Atherosclerotic Cardiovascular Disease (ASCVD)Phase 3NCT06383390
The Effect of Retatrutide Once Weekly on Cardiovascular Outcomes and Kidney Outcomes in Adults Living With Obesity (TRIUMPH-Outcomes)
A Phase 3 study testing Retatrutide in people with Atherosclerotic Cardiovascular Disease (ASCVD) and Chronic Kidney Disease (CKD), run by Eli Lilly and Company at 742 sites in 27 countries.
Trial summary
The main purpose of this study is to determine if retatrutide can significantly lower the incidence of serious heart-related complications or prevent the worsening of kidney function. Read more about this study
- Who is it for?
- Ages 45 years and older
- Conditions the study is for
- Atherosclerotic Cardiovascular Disease (ASCVD), Chronic Kidney Disease (CKD)
- What is being tested?
- Retatrutide
- Type of treatment
- Injection or infusion
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 10,000 participants
- Where
- 742 sitesin 27 countries
- Study dates
- 30 Apr 2024to Feb 2029
- Phase
- Phase 3
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 45 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Participants may be without type 2 diabetes (T2D), or with T2D if their hemoglobin A1c (HbA1c) is 10% or lower
- Participants have established atherosclerotic cardiovascular disease (ASCVD) and/or chronic kidney disease (CKD), as evidenced at least one of the following:
- Coronary artery disease
- Cerebrovascular disease
- Peripheral arterial disease
- Chronic kidney disease defined as:
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- eGFR <45 millilitres/minute/1.73 meter squared (mL/min/1.73m^2) and UACR >30 milligram/gram (mg/g) (0.030 mg/mg)
- eGFR <60 mL/min/1.73 m^2 and UACR >100 mg/g (0.100 mg/mg), or
- eGFR <75 mL/min/1.73 m^2 and UACR >300 mg/g (0.300 mg/mg) (eGFR is calculated by central lab based on Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) creatinine-cystatin c equation as determined by central lab)
- A Body Mass Index of ≥27.0 kilograms per meter squared (kg/m^2)
Who cannot join
- Diabetes related:
- Participants have Type 1 Diabetes or any history of diabetic ketoacidosis
- CV related:
- Participants have any of the following cardiovascular conditions ≤ 90 days prior to randomization:
- Myocardial infarction
- Acute coronary syndrome
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- Stroke, or
- Coronary, peripheral, or carotid artery arterial revascularization procedure.
- Have acute decompensated heart failure requiring hospitalization.
- Have New York Heart Association (NYHA) Classification Class IV heart failure at screening
- Kidney related:
- Participants have an eGFR <20 mL/min/1.73 m^2 at screening
- Have UACR >5000 mg/g (5.000 mg/mg) at screening
- Have received any form of dialysis ≤ 90 days from the date of randomization
- Have either undergone a kidney transplant or have a transplant procedure scheduled
- Other medical conditions:
- Participants have had or plan to have a surgical treatment for obesity,
- Have a history of chronic or acute pancreatitis
- Have a family or personal history of medullary thyroid carcinoma or multiple endocrine neoplasia (MEN) syndrome type 2
- Have a known clinically significant gastric emptying abnormality, such as severe gastroparesis or gastric outlet obstruction
Trial locations and contacts
742 sites in 27 countries.
742 sites in 27 countries
United States204 sites
American Clinical Trials - Acworth
Acworth, Georgia, 30101
Alabama Kidney Research
Alabaster, Alabama, 35007
Albany Medical College, Division of Community Endocrinology
Albany, New York, 12203
Capital Cardiology Associates
Albany, New York, 12211
Omega Research Orlando
Altamonte Springs, Florida, 32714
Trident Clinical Research Services, Inc.
