AzTrials
AzTrials

Heart FailureBRING-UP3HFNCT06279988

BRING-UP 3 Heart Failure

An observational study of Heart Failure, run by Heart Care Foundation at 187 sites in Italy.

Unknown status

Status not confirmed. The sponsor has not verified this record for over two years, so it may be out of date.

Official record
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Trial summary

The aim of this observational study is to assess the level of adherence to guideline recommendations regarding the management of patients with Heart Failure with Reduced Ejection Fraction (HFrEF); - the safety profile of the implementation of recommended treatments; - to monitor treatment patterns of patients with… Read more about this study

Who is it for?
Ages 18 years and older
Conditions the study is for
Heart Failure
How many people
10,000 participants
Where
187 sitesItaly
Study dates
15 Sep 2023to 30 Jul 2026
Phase
Observational
Are there results?
None posted in the registry

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 18 years and older
  • All sexes
  • No healthy volunteers
  • Adult, Older adult

Study population: All consecutive patients with chronic HF and those admitted for acute (de novo or worsening) HF.

Who may be able to join

  • Age ≥18 years old.
  • Males and females at birth.
  • Any ejection fraction level (level of ejection fraction measured in the 6 months preceding enrollment).
  • Ambulatory chronic HF or Hospitalized de-novo or worsening HF.
  • Signed informed consent
  • Diagnosis will be made by the local attending physician following the ESC guidelines recommendations.

Who cannot join

  • Active neoplasia or very severe disease compromising short-medium term life expectancy.
  • Participation in interventional studies.
  • Patients already enrolled into the study from another participating center or in the previous enrolling phase.

Trial locations and contacts

187 sites in 1 country.

Fabrizio G Oliva, MD contact

055/5101361

bringup3.scompenso@heartcarefoundation.it

Aldo P Maggioni, MD contact

055/5101361

maggioni@heartcarefoundation.it

187 sites in 1 country

Italy187 sites, 178 recruiting

  • Ospedale Miulli - U.O.C. Cardiologia - Utic

    Acquaviva delle Fonti, BA, 70021

    NICOLA VITULANO, MD

    Recruiting

  • Ospedale Della Murgia - Fabio Perinei - S.C. Cardiologia-Utic

    Altamura, BA, 70022

    PIETRO SCICCHITANO, MD

    Recruiting

  • Ospedali Riuniti - Sod Cardiologia Ospedaliera E Utic

    Ancona, AN, 60122

    ILARIA BATTISTONI, MD

    Recruiting

  • Irccs Inrca - Uo Cardiologia/Utic/Telecardiologia

    Ancona, AN, 60131

    PAOLA TAMBURRINI, MD

    Recruiting

  • Ospedale San Donato - U.O.C Cardiologia

    Arezzo, AR, 52100

    MATTEO ROCCO RECCIA, MD

    Recruiting

  • Ospedale Dei Castelli - U.O.C. Di Cardiologia E Utic

    Ariccia, RM, 00072

    ANNA R FELICI, MD

    Recruiting

  • Ospedale Civile - U.O.C. Di Cardiologia

    Arzignano, VI, 36071

    CLAUDIO BILATO, MD

    Recruiting

  • Ospedale E. Muscatello - U.O. Di Cardiologia - Utic

    Augusta, SR, 96011

    GIOVANNI LICCIARDELLO, MD

    Recruiting

  • Aorn San Giuseppe Moscati - U.O. Cardiologia/Utic 'D. Rotiroti'

