Atherosclerotic Cardiovascular Disease (ASCVD)Phase 3NCT06292013
A Study to Investigate the Effect of Lepodisiran on the Reduction of Major Adverse Cardiovascular Events in Adults With Elevated Lipoprotein(a) - ACCLAIM-Lp(a)
A Phase 3 study testing Lepodisiran Sodium in people with Atherosclerotic Cardiovascular Disease (ASCVD) and Elevated Lp(a), run by Eli Lilly and Company at 928 sites in 28 countries.
Trial summary
The purpose of this study is to evaluate the efficacy of lepodisiran in reducing cardiovascular risk in participants with high lipoprotein(a) who have cardiovascular disease or are at risk of a heart attack or stroke. The study drug will be administered subcutaneously (SC) (under the skin). Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Atherosclerotic Cardiovascular Disease (ASCVD), Elevated Lp(a)
- What is being tested?
- Lepodisiran Sodium
- Type of treatment
- Injection or infusion
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 17,300 participants
- Where
- 928 sitesin 28 countries
- Study dates
- 5 Mar 2024to Mar 2029
- Phase
- Phase 3
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Have Lipoprotein(a) [Lp(a)] ≥175 nanomoles per liter (nmol/L).
- Meet criteria of either 2a or 2b:
- 2a: Individuals 18 years of age or older with established atherosclerotic cardiovascular disease (ASCVD) with an event or revascularization.
- 2b: Individuals 55 years of age or older who are at risk for a first cardiovascular (CV) event and either: Documented coronary artery disease (CAD), carotid stenosis, or peripheral artery disease (PAD) without history of event or revascularization; known familial hypercholesteremia; or a combination of high-risk factors.
Who cannot join
- Have had a major cardiovascular event or surgery, such as myocardial infarction (MI), stroke or coronary or peripheral revascularization, < 60 days before screening
- Have uncontrolled hypertension
- Have New York Heart Association class IV heart failure.
- Have lipoprotein apheresis within 90 days of screening, or planned lipoprotein apheresis during the study.
- Have severe renal failure, defined as
- Estimated glomerular rate (eGFR) <15 milliliters per minute per 1.73 meters squared (mL/min/1.73m2) at screening Visit 1, or ongoing dialysis.
- Have a diagnosis of active nephrotic syndrome, or urine albumin-creatinine ratio (UACR) of ≥5000 mg/g at screening Visit 1.
- Have acute or chronic hepatitis, known cirrhosis, signs and symptoms of any other liver disease other than metabolic-associated steatotic liver disease, or exclusionary laboratory results as determined by the central laboratory during screening.
Trial locations and contacts
928 sites in 28 countries.
928 sites in 28 countries
United States222 sites
American Clinical Trials - Acworth
Acworth, Georgia, 30101
Albany Medical College, Division of Community Endocrinology
Albany, New York, 12203
IMA Clinical Research
Albuquerque, New Mexico, 87109
Lehigh Valley Health Network
Allentown, Pennsylvania, 18103
PharmaTex Research
Amarillo, Texas, 79106
Amarillo Heart Clinical Research Institute Inc.
Amarillo, Texas, 79124
Atlanta Diabetes Associates
Atlanta, Georgia, 30318
Emory University School of Medicine
Atlanta, Georgia, 30322
Southeastern Clinical Research Institute
Augusta, Georgia, 30904
University of Colorado Anschutz Medical Campus
Aurora, Colorado, 80045
IMA Clinical Research Austin
Austin, Texas, 78745
Velocity Clinical Research, Austin
Austin, Texas, 78759
American Health Network of Indiana, LLC - Avon
Avon, Indiana, 46123
Sinai Hospital Of Baltimore
Baltimore, Maryland, 21209
Care Access - Baltimore
Baltimore, Maryland, 21213
Ascension Saint Agnes Heart Care
Baltimore, Maryland, 21229
MedStar Good Samaritan Hospital
Baltimore, Maryland, 21239
Velocity Clinical Research, Cleveland
Beachwood, Ohio, 44122
Heritage Valley Multispecialty Group, Inc
Beaver, Pennsylvania, 15009
Jadestone Clinical Research
Beltsville, Maryland, 20705
National Heart Institute
Beverly Hills, California, 90211
Birmingham Clinical Research
Birmingham, Alabama, 35209
Excel Medical Clinical Trials
Boca Raton, Florida, 33434
Grace Research - Bossier
Bossier City, Louisiana, 71111
Brigham and Women's Hospital Diabetes Program
Boston, Massachusetts, 02115
Flourish Research - Bowie
Bowie, Maryland, 20715
Qualmedica Research
Bowling Green, Kentucky, 42101
Bridgeport Hospital
Bridgeport, Connecticut, 06610
Internal Medicine Associates
Bridgeton, New Jersey, 08302
Headlands Horizons LLC
Brownsville, Texas, 78526
Mercury Street Medical Group, PLLC
Butte, Montana, 59701
Capital Area Research, LLC
Camp Hill, Pennsylvania, 17011
East Coast Institute for Research - Canton
Canton, Georgia, 30114
Accellacare Trident Cardiology
Charleston, South Carolina, 29456
Chicago Clinical Research Institute
Chicago, Illinois, 60607
Great Lakes Clinical Trials - Ravenswood
Chicago, Illinois, 60640
Velocity Clinical Research, Mt. Auburn
Cincinnati, Ohio, 45219
Velocity Clinical Research, Springdale
Cincinnati, Ohio, 45246
StudyMetrix Research
City of Saint Peters, Missouri, 63303
Clearwater Cardiovascular & Interventional Consultants M.D., P.A.
Clearwater, Florida, 33756
Clinical Research of West Florida, Inc. (Clearwater)
Clearwater, Florida, 33765
Cleveland Clinic
Cleveland, Ohio, 44195
Alpine Research Organization
Clinton, Utah, 84015
Kur Research - Columbia Medical
Columbia, Maryland, 21045
Ohio State University
Columbus, Ohio, 43210
Centricity Research Columbus Ohio Multispecialty
Columbus, Ohio, 43213
South Texas Clinical Research
Corpus Christi, Texas, 78404
Good Samaritan Regional Medical Center
Corvallis, Oregon, 97330
Valley Clinical Trials, Inc.
Covina, California, 91723
Private Practice - Dr. James E. Race
Dallas, Texas, 75224
Baylor Soltero CV Research Center
Dallas, Texas, 75226
Zenos Clinical Research
Dallas, Texas, 75230
Cedar Health Research
Dallas, Texas, 75251
UT Southwestern Medical Center
Dallas, Texas, 75390
Alliance for Multispecialty Research, LLC
Daphne, Alabama, 36526
Alliance for Multispecialty Research, LLC.
Dearborn, Michigan, 48126
Revival Research Institute, LLC
Dearborn, Michigan, 48126
Cardio Voyage
Denison, Texas, 75020
Henry Ford Hospital
Detroit, Michigan, 48202
Memorial Hospital at Gulfport
Diamondhead, Mississippi, 39525
SEC Clinical Research
Dothan, Alabama, 36305
American Clinical Trials - Douglasville
Douglasville, Georgia, 30134
South Texas Research Institute
Edinburg, Texas, 78539
Neighborhood Healthcare Institute of Health
Escondido, California, 92025
NECCR PrimaCare Research
Fall River, Massachusetts, 02721
Virginia Heart
Falls Church, Virginia, 22042
Care Access - Fayetteville
Fayetteville, North Carolina, 28314
Jellinger and Lerman, MD PA dba The Center for Diabetes and Endocrine Care
Fort Lauderdale, Florida, 33312
Texas Health Research & Education Institute - Fort Worth
Fort Worth, Texas, 76104
HB Clinical Trials - Fountain Valley
Fountain Valley, California, 92708
Anderson Medical Research
Ft. Washington, Maryland, 20744
Center for Advanced Research & Education
Gainesville, Georgia, 30501
Prime Medical Group, LLC dba Gilbert Center for Family Medicine, LLC
Gilbert, Arizona, 85296
Mercy Gilbert Medical Center
Gilbert, Arizona, 85297
Sun City Clinical Research
Glendale, Arizona, 85304
Medication Management
Greensboro, North Carolina, 27401
Triad Clinical Trials
Greensboro, North Carolina, 27410
Physician's East Endocrinology
Greenville, North Carolina, 27834
Tribe Clinical Research, LLC
Greenville, South Carolina, 29607
Clinical Investigation Specialists
Gurnee, Illinois, 60031
CMR of Greater New Haven, LLC
Hamden, Connecticut, 06517
Hartford Hospital (HH)
Hartford, Connecticut, 06102
Las Vegas Endocrinology
Henderson, Nevada, 89074
Elite Cardiac Research Center
Hialeah, Florida, 33013
Abington Medical Specialists
Horsham, Pennsylvania, 19044
Center for Cardiometabolic Disease Prevention/Baylor College of Medicine
Houston, Texas, 77030
Juno Research
Houston, Texas, 77040
Biopharma Informatic, LLC
Houston, Texas, 77043
PlanIt Research, PLLC
Houston, Texas, 77079
Research Physicians Network, LLC
Houston, Texas, 77089
Accurate Clinical Research - Humble
Humble, Texas, 77338
Care Access - Huntington Beach
Huntington Beach, California, 92648
MedStar Health Research Institute (MedStar Physician Based Research Network)
Hyattsville, Maryland, 20782
Indiana University Health Methodist Hospital
Indianapolis, Indiana, 46202
Care Access - South Indianapolis
Indianapolis, Indiana, 46254
310 Clinical Research
Inglewood, California, 90301
Westside Center for Clinical Research
Jacksonville, Florida, 32205
Jacksonville Center for Clinical Research
Jacksonville, Florida, 32216
Clinical Investigation Specialists
Kenosha, Wisconsin, 53144
Alliance for Multispecialty Research, LLC
Knoxville, Tennessee, 37909
UCSD - Altman Clinical and Translational Research Institute (ACTRI)
La Jolla, California, 92037-7410
Scripps Whittier Diabetes Institute
La Jolla, California, 92037
Care Access - Lake Charles
Lake Charles, Louisiana, 70601
First Valley Medical Group
Lancaster, California, 93534
Lancaster General Hospital
Lancaster, Pennsylvania, 17602
Clearwater Cardiovascular & Interventional Consultants M.D., P.A.
