Knee OsteoarthritisNCT06265675
Comparison of the Efficacy of Phenol Block and Corticosteroid-Local Anesthetic Block Applied to the Genicular Nerve
A study testing Phenol, Celestone and Lidocain in people with Knee Osteoarthritis, run by Gaziler Physical Medicine and Rehabilitation Education and Research Hospital at 1 site in Turkey (Türkiye).
Trial summary
There are different neurolysis methods. Aim of this study is to compare two different methods, phenol block and corticosteroid local anesthetic block. Read more about this study
- Who is it for?
- Ages 50 to 80 years
- Conditions the study is for
- Knee Osteoarthritis
- What is being tested?
- Phenol, Celestone and Lidocain
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 88 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 24 Jan 2024to 7 Feb 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 50 to 80 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Patients with knee osteoarthritis must have pain at least 6 months
- NRS score of knee pain equal or more than 5
- At least grade 3 in Kellgren-Lawrence grading scale
- Non responsive to life style change, weight control, exercises program, medical treatment and the other conservative treatments (physical therapy, intraarticular injections)
- Decreasing at NRS score more than %50 after diagnostic block
- Those who accept the consent form
Who cannot join
- Patients who have acute knee injury
- Surgery history in knee
- Connective tissue disease that affect knee
- Sciatica
- Injection story in last 3 months
- Psychiatric or neurologic diseases that affect study
Show all 10Show fewer
- Septic arthritis, active local or systemic infection
- Coagulopathy
- Pregnancy
- Allergic reaction
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Comparison of the Efficacy of Ultrasound-Guided Phenol Block and Corticosteroid-Local Anesthetic Block Applied to the Genicular Nerve in Patients With Knee Osteoarthritis
There are different neurolysis methods. Aim of this study is to compare two different methods, phenol block and corticosteroid local anesthetic block.
Read the detailed description
Knee osteoarthritis is one of most frequent reason of knee pain. There are different treatment methods such as analgesic drug treatment, physical therapy techniques, intraarticular injections and neurolysis techniques. In this study, we will compare neurolysis techniques these are phenol block and corticosteroid local anesthetic block.
- Conditions
- Knee Osteoarthritis
- Being tested
- Phenol, Celestone, Lidocain
- Keywords
- Genicular nerve, Phenol, Knee Osteoarthritis, Neurolysis, Nerve Blockage
- Medical subject headings
- Osteoarthritis, Knee
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
PhenolDrug
Chemical neurolysis
CelestoneDrug
Chemical neurolysis with corticosteroid
LidocainDrug
Chemical neurolysis with local anesthetic
| Study group | Role | What they receive |
|---|---|---|
| Phenol block group | Experimental | Not described Receives: Drug: Phenol |
| Corticosteroid and local anesthetic | Active comparator | Not described Receives: Drug: Celestone; Drug: Lidocain |
What is being measured
The primary outcome is the main question the study is designed to answer.
Numeric Rating Scale (NRS)
Average knee pain is assessed using an 11-point NRS with terminal descriptors of no pain (score 0) and extreme pain (score 10).
Measured: Before the intervention, 4 weeks after the intervention and 3 months later
Secondary outcomes (5)
Western Ontario and McMaster Universities Arthritis Index (WOMAC)
We will use the WOMAC in the Likert version where question are scored on a scale of 0-4, which correspond to: None (0), Mild (1), Moderate (2), Severe (3), and Extreme (4). The scores for each subscale are summed up, with a possible score range of 0-20 for Pain, 0-8 for Stiffness, and 0-68 for Physical Function. So the sum of the scores ranges from 0 (the best) to 96 (the worse).
Measured: Before the intervention, 4 weeks after the intervention and 3 months later
Patient Global Impression of Change (PGIC)
The PGIC in pain and function will be measured with a 5-point Likert scale (1-5) on the applicable follow up visits. The patients will be asked to rate the following statements:
Please imagine how you would have described your pain intensity before the procedure. How do you feel today as compared to baseline (Start of the study) as far as your knee pain caused by OA is concerned? Please imagine how you would have described the functionality of your knee before the procedure. How do you feel today as compared to baseline (start of the study) as far as your knee functionality caused by OA is concerned?
The options on the Likert scale are:
much better slightly better no change slightly worse much worse
Measured: 4 weeks after the intervention and 3 months later
Sixt Minute Walk Test (6MWT)
A 6 minute walk test is a submaximal exercise test that measures the distance walked over the span of 6 minutes.
Measured: Before the intervention, 4 weeks after the intervention and 3 months later
The Timed-Up and Go test
This test measures the dynamic balance and functional mobility in older adults.A patient getting up from a chair from the sitting to the bipedal position, walking three meters, turning, returning, and sitting on the chair again.