    Avellino, AV, 83100

    EMILIO DI LORENZO, MD

    Recruiting

  • Ospedale G. Di Maria - Cardiologia Utic

    Avola, SR, 96012

    PAOLO COSTA, MD

    Recruiting

  • Ospedale San Paolo - Cardiologia-Utic

    Bari, BA, 70123

    PASQUALE CALDAROLA, MD

    Recruiting

  • Ics Maugeri Spa Societa' Benefit Irccs Bari - Cardiologia Riabilitativa

    Bari, BA, 70124

    ANDREA PASSANTINO, MD

    Recruiting

  • Mater Dei Hospital - Riabilitazione Cardiologica

    Bari, BA, 70124

    ROCCO LAGIOIA, MD

    Recruiting

  • Ospedale Monsignor Angelo R. Di Miccoli - Uoc Cardiologia/Utic

    Barletta, BT, 76121

    Active, not recruiting

  • Ospedale Di Bentivoglio - U.O. Cardiologia Pianura

    Bentivoglio, BO, 40010

    GIANFRANCO TORTORICI, MD

    Recruiting

  • Asst Papa Giovanni Xxiii - Sc Cardiologia 1

    Bergamo, MI, 24127

    EMILIA D'ELIA, MD

    Recruiting

  • Ospedale Maggiore - U.O.C. Di Cardiologia

    Bologna, BO, 40133

    GIULIA BUGANI, MD

    Recruiting

  • Ospedale Policlinico S. Orsola-Malpighi - Medicina Interna - Borghi

    Bologna, BO, 40138

    CLAUDIO BORGHI, MD

    Recruiting

  • Ospedale Centrale Bolzano - Cardiologia E Prove Funzionali

    Bolzano, BZ, 39100

    PRISCILLA MILEWSKI, MD

    Recruiting

  • Ospedale Ss. Trinita' - S.C. Di Cardiologia

    Borgomanero, 28021

    PIERFRANCO S DELLAVESA, MD

    Recruiting

  • Istituto Ospedaliero Fondazione Poliambulanza - Unita Operativa Di Cardiologia E Utic

    Brescia, BS, 25124

    LORENZO CAPRINI, MD

    Recruiting

  • Ospedale Perrino - U.O.C. Di Cardiologia

    Brindisi, BR, 72100

    GIAN PAOLO GIORDA, MD

    Recruiting

  • Nuovo Ospedale Versilia - Sc Cardiologia

    Camaiore, LU, 55041

    GIANCARLO CASOLO, MD

    Recruiting

  • Ospedale Caduti in Guerra - U.O.S.V.D Di Riabilitazione Cardiologica

    Canosa di Puglia, BT, 76012

    FRANCESCO BARTOLOMUCCI, MD

    Recruiting

  • Ospedale Di Venere - U.O.C. Di Cardiologia

    Carbonara di Bari, BA, 70012

    MASSIMO V BONFANTINO, MD

    Recruiting

  • Ospedale Santo Spirito - Sc Cardiologia

    Casale Monferrato, AL, 15033

    FEDERICO NARDI, MD

    Recruiting

  • Ospedale Oglio Po - U.O. Di Cardiologia-Utic

    Casalmaggiore, CR, 26041

    CARLO PISCICELLI, MD

    Recruiting

  • Azienda Ospedaliera S. Anna E S. Sebastiano - U.O. Cardiologia D'Emergenza Con Utic

    Caserta, CE, 81100

    PAOLO CALABRO', MD

    Recruiting

  • Villa Delle Magnolie - Riabilitazione Cardiologica

    Castel Morrone, CE, 81020

    FRANCESO PERONE, MD

    Recruiting

  • Ospedale Unico Della Val Tidone - Cardiologia E Riabilitazione

    Castel San Giovanni, PC, 29015

    GIANLUCA LANATI, MD

    Recruiting

  • Ospedale Multimedica Castellanza - Cardiologia

    Castellanza, VA, 21053

    LUCIA SAPORITI, MD

    Recruiting

  • Ospedale Santa Croce - Uosd Cardiologia E Di Continuita Assist.

    Castelnuovo di Garfagnana, LU, 55032

    Active, not recruiting

  • Ospedale Civile Ferrari - U.O.C. Cardiologia-Utic

    Castrovillari, CS, 87012

    ANDREA MADEO, MD

    Recruiting

  • P.O. Garibaldi-Nesima - Arnas Garibaldi - U.O.C. Di Cardiologia Con Utic

    Catania, CT, 95122

    MICHELE M GULIZIA, MD

    Recruiting

  • Policlinico Catania Po G. Rodolico - Cardiologia Utic

    Catania, CT, 95125

    GIUSEPPE LEONARDI, MD

    Recruiting

  • Azienda Ospedaliera Cannizzaro - Uoc Cardiologia

    Catania, CT, 95126

    FRANCESCO AMICO, MD

    Recruiting

  • P.O. "Materdomini" - A.O.U. "Renato Dulbecco" - Ssd Cardiologia Riabilitativa

    Catanzaro, CZ, 88100

    DOMENICO ZUCCO, MD

    Recruiting

  • P.O. "Pugliese" - A.O.U. "Renato Dulbecco" - Utic-Emodinamica E Cardiologia Interventistica

    Catanzaro, CZ, 88100

    FRANCESCO CASSADONTE, MD

    Recruiting

  • Fondazione G. Giglio - U.O. Di Cardiologia

    Cefalù, PA, 90015

    TOMMASO A CIPOLLA, MD

    Recruiting

  • Ospedale Ss. Annunziata - U.O. Di Cardiologia Provinciale

    Cento, FE, 44042

    BIAGIO SASSONE, MD

    Recruiting

  • Ospedale Di Cernusco Sul Naviglio - U. O. Di Cardiologia E Ucc

    Cernusco sul Naviglio, MI, 20063

    SERGIO SALA, MD

    Recruiting

  • Ospedale Policlinico Ss. Annunziata - Uoc Cardiologia-Utic

    Chieti, CH, 66013

    MARCO ZIMARINO, MD

    Recruiting

  • Ospedale Civico - Sc Cardiologia

    Chivasso, TO, 10034

    CLAUDIO MORETTI, MD

    Recruiting

  • Ospedale Edoardo Bassini - Sc Cardiologia-Ucc Asst Nord Milano (Bassini-Ssg)