Largo, Florida, 33777
DaVita Clinical Research - Las Vegas
Las Vegas, Nevada, 89107
Palm Research Center Tenaya
Las Vegas, Nevada, 89128
Vector Clinical Trials
Las Vegas, Nevada, 89128
Georgia Clinical Research - Lawrenceville
Lawrenceville, Georgia, 30044
Alliance for Multispecialty Research, LLC
Lexington, Kentucky, 40509
Walker Family Care
Little River, South Carolina, 29566
Cardiology and Medicine Clinic
Little Rock, Arkansas, 72204
MemorialCare Health System - Long Beach Medical Center
Long Beach, California, 90806
Ark Clinical Research
Long Beach, California, 90815
Keck School of Medicine of USC
Los Angeles, California, 90033
Cardiovascular Research Foundation of Southern California
Los Angeles, California, 90210
The Heart Institute of East Texas
Lufkin, Texas, 75904
The Jones Center Clinical Research
Macon, Georgia, 31210
K2 Medical Research - Maitland
Maitland, Florida, 32751
South Florida Clinical Research Institute
Margate, Florida, 33063
Care Access - Mauldin
Mauldin, South Carolina, 29662
Biopharma Informatic, LLC
McAllen, Texas, 78503
Wellness Clinical Research
McKinney, Texas, 75069
North Texas Research Associates
McKinney, Texas, 75071
Revival Research Institute, LLC
McKinney, Texas, 75071
Texas Institute of Cardiology, PA
McKinney, Texas, 75071
Care Access - Memphis 2
Memphis, Tennessee, 38119
High Desert Heart & Vascular
Meridian, Idaho, 83642
PRX Research
Mesquite, Texas, 75149
Southern Endocrinology Associates
Mesquite, Texas, 75149
Flourish Research - Miami, LLC
Miami, Florida, 33135
Inpatient Research Clinic
Miami Lakes, Florida, 33014
Alliance for Multispecialty Research, LLC
Mobile, Alabama, 36608
Mobile Heart Specialists
Mobile, Alabama, 36608
IMA Clinical Research
Monroe, Louisiana, 71201
IMA Clinical Research West Virginia
Morgantown, West Virginia, 26505
IMA Clinical Research Mount Airy
Mount Airy, North Carolina, 27030
Accellacare - Mt Pleasant
Mt. Pleasant, South Carolina, 29464
Intermountain Medical Center
Murray, Utah, 84107
Advanced Research for Health Improvement, LLC
Naples, Florida, 34102
St. Francis Hospital & Heart Center
New Hyde Park, New York, 11576
Alliance for Multispecialty Research, LLC
New Orleans, Louisiana, 70119
NYU Langone Health
New York, New York, 10016
Icahn School of Medicine at Mount Sinai
New York, New York, 10029
IMA Clinical Research Manhattan
New York, New York, 10036
Lenox Hill Hospital
New York, New York, 10075
Alliance for Multispecialty Research, LLC
Niles, Illinois, 60714
Alliance for Multispecialty Research, LLC
Norfolk, Virginia, 23502
Valley Clinical Trials, LLC dba Flourish Research
Northridge, California, 91325
Renstar Medical Research
Ocala, Florida, 34470
CTR Oakwater, LLC
Orlando, Florida, 32806
Florida Institute For Clinical Research, LLC
Orlando, Florida, 32825
Desert Oasis Healthcare Medical Group
Palm Springs, California, 92262
Penn Medicine: University of Pennsylvania Health System
Philadelphia, Pennsylvania, 19104
Clinical Research of Philadelphia
Philadelphia, Pennsylvania, 19114
Elite Clinical Studies, LLC
Phoenix, Arizona, 85018
Helios Clinical Research - Phoenix
Phoenix, Arizona, 85028
Absolute Clinical Research
Phoenix, Arizona, 85051
AHN Allegheny General Hospital
Pittsburgh, Pennsylvania, 15212
Keystone Clinical Studies
Plymouth Meeting, Pennsylvania, 19462
Innovative Research Institute - Port Charlotte
Port Charlotte, Florida, 33952
Peace River Cardiovascular Center
Port Charlotte, Florida, 33952
Progressive Medical Research
Port Orange, Florida, 32127
Care Access - Quincy
Quincy, Massachusetts, 02169
Accellacare - Raleigh
Raleigh, North Carolina, 27609
Monument Health Rapid City Hospital
Rapid City, South Dakota, 57701
Eastside Research Associates
Redmond, Washington, 98052
Northwell Health Physician Peconic
Riverhead, New York, 11901
University of Rochester Medical Center
Rochester, New York, 14642
Clearwater Cardiovascular & Interventional Consultants M.D., P.A.
Safety Harbor, Florida, 34695
Clinical Advancement Center
San Antonio, Texas, 78212
Clinical Trials of Texas, LLC
San Antonio, Texas, 78229
IMA Clinical Research San Antonio
San Antonio, Texas, 78229
Endeavor Clinical Trials
San Antonio, Texas, 78240
Artemis Institute for Clinical Research
San Diego, California, 92123
Care Access - Santa Clarita
Santa Clarita, California, 91321
Saratoga Clinical Research
Saratoga Springs, New York, 12866
Consano Clinical Research, LLC
Shavano Park, Texas, 78231
DaVita Clinical Research - North Houston
Shenandoah, Texas, 77384
Sherman Clinical Research
Sherman, Texas, 75090
Louisiana Heart Center - Slidell
Slidell, Louisiana, 70458
Cardio Metabolic Institute
Somerset, New Jersey, 08873
Central Illinois Diabetes and Clinical Research a Division of Prairie Education and Research Cooperative
Springfield, Illinois, 62702
Clinvest Headlands Llc
Springfield, Missouri, 65807
Cardiology Associates of Fairfield County, P.C.
Stamford, Connecticut, 06905
Stanford University Medical Center
Stanford, California, 94305
Stony Brook University
Stony Brook, New York, 11794
Atlantic Health System Overlook Medical Center
Summit, New Jersey, 07901
Clinical Research Institute of Arizona (CRI) - Sun City West
Sun City West, Arizona, 85375
Olive View-UCLA Medical Center
Sylmar, California, 91342
Care Access - Tamarac
Tamarac, Florida, 33321
Clinical Research of West Florida
Tampa, Florida, 33606
Care Access - Tampa
Tampa, Florida, 33625
Care Access - Thousand Oaks
Thousand Oaks, California, 91360
Med Partners, Inc. dba Premiere Medical Center of Burbank, Inc.
Toluca Lake, California, 91602
Cotton O'Neil Clinical Research Center
Topeka, Kansas, 66606
Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Torrance, California, 90502
UCLA South Bay Endocrinology
Torrance, California, 90505
Arcturus Healthcare , PLC, Troy Internal Medicine Research Division
Troy, Michigan, 48098
Pima Heart
Tucson, Arizona, 85741
Synexus Clinical Research US, Inc./Orange Grove Family Practice
Tucson, Arizona, 85741
Eclipse Clinical Research
Tucson, Arizona, 85745
Preferred Primary Care Physicians
Uniontown, Pennsylvania, 15401
InvivoCure
Van Nuys, California, 91405
Synexus Clinical Research US, Inc.