Measured: Before the intervention, 4 weeks after the intervention and 3 months later
Frequency of analgesic usage
Assessment of analgesic number that used by patient with knee osteoarthritis
Measured: Before the intervention, 4 weeks after the intervention and 3 months later
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted20 Feb 2024
- Study start24 Jan 2024
- Primary completion7 Feb 2025
- Study completion7 Feb 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Knee OsteoarthritisStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind
- Who is masked
- Participant, Outcomes assessor
- Enrolment
- 88 participants (actual)
Sponsor and investigators
- Lead sponsor
- Gaziler Physical Medicine and Rehabilitation Education and Research Hospital
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Rabia Layık, Gaziler Physical Medicine and Rehabilitation Education and Research Hospital
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06265675
- Sponsor's protocol ID
- E1-4066/2023
- Status last verified
- Nov 2026
- First submitted
- 10 Feb 2024
- Last updated
- 4 Nov 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 4 Nov 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Comparison of the Efficacy of Ultrasound-Guided Phenol Block and Corticosteroid-Local Anesthetic Block Applied to the Genicular Nerve in Patients With Knee Osteoarthritis
- ClinicalTrials.gov ID
- NCT06265675
- Acronym / sponsor ID
- E1-4066/2023
- Conditions
- Knee Osteoarthritis
- Keywords
- Genicular nerve, Phenol, Knee Osteoarthritis, Neurolysis, Nerve Blockage
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 88 participants (actual)
- Lead sponsor
- Gaziler Physical Medicine and Rehabilitation Education and Research HospitalUniversity, hospital or other
- Study start
- 24 Jan 2024 (actual)
- Primary completion
- 7 Feb 2025 (actual)
- Study completion
- 7 Feb 2025 (actual)
- First posted
- 20 Feb 2024 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
There are different neurolysis methods. Aim of this study is to compare two different methods, phenol block and corticosteroid local anesthetic block.
Detailed description
Knee osteoarthritis is one of most frequent reason of knee pain. There are different treatment methods such as analgesic drug treatment, physical therapy techniques, intraarticular injections and neurolysis techniques. In this study, we will compare neurolysis techniques these are phenol block and corticosteroid local anesthetic block.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind (participant, outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Phenol block group | Experimental | Drug: Phenol |
| Corticosteroid and local anesthetic | Active comparator | Drug: Celestone, Drug: Lidocain |
Who may qualify
- Ages
- 50 to 80 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (6 listed)
- Patients with knee osteoarthritis must have pain at least 6 months
- NRS score of knee pain equal or more than 5
- At least grade 3 in Kellgren-Lawrence grading scale
- Non responsive to life style change, weight control, exercises program, medical treatment and the other conservative treatments (physical therapy, intraarticular injections)
- Decreasing at NRS score more than %50 after diagnostic block
Key exclusion criteria (10 listed)
- Patients who have acute knee injury
- Surgery history in knee
- Connective tissue disease that affect knee
- Sciatica
- Injection story in last 3 months
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| PhenolChemical neurolysis | Drug | Phenol block group |
| CelestoneChemical neurolysis with corticosteroid | Drug | Corticosteroid and local anesthetic |
| LidocainChemical neurolysis with local anesthetic | Drug | Corticosteroid and local anesthetic |
Primary outcome
Numeric Rating Scale (NRS)
Time frame: Before the intervention, 4 weeks after the intervention and 3 months later
Average knee pain is assessed using an 11-point NRS with terminal descriptors of no pain (score 0) and extreme pain (score 10).
5 secondary outcomes
Western Ontario and McMaster Universities Arthritis Index (WOMAC)
Time frame: Before the intervention, 4 weeks after the intervention and 3 months later
Patient Global Impression of Change (PGIC)
Time frame: 4 weeks after the intervention and 3 months later
Sixt Minute Walk Test (6MWT)
Time frame: Before the intervention, 4 weeks after the intervention and 3 months later
The Timed-Up and Go test
Time frame: Before the intervention, 4 weeks after the intervention and 3 months later
Frequency of analgesic usage
Time frame: Before the intervention, 4 weeks after the intervention and 3 months later
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 4 Nov 2026.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Phenol, Celestone and Lidocain in people with Knee Osteoarthritis, run by Gaziler Physical Medicine and Rehabilitation Education and Research Hospital at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 10 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 4 Nov 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Numeric Rating Scale (NRS) (time frame: Before the intervention, 4 weeks after the intervention and 3 months later). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 4 Nov 2026.