    Cinisello Balsamo, MI, 20092

    GRAZIA M CASTELLI, MD

    Recruiting

  • Por Cirié- Lanzo Presidio Cirié - S.C. Cardiologia

    Cirié, TO, 10073

    MICHELE CAPRIOLO, MD

    Recruiting

  • Presidio Ospedaliero Citta' Di Castello - U.O. Cardiologia/Utic

    Città di Castello, PG, 06012

    KWAME MBOUMI, MD

    Recruiting

  • Ospedale Civita Castellana - Ssd Cardiologia

    Civita Castellana, VT, 01033

    Active, not recruiting

  • Ospedale Civile San Paolo - U.O.C. Cardiologia - Utic

    Civitavecchia, RM, 00053

    SERGIO CALCAGNO, MD

    Recruiting

  • Ospedale San Giuseppe Da Copertino - U.O. Di Cardiologia

    Copertino, LE, 73043

    Active, not recruiting

  • Ospedale Valdichiana Santa Margherita - Uosd Cardiologia S.O. Cortona

    Cortona, AR, 52044

    SIMONA D'ORAZIO, MD

    Recruiting

  • Azienda Ospedaliera Santa Croce E Carle - Sc Cardiologia

    Cuneo, CN, 12100

    ROBERTA ROSSINI, MD

    Recruiting

  • Ospedale Di Desenzano Del Garda - Divisione Di Cardiologia - U.C.C.

    Desenzano del Garda, BS, 25015

    GIOSUE' MASCIOLI, MD

    Recruiting

  • Ospedale Pio Xi - U.O.C. Di Cardiologia

    Desio, MB, 20832

    FELICE ACHILLI, MD

    Recruiting

  • Ospedale Maria Ss. Addolorata - U.O. Di Cardiologia Utic

    Eboli, SA, 84025

    ELISA DI IACONI, MD

    Recruiting

  • Ospedale San Giuseppe - Cardiologia

    Empoli, FI, 50053

    FLAVIO VENTURI, MD

    Recruiting

  • Presidio Ospedaliero Umberto I - Cardiologia - Utic- Riabilitazione

    Enna, EN, 94100

    RAFFAELLA IUDICELLO, MD

    Recruiting

  • Presidio Ospedaliero "Santa Maria Del Prato" - U.O.C. Di Cardiologia-Utic

    Feltre, BL, 32032

    FRANCESCA DE CIAN, MD

    Recruiting

  • Arcispedale Sant'Anna - U.O. Cardiologia

    Ferrara, FE, 44124

    ALESSANDRO FUCILI, MD

    Recruiting

  • Ospedale Civile - U.O.C. Cardiologia - Utic

    Fidenza, PR, 43036

    GIOVANNI TORTORELLA, MD

    Recruiting

  • Ospedale Santa Maria Nuova - Cardiologia

    Florence, FI, 50122

    MASSIMO MILLI, MD

    Recruiting

  • Ospedale San Giovanni Di Dio - Sos Cardiologia

    Florence, FI, 50124

    MASSIMO MILLI, MD

    Recruiting

  • Aou Careggi - Geriatria - Utig

    Florence, FI, 50141

    ANDREA UNGAR, MD

    Recruiting

  • Policlinico Riuniti - S.C. Di Cardiologia Universitaria-Utic

    Foggia, FG, 71100

    NATALE D BRUNETTI, MD

    Recruiting

  • Nuovo Ospedale San Giovanni Battista - S.C. Cardiologia

    Foligno, PG, 06034

    EMILIA BISCOTTINI, MD

    Recruiting

  • Ospedale G.B. Morgagni - L. Pierantoni - U.O. Cardiologia

    Forlì, FC, 47121

    ELISA GARDINI, MD

    Recruiting

  • Istituti Clinici Scientifici Maugeri Irccs Sede Di Veruno - Uo Cardiologia Riabilitativa

    Gattico, 28013

    MASSIMO PISTONO, MD

    Recruiting

  • Ospedale Civile 'La Memoria' - U.O. Di Cardiologia

    Gavardo, BS, 25085

    MARCO TRIGGIANI, MD

    Recruiting

  • Ospedale Padre Antero Micone - Sc Cardiologia - Utic

    Genova, GE, 16100

    SILVIA COSTA, MD

    Recruiting

  • Irccs Ospedale Policlinico San Martino - Clinica Malattie Apparato Cardiovascolare