Vista, California, 92083
IMA Clinical Research Warren
Warren Township, New Jersey, 07059
MedStar Washington Hospital Center
Washington D.C., District of Columbia, 20010
Chase Medical Research, LLC
Waterbury, Connecticut, 06708
Cardiology Partners Clinical Research Institute - Wellington
Wellington, Florida, 33449
Iowa Diabetes and Endocrinology Research Center
West Des Moines, Iowa, 50266
Interventional Cardiology Medical Group
West Hills, California, 91307
Millennium Clinical Trials
Westlake Village, California, 91361
American Health Network of Indiana, LLC - Whiteland
Whiteland, Indiana, 46184
AMR Clinical
Wichita, Kansas, 67226
Accellacare - Wilmington
Wilmington, North Carolina, 28401
Accellacare - DuPage
Winfield, Illinois, 60190
Wake Forest Baptist Health
Winston-Salem, North Carolina, 27157
North Georgia Clinical Research
Woodstock, Georgia, 30189
Cardiology Consultants of Philadelphia Yardley
Yardley, Pennsylvania, 19067
Heart and Vascular Research at WellSpan Health
York, Pennsylvania, 17403
Michigan Heart & Vascular Institute
Ypsilanti, Michigan, 48197
Japan66 sites
Asahi Hospital - Asahi
Asahi, 289-2511
Asahikawa City Hospital
Asahikawa, 070-8610
Saiseikai Futsukaichi Hospital
Chikushino-shi, 818-8516
University of Yamanashi Hospital
Chūō, 409-3898
The Institute of Medical Science, Asahi Life Foundation
Chūōku, 103-0002
Tokyo-Eki Center-building Clinic
Chūōku, 103-0027
Fukuwa Clinic
Chūōku, 104-0031
Fukuoka Wajiro Hospital
Fukuoka, 811-0213
Hakodate Municipal Hospital
Hakodate, 041-8680
Public Matto Ishikawa Central Hospital
Hakusan, 924-0865
Hyogo Prefectural Harima-Himeji General Medical Center
Himeji, 670-8560
Tokai University Hospital
Isehara, 259-1193
Rinku General Medical Center
Izumisano, 598-8577
Tenyoukai Central Clinic
Kagoshima, 892-0822
Takai Internal Medicine Clinic
Kamakura-shi, 247-0056
Ishikawa Prefectural Central Hospital
Kanazawa, 920-8530
Kanazawa University Hospital
Kanazawa, 920-8641
National Hospital Organization Kanazawa Medical Center
Kanazawa, 920-8650
Kasugai Municipal Hospital
Kasugai, 486-8510
Kokura Memorial Hospital
Kitakyushu, 802-8555
Kobe City Medical Center General Hospital
Kobe, 650-0047
Komatsu Municipal Hospital
Komatsu, 923-8560
Jinnouchi Hospital
Kumamoto, 862-0976
Chugoku Rosai Hospital
Kure, 737-0193
Rakuwakai Marutamachi Hospital
Kyoto, 604-8401
Rakuwakai Otowa Hospital
Kyoto, 607-8062
Aizawa Hospital
Matsumoto, 390-8510
National Hospital Organization Tokyo Medical Center
Meguro-ku, 152-8902
Tokyo Saiseikai Central Hospital
Minatoku, 108-0073
Miyakonojo Medical Association Hospital - Tarobocho
Miyakonojō, 885-0002
Miyazaki Medical Association Hospital
Miyazaki, 880-2102
Iwate Prefectural Central Hospital
Morioka, 020-0066
Kanazawa Medical University Hospital
Mukai-awagasaki, 920-0293
Tachikawa Medical Center
Nagaoka, 940-8621
Nagoya City University Hospital
Nagoya, 467-8602
Shonan Oiso Hospital
Naka-gun, 259-0114
Nogata Clinic
Nakano, 165-0027
Okayama City General Medical Center Okayama City Hospital
Okayama, 700-8557
National Hospital Organization Okayama Medical Center
Okayama, 701-1192
Medical Corporation Sato Medical clinic
Ootaku, 143-0015
National Hospital Organization - Osaka National Hospital - Institute For Clinical Research
Osaka, 540-0006
Osaka Keisatsu Hospital
Osaka, 543-8922
Kansai Electric Power Hospital
Osaka, 553-0003
Osaka General Medical Center
Osaka, 558-8558
Osaki Citizen Hospital - Furukawahonami
Ōsaki, 989-6183
Saga University Hospital
Saga, 849-8501
Kitasato University Hospital
Sagamihara, 252-0375
Sanai Hospital - Saitama
Saitama, 338-0837
Sapporo Medical University Hospital
Sapporo, 060-0906
Sapporo Medical University Hospital
Sapporo, 060-8543
Japan Community Healthcare Organization Hokkaido Hospital
Sapporo, 062-8618
Heishinkai Medical Group ToCROM Clinic
Shinjuku-ku, 160-0008
National Center for Global Health and Medicine
Shinjyuku-ku, 162-8655
Tokuyama Central Hospital
Shūnan, 745-8522
National Cerebral and Cardiovascular Center
Suita, 564-8565
Medical Corporation Heishinkai OCROM Clinic
Suita-shi, 565-0853
Shizuoka Medical Center
Sunto-gun, 411-8611
Kagawa Prefectural Central Hospital
Takamatsu, 760-8557
Higashi Takarazuka Satoh Hospital
Takarazuka, 665-0873
Takasago Seibu Hospital
Takasago, 676-0812
Osaka Medical and Pharmaceutical University Hospital
Takatsuki, 569-8686
Sekino Hospital
Toshimaku, 171-0014
Tsuchiura Kyodo General Hospital
Tsuchiura, 300-0028
National Hospital Organization Shinshu Ueda Medical Center
Ueda, 386-8610
Saiseikai Yokohamashi Tobu Hospital
Yokohama, 230-8765
Yokosukakyosai
Yokosuka, 238-8558
China64 sites
Beijing Chaoyang Hospital, Capital Medical University
Beijing, 100020
Beijing Friendship Hospital Affiliate of Capital University
Beijing, 100050
Peking University Third Hospital
Beijing, 100091
The First Hospital of Jilin University
Changchun, 100012
China-Japan Union Hospital
Changchun, 130033
Changde First People's Hospital
Changde, 415000
The Third Xiangya Hospital of Central South University
Changsha, 410013
Changzhou Second People's Hospital
Changzhou, 213000
Sichuan Provincial People's Hospital
Chengdu, 610072
West China Hospital Sichuan University
Chengdu, 610041
Chifeng Hospital
Chifeng, 024099
2nd Affiliated Hospital Chongqing Medical Universi
Chongqing, 400000
Dalian Municipal Central Hospital Affiliated of Dalian Medical University
Dalian, 116033
Shunde Hospital of Southern Medical Univesity
Foshan, 528399
Guangdong Provincial People's Hospital
Guangzhou, 510000
Guangzhou First People's Hospital
Guangzhou, 510180
Zhejiang Provincial People's Hospital
Hangzhou, 310014
The First Hospital of Harbin Medical University
Harbin, 150001
The Fourth Affiliated Hospital of Harbin Medical University
Harbin, 150001
The Second People's Hospital of Hefei
Hefei, 230011
Inner Mongolia People's Hospital
Hohhot, 010017
Huizhou Municipal Central Hospital
Huizhou, 516001
Jinan Central Hospital
Jinan, 250013
Jingzhou Central Hospital
Jingzhou, 434020
The First Hospital of Lanzhou University
Lanzhou, 730000
Lishui Central Hospital
Lishui
The First Affiliated Hospital of Henan University of Science &Technology
Luoyang, 471000
The First Affiliated Hospital of Henan University of Science &Technology
Luoyang, 471003
The Second Affiliated Hospital of Nanchang University
Nanchang, 330006
The Third Hospital of Nanchang
Nanchang, 330009
Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School
Nanjing, 210000
The Second Affiliated Hospital of Nanjing Medical University
Nanjing, 210011
Guangxi People's Hospital
Nanning, 530021
Nanyang Second General Hospital
Nanyang, 473000
The First Affiliated Hospital of Nanyang Medical College
Nanyang, 473007
The First Affiliated Hospital of Nanyang Medical College
Nanyang
Ningbo First Hospital
Ningbo, 315010
Ruijin Hospital Shanghai Jiaotong University School of Medicine
Shanghai, 200001
Zhongshan Hospital,Fudan University
Shanghai, 200032
Shanghai Putuo District Center Hospital
Shanghai, 200062
Shanghai East Hospital
Shanghai, 200120
Shanghai No. 6 People's Hospital - Jinshan Central Hospital
Shanghai, 201500
The People's Hospital of Liaoning Province
Shenyang, 110000
Shenzhen Sun Yat-sen Cardiovascular Hospital
Shenzhen, 518057
Siping Central People's Hospital
Siping, 136000
The First Affiliated Hospital of Soochow University
Suzhou, 215006
Tianjin Fourth Centre Hospital
Tianjin, 300140
TEDA International Cardiovascular Hospital
Tianjin, 300457
The First Affiliated Hospital of Xinjiang Medical University
Ürümqi, 830054
Chongqing Three Gorges Central Hospital
Wanzhou, 404199
The First Affiliated Hospital of Wenzhou Medical University
Wenzhou, 325000
Wuhan University Medical College - Hubei Zhongshan Hospital
Wuhan, 430000
Wuhan Asia Heart Hospital
Wuhan, 430022
Renmin Hospital of Wuhan University
Wuhan, 430060
Wuxi People's Hospital
Wuxi, 214023
Tangdu Hospital of Fourth Military Medical University of Chinese People's Liberation Army
Xi'an, 710038
The First Affiliated Hospital of Xi'an Jiaotong University
Xi'an, 710061
Shaanxi provincial people's hospital
Xi'an, 710068
Xiamen Cardiovascular Hospital
Xiamen, 361006
The Affiliated Hospital of Xuzhou Medical College
Xuzhou, 221006
General Hospital of Ningxia Medical University
Yinchuan, 750001
The First People's Hospital of Yueyang
Yueyang, 414000
The Second Affiliated Hospital of Zhengzhou University
Zhengzhou, 450014
Zigong First People's Hospital
Zigong, 643000
Argentina55 sites
Clínica Privada del Prado SRL
Alberdi, 5000
Buenos Aires Macula S.A
Buenos Aires, 1061
Instituto Médico Especializado (IME)
Buenos Aires, 1405
Consultorio Medico Dr Litvak Bruno
Buenos Aires, 1406
Consultorio Medico Investigador Principal Dr Besada
Buenos Aires, 1426
Stat Research S.A.