Apple Valley, California, 92307
Western Nephrology
Arvada, Colorado, 80002
Atlanta Diabetes Associates
Atlanta, Georgia, 30318
Emory University School of Medicine
Atlanta, Georgia, 30322
Fides Clinical Research
Atlanta, Georgia, 30342
Southeastern Clinical Research Institute
Augusta, Georgia, 30904
University of Colorado Anschutz Medical Campus
Aurora, Colorado, 80045
IMA Clinical Research Austin
Austin, Texas, 78745
Invivo - Bakersfield
Bakersfield, California, 93309
Sinai Hospital Of Baltimore
Baltimore, Maryland, 21209
Care Access - Baltimore
Baltimore, Maryland, 21213
Ascension Saint Agnes Heart Care
Baltimore, Maryland, 21229
MedStar Good Samaritan Hospital
Baltimore, Maryland, 21239
Heritage Valley Multispecialty Group, Inc
Beaver, Pennsylvania, 15009
Jadestone Clinical Research
Beltsville, Maryland, 20705
Northeast Clinical Research Center
Bethlehem, Pennsylvania, 18017
American Institute of Research
Beverly Hills, California, 90211
Central Research Associates
Birmingham, Alabama, 35205
Excel Medical Clinical Trials
Boca Raton, Florida, 33434
Qualmedica Research
Bowling Green, Kentucky, 42101
Headlands Research - Brownsville
Brownsville, Texas, 78526
Mercury Street Medical Group, PLLC
Butte, Montana, 59701
Capital Area Research, LLC
Camp Hill, Pennsylvania, 17011
Hope Clinical Research, Inc.
Canoga Park, California, 91303
Medical University of South Carolina
Charleston, South Carolina, 29425
Great Lakes Clinical Trials - Ravenswood
Chicago, Illinois, 60640
StudyMetrix Research
City of Saint Peters, Missouri, 63303
Alpine Research Organization
Clinton, Utah, 84015
South Texas Clinical Research
Corpus Christi, Texas, 78404
Private Practice - Dr. Osvaldo A. Brusco
Corpus Christi, Texas, 78414
Valley Clinical Trials, Inc.
Covina, California, 91723
American Research Institute
Cutler Bay, Florida, 33157
Baylor Soltero CV Research Center
Dallas, Texas, 75226
Velocity Clinical Research, Dallas
Dallas, Texas, 75230
North Texas Endocrine Center
Dallas, Texas, 75231
Renal Disease Research Institute
Dallas, Texas, 75246
UT Southwestern Medical Center
Dallas, Texas, 75390-9302
Geisinger Medical Center
Danville, Pennsylvania, 17822
Alliance for Multispecialty Research, LLC
Daphne, Alabama, 36526
Revival Research Institute, LLC
Dearborn, Michigan, 48126
Soma Clinical Trials
Denison, Texas, 75020
American Clinical Trials - Douglasville
Douglasville, Georgia, 30134
South Texas Research Institute
Edinburg, Texas, 78539
Medresearch Inc
El Paso, Texas, 79902-4646
North Coast Cardiology
Encinitas, California, 92024
Neighborhood Healthcare Institute of Health
Escondido, California, 92025
Qualmedica Research, LLC
Evansville, Indiana, 47715
The University of Kansas - Clinical Research Center
Fairway, Kansas, 66205
NECCR PrimaCare Research
Fall River, Massachusetts, 02721
Care Access - Fayetteville
Fayetteville, North Carolina, 28314
Fleming Island Center for Clinical Research
Fleming Island, Florida, 32003
Jellinger and Lerman, MD PA dba The Center for Diabetes and Endocrine Care
Fort Lauderdale, Florida, 33312
Florida Kidney Physicians - Fort Lauderdale
Fort Lauderdale, Florida, 33316
Nephrology Associates of Northern Illinois and Indiana (NANI) - Fort Wayne
Fort Wayne, Indiana, 46804
Diabetes and Thyroid Center of Ft. Worth
Fort Worth, Texas, 76132
Valley Institute of Research - Fort Worth
Fort Worth, Texas, 76164
HB Clinical Trials - Fountain Valley
Fountain Valley, California, 92708
Anderson Medical Research
Ft. Washington, Maryland, 20744
Center for Advanced Research & Education