    Genova, GE, 16132

    MARCO CANEPA, MD

    Recruiting

  • Ospedale San Giovanni Di Dio - Sc Cardiologia (Gorizia-Monfalcone)

    Gorizia, GO, 34170

    GERARDINA LARDIERI, MD

    Recruiting

  • Ospedale Civile Di Guastalla - Sos Cardiologia E Riabilitazione Card Area Nord

    Guastalla, RE, 42016

    ALESSANDRO NAVAZIO, MD

    Recruiting

  • Ospedale Gubbio-Gualdo Tadino - U.O. Di Utic E Cardiologia

    Gubbio, PG, 06024

    DEBORAH COSMI, MD

    Recruiting

  • Ospedale Civile - S.C. Cardiologia

    Ivrea, TO, 10015

    MARCO M CINGOLANI, MD

    Recruiting

  • Ospedale Anna Rizzoli - Cardiologia-Utic

    Lacco Ameno, 80076

    Active, not recruiting

  • Ospedale Del Delta - U.O. Cardiologia

    Lagosanto, FE, 44023

    BIAGIO SASSONE, MD

    Recruiting

  • Ospedale Del Tigullio Polo Lavagna - Sc Cardiologia E Utic

    Lavagna, GE, 16033

    GUIDO PARODI, MD

    Recruiting

  • Ospedale Vito Fazzi - Uoc Cardiologia-Utic Ed Emodinamica

    Lecce, LE, 73100

    STEFANIA MARAZIA, MD

    Recruiting

  • Ospedale Alessandro Manzoni - S.C. Di Cardiologia

    Lecco, LC, 23900

    ROBERTO SPOLADORE, MD

    Recruiting

  • Asst Ovest Milanese - Po Di Legnano - Cardiologia E Unita' Coronarica

    Legnano, MI, 20025

    CORINNA A INSERRA, MD

    Recruiting

  • Ospedali Riuniti - U.O.C. Cardiologia E Utic

    Livorno, LI, 57124

    EMILIO M PASANISI, MD

    Recruiting

  • Ospedale Civile - Uo Servizio Cardiologia

    Lugo, RA, 48022

    GIULIA RICCI LUCCHI, MD

    Recruiting

  • Istituti Clinici Scientifici Maugeri Irccs Sede Di Lumezzane - U.O. Di Cardiologia Riabilitativa

    Lumezzane, BS, 25065

    EMANUELA ZANELLI, MD

    Recruiting

  • Casa Di Cura San Michele - Uo Cardiologia

    Maddaloni, CE, 81024

    MARCO PEPE, MD

    Recruiting

  • Ospedale S. Andrea - Alta Maremma - Uosd Cardiologia

    Massa Marittima, GR, 58024

    NICOLA D'APRILE, MD

    Recruiting

  • Ospedale Madonna Delle Grazie - Ssd Utic

    Matera, Mount, 75100

    Active, not recruiting

  • Irccs Centro Neurolesi Bonino Pulejo - P.O Piemonte - Cardiologia E Utic

    Messina, ME, 98124

    MYRIAM D'ANGELO, MD

    Recruiting

  • Azienda Ospedaliera Papardo - U.O. Cardiologia Con Utic - Emodinamica

    Messina, ME, 98158

    MARIA C TODARO, MD

    Recruiting

  • Ospedale Dell'Angelo - U.O.C. Cardiologia

    Mestre, VE, 30171

    SAKIS THEMISTOCLAKIS, MD

    Recruiting

  • Fondazione Irccs Ca' Granda Ospedale Maggiore Policlinico - Uoc Malattie Cardiovascolari

    Milan, MI, 20122

    STEFANO CARUGO, MD

    Recruiting

  • Ospedale Fatebenefratelli E Oftalmico - Cardiologia E U.C.C.

    Milan, MI, 20122

    ADA F GIGLIO, MD

    Recruiting

  • Centro Cardiologico Monzino Irccs - Scompenso,Cardiologia Clinica

    Milan, MI, 20138

    PIETRO PALERMO, MD

    Recruiting

  • Istituti Clinici Scientifici Maugeri Irccs Sede Di Milano - Riabilitazione Cardiologica

    Milan, MI, 20138

    MAURO MONELLI, MD

    Recruiting

  • Istituti Clinici Scientifici Maugeri Irccs Sede Di Milano - Uo Cure Subacute

    Milan, MI, 20138

    MAURO PROIETTI, MD

    Recruiting

  • ASST SANTI PAOLO E CARLO - PO San Carlo - CARDIOLOGIA-UCC

    Milan, MI, 20153

    STEFANO LUCREZIOTTI, MD

    Recruiting

  • Irccs Ospedale Galeazzi - Sant'Ambrogio - Cardiologia Universitaria Ed Imaging Cardiaco