Buenos Aires, C1023AAB
Investigaciones Medicas Imoba Srl
Buenos Aires, C1056ABH
Centro de Investigaciones Metabólicas (CINME)
Buenos Aires, C1056ABI
CIPREC
Buenos Aires, C1061AAS
Fundación favaloro para la Docencia e Investigación Médica
Buenos Aires, C1093AAS
CIPREC
Buenos Aires, C1119ACN
CEMEDIC
Buenos Aires, C1407GTN
Centro Medico Dra. Laura Maffei- Investigacion Clinica Aplicada
Buenos Aires, C1425AGC
Fundación Respirar
Buenos Aires, C1426ABP
Centro Médico Arsema
Buenos Aires, C1427CCL
Glenny Corp. S.A.
Buenos Aires, C1430CKE
CEDIC
CABA, C1060ABN
IDIM - Instituto de Investigaciones Metabólicas
Ciudad de Buenos Aires, C1012AAR
Instituto de Investigaciones Clínicas Córdoba
Córdoba, 5000
Sanatorio Privado Duarte Quirós
Córdoba, 5002
Centro Médico Colón
Córdoba, 5003
CIDIM-Centro Integral de Diagnostico por Imagenes Marchegiani
Córdoba, X5000AVE
Instituto de Cardiología "Juana F. Cabral"
Corrientes, 3400
MICA - Medicina e Investigación Cardiometabólica
Del Viso, 1669
CIPADI - Centro Integral de Prevencion y Atencion en Diabetes
Godoy Cruz, 5501
Centro de Investigaciones Clínicas Baigorria
Granadero Baigorria, 2152
Hospital Italiano de La Plata
La Plata, 1900
CIMeL
Lanus, B1824KAJ
Centro de Investigaciones Médicas Mar del Plata
Mar del Plata, 7600
Instituto de Investigaciones Clínicas Mar del Plata
Mar del Plata, B7600FZO
Instituto de Cardiología Wolff
Mendoza, 5500
Clínica Privada Independencia
Munro, 1605
Centro Privado de Medicina Respiratoria
Paraná, 3100
CER medical Institute
Quilmes, 1878
Instituto De Investigaciones Clinicas Quilmes
Quilmes, 1878
DIM Clínica Privada
Ramos Mejía, B1704ETD
Instituto Médico Río Cuarto
Río Cuarto, X5800AEV
Fundacion Estudios Clinicos
Rosario, 2000
INECO Neurociencias Oroño
Rosario, 2000
Instituto Especialidades de la Salud Rosario
Rosario, 2000
Instituto Médico Catamarca IMEC
Rosario, 2000
Instituto Médico Fundación Grupo Colaborativo Rosario Investigación y Prevención Medica
Rosario, 2000
Instituto de Investigaciones Clinicas Rosario
Rosario, S2000CVD
Laboratorio de Hemostasia y Trombosis
Rosario, S2000DTB
Hospital Provincial del Centenario
Rosario, S2002KDS
Centro Cardiovascular Salta
Salta, 4400
Corporación Médica San Martín
San Martin, 1650
Centro Modelo de Cardiología
San Miguel de Tucumán, 4000
Clínica Mayo de Urgencias Médicas Cruz Blanca S.R.L
San Miguel de Tucumán, 4000
Investigaciones Clínicas Tucumán
San Miguel de Tucumán, 4000
Go Centro Medico San Nicolás
San Nicolás, 2900
Centro de Diagnóstico y Rehabilitación (CEDIR)
Santa Fe, 3000
Clínica de Nefrología, Urología y Enfermedades Cardiovasculares
Santa Fe, 3000
Centro de Investigaciones Clinicas del Litoral
Santa Fe, S3000FWO
Sanatorio San Martin
Venado Tuerto, 2600
Brazil50 sites
Centro de Pesquisa Clinica do Coracao
Aracaju, 49055-530
Instituto Aramari Apo
Asa Norte, 70712-903
Hospital Universitário João de Barros Barreto
Belém, 66073-000
Santa Casa de Misericordia de Belo Horizonte
Belo Horizonte, 30150-221
Freire Pesquisa Clínica
Belo Horizonte, 30150-320
NUPEC - Cardio
Belo Horizonte, 30220-140
AngioKormann Blumenau
Blumenau, 89020-430
L2IP - Instituto de Pesquisas Clínicas
Brasília, 70200730
Instituto D'Or de Pesquisa e Ensino (IDOR) - Filial Brasília
Brasília, 70390-140
Chronos Pesquisa Clínica
Brasília, 72145-450
Instituto de Pesquisa clinica de Campinas
Campinas, 13060-080
Centro de Pesquisa Sao Lucas
Campinas, 13060-803
Quanta Diagnóstico e Terapia
Curitiba, 80040-110
PUC Trials- Nucleo de Pesquisa clinica da Escola de Medicina da PUCPR
Curitiba, 80230-130
Nucleo De Pesquisa Clinica
Curitiba, 80370-150
Universidade Federal de Goias
Goiânia, 74605-020
Centro de Pesquisas Clínicas Dr. Marco Mota
Maceió, 57051-160
Instituto Do Coracao De Marilia
Marília, 17515-000
CHN - Complexo Hospitalar de Niterói
Niterói, 24020-096
Instituto Méderi de Pesquisa e Saúde
Passo Fundo, 99010-120
Hospital de Clinicas de Porto Alegre
Porto Alegre, 90035-903
Hospital Moinhos de Vento
Porto Alegre, 90035001
Núcleo de Pesquisa Clínica do Rio Grande do Sul
Porto Alegre, 90430-001
Hospital São Lucas da PUCRS
Porto Alegre, 90610000
Hospital Nossa Senhora da Conceição
Porto Alegre, 91350-280
CAPED Centro Avancado Pesquisa e Diagnostica
Ribeirão Preto, 14026-020
IBPClin - Instituto Brasil de Pesquisa Clínica
Rio de Janeiro, 20241-180
Ruschel Medicina e Pesquisa Clínica
Rio de Janeiro, 22270-060
Instituto D'Or Pesquisa e Ensino
Rio de Janeiro, 22281-100
Instituto D'Or de Pesquisa e Ensino (IDOR) - Filial Salvador
Salvador, 40170-130
Hospital Ana Nery (HAN) - Salvador
Salvador, 40320-010
Hospital Da Bahia
Salvador, 41810-011
Faculdade de Medicina do ABC
Santo André, 09060-870
Praxis Pesquisa Medica
Santo André, 09790790
Centro Multidisciplinar de Estudos Clinicos
São Bernardo do Campo, 09715-090
Fundação Faculdade Regional de Medicina de São José do Rio Preto
São José do Rio Preto, 15090000
Centro Internacional de Pesquisa Clínica (CIPES)
São José dos Campos, 12230-001
CPQuali Pesquisa Clínica
São Paulo, 01228-000
CPCLIN
São Paulo, 01228-200
BP - A Beneficencia Portuguesa de São Paulo
São Paulo, 01321-001
Hospital Alemao Oswaldo Cruz
São Paulo, 01323-903
Hospital do Coracao
São Paulo, 04003-905
Instituto Dante Pazzanese de Cardiology
São Paulo, 04012-909
IBCC - Núcleo de Pesquisa e Ensino
São Paulo, 04014-002
CEPIC - Centro Paulista de Investigação Clínica
São Paulo, 04266-010
Incor - Instituto do Coracao
São Paulo, 05403-900
Instituto de Molestias Cardiovasculares de Tatui
Tatuí, 18270-170
Eurolatino Pesquisas Medicas
Uberlândia, 38400-500
CEDOES
Vitória, 29055450
Integral Pesquisa e Ensino
Votuporanga, 15502-269
Spain43 sites
CHUAC-Complejo Hospitalario Universitario A Coruña
A Coruña, 15001
Hospital Universitario Fundacion ALcorcon
Alcorcón, 28922
Hospital Germans Trias i Pujol
Badalona, 08916
Parc de Salut Mar - Hospital del Mar
Barcelona, 08003
Hospital Clínic de Barcelona
Barcelona, 08036
Hospital de la Santa Creu i Sant Pau
Barcelona, 08041
Hospital Universitario Reina Sofia
Córdoba, 14004
Hospital de Denia Marina Salud
Denia, 03700
Hospital Clínico Universitario Virgen de la Arrixaca
El Palmar, Murcia, 30120
Complejo Hospitalario Universitario de Ferrol (CHUF)- Hospital Naval
Ferrol, 15405
Hospital de Cabueñes
Gijón, 33394
Hospital Universitari de Girona Doctor Josep Trueta
Girona, 17007
Hospital Universitario Virgen Nieves
Granada, 18014
Hospital Infanta Elena
Huelva, 21007
Hospital Universitario de Jaen
Jaén, 23007
Hospital Universitari de Bellvitge
L'Hospitalet de Llobregat, 08907
Hospital Insular de Gran Canaria
Las Palmas de Gran Canaria, 35016
Hospital Lucus Augusti
Lugo, 27003
FutureMeds - Madrid
Madrid, 28003
Hospital Universitario La Paz
Madrid, 28029
Hospital Universitario Ramón y Cajal
Madrid, 28034
Hospital Clinico San Carlos
Madrid, 28040
Hospital Universitario 12 de Octubre
Madrid, 28041
Hospital Universitario Puerta de Hierro Majadahonda
Majadahonda, 28220
Hospital Universitario Virgen de la Victoria
Málaga, 29010
Hospital Universitari Son Espases
Palma, 07120
Hospital Universitario Quironsalud Madrid
Pozuelo de Alarcón, 28223
Salut Sant Joan de Reus-Baix Camp (Edp)
Reus, 43204
Hospital Universitario de Salamanca - Complejo Asistencial Universitario de Salamanca
Salamanca, 37007
Hospital Virgen del Camino
Sanlúcar de Barrameda, 11540
Hospital de Sant Joan Despí Moisès Broggi
Sant Joan Despí, 08970
Hospital Universitario Marqués de Valdecilla
Santander, 39008
CHUS - Hospital Clinico Universitario
Santiago de Compostela, 15706
Hospital General de Segovia
Segovia, 40002
Hospital Universitario Virgen Macarena
Seville, 41009
FutureMeds - Sevilla
Seville, 41012
Hospital Universitario Virgen Del Rocio
Seville, 41013
Vithas Hospital Sevilla
Seville, 41950
Hospital Clinico de Valencia
Valencia, 46010
Hospital General Universitario de Valencia
Valencia, 46014
Hospital Arnau de Vilanova
Valencia, 46015
Hospital Virgen de las Montañas
Villamartín, 11650
Hospital Universitario Miguel Servet
Zaragoza, 50009
Mexico42 sites
Centro de Investigación Cardiometabólica de Aguascalientes
Aguascalientes, 20230
Fundación Cardiovascular de Aguascalientes A.C.