Gainesville, Georgia, 30501
Prime Medical Group, LLC dba Gilbert Center for Family Medicine, LLC
Gilbert, Arizona, 85296
Sun City Clinical Research
Glendale, Arizona, 85304
Arizona Kidney Disease & Hypertension Center (AKDHC) - Thunderbird
Glendale, Arizona, 85306
St. Vincent Hospital d/b/a Prevea Health
Green Bay, Wisconsin, 54303
Medication Management
Greensboro, North Carolina, 27401
Physician's East Endocrinology
Greenville, North Carolina, 27834
Clinical Investigation Specialists
Gurnee, Illinois, 60031
Henderson Clinical Trials
Henderson, Nevada, 89052
Nephrology Associates of Northern Illinois and Indiana (NANI) - Hinsdale
Hinsdale, Illinois, 60521
Juno Research
Houston, Texas, 77040
Biopharma Informatic, LLC
Houston, Texas, 77043
Aqua Research Institute
Houston, Texas, 77058
Northwest Houston Cardiology - Cypress
Houston, Texas, 77070
Clinical Trial Network
Houston, Texas, 77074
PlanIt Research, PLLC
Houston, Texas, 77079
Biopharma Informatic, LLC
Houston, Texas, 77084
Research Physicians Network, LLC
Houston, Texas, 77089
Accurate Clinical Research, Inc
Humble, Texas, 77346
Care Access - Huntington Beach
Huntington Beach, California, 92648
Nephrology Consultants
Huntsville, Alabama, 35805
MedStar Health Research Institute (MedStar Physician Based Research Network)
Hyattsville, Maryland, 20782
Indiana University Health Methodist Hospital
Indianapolis, Indiana, 46202
Nephrology Associates of Northern Illinois and Indiana - IKS - Indianapolis South
Indianapolis, Indiana, 46227
Care Access - South Indianapolis
Indianapolis, Indiana, 46254
Irvine Clinical Research
Irvine, California, 92614
East Coast Institute for Research, LLC
Jacksonville, Florida, 32216
Alliance for Multispecialty Research, LLC
Kansas City, Missouri, 64114
Clinical Investigation Specialists
Kenosha, Wisconsin, 53144
Westchester Medical Center Advanced Physicians Service
Kingston, New York, 12401
Alliance for Multispecialty Research, LLC
Knoxville, Tennessee, 37920
Scripps Whittier Diabetes Institute
La Jolla, California, 92037
Care Access - Lake Charles
Lake Charles, Louisiana, 70601
Lancaster General Hospital
Lancaster, Pennsylvania, 17602
DaVita Clinical Research - Las Vegas
Las Vegas, Nevada, 89107
Excel Clinical Research, LLC
Las Vegas, Nevada, 89109
Alliance for Multispecialty Research, LLC
Las Vegas, Nevada, 89119
Advanced Biomedical Research of America - South Eastern Avenue
Las Vegas, Nevada, 89123
Vector Clinical Trials
Las Vegas, Nevada, 89128
Alliance for Multispecialty Research, LLC
Layton, Utah, 84041
Lakeview Institute of Clinical Research
Leesburg, Florida, 34748
IMA Clinical Research - Lenoir
Lenoir, North Carolina, 28645
Alliance for Multispecialty Research, LLC
Lexington, Kentucky, 40509
Walker Family Care
Little River, South Carolina, 29566
Cardiology and Medicine Clinic
Little Rock, Arkansas, 72204
Accellacare - DuPage
Lombard, Illinois, 60148
Long Beach Research Institute
Long Beach, California, 90805
Ark Clinical Research
Long Beach, California, 90815
Monroe Biomedical Research - Louisville
Louisville, Kentucky, 40213
Texas Institute for Kidney and Endocrine Disorders
Lufkin, Texas, 75904
North America Research Institute
Lynwood, California, 90262
The Jones Center Clinical Research
Macon, Georgia, 31210
Care Access - Mauldin
Mauldin, South Carolina, 29662
Advanced Medical Research
Maumee, Ohio, 43537
Wellness Clinical Research
McKinney, Texas, 75069
Revival Research Institute, LLC
McKinney, Texas, 75071
Clinical Renal Associates Ltd.