    Milan, MI, 20157

    EDOARDO CONTE, MD

    Recruiting

  • Asst Ospedale Metropolitano Niguarda - Cardiologia 2 - Insufficienza Cardiaca E Trapianto

    Milan, MI, 20162

    ANDREA GARASCIA, MD

    Recruiting

  • Ospedale Santa Maria Bianca - U.O. Di Cardiologia

    Mirandola, MO, 41037

    BENEDETTA VERONESI, MD

    Recruiting

  • Ospedale Regina Montis Regalis - U.O. Cardiologia-Utic

    Mondovì, CN, 12084

    MAURO FEOLA, MD

    Recruiting

  • Ospedale Civile San Polo - Sc Cardiologia (Gorizia-Monfalcone)

    Monfalcone, GO, 34074

    GERARDINA LARDIERI, MD

    Recruiting

  • Ospedale San Giacomo - Uoc Cardiologia

    Monopoli, BA, 70043

    ONOFRIO ROSSI, MD

    Recruiting

  • Ospedali Riuniti Padova Sud - U.O.C. Cardiologia

    Monselice, PD, 35043

    FRANCESCA E BOVOLATO, MD

    Recruiting

  • Policlinico Di Monza - Cardiologia Clinica E Utic

    Monza, MB, 20900

    MATTEO OLDANI, MD

    Recruiting

  • Ospedale Buon Consiglio Fatebenefratelli - U.O.Complessa Di Cardiologia E Utic

    Naples, 80123

    GAETANO M RUOCCO, MD

    Recruiting

  • Aorn Cardarelli - U.O. Cardiologia Con Utic

    Naples, 80131

    CIRO MAURO, MD

    Recruiting

  • Aorn Ospedale Dei Colli - P.O. Monaldi - Uosd Card. Riabilitativa Intensiva E Scompenso

    Naples, 80131

    GIUSEPPE PACILEO, MD

    Recruiting

  • Aorn Ospedale Dei Colli - P.O. Monaldi - Uosd Malattie Cardiologiche Congenite Adulti-Guch

    Naples, 80131

    BERARDO SARUBBI, MD

    Recruiting

  • Ospedale S. Giovanni Bosco - Sc Cardiologia - Utic

    Naples, 80134

    PAOLO TAMMARO, MD

    Recruiting

  • Ospedale P.F. Calvi - Uos Di Cardiologia Riabilitativa

    Noale, VE, 30033

    VALENTINA PESCATORE, MD

    Recruiting

  • Aou Maggiore Della Carita' - Scdo Cardiologia Ii

    Novara, 28100

    LIDIA ROSSI, MD

    Recruiting

  • Ospedale San Giacomo - Sc Cardiologia

    Novi Ligure, AL, 15067

    MARIA E ROVERE, MD

    Recruiting

  • Ospedale Giovanni Paolo Ii - Utic - Cardiologia

    Olbia, OT, 07026

    MARIA ELENA L PICOI, MD

    Recruiting

  • Aou San Luigi Gonzaga - S.C.D.O. Cardiologia

    Orbassano, TO, 10043

    CARLOALBERTO BIOLÉ, MD

    Recruiting

  • Clinica San Carlo - U.O. Cardiologia-Unita'Cure Coronariche

    Paderno Dugnano, MI, 20037

    ALESSIO CAPPELLERI, MD

    Recruiting

  • Ospedale Buccheri La Ferla Fatebenefratelli - Ssd Riabilitazione Cardiovascolare

    Palermo, PA, 90123

    FILIPPO M SARULLO, MD

    Recruiting

  • Arnas P.O. Civico E Benfratelli - Uoc Utic

    Palermo, PA, 90127

    IGNAZIO M SMECCA, MD

    Recruiting

  • Arnas P.O. Civico E Benfratelli - Uosd Cardiologia Clinica Trattam. Scompenso Card.

    Palermo, PA, 90127

    EGLE INCALCATERRA, MD

    Recruiting

  • Maria Eleonora Hospital - Cardiologia

    Palermo, PA, 90135

    VINCENZO PERNICE, MD

    Recruiting

  • Aor Villa Sofia-Cervello P.O. Cervello - U.O. Cardiologia - Cervello

    Palermo, PA, 90146

    VINCENZO POLIZZI, MD

    Recruiting

  • Aor Villa Sofia-Cervello Po Villa Sofia - Uoc Cardiologia E Utic E Emodinamica -Villa Sofia

    Palermo, PA, 90146

    AGATA M FLORESTA, MD

    Recruiting

  • Ospedale Spoke Paola- Cetraro Po Paola - Utic Cardiologia

    Paola, CS, 87027

    MARIA T MANES, MD

    Recruiting

  • Presidio Ospedaliero Di Passirana - Cardiologia Riabilitativa

    Passirana, MI, 20017

    ANNA FRISINGHELLI, MD

    Recruiting

  • Fondazione Irccs Policlinico San Matteo - Uoc Cardiologia 1

    Pavia, PV, 27100

    ANNALISA TURCO, MD

    Recruiting

  • Istituti Clinici Scientifici Maugeri Irccs Sede Di Pavia - U.O. Di Riabilitazione Cardiologica