Aguascalientes, 20230
Hospital Cardiologica Aguescalientes
Aguascalientes, 20230
Enclifar Ensayos Clínicos Farmacológicos Sc
Chihuahua City, 31110
Instituto de Diabetes, Obesidad y Nutricion
Cuernavaca, 62250
Centro Para El Desarrollo de La Medicina Y de Asistencia Medica Especializada S.C.
Culiacán, 80230
Lahoja. Asociacion Para La Investigacion Y La Farmacovigilancia
Durango, 34000
Instituto Jalisciense de Investigacion en Diabetes y Obesidad
Guadalajara, 04460
Diseno y Planeacion en Investigacion Medica
Guadalajara, 44130
Centro de Investigacion Medica Integral
Guadalajara, 44160
Unidad de Investigación Clínica y Atención Médica HEPA S.C.
Guadalajara, 44670
Virgen Cardiovascular Research SC
Guadalajara, 44670
CINVEC Medica
Guadalajara, 44690
Investigación Médica Sonora, S.C.
Hermosillo, 83270
Instituto Cardiovascular de León S.C.
León, 37520
Medical Care and Research SA de CV
Mérida, 97070
Clinstile, S.A. de C.V.
México, 06700
RM Pharma Specialists
Mexico City, 03100
Clínicos Asociados BOCM
Mexico City, 03300
Grupo Medico Camino Sc
Mexico City, 03310
Hospital de Jésus, I.A.P.
Mexico City, 06090
Clinica Omega
Mexico City, 06700
Centro Médico Nacional Siglo XXI
Mexico City, 06720
Centro Especializado En Diabetes, Obesidad Y Prevencion De Enfermedades Cardiovasculares
Mexico City, 11650
ProcliniQ Investigación Clínica SA de CV
Mexico City, 14050
Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Mexico City, 14080
Accelerium Clinical Research
Monterrey, 64000
Cardiolink Clin Trials
Monterrey, 64060
Christus - Latam Hub Center of Excellence and Innovation S.C.
Monterrey, 64060
Hospital Universitario "Dr. Jose Eleuterio Gonzalez"
Monterrey, 64460
UBAM Unidad Biomedica Avanzada Monterrey
Monterrey, 64460
Clínica García Flores SC
Monterrey, 64610
Centro de investigación y control metabólico
Monterrey, 66465
Clinica de Enfermedades Crónicas y de Procedimientos Especiales
Morelia, 58249
Centro de Estudios Clínicos de Querétaro (CECLIQ)
Querétaro, 76000
PanAmerican Clinical Research - Querétaro - Avenida Antea
Querétaro, 76100
Centro de Atención e Investigación Cardiovascular del Potosí
San Luis Potosí City, 78200
Servicios Integrales Nova de Monterrey S.A. de C.V.
San Nicolás de los Garza, 66450
Centro de Investigacion Cardiovascular y Metabólica
Tijuana, 22500
Medimanage Research
Tlalpan, 14050
Instituto Veracruzano en Investigación Clínica S.C.
Veracruz, 91851
Hospital Angeles Xalapa
Xalapa, 91193
Australia32 sites
Nightingale Research
Adelaide, 5000
Advara HeartCare Leabrook
Adelaide, 5068
Paratus Clinical Research Western Sydney
Blacktown, 2148
Emeritus Research
Botany, 2019
Box Hill Hospital
Box Hill, 3128
Royal Brisbane and Women's Hospital
Brisbane, 4029
Core Research Group
Brisbane, 4064
Heart of Australia
Brisbane, 4068
Cholesterol Care
Brisbane, 4102
Paratus Clinical Research Canberra
Bruce, 2617
Emeritus Research
Camberwell, 3124
Victorian Heart Hospital
Clayton, 3168
Barwon Health
Geelong, 3220
Austin Health - Repatriation Hospital
Heidelberg West, 3081
Paratus Clinical Research Brisbane
Herston, 4010
Advara HeartCare Joondalup
Joondalup, 6027
Paratus Clinical Research Central Coast
Kanwal, 2259
Liverpool Hospital
Liverpool, 2170
Logan Hospital
Meadowbrook, 4131
University of the Sunshine Coast (UniSC) Clinical Trials - Meadowbrook
Meadowbrook, 4131
AusTrials - Sunshine
Melbourne, 3021
The AIM Centre / Hunter Diabetes Centre
Merewether, 2291
USC Clinical Trials Moreton Bay
Morayfield, 4506
Advara HeartCare - Mulgrave
Mulgrave, 3170
University of the Sunshine Coast (UniSC) Clinical Trials - Noosa
Noosaville, 4566
Fusion Clinical Research
Norwood, 5067
Royal Perth Hospital
Perth, 6000
USC Clinical Trials Sunshine Coast
Sippy Downs, 4556
USC Clinical Trials Brisbane (South Bank)
South Brisbane, 4101
Momentum St. Leonards
Sydney, 2065
Townsville University Hospital
Townsville, 4814
Clinitrials
West Perth, 6005
Germany32 sites
Universitätsklinikum Aachen
Aachen, 52074
Klinikum am Plattenwald
Bad Friedrichshall, 74177
Zentrum für klinische Studien Bad Homburg
Bad Homburg, 61348
Kardiologische Praxen im Spreebogen
Berlin, 10559
Praxis Rankestrasse
Berlin, 10789
DRK Kliniken Berlin - Köpenick
Berlin, 12559
Charité Campus Virchow-Klinikum
Berlin, 13353
Klinikum Bielefeld Mitte
Bielefeld, 33604
Universitaetsklinikum Koeln
Cologne, 50937
Hausärztlich-Kardiologisches MVZ am Felsenkeller GmbH/Zentrum für klinische Studien
Dresden, 01277
Herzzentrum Dresden GmbH Universitätsklinik
Dresden, 01307
Universitaetsklinikum Carl Gustav Carus Dresden
Dresden, 01307
Medizentrum Essen Borbeck
Essen, 45355
Cardioangiologisches Centrum Bethanien
Frankfurt, 60389
BAG Diabeteszentrum Dr. Tews & Partner
Gelnhausen, 63571
Cardiologicum Hamburg
Hamburg, 22041
Universitaetsklinikum Heidelberg
Heidelberg, 69120
Universitätsklinikum Jena
Jena, 07747
Universitätsklinikum Leipzig
Leipzig, 04103
Herzzentrum Leipzig GmbH
Leipzig, 04289
Praxis Oedeme
Lüneburg, 21339
Otto-von-Guericke-Universität Magdeburg
Magdeburg, 39120
ze:ro ARZTPRAXEN
Mannheim, 68165
Universitätsmedizin Mannheim
Mannheim, 68167
Deutsches Herzzentrum München
Munich, 80636
Institut für Diabetesforschung GmbH Münster
Münster, 48145
Kardiologische Gemeinschaftspraxis am Park Sanssouci
Potsdam, 14471
Universitätsklinikum Regensburg
Regensburg, 93053
Universitaet zu Koeln - Sana-Klinikum Remscheid GmbH - Klinik fuer Kardiologie, Pneumologie und Internisti -T
Remscheid, 42859
GPR Gesundheits- und Pflegezentrum Rüsselsheim
Rüsselsheim am Main, 65428
Zentrum für klinische Studien
Saint Ingbert, 66386
Studienzentrum Herzklinik Ulm MVZ
Ulm, 89077
Poland31 sites
Specderm Poznanska sp.j.
Bialystok, 15-375
NZOZ Centrum Medyczne KERmed
Bydgoszcz, 85-231
Centrum Medyczne INTERCOR Sp. z o.o.