Media, Pennsylvania, 19063
Care Access - Memphis 2
Memphis, Tennessee, 38119
PRX Research
Mesquite, Texas, 75149
Southern Endocrinology Associates
Mesquite, Texas, 75149
Flourish Research - Miami, LLC
Miami, Florida, 33135
New Age Medical Research Corporation
Miami, Florida, 33186
Onhealth Research Center
Miami, Florida, 33186
Inpatient Research Clinic
Miami Lakes, Florida, 33014
Boeson Research MSO
Missoula, Montana, 59804
Alliance for Multispecialty Research, LLC
Mobile, Alabama, 36608
IMA Clinical Research Monroe - Armand
Monroe, Louisiana, 71201
West Clinical Research
Morehead City, North Carolina, 28557
IMA Clinical Research West Virginia
Morgantown, West Virginia, 26505
St. Francis Hospital & Heart Center
New Hyde Park, New York, 11576
Alliance for Multispecialty Research, LLC
New Orleans, Louisiana, 70119
NYU Langone Health
New York, New York, 10016
Icahn School of Medicine at Mount Sinai
New York, New York, 10029
Alliance for Multispecialty Research, LLC
Newton, Kansas, 67114
Alliance for Multispecialty Research, LLC
Niles, Illinois, 60714
Alliance for Multispecialty Research, LLC
Norfolk, Virginia, 23502
Alliance for Multispecialty Research, LLC
Norman, Oklahoma, 73069
Valley Clinical Trials, Inc.
Northridge, California, 91325
CTR Oakwater, LLC
Orlando, Florida, 32806
Desert Oasis Healthcare Medical Group
Palm Springs, California, 92262
Helios Clinical Research - SAZ-PDV-026
Paradise Valley, Arizona, 85253
California Liver Research Institute
Pasadena, California, 91105
Tristar Clinical Investigations
Philadelphia, Pennsylvania, 19114
Banner University Medical Center Phoenix
Phoenix, Arizona, 85006
Elite Clinical Studies, LLC
Phoenix, Arizona, 85018
Absolute Clinical Research
Phoenix, Arizona, 85051
Preferred Primary Care Physicians, Preferred Clinical Research-St. Clair
Pittsburgh, Pennsylvania, 15243
Western University of Health Sciences
Pomona, California, 91766
Elixia MKC, LLC
Pontiac, Michigan, 48341
Florida Kidney Physicians, LLC
Port Charlotte, Florida, 33952
Care Access - Quincy
Quincy, Massachusetts, 02169
Accellacare - Raleigh
Raleigh, North Carolina, 27609
Eastside Research Associates
Redmond, Washington, 98052
Reid Physician Associates
Richmond, Indiana, 47374
Dominion Medical Associates, Inc.
Richmond, Virginia, 23219
Florida Kidney Physicians - Tampa
Riverview, Florida, 33578
Rockford Nephrology Associates
Rockford, Illinois, 61107
Lake Michigan Nephrology
Saint Joseph, Michigan, 49085
Synexus Clinical Research US, Inc.
Salt Lake City, Utah, 84106
Utah Kidney Research Institute
Salt Lake City, Utah, 84115
Clinical Advancement Center
San Antonio, Texas, 78212
Discovery Clinical Trials - San Antonio
San Antonio, Texas, 78229
IMA Clinical Research San Antonio
San Antonio, Texas, 78229
Endeavor Clinical Trials
San Antonio, Texas, 78240
California Kidney Specialists
San Dimas, California, 91773
Southern California Clinical Research
Santa Ana, California, 92701
Care Access - Santa Clarita
Santa Clarita, California, 91321
Cardiovascular Center of Sarasota
Sarasota, Florida, 34239
Saratoga Clinical Research
Saratoga Springs, New York, 12866
Guthrie Medical Group, P.C.
Sayre, Pennsylvania, 18840
Scottsdale Clinical Trials
Scottsdale, Arizona, 85260
DaVita Clinical Research - North Houston
Shenandoah, Texas, 77384
Circle Clinical Research
Sioux Falls, South Dakota, 57104
Great Lakes Research Institute
Southfield, Michigan, 48075
Encompass Clinical Research
Spring Valley, California, 91978
Central Illinois Diabetes and Clinical Research a Division of Prairie Education and Research Cooperative
Springfield, Illinois, 62711
Clinvest Headlands Llc
Springfield, Missouri, 65807
Cardiology Associates of Fairfield County, P.C.