    Pavia, PV, 27100

    GIOVANNI FORNI, MD

    Recruiting

  • Centro Servizi Grocco - Cardiologia Riabilitativa E Prevenzione

    Perugia, PG, 06123

    LUCIA FILIPPUCCI, MD

    Recruiting

  • Ospedale Civile Dello Spirito Santo - Cardiologia Con Utic

    Pescara, PE, 65124

    MASSIMO DI MARCO, MD

    Recruiting

  • Ospedale Civile 'Guglielmo Da Saliceto' - Uoc Cardiologia E Utic

    Piacenza, PC, 29100

    DANIELA ASCHIERI, MD

    Recruiting

  • Po Ponente - Ospedale Santa Corona - Sc Cardiologia Ponente

    Pietra Ligure, SV, 17027

    CHIARA BERNELLI, MD

    Recruiting

  • Ospedale Villamarina - Cardiologia E Utic Piombino Elba

    Piombino, LI, 57025

    LARA FREDIANI, MD

    Recruiting

  • Ftgm - Stabilimento Di Pisa - Cardiologia E Medicina Cardiovascolare

    Pisa, PI, 56124

    MICHELE EMDIN, MD

    Recruiting

  • Ospedale San Jacopo - Soc Cardiologia

    Pistoia, Point, 51100

    MICHELA TAGLIOLI, MD

    Recruiting

  • Ospedale Dell'Alta Val D'Elsa - Uosd Cardiologia-Utic

    Poggibonsi, SI, 53036

    VALERIO ZACA', MD

    Recruiting

  • Ospedale Giovanni Paolo Ii - Uosd Utic

    Policoro, Mount, 75025

    ANDREA ANDRIANI, MD

    Recruiting

  • Ospedale Degli Infermi - Sc Di Cardiologia

    Ponderano, BI, 13875

    ANDREA ROGNONI, MD

    Recruiting

  • Ospedale Generale Provinciale Lotti - U.O. Malattie Cardiovascolari Vde E Avc

    Pontedera, PI, 56025

    Active, not recruiting

  • Ospedale Santa Maria Delle Grazie - U.O. Cardiologia - Utic Con Emodinamica

    Pozzuoli, 80078

    MARIANO AVERSA, MD

    Recruiting

  • Ospedale Generale Provinciale - U.O. Cardiologia

    Province of Macerata, MC, 62100

    DANIELE CONTADINI, MD

    Recruiting

  • Ospedale Civile Santa Maria Delle Croci - Uoc Cardiologia

    Ravenna, RA, 48121

    ANDREA RUBBOLI, MD

    Recruiting

  • Po Santa Maria Nuova - Ausl Re Irccs - Soc Cardiologia Ospedaliera

    Reggio Emilia, RE, 42100

    ALESSANDRO NAVAZIO, MD

    Recruiting

  • P.O. San Camillo de Lellis - U.O.C. Cardiologia

    Rieti, RI, 02100

    AMIR KOL, MD

    Recruiting

  • Ospedale Infermi - U.O. Cardiologia

    Rimini, RN, 47900

    SAMUELA CARIGI, MD

    Recruiting

  • Campus Biomedico - Cardiologia

    Roma, RM, 00128

    FRANCESCA GRIGIONI, MD

    Recruiting

  • P.O. San Filippo Neri - Asl Roma 1 - Cardiologia Clinica E Riabilitativa

    Roma, RM, 00135

    FURIO COLIVICCHI, MD

    Recruiting

  • Inmi Lazzaro Spallanzani Irccs - Servizio Di Cardiologia Del Dipartimento Clinico

    Roma, RM, 00149

    MARIA C GATTO, MD

    Recruiting

  • Ospedale San Camillo - Uoc Cardiologia

    Roma, RM, 00152

    GIOVANNI PULIGNANO, MD

    Recruiting

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    Roma, RM, 00157

    ANTONINO GRANATELLI, MD

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    Roma, RM, 00169

    LEONARDO CALO', MD

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    Roma, RM, 00184

    VITTORIA RIZZELLO, MD

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    Roma, RM, 00188

    MATTEO RUZZOLINI, MD

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    Roma, RM, 00189

    EMANUELE BARBATO, MD

    Recruiting

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    Roma, RM, 00193

    ANGELA B SCARDOVI, MD

    Recruiting

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    Rovereto, Trento, 38068

    ANNA MANICA, MD

    Recruiting

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    GIUSEPPE PINTO, MD

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    Salerno, SA, 84131

    MICHELE R DI MURO, MD

    Recruiting

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    Salerno, SA, 84131

    AMELIA RAVERA, MD

    Recruiting

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    San Bonifacio, VR, 37047