Bydgoszcz, 85-605
Polsko-Amerykańskie Kliniki Serca PAKS Małopolskie Centrum Sercowo-Naczyniowe
Chrzanów, 32-500
Polsko-Amerykańskie Kliniki Serca
Dąbrowa Górnicza, 41-300
Centrum Kliniczno-Badawcze
Elblag, 82-300
NZOZ Twoje Zdrowie EL Sp. z o. o.
Elblag, 82-300
Uniwersyteckie Centrum Kliniczne
Gdansk, 80-952
Przychodnie Grudziądz
Grudziądz, 86-300
NZOZ Salvia CM
Katowice, 40-772
Polsko-Amerykańskie Kliniki Serca
Kędzierzyn-Koźle, 47-200
Centrum Medyczne Linden
Krakow, 30-105
Medyczne Centrum Diabetologiczno Endokrynologiczno Metaboliczne DIAB-ENDO-MET
Krakow, 31-261
Poliklinika Kardiologiczna Serce
Leszno, 64-100
Centra Medyczne Medyceusz
Lodz, 91-053
Pro Salus Centrum Medyczne
Lodz, 91-473
Instytut Centrum Zdrowia Matki Polki
Lodz, 93-338
Clinical Best Solutions
Lublin, 20-011
1 Wojskowy Szpital Kliniczny w Lublinie
Lublin, 20-043
CenterMed Lublin NZOZ
Lublin, 20-044
Private Practice - Dr. Michał Tomaszewski
Lublin, 20-068
Wielospecjalistyczny Szpital Samodzielny Publiczny Zakład Opieki Zdrowotnej w Nowej Soli
Nowa Sól, 67-100
Wojewodzki Szpital im. Sw. Ojca Pio w Przemyslu
Przemyśl, 37-700
AKA-MED Centrum
Ruda Śląska, 41-710
Centrum Szybkiej Diagnostyki Kardiologicznej "Kardiomed" M. Żabówka E. Żabówka
Tarnów, 33-100
Polsko-Amerykańskie Kliniki Serca
Tychy, 43-100
Clinical Best Solutions
Warsaw, 00-710
Balsam Medica
Warsaw, 01-249
Medical Network Spółka z o.o. WIP Warsaw IBD Point Profesor Kierkuś
Warsaw, 04-501
4 Wojskowy Szpital Kliniczny z Polikliniką SPZOZ
Wroclaw, 50-981
NZOZ Centurm Medyczne SERAFIN-MED
Żarów, 58-130
Netherlands30 sites
Meander Medisch Centrum
Amersfoort, 3813 TZ
Amsterdam UMC, locatie AMC
Amsterdam, 1105 AZ
Gelre Ziekenhuis
Apeldoorn, 7334 DZ
Rode Kruis Ziekenhuis
Beverwijk, 1942 LE
Reinier de Graaf Ziekenhuis, locatie Delft
Delft, 2625 AD
Deventer Ziekenhuis
Deventer, 7416 SE
Slingeland Ziekenhuis
Doetinchem, 7009 BL
Ziekenhuis Gelderse Vallei
Ede, 6716 RP
Catharina Ziekenhuis
Eindhoven, 5623 EJ
Admiraal de Ruyter Ziekenhuis, locatie Goes
Goes, 4462 RA
Groene Hart Ziekenhuis
Gouda, 2803HH
General Practitioners Research Institute (GPRI)
Groningen, 9713 GH
Martini Ziekenhuis
Groningen, 9728 NT
Spaarne Gasthuis, Haarlem Zuid
Haarlem, 2035 RC
Saxenburgh Medisch Centrum
Hardenberg, 7772 SE
Ziekenhuis St. Jansdal
Harderwijk, 3844 DG
Tergooiziekenhuizen, locatie Hilversum
Hilversum, 1212 VG
Medische Centrum Leeuwarden
Leeuwarden, 8934 AD
Leids Universitair Medisch Centrum
Leiden, 2333 ZA
Radboudumc
Nijmegen, 6525 GA
Bravis Ziekenhuis, locatie Roosendaal
Roosendaal, 4708 AE
Erasmus Medisch Centrum
Rotterdam, 3015 GD
Ikazia Ziekenhuis
Rotterdam, 3083 AN
Antonius Ziekenhuis, locatie D&A Research and Genetics
Sneek, 8601 ZR
Haga Ziekenhuis locatie Leyweg
The Hague, 2545 AA
ETZ TweeSteden
Tilburg, 5042 AD
Universitair Medisch Centrum Utrecht
Utrecht, 3584 CX
Maxima Medisch Centrum, locatie Veldhoven
Veldhoven, 5504 DB
VieCuri Medisch Centrum, locatie Venlo
Venlo, 5912 BL
Zaans Medisch Centrum
Zaandam, 1502 DV
Canada27 sites
Cardio Health Clinical Trial - Brampton
Brampton, L6Y 6H4
Ecogene-21
Chicoutimi, G7H 7K9
Premier Clinical Trial Network
Hamilton, L8L5G4
Diex Recherche Inc. Division Joliette
Joliette, J6E 6A9
Milestone Research Inc.
London, N5W 6A2
Cardio Health Clinical Trial - London
London, N6H 5L4
Viacar Recherche Clinique
Longueuil, J4H 4B9
G A Research Associates
Moncton, E1G 1A7
Fraser Clinical Trials Inc
New Westminster, V3L 3W4
The Medical Arts Health Research Group
North Vancouver, V7P 2T4
North York Diagnostic and Cardiac Centre
North York, M6B 3H7
Oakville Cardiovascular Research LP
Oakville, L6K 3W7
Medical Arts Health Research Group
Penticton, V2A 5L5
Clinique des Maladies Lipidiques de Québec
Québec, G1V 4W2
ALPHA Recherche Clinique
Québec, G3K 2P8
Unité de Recherche Clinique du CISSS des Laurentides
Saint-Jérôme, J7Z 2V4
Cardio Health Clinical Trial - St. Thomas
St. Thomas, N5R 2R4
SMH Cardiology Clinical Trials
Surrey, V3V 0C6
Care Access - Cape Breton
Sydney, B1M 0A1
Centre de Medecine Metabolique de Lanaudiere (CMML)
Terrebonne, J6X 4P7
Corcare
Toronto, M1B 5N1
Diabetes Heart Research Centre
Toronto, M6G 1M2
Diex Recherche Inc. Division Trois-Rivieres
Trois-Rivières, G9A 4P3
ARC Biosystems
Vancouver, V6Z 2H2
Victoria Heart Institute Foundation
Victoria, V8R 1B2
Discovery Clinical Services
Victoria, V8T 5G4
Winnipeg Clinic
Winnipeg, R3C 0N2
France25 sites
Hôpital Avicenne
Bobigny, 93000
Hospices Civils de Lyon - Hopital Louis Pradel
Bron, 69677
CHRU Troussau
Chambray-lès-Tours, 37170
Centre Hospitalier Compiègne-Noyon
Compiègne, 60200
Centre Hospitalier Universitaire Dijon Bourgogne - Hôpital François Mitterrand
Dijon, 21079
Centre Hospitalier Louis Pasteur
Le Coudray, 28630
Hopital Claude Huriez - CHU de Lille
Lille, 59037
Centre Hospitalier Saint Joseph - Saint Luc
Lyon, 69007
Hôpital de la Conception
Marseille, 13005
Hôpital Saint Joseph
Marseille, 13285
CHU Montpellier Lapeyronie Hospital
Montpellier, 34295
Hôpital Nord Guillaume-et-René-Laennec / CHU de Nantes
Nantes, 44093
Centre Hospitalier Universitaire de Nice - Hopital Pasteur
Nice, 06000
Centre Hospitalier Universitaire de Nîmes - Hôpital Universitaire Carémeau
Nîmes, 30029
Pitie Salpetriere University Hospital
Paris, 75013
Hôpital Européen Georges Pompidou
Paris, 75015
Hôpital Bichat - Claude-Bernard
Paris, 75018
Hôpital Saint Antoine
Paris, 75571
Centre Hospitalier de Pau
Pau, 64000
CHU Bordeaux Haut-Leveque
Pessac, 33600
Centre Hospitalier Universitaire de Rennes - Hôpital Pontchaillou
Rennes, 35033
CHU Charles Nicolle
Rouen, 76031
CHU Strasbourg-Hautepierre
Strasbourg, 67098
CHU Rangueil
Toulouse, 31059
Polyclinique Vauban
Valenciennes, 59300
Czechia22 sites
MEDICUS SERVICES s.r.o., kardiologicka ambulance
Brandýs nad Labem, 250 01
Fakultni Nemocnice u sv. Anny v Brne
Brno, 60200
Kardiologická ambulance Brno
Brno, 612 00
EFERTUS healthcare s.r.o.