Stamford, Connecticut, 06905
Clinical Research Institute of Arizona (CRI) - Sun City West
Sun City West, Arizona, 85375
Universal Research Group
Tacoma, Washington, 98405
Care Access - Tamarac
Tamarac, Florida, 33321
MOORE Clinical Research, Inc. d/b/a TrueBlue Clinical Research
Tampa, Florida, 33607
Care Access - Tampa
Tampa, Florida, 33625
Valiance Clinical Research
Tarzana, California, 91356
Care Access - Thousand Oaks
Thousand Oaks, California, 91360
Med Partners, Inc. dba Premiere Medical Center of Burbank, Inc.
Toluca Lake, California, 91602
Cotton O'Neil Clinical Research Center
Topeka, Kansas, 66606
Cotton O'Neil Diabetes & Endocrinology
Topeka, Kansas, 66606
Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Torrance, California, 90502
UCLA South Bay Endocrinology
Torrance, California, 90505
Arcturus Healthcare , PLC, Troy Internal Medicine Research Division
Troy, Michigan, 48098
Synexus Clinical Research US, Inc./Orange Grove Family Practice
Tucson, Arizona, 85741
InvivoCure
Van Nuys, California, 91405
National Institute of Clinical Research (NICR) - High Desert
Victorville, California, 92392
Synexus Clinical Research US, Inc.
Vista, California, 92083
Chase Medical Research, LLC
Waterbury, Connecticut, 06708
Iowa Diabetes and Endocrinology Research Center
West Des Moines, Iowa, 50266
Millennium Clinical Trials
Westlake Village, California, 91361
Accellacare - Wilmington - 1917 Tradd Court
Wilmington, North Carolina, 28401
North Georgia Clinical Research
Woodstock, Georgia, 30189
Medrasa Clinical Research
Wylie, Texas, 75098
Argentina59 sites
CONEXA Investigacion Clinica S.A.
Buenos Aires, 1012
Centro de Investigaciones Metabólicas (CINME)
Buenos Aires, 1056ABI
Buenos Aires Macula S.A
Buenos Aires, 1061
Cicemo Srl
Buenos Aires, 1424
Cardiología Palermo
Buenos Aires, 1425
Stat Research S.A.
Buenos Aires, C1023AAB
Investigaciones Medicas Imoba Srl
Buenos Aires, C1056ABH
CIPREC
Buenos Aires, C1061AAS
CIPREC
Buenos Aires, C1119
Centro Médico Viamonte
Buenos Aires, C1120AAC
Mautalen Salud e Investigación
Buenos Aires, C1128AAF
CEMEDIC
Buenos Aires, C1407GTN
Centro Medico Dra. Laura Maffei- Investigacion Clinica Aplicada
Buenos Aires, C1425AGC
Fundación Respirar
Buenos Aires, C1426ABP
Glenny Corp. S.A.
Buenos Aires, C1430CKE
CEMEDIAB
C.a.b.a., C1205AAO
CEDIC
CABA, C1060ABN
Instituto Médico Especializado (IME)
CABA, C1405BCG
Centro Medico Privado CEMAIC
Capital, X5008HHW
IDIM - Instituto de Investigaciones Metabólicas
Ciudad de Buenos Aires, C1012AAR
Centro Diabetológico Dr. Waitman
Córdoba, 5000
Instituto de Investigaciones Clínicas Córdoba
Córdoba, 5000
Sanatorio Privado Duarte Quirós
Córdoba, 5002
Centro Médico Colón
Córdoba, 5003
Centro Medico Privado San Vicente Diabetes
Córdoba, 5006
CIDIM-Centro Integral de Diagnostico por Imagenes Marchegiani
Córdoba, X5000AVE
CIPADI - Centro Integral de Prevencion y Atencion en Diabetes
Godoy Cruz, M5501ARP
Centro de Investigaciones Clínicas Baigorria
Granadero Baigorria, 2152
CMD-Centro Médico y Diagnóstico por Imágenes
Junín, 6000
Hospital Italiano de La Plata
La Plata, 1900
CIMeL
