the website version, three words appear on the screen, one at the top, and two at the bottom. Subjects click the word at the bottom that matches the color at the top for 90 seconds and 1 point for each correct answer. Higher scores represent better reasoning skills \& neurocognitive function.
Measured: Day 1, Day 2, Day 3, Day 4
Grammatical Reasoning Test Score
The Grammatical Reasoning Test is a computer based reasoning assessment that measures the capacity of a person to reason the relationships among different objects and shapes. A statement appears at the top of the screen with two shapes at the bottom. Participants clicked on 'True' or 'False' to indicate whether the sentence accurately described the relationship between the shapes in 90 seconds and participants obtained 1 point for each correct answer. Higher scores represent better reasoning skills \& neurocognitive function.
Measured: Day 1, Day 2, Day 3, Day 4
Odd One Out Test Score
The Odd One Out Test is a computer based reasoning assessment which evaluates the person's Intelligence Quotient. It measures fluid intelligence or the capacity to reason abstractly and solve problems. Derived from Raven's and Cattell's intelligence tests. During the test, 9 patterns (color, shape, and number) appeared on the screen; participants chose the pattern (odd one) that differed from the others for 3 minutes and got 1 point for each correct answer. Higher scores represent better reasoning skills \& neurocognitive function.
Measured: Day 1, Day 2, Day 3, Day 4
Object Reasoning Task Score
The Object Reasoning Task is a computer based reasoning assessment that evaluates an individual's capability to make logical deductions from a sequence of complex images. Subjects look at 4 panels, 3 at the top and 1 at the bottom. Each panel contained four separate diagrams; subjects decided whether the panel at the bottom was the next in the series or not. It takes 3 minutes and 1 point for each correct answer. Higher scores represent better reasoning skills \& neurocognitive function.
Measured: Day 1, Day 2, Day 3, Day 4
Spatial Span Task Score
The Spatial Span Task is a computer based memory assessment that assesses the visuospatial working memory that depends on the unitary short-term memory system. Participants must remember a sequence of flashing boxes and click to the correct order; when they make a mistake the test ends and they have 3 opportunities. When they click in the right order, the following sequence increases difficulty. 4 points are the baseline; for each correct answer subjects get 1 point; if incorrect, they lose points. Higher scores represent better memory skills \& neurocognitive function.
Measured: Day 1, Day 2, Day 3, Day 4
Monkey Ladder Task Score
The Monkey Ladder Task is a computer based memory assessment that assesses the visual working memory better developed in chimpanzees than humans. Participants must remember which number appears in specific boxes, after a short period, the numbers disappear and they have to click on the boxes in numerical sequence, after three errors the test ends. 2 points are the baseline. Participants get 1 point for the correct answers; if incorrect, they lose the points earned. Higher scores represent better memory skills \& neurocognitive function.
Measured: Day 1, Day 2, Day 3, Day 4
Digit Span Task Score
The Digit Span Task is a computer based memory assessment that evaluates the verbal working memory that allows the temporary storage and manipulation of information. Participants must remember a sequence of numbers by typing them using the keyboard; after typing the correct sequence of numbers, the difficulty increases and after 3 mistakes the test ends. Participants get 1 point for a proper sequence; if incorrect, they lose points. Higher scores represent better memory skills \& neurocognitive function.
Measured: Day 1, Day 2, Day 3, Day 4
Paired Associates Task Score
The Paired Associates Task is a computer based memory assessment that assesses the paired-associate learning skills, a mental skill that requires learning to pair two items in memory. When the difficulty increases, several regions in the brain activate. During the task, a set of boxes appear on the screen. The boxes open, one after the other to reveal the figure inside, and subjects must remember and click which figure appears in which box. The difficulty increases in the number of figures after clicking the correct sequence and subjects will have three opportunities. Participants get 1 point for the right answers; if incorrect, they lose the points. Higher scores represent better memory skills \& neurocognitive function.
Measured: Day 1, Day 2, Day 3, Day 4
Rotations Task Score
The Rotations Task is a computer based concentration assessment that measures the ability to rotate objects mentally. Two rotated boxes appear on the screen, each filled with red and green squares. Participants click the boxes 'Match' or 'Mismatch' in 90 seconds, if the answer is correct, they get 8 points; if not, they lose the points. Higher scores represent better concentration skills \& neurocognitive function.