    MAURIZIO ANSELMI, MD

    Recruiting

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    San Donato Milanese, MI, 20097

    MASSIMO PIEPOLI, MD

    Recruiting

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    San Fermo della Battaglia, CO, 22020

    Recruiting

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    San Gavino Monreale, SU, 09037

    MARGHERITA CASULA, MD

    Recruiting

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    San Giovanni Rotondo, FG, 71013

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    San Vito al Tagliamento, PN, 33078

    ARIANNA GARDIN, MD

    Recruiting

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    GIOVANNI MORANI, MD

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    DANIELE NASSIACOS, MD

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    DANIELE BERTOLI, MD

    Recruiting

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    Sassari, SS, 07100

    GAVINO CASU, MD

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    Sassuolo, MO, 41049

    ANNA MARTELLI, MD

    Recruiting

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    MICHELE DE BENEDICTIS, MD

    Recruiting

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    Savona, SV, 17100

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    Scorrano, LE, 73020

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    Recruiting

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    Sesto San Giovanni, MI, 20099

    GIUSEPPE GALATI, MD

    Recruiting

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    Siena, SI, 53100

    SERAFINA VALENTE, MD

    Recruiting

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    Taranto, TA, 74100

    ANGELO ALOISIO, MD

    Recruiting

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    Tivoli, RM, 00019

    ALFREDO POSTERARO, MD

    Recruiting

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    Torino, TO, 10126

    Gaetano M De Ferrari, MD

    Recruiting

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    Torino, TO, 10142

    MASSIMO GIAMMARIA, MD

    Recruiting

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    Torino, To, 10149

    Active, not recruiting

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    Torino, TO, 10154

    PIERLUIGI SBARRA, MD

    Recruiting

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    Tradate, VA, 21049

    PAOLA ANTOGNAZZA, MD

    Recruiting

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    Trento, TN, 38122

    MICHELE MORETTI, MD

    Recruiting

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    Trieste, TS, 34125

    GIULIA RUSSO, MD

    Recruiting

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    Udine, UD, 33100

    MARZIA DE BIASIO, MD

    Recruiting

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    Vallo della Lucania, SA, 84078

    ANTONIO ALOIA, MD

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    ELISA RONDANO, MD

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    VIRGINIA BOVOLO, MD

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    ANTONIO CIRO', MD

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    Viterbo, VT, 01100

    LUIGI SOMMARIVA, MD

    Recruiting

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    Vittoria, RG, 97019

    GIUSEPPE DI STABILE, MD

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    Voghera, PV, 27058

    MICHELA G COCCIA, MD

    Recruiting

Other trials in Italy

About this study

The aim of this observational study is to assess the level of adherence to guideline recommendations regarding the management of patients with Heart Failure with Reduced Ejection Fraction (HFrEF); - the safety profile of the implementation of recommended treatments; - to monitor treatment patterns of patients with acute hert failure (HF); - to monitor treatment patterns of all patients with chronic HF irrespective of the level of ejection fraction (EF).

Read the detailed description

Observational, prospective, multicenter study conducted in a large, representative sample of Italian cardiology centers.

Phases 1:

  1. First educational intervention to discuss the recommendations of guidelines and treatment patterns in specific phenotypes of patients.
  2. Data collection for 3 months or up to 30 consecutive patients with chronic HF or acute HF (both de novo and worsening).
  3. Evaluation of the primary and secondary end-points of the study at 6 months after enrollment. Modifications of treatments will be monitored during the 6 months follow-up.
  4. Second educational intervention to share the results of the first enrollment period of the study focusing the attention on existing gaps between guidelines recommendations and clinical practice.
  5. New data collection for other 3 months or up to 30 consecutive patients with chronic HF or acute HF (both de novo and worsening).
  6. Additional evaluation of the primary and secondary end-points of the study at 6 months after enrollment. Modifications of treatments will be monitored during the 6 months follow-up.
  7. 12-month follow-up for all patients included in both enrolment phases of the study.
Conditions
Heart Failure
Medical subject headings
Heart Failure

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Rate of adherence to Guideline-Directed Medical Therapy (GDMTs) in HFrEF

    To assess the rate of patients with HFrEF appropriately treated with the 4 therapeutic pillars [Angiotensin Converting Enzyme Inhibitors (ACE-i)/Angiotensin Receptor Blockers (ARBs)/Angiotensin Receptor/Neprilysin Inhibitor (ARNI), betablockers, mineralocorticoid receptor antagonist (MRAs), Sodium-Glucose Co-Transporter-2 (SGLT2i)] recommended by current European Society of Cardiology (ESC) 2021 guidelines. Patients with a documented contraindication to one or more of the 4 recommended therapeutic pillars will be included in the group of appropriately treated patients.