Brno, 615 00
Vojenská Nemocnice Brno
Brno, 636 00
Fakultni Nemocnice u sv. Anny v Brne
Brno, 656 91
Kardiologicka ambulance
Litovel, 784 01
EDUMED - Náchod
Náchod, 547 01
Agentura Science Pro
Olomouc, 779 00
PreventaMed
Olomouc, 779 00
Kardiologicka a Angiologicka Ambulance
Ostrava, 700 30
Private Practice - Dr. Miroslav Koliba
Ostrava, 702 00
Kardio Uhrineves
Prague, 104 00
Synexus Czech
Prague, 120 00
Angiocentrum Komorany
Prague, 143 00
Nefrologie
Prague, 149 00
Poliklinika Lípa Centrum
Prague, 158 00
Centrum Kardiovaskularni Mediciny
Prague, 169 00
Nova kardiologie - Kardiologicka ambulance
Říčany, 251 01
Kardiologicka ambulance MUDr. Ferkl s.r.o.
Trutnov, 541 01
Clinical Trials Service s.r.o.
Uherské Hradiště, 686 01
Cardio Research, s.r.o
Zlín, 760 01
Romania20 sites
CMI Cardiologie - Dr. Mercea Corina Delia
Baia Mare, 430124
C.M.D.T.A. Neomed
Brasov, 500283
Nicodiab
Bucharest, 010507
Hightech Medical Services SRL-Centrul pentru Studiul Metabolismului
Bucharest, 011053
Centrul Medical NutriLife
Bucharest, 013764
Spitalul Universitar de Urgență București
Bucharest, 050098
Centrul Medical Endocrinologie si Diabet Dr. Paveliu
Bucharest, 50538
Mat Cord Biomedica S.R.L.
Buzău
Diamed Obesity
Galați, 800291
Centrul Medical Consultmed
Iași, 700547
Cardiomed Iași
Iași, 700687
Clinica Korall
Satu Mare, 440055
Gensan S.R.L. - Policlinica Astra Sibiu
Sibiu, 550371
SC Dentosim Queen SRL - Centrul Medical Diamed
Târgu Mureş, 540098
Cardiomed
Târgu Mureş, 540124
Centrul Medical Mediab
Târgu Mureş, 540142
Mediab S.R.L.
Târgu Mureş, 540142
Private Practice - Dr. Cristian Podoleanu
Târgu Mureş, 540143
Cabinet Medical Dr.Geru
Timișoara, 300288
Institutul de Boli Cardiovasculare Timișoara
Timișoara, 300310
South Korea20 sites
The Catholic University of Korea, Bucheon St. Mary's Hospital
Bucheon-si, 14647
Daegu Catholic University Medical Center
Daegu, 42472
Keimyung University Dongsan Hospital
Daegu, 42601
Eulji University Hospital
Daejeon, 01830
Boramae Medical Center
Dongjak-gu, 07061
Chonnam National University Hospital
Gwangju, 61469
Gachon University Gil Medical Center
Namdong-gu, 21565
Seoul National University Bundang Hospital
Seongnam, 13620
Kyung Hee University Hospital
Seoul, 02447
Korea University Anam Hospital
Seoul, 02841
Seoul National University Hospital
Seoul, 03080
Kangbuk Samsung Hospital
Seoul, 03181
Severance Hospital, Yonsei University Health System
Seoul, 03722
Asan Medical Center
Seoul, 05505
The Catholic Univ. of Korea Seoul St. Mary's Hospital
Seoul, 06591
Korea University Guro Hospital
Seoul, 08308
Kyung Hee University Hospital at Gangdong
Seoul, 134-090
Sejong General Hospital
Sosa-gu, 14754
The Catholic University Of Korea St. Vincent's Hospital
Suwon, 16247
Ulsan University Hospital
Ulsan, 44033
Belgium18 sites
ZAS Middelheim
Antwerp, 2020
Imelda General Hospital
Bonheiden, 2820
Algemeen Ziekenhuis klina
Brasschaat, 2930
Centre Hospitalier Universitaire Brugmann
Brussels, 1020
Université Libre de Bruxelles - Hôpital Erasme
Brussels, 1070
Cliniques universitaires Saint-Luc
Brussels, 1200
Grand Hôpital de Charleroi
Charleroi, 6060
AZ Sint-Blasius
Dendermonde, 9200
Antwerp University Hospital
Edegem, 2650
Ziekenhuis Oost-Limburg, Campus St.-Jan
Genk, 3600
AZ Maria Middelares
Ghent, 9000
UZ Gent
Ghent, 9000
Jessa Ziekenhuis
Hasselt, 3500
AZ Groeninge Campus Kennedylaan
Kortrijk, 8500
UZ Leuven
Leuven, 3000
AZ Sint-Maarten
Mechelen, 2800
AZ Oostende vzw
Ostend, 8400
AZ Delta vzw
Roeselare, 8800
United Kingdom17 sites
Layton Medical Centre
Blackpool, FY3 7EN
Bristol Royal Infirmary
Bristol, BS2 8HW
Cheadle Community Hospital
Cheadle, ST10 1NS
Panthera Biopartners - North London
Enfield, EN3 4GS
Panthera Biopartners - Glasgow
Glasgow, G51 4RY
Hull Royal Infirmary
Hull, HU3 2JZ
Royal Free Hospital
London, NW32QG
Royal Victoria Infirmary
Newcastle upon Tyne, NE1 4LP
Panthera Biopartners - Preston
Preston, PR2 9QB
Panthera Biopartners - Manchester
Rochdale, OL11 4AU
Salford Royal Hospital
Salford, M6 8HD
Panthera Biopartners - Sheffield
Sheffield, S2 5FX
Lister Hospital
Stevenage, SG1 4AB
Torbay Hospital
Torquay, TQ2 7AA
Sunderland Royal Hospital
Tyne and Wear, SR4 7TP
Sandwell General Hospital
West Bromwich, B71 4HJ
Panthera Clinic - York
York, YO24 4LJ
Israel16 sites
Emek Medical Center
Afula, 1834111
Soroka Medical Center
Beersheba, 8410101
Rambam Health Care Campus
Haifa, 3109601
Carmel Hospital
Haifa, 3436212
Linn Medical Center
Haifa, 3515209
Edith Wolfson Medical Center
Holon, 5810001
Shaare Zedek Medical Center
Jerusalem, 9013102
Hadassah Medical Center
Jerusalem, 9112001
Meir Medical Center
Kfar Saba, 4428164
Galilee Medical Center
Nahariya, 2210001
Rabin Medical Center
Petah Tikva, 4941492
Sheba Medical Center
Ramat Gan, 5262100
Sheba Medical Center
Ramat Gan, 5265601
Kaplan Medical Center
Rehovot, 7610001
Clalit Health Services - Sakhnin Community Clinic
Sakhnin, 3081000
Sourasky Medical Center
Tel Aviv, 6423906
Austria15 sites
Krankenhaus St. Josef Braunau
Braunau am Inn, 5280
VIVIT
Feldkirch, 6800
Medizinische Universitaet Innsbruck
Innsbruck, 6020
Ordensklinikum Linz GmbH Elisabethinen
Linz, 4020
Konventhospital der Barmherzigen Brüder Linz
Linz, 4021
Landesklinikum Mistelbach
Mistelbach, 2130
Uniklinikum Salzburg
Salzburg, 5020
Universitätsklinikum St. Pölten
Sankt Pölten, 3100
Klinik Landstraße
Vienna, 1030
Zentrum für klinische Studien Dr Hanusch Gmbh
Vienna, 1060
Medizinische Universität Wien
Vienna, 1090
Universitaetsklinikum Allgemeines Krankenhaus Wien
Vienna, 1090
Klinik Hietzing
Vienna, 1130
Herz Zentrum Währing - Innere Medizin und Kardiologie | Alle Kassen und Privat
Vienna, 1180
Klinik Floridsdorf
Vienna, 1210
Taiwan15 sites
Changhua Christian Hospital
Changhua County, 50006
Kaohsiung Medical University Chung-Ho Memorial Hospital
Kaohsiung City, 807
Chang Gung Memorial Hospital at Kaohsiung
Kaohsiung Niao Sung Dist, 83301
Fu Jen Catholic University Hospital
New Taipei City, 24352
Chung Shan Medical University Hospital
Taichung, 402
National Cheng Kung University Hospital
Tainan, 704
Chi Mei Medical Center
Tainan, 71004
National Taiwan University Hospital
Taipei, 10002
Cathay General Hospital
Taipei, 106
Taipei Medical University Hospital
Taipei, 110
Shin Kong Wu Ho-Su Memorial Hospital
Taipei, 111
Taipei Veterans General Hospital
Taipei, 11217
Tri-Service General Hospital
Taipei, 114
Chang Gung Medical Foundation-Linkou Branch
Taoyuan, 333
National Yang Ming Chiao Tung University Hospital
Yilan, 260006
Italy14 sites
Ospedale Cazzavillan di Arzignano
Arzignano, 36071
Ospedale di Baggiovara
Baggiovara, 41126
IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico di Sant'Orsola
Bologna, 40138
Ospedale Bassini
Cinisello Balsamo, 20092
Azienda Ospedaliero Universitaria S.Anna
Ferrara, 44100
Azienda Ospedaliera Universitaria Careggi
Florence, 50134
Ospedale San Martino
Genova, 16132
Centro Cardiologico Monzino
Milan, 20138
ASST Grande Ospedale Metropolitano Niguarda
Milan, 20162
Ospedale San Raffaele
Milan, 20132
Azienda Ospedale - Università Padova
Padova, 35128
Hospital Santa Maria della Misericordia in Perugia
Perugia, 06156
Fondazione G. Monasterio
Pisa, 56124
AOU Policlinico Umberto I
Rome, 00161
Slovakia14 sites
Cliniq s.r.o.