Measured: Day 1, Day 2, Day 3, Day 4
Feature Match Task Score
The Feature Match Task is a computer based concentration assessment that measures perception, requires concentration and focuses on complex images. Two boxes appear on the screen one at the left and the other to the right, each containing a complex array of abstract shapes. Subjects will click if the figures 'Match' or 'Mismatch' for 90 seconds. If correct, the next problem will be more difficult. The points are given according to the problem's difficulty; they can vary from 1-11and above. Higher scores represent better concentration skills \& neurocognitive function.
Measured: Day 1, Day 2, Day 3, Day 4
Polygons Task Score
The Polygons Task Score is a computer based concentration assessment that measures the mental ability to compare complex images. Two overlapping images appear on one side of the monitor, and another figure appears on the other side and contains just one shape. Subjects click 'Match' or 'Mismatch' to indicate if the single figure is identical or different in shape from one of the overlapping figures. Each chance will increase in difficulty. Subjects in 90 seconds will try to score as many points as they can, points per correct answer can vary from 1-6 points and above. Higher scores represent better concentration skills \& neurocognitive function.
Measured: Day 1, Day 2, Day 3, Day 4
Typing Test Score
The Typing Test is a computer based fine motor skills assessment. It is measured using the Split Screen Typing Program (Typing Master Inc., Helsinki, Finland). Subjects completed a 3-minute test typing as fast and accurately as they could, the top of the screen showed the text that participants had to type, and the typed text was seen at the bottom of the computer monitor. Participants typed one different script for each station. Typing speed, as well as accuracy represented by number of errors, and adjusted individual typing speed at each workstation were scored. The higher typing speed \& accuracy scores (low number of errors) represent better fine motor skills.
Measured: Day 1, Day 2, Day 3, Day 4
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted5 Feb 2024
- Study startOct 2015
- Primary completionNov 2015
- Study completionNov 2015
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for HealthyStudies of the same condition, open and under way.
- More trials run by Mayo ClinicThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- None (open label)
- Enrolment
- 44 participants (actual)
Sponsor and investigators
- Lead sponsor
- Mayo Clinic
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Francisco Lopez-Jimenez, Mayo Clinic
- Investigators
- Francisco Lopez-Jimenez, MD, MS, Principal investigator, Mayo Clinic
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06240286
- Sponsor's protocol ID
- 15-005471
- Status last verified
- Jan 2024
- First submitted
- 25 Jan 2024
- Last updated
- 5 Feb 2024
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Medina-Inojosa JR, Gomez Ibarra MA, Medina-Inojosa BJ, Supervia M, Jenkins S, Johnson L, Suarez NP, Bonikowske A, Somers VK, Lopez-Jimenez F. Effect of Active Workstations on Neurocognitive Performance and Typing Skills: A Randomized Clinical Trial. J Am Heart Assoc. 2024 Apr 16;13(8):e031228. doi: 10.1161/JAHA.123.031228. Epub 2024 Apr 4.
PubMed 38572691
Study at a glance
From the registry record, last updated by the sponsor on 5 Feb 2024. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Comparing Manual and Neurocognitive Skills-While Sitting, Standing, Walking on a Treadmill and Using a Stepper.
- ClinicalTrials.gov ID
- NCT06240286
- Acronym / sponsor ID
- 15-005471
- Conditions
- Healthy
- Keywords
- Neurocognitive function
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 44 participants (actual)
- Lead sponsor
- Mayo ClinicUniversity, hospital or other
- Study start
- Oct 2015 (actual)
- Primary completion
- Nov 2015 (actual)
- Study completion
- Nov 2015 (actual)
- First posted
- 5 Feb 2024 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study is being performed to evaluate the effect of different active workstations (e.g., standing, stepping, or walking stations) on work performance through the evaluation of neurocognitive function using reasoning, memory, concentration, and fine motor skills evaluation tools.
Study design
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- None (open label)
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Healthy Subjects | Experimental | Behavioral: Sitting workstation, Behavioral: Standing workstation, Behavioral: Stepping workstation, Behavioral: Walking workstationHealthy subjects will attend the the Active Wellness Office at the Dan Abraham Healthy Living Center (DAHLC) at Mayo Clinic in Rochester, Minnesota, for four consecutive days. On day one, individuals will use a sitting workstation (control); based on randomization, three active workstations (standing, stepping, or walking stations) will be randomly assigned on the following days (2-4). |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (1 listed)
- Dan Abraham Healthy Living Center (DAHLC) members and non-members that have provided informed consent to participate in this study.