    Measured: 6 months

Secondary outcomes (4)

  1. Rate of patient achieving appropriate dosages of GDMTs

    to assess the rate of patients treated with appropriate dosages* of:ACE-i/ARBs/ARNI, betablockers, MRAs, SGLT2i and to describe and assess the rate of adverse reactions reported by the Investigators when detected during their usual clinical practice

    *For the purpose of the present study appropriate dosage is defined as a dosage ≥50% of the maximal recommended dosage by the current guidelines

    Measured: 6 months

  2. Treatment patterns of patients with Heart failure with mildly reduced ejection fraction (HFmrEF) and Heart failure with preserved ejection fraction (HFpEF)

    To assess how novel treatment recommendations for HFmrEF and HFpEF are implemented in practice, specifically the rate of use of ARNI and SGLT2i and to describe and assess the rate of adverse reactions reported by the Investigators when detected during their usual clinical practice

    Measured: 6 months

  3. Treatment patterns of patients with Acute Heart Failure (AHF) irrespective of the level of EF

    To assess the rate of use of vasopressors, vasodilators, renal replacement therapy and mechanical circulatory support, pharmacological treatments and follow-up planning at discharge and to describe and assess the rate of adverse reactions reported by the Investigators when detected during their usual clinical practice.

    Measured: 6 months

  4. All cause and specific causes of death and hospitalization (Exploratory endpoint)

    To evaluate the rate of occurrence of clinical events during the 12 months follow-up of each enrolment phase. Specifically all-cause death, all-cause hospitalizations, specific causes of death and hospitalizations.

    Measured: 12 months

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted28 Feb 2024
  2. Study start15 Sep 2023
  3. Primary completion30 Jun 2026 (estimated)
  4. Study completion30 Jul 2026 (estimated)

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Observational
Observational model
Cohort
Time perspective
Prospective
Enrolment
10,000 participants (estimated)
IDs, dates and publications
ClinicalTrials.gov ID
NCT06279988
Sponsor's protocol ID
K24
Acronym
BRING-UP3HF
Status last verified
Feb 2024
First submitted
19 Feb 2024
Last updated
28 Feb 2024
Results posted
No
Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No

Publications

  • BRING-UP 3 Heart Failure Investigators. Discharge medical treatment implementation and predictors of a successful decongestion in patients with acute heart failure: first data from the BRING-UP 3 Heart Failure Study. Eur J Intern Med. 2026 May 8:106860. doi: 10.1016/j.ejim.2026.106860. Online ahead of print.

    PubMed 42218046

  • Basile C, Oliva F, Orso F, Colivicchi F, Cipriani MG, Di Lenarda A, Gori M, Gorini M, Iacoviello M, Marini M, Gabrielli D, Maggioni AP. Age- and sex-related differences in heart failure characteristics and treatment patterns across the ejection fraction spectrum: first data from the BRING-UP 3 Heart Failure study. Eur Heart J Qual Care Clin Outcomes. 2026 Mar 5;12(2):221-240. doi: 10.1093/ehjqcco/qcaf113.

    PubMed 40987455

  • Oliva F, Orso F, Colivicchi F, Cipriani MG, DI Lenarda A, Gabrielli D, Gori M, Gorini M, Iacoviello M, Lucci D, Marini M, Amico F, Bertoli D, Carigi S, D'Elia E, DI Fusco SA, Fucili A, Lanati G, Menegato A, Moretti M, Navazio A, Passantino A, Pulignano G, Ruzzolini M, Scardovi AB, Somaschini A, Maggioni AP; on the behalf of BRING-UP-3 Heart Failure Investigators. Medical Treatments in Patients With Ambulatory Heart Failure: First Data From the BRING-UP-3 Heart Failure Study. J Card Fail. 2025 Dec;31(12):1847-1857. doi: 10.1016/j.cardfail.2025.02.019. Epub 2025 Mar 20.

    PubMed 40118200

Questions about this trial

What is this clinical trial studying?

An observational study of Heart Failure, run by Heart Care Foundation at 187 sites in Italy.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 6 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: status not confirmed, as of the sponsor's last update on 28 Feb 2024. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 187 sites in Italy. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

Results are not available in the source record.

How can a doctor refer a patient or contact the research team?

Contact Fabrizio G Oliva, MD (055/5101361, bringup3.scompenso@heartcarefoundation.it), or a site near the patient. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Rate of adherence to Guideline-Directed Medical Therapy (GDMTs) in HFrEF (time frame: 6 months). It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT06279988, which also lists 3 linked publications.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 28 Feb 2024.

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