Bratislava, 81109
ENDIAMED s.r.o
Dolný Kubín, 026 01
JM-Interna s.r.o
Dolný Kubín, 02601
NEDÚ - Národný endokrinologický a diabetologický ústav n.o.
Ľubochňa, 034 91
IN-DIA
Lučenec, 984 01
Sin Azucar
Malacky, 901 01
AMBORA s.r.o. Interna ambulancia
Martin, 036 01
Fakultná nemocnica Nitra
Nitra, 950 01
MEDIKALS
Piešťany, 921 01
MEDISPOL
Prešov, 080 01
ENRIN, s.r.o.
Rimavská Sobota, 979 01
Tatratrial s.r.o.
Rožňava, 04801
Areteus s.r.o.
Trebišov, 075 01
MediPrax, s.r.o.
Trstená, 028 01
India10 sites
KLES Dr. Prabhakar Kore Hospital & M.R.C
Belagavi, 590010
Sardar Patel Medical College
Bikaner, 334001
Shri Mahant Indiresh Hospital
Dehradun, 248001
K care Hospital
Kanpur, 208001
Lisie Hospital
Kochi, 682018
Government Medical College - Kozhikode
Kozhikode, 673008
King George's Medical University
Lucknow, 226003
Vijan Hospital & Research Centre
Nashik, 422005
G.B. Pant Institute of Postgraduate Medical Education & Research
New Delhi, 110002
All India Institute of Medical Sciences
Raipur, 492099
Denmark9 sites
Sygehus Sønderjylland i Aabenraa
Aabenraa, 6200
Aarhus Universitetshospital, Skejby
Aarhus, 8200
Rigshospitalet
Copenhagen, 2100
Esbjerg sygehus, Syddansk Universitetshospital
Esbjerg, 6700
Sanos Clinic - Nordjylland
Gandrup, 9362
Herlev and Gentofte Hospital
Herlev, 2730
Sanos Clinic
Herlev, 2730
Holbæk Sygehus
Holbæk, 4300
Sanos Clinic - Syddanmark
Vejle, 7100
Greece9 sites
Athens Naval Hospital
Athens, 11521
General Hospital of Athens Laiko
Athens, 11527
Athens Medical Center
Athens, 151 25
Attikon General University Hospital
Chaïdári, 12462
University General Hospital of Heraklion
Heraklion, 71110
University Hospital of Ioannina
Ioannina, 45500
Iatriko Paleou Falirou Medical Center
Palaió Fáliro, 17562
Papageorgiou General Hospital of Thessaloniki
Thessaloniki, 564 03
European Interbalkan Medical Center
Thessaloniki, 570 01
Hungary8 sites
DRC Gyógyszervizsgáló Központ
Balatongyörök, 8313
Semmelweis University
Budapest, 1122
Privát Doktor Egészségügyi Zrt
Budapest, 1132
Eszak-Pesti Centrumkorhaz-Honvedkorhaz
Budapest, 1143
Debreceni Egyetem Klinikai Kozpont
Debrecen, 4032
Medifarma 98 Kft
Nyíregyháza, 4400
Szegedi Tudományegyetem Szent-Györgyi Albert Klinikai Központ
Szeged, 6725
Vita Verum Medical Egeszsegugyi Szolgaltato
Székesfehérvár, 8000
Puerto Rico2 sites
Advanced Clinical Research, LLC
Bayamón, 00959
GCM Medical Group, PSC - Hato Rey Site
San Juan, 00917
About this study
Official title: A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Investigate the Effect of Lepodisiran on the Reduction of Major Adverse Cardiovascular Events in Adults With Elevated Lipoprotein(a) Who Have Established Atherosclerotic Cardiovascular Disease or Are at Risk for a First Cardiovascular Event - ACCLAIM-Lp(a)
The purpose of this study is to evaluate the efficacy of lepodisiran in reducing cardiovascular risk in participants with high lipoprotein(a) who have cardiovascular disease or are at risk of a heart attack or stroke. The study drug will be administered subcutaneously (SC) (under the skin). Approximately 1700 additional participants will be enrolled in an addendum to explore Lp(a) lowering with an alternative dosing schema.
- Being tested
- Lepodisiran Sodium, Placebo
- Keywords
- ASCVD, LY3819469, lepodisiran
- Medical subject headings
- Atherosclerosis
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Lepodisiran SodiumDrug
Also called LY3819469
Administered SC
PlaceboDrug
Administered SC
| Study group | Role | What they receive |
|---|---|---|
| Lepodisiran Sodium | Experimental | Lepodisiran sodium administered subcutaneously (SC). Receives: Drug: Lepodisiran Sodium |
| Placebo | Placebo comparator | Placebo administered SC. Receives: Drug: Placebo |
What is being measured
The primary outcome is the main question the study is designed to answer.
Time to First Occurrence of Any Component of the Major Adverse Cardiac Event (MACE)-4 Composite Endpoint
Time to first event in a MACE-4 composite endpoint, comprised of cardiovascular death, nonfatal myocardial infarction, nonfatal ischemic stroke, and urgent coronary revascularization.
Measured: Baseline up to End of Study (About 4.5 Years)
Secondary outcomes (10)
Change from Baseline in Lipoprotein(a) [Lp(a)] at Week 4
Change from Baseline in Lp(a)
Measured: Baseline, Week 4
Time to First Occurrence of Any of the Component of MACE-3 Composite Endpoint
Time to first occurrence MACE-3
Measured: Baseline up to End of Study (About 4.5 Years)
Time to First Occurrence of Fatal or Non-Fatal Myocardial Infarction
Time to first occurrence of fatal or non-fatal myocardial infarction.
Measured: Baseline up to End of Study (About 4.5 Years)
Time to Cardiovascular Death
Time to cardiovascular death.
Measured: Baseline up to End of Study (About 4.5 Years)
Time to Occurrence of All-Cause Death
Time to occurrence of all-cause death
Measured: Baseline up to End of Study (About 4.5 Years)
Time to First Occurrence of Any Component of the MACE-4 Composite Endpoint (In the Population with Established ASCVD and CV Event, or Revascularization)
Time to first occurrence of any component of the MACE-4 composite endpoint.
Measured: Baseline up to End of Study (About 4.5 Years)
Time to First Occurrence of any Component of the MACE-4 Composite Endpoint (In the Population At Risk for First CV event)
Time to first occurrence of any component of the MACE-4 composite endpoint.
Measured: Baseline up to End of Study (About 4.5 Years)
Time to First Occurrence of any Component of the MACE-4 Composite Endpoint (In the Population with Lp(a) ≥ 200 nmol/L)
Time to first occurrence of any component of the MACE-4 composite endpoint.
Measured: Baseline up to End of Study (About 4.5 Years)
Time to First Occurrence of Any Component of MACE-3 + MALE Composite Endpoint
Time to first occurrence of any component of MACE-3 + MALE composite endpoint.
Measured: Baseline up to End of Study (About 4.5 Years)
Time to First Occurrence of Any Component of Coronary MACE-3 Composite Endpoint
Time to first Occurrence of any component of coronary MACE-3 composite endpoint.
Measured: Baseline up to End of Study (About 4.5 Years)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted4 Mar 2024
- Study start5 Mar 2024
- Primary completionMar 2029 (estimated)
- Study completionMar 2029 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (3)Papers the sponsor has linked to this study.
- Other trials for Atherosclerotic Cardiovascular Disease (ASCVD)Studies of the same condition, open and under way.
- More trials run by Eli Lilly and CompanyThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase 3
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind
- Who is masked
- Participant, Investigator
- Enrolment
- 17,300 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Eli Lilly and Company
- Sponsor type
- Industry (pharma, biotech, devices)
- Responsible party
- Sponsor
- Investigators
- Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 8 AM - 8 PM Eastern time (UTC/GMT - 5 hours, EST), Study director, Eli Lilly and Company
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06292013
- Sponsor's protocol ID
- 18812
- Other IDs
- J3L-MC-EZEF, 2023-509190-23, 2023
- Status last verified
- Oct 2026
- First submitted
- 27 Feb 2024
- Last updated
- 8 Oct 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- Yes
- FDA-regulated device
- No
- Individual data sharing
- Yes: Anonymized individual patient level data will be provided in a secure access environment upon approval of a research proposal and a signed data sharing agreement.
Publications
Byambaa E, Roshanravan B, Berglund L. Lipoprotein(a) and CKD: Insights into New Therapeutic Opportunities. Clin J Am Soc Nephrol. 2026 Aug 1;21(8):1469-1481. doi: 10.2215/CJN.0000000968. Epub 2025 Dec 2.
PubMed 41329869Nicholls SJ. Therapeutic lowering of lipoprotein(a): implications for improving outcomes in patients with peripheral arterial disease. Curr Opin Lipidol. 2025 Oct 1;36(5):232-237. doi: 10.1097/MOL.0000000000001002. Epub 2025 Jul 21.
PubMed 40699211Nicholls SJ, Nelson AJ, Michael LF. Oral agents for lowering lipoprotein(a). Curr Opin Lipidol. 2024 Dec 1;35(6):275-280. doi: 10.1097/MOL.0000000000000953. Epub 2024 Sep 25.
PubMed 39329200