Key exclusion criteria (5 listed)
- Unable to stand up, walk on a treadmill or use a stepper.
- Alzheimer, dementia or any memory impairment.
- Cannot attempt fine motor skills.
- Not willing to use a treadmill, stepper or standing desk.
- Not a present user of an active office.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Sitting workstationSubjects will conduct reasoning, memory, concentration, and fine motor skills (neurocognitive function) assessments on a computer station in a seated position. | Behavioural | Healthy Subjects |
| Standing workstationSubjects will conduct reasoning, memory, concentration, and fine motor skills (neurocognitive function) assessments on a computer station while standing. | Behavioural | Healthy Subjects |
| Stepping workstationSubjects will conduct reasoning, memory, concentration, and fine motor skills (neurocognitive function) assessments on a computer station while utilizing a stepper. | Behavioural | Healthy Subjects |
| Walking workstationSubjects will conduct reasoning, memory, concentration, and fine motor skills (neurocognitive function) assessments on a computer station while walking on a treadmill. | Behavioural | Healthy Subjects |
Primary outcome
Double Trouble Task Score
Time frame: Day 1, Day 2, Day 3, Day 4
The Double Trouble Task is a computer based reasoning assessment that evaluates the Stroop effect which relates to the increased difficulty a person has in naming the print color of a word when the text of that word refers to an 'incongruent' color. It evaluates the capacity to inhibit automatic word recognition by selectively focusing the attention to impede the automated access of distracting word information. In the website version, three words appear on the screen, one at the top, and two at the bottom. Subjects click the word at the bottom that matches the color at the top for 90 seconds and 1 point for each correct answer. Higher scores represent better reasoning skills \& neurocognitive function.
Grammatical Reasoning Test Score
Time frame: Day 1, Day 2, Day 3, Day 4
The Grammatical Reasoning Test is a computer based reasoning assessment that measures the capacity of a person to reason the relationships among different objects and shapes. A statement appears at the top of the screen with two shapes at the bottom. Participants clicked on 'True' or 'False' to indicate whether the sentence accurately described the relationship between the shapes in 90 seconds and participants obtained 1 point for each correct answer. Higher scores represent better reasoning skills \& neurocognitive function.
Odd One Out Test Score
Time frame: Day 1, Day 2, Day 3, Day 4
The Odd One Out Test is a computer based reasoning assessment which evaluates the person's Intelligence Quotient. It measures fluid intelligence or the capacity to reason abstractly and solve problems. Derived from Raven's and Cattell's intelligence tests. During the test, 9 patterns (color, shape, and number) appeared on the screen; participants chose the pattern (odd one) that differed from the others for 3 minutes and got 1 point for each correct answer. Higher scores represent better reasoning skills \& neurocognitive function.
Object Reasoning Task Score
Time frame: Day 1, Day 2, Day 3, Day 4
The Object Reasoning Task is a computer based reasoning assessment that evaluates an individual's capability to make logical deductions from a sequence of complex images. Subjects look at 4 panels, 3 at the top and 1 at the bottom. Each panel contained four separate diagrams; subjects decided whether the panel at the bottom was the next in the series or not. It takes 3 minutes and 1 point for each correct answer. Higher scores represent better reasoning skills \& neurocognitive function.
Spatial Span Task Score
Time frame: Day 1, Day 2, Day 3, Day 4
The Spatial Span Task is a computer based memory assessment that assesses the visuospatial working memory that depends on the unitary short-term memory system. Participants must remember a sequence of flashing boxes and click to the correct order; when they make a mistake the test ends and they have 3 opportunities. When they click in the right order, the following sequence increases difficulty. 4 points are the baseline; for each correct answer subjects get 1 point; if incorrect, they lose points. Higher scores represent better memory skills \& neurocognitive function.
Monkey Ladder Task Score
Time frame: Day 1, Day 2, Day 3, Day 4
The Monkey Ladder Task is a computer based memory assessment that assesses the visual working memory better developed in chimpanzees than humans. Participants must remember which number appears in specific boxes, after a short period, the numbers disappear and they have to click on the boxes in numerical sequence, after three errors the test ends. 2 points are the baseline. Participants get 1 point for the correct answers; if incorrect, they lose the points earned. Higher scores represent better memory skills \& neurocognitive function.
Digit Span Task Score
Time frame: Day 1, Day 2, Day 3, Day 4
The Digit Span Task is a computer based memory assessment that evaluates the verbal working memory that allows the temporary storage and manipulation of information. Participants must remember a sequence of numbers by typing them using the keyboard; after typing the correct sequence of numbers, the difficulty increases and after 3 mistakes the test ends. Participants get 1 point for a proper sequence; if incorrect, they lose points. Higher scores represent better memory skills \& neurocognitive function.
Paired Associates Task Score
Time frame: Day 1, Day 2, Day 3, Day 4
The Paired Associates Task is a computer based memory assessment that assesses the paired-associate learning skills, a mental skill that requires learning to pair two items in memory. When the difficulty increases, several regions in the brain activate. During the task, a set of boxes appear on the screen. The boxes open, one after the other to reveal the figure inside, and subjects must remember and click which figure appears in which box. The difficulty increases in the number of figures after clicking the correct sequence and subjects will have three opportunities. Participants get 1 point for the right answers; if incorrect, they lose the points. Higher scores represent better memory skills \& neurocognitive function.
Rotations Task Score
Time frame: Day 1, Day 2, Day 3, Day 4
The Rotations Task is a computer based concentration assessment that measures the ability to rotate objects mentally. Two rotated boxes appear on the screen, each filled with red and green squares. Participants click the boxes 'Match' or 'Mismatch' in 90 seconds, if the answer is correct, they get 8 points; if not, they lose the points. Higher scores represent better concentration skills \& neurocognitive function.
Feature Match Task Score
Time frame: Day 1, Day 2, Day 3, Day 4
The Feature Match Task is a computer based concentration assessment that measures perception, requires concentration and focuses on complex images. Two boxes appear on the screen one at the left and the other to the right, each containing a complex array of abstract shapes. Subjects will click if the figures 'Match' or 'Mismatch' for 90 seconds. If correct, the next problem will be more difficult. The points are given according to the problem's difficulty; they can vary from 1-11and above. Higher scores represent better concentration skills \& neurocognitive function.
Polygons Task Score
Time frame: Day 1, Day 2, Day 3, Day 4
The Polygons Task Score is a computer based concentration assessment that measures the mental ability to compare complex images. Two overlapping images appear on one side of the monitor, and another figure appears on the other side and contains just one shape. Subjects click 'Match' or 'Mismatch' to indicate if the single figure is identical or different in shape from one of the overlapping figures. Each chance will increase in difficulty. Subjects in 90 seconds will try to score as many points as they can, points per correct answer can vary from 1-6 points and above. Higher scores represent better concentration skills \& neurocognitive function.
Typing Test Score
Time frame: Day 1, Day 2, Day 3, Day 4
The Typing Test is a computer based fine motor skills assessment. It is measured using the Split Screen Typing Program (Typing Master Inc., Helsinki, Finland). Subjects completed a 3-minute test typing as fast and accurately as they could, the top of the screen showed the text that participants had to type, and the typed text was seen at the bottom of the computer monitor. Participants typed one different script for each station. Typing speed, as well as accuracy represented by number of errors, and adjusted individual typing speed at each workstation were scored. The higher typing speed \& accuracy scores (low number of errors) represent better fine motor skills.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 5 Feb 2024.
- Derived from this study: PubMed 38572691Medina-Inojosa JR, Gomez Ibarra MA, Medina-Inojosa BJ, Supervia M, Jenkins S, Johnson L, Suarez NP, Bonikowske A, Somers VK, Lopez-Jimenez F. Effect of Active Workstations on Neurocognitive Performance and Typing Skills: A Randomized Clinical Trial. J Am Heart Assoc. 2024 Apr 16;13(8):e031228. doi: 10.1161/JAHA.123.031228. Epub 2024 Apr 4.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Francisco Lopez-Jimenez, MD, MS principal investigator
Mayo Clinic
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Sitting workstation, Standing workstation and Stepping workstation in people with Healthy, run by Mayo Clinic at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 5 Feb 2024. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Double Trouble Task Score (time frame: Day 1, Day 2, Day 3, Day 4). The study lists 12 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT06240286, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 5 Feb 2024.