Lanus, B1824KAJ
Polo de Salud Vistalba
Lujan de Cuyo, 5509
Centro de Investigaciones Médicas Mar del Plata
Mar del Plata, 7600
Instituto de Investigaciones Clínicas Mar del Plata
Mar del Plata, B7600FZO
Instituto De Investigaciones Clinicas Quilmes
Quilmes, 1878
DIM Clínica Privada
Ramos Mejía, B1704ETD
Instituto Médico Río Cuarto
Río Cuarto, X5800AEV
Fundacion Estudios Clinicos
Rosario, 2000
INECO Neurociencias Oroño
Rosario, 2000
Instituto Especialidades de la Salud Rosario
Rosario, 2000
Instituto Médico Catamarca IMEC
Rosario, 2000
Instituto Médico Fundación Grupo Colaborativo Rosario Investigación y Prevención Medica
Rosario, 2000
Instituto de Investigaciones Clinicas Rosario
Rosario, S2000CVD
Laboratorio de Hemostasia y Trombosis
Rosario, S2000DTB
Hospital Provincial del Centenario
Rosario, S2002KDS
Centro de Investigaciones Médicas Tucuman
SAN M. de Tucuman, T4000AXL
Corporación Médica San Martín
San Martin, 1650
Centro Modelo de Cardiología
San Miguel de Tucumán, 4000
Investigaciones Clínicas Tucumán
San Miguel de Tucumán, 4000
Go Centro Medico San Nicolás
San Nicolás, 2900
Centro de Diagnóstico y Rehabilitación (CEDIR)
Santa Fe, 3000
Clínica de Nefrología, Urología y Enfermedades Cardiovasculares
Santa Fe, 3000
Centro de Investigaciones Clinicas del Litoral
Santa Fe, S3000FWO
Centro de Salud e Investigaciones Médicas
Santa Rosa, 6300
Sanatorio Norte
Santiago del Estero, 4200
Centro de Investigaciones Medicas Temperley
Temperley, 1834
Sanatorio San Martin
Venado Tuerto, 2600
CEREHA
Villa Domínico, 1874
Instituto de Investigaciones Clinicas Zarate
Zárate, B2800DGH
Brazil48 sites
Centro de Pesquisa Clinica do Coracao
Aracaju, 49055-530
Hospital Universitário João de Barros Barreto
Belém, 66073-000
Santa Casa de Misericordia de Belo Horizonte
Belo Horizonte, 30150-221
Freire Pesquisa Clínica
Belo Horizonte, 30150-320
AngioKormann Blumenau
Blumenau, 89020-430
L2IP - Instituto de Pesquisas Clínicas
Brasília, 70200730
Chronos Pesquisa Clínica
Brasília, 72145-450
Instituto de Pesquisa clinica de Campinas
Campinas, 13060-080
Centro de Pesquisa Sao Lucas
Campinas, 13060-803
Centro de Endocrinologia Geloneze
Campinas, 13073-350
Fundação Universidade de Caxias do Sul (FUCS)
Caxias do Sul, 95070-560
Cline Research Center
Curitiba, 80030-480
Quanta Diagnóstico e Terapia
Curitiba, 80040-110
PUC Trials- Nucleo de Pesquisa clinica da Escola de Medicina da PUCPR
Curitiba, 80230-130
Instituto Pro Renal Brasil
Curitiba, 80240-220
Centro de Diabetes Curitiba
Curitiba, 80810-040
Instituto de Ensino e Pesquisa Clinica do Ceara
Fortaleza, 60.125-058
Instituto de Estudos e Pesquisas Clinicas do Ceara IEP-CE
Fortaleza, 60160-230
Private Practice - Dr.Miguel N. Hissa
Fortaleza, 60430-350
Universidade Federal de Goias
Goiânia, 74605-020
Centro de Pesquisas Clínicas Dr. Marco Mota
Maceió, 57051-160
CPHOSP Manaus Medicina, Ensino e Pesquisa
Manaus, 69057-088
Centro de Pesquisa Clínica de Marília - CPCLIM
Marília, 17504-072
Instituto Méderi de Pesquisa e Saúde
Passo Fundo, 99010-120
Núcleo de Pesquisa Clínica do Rio Grande do Sul
Porto Alegre, 90430-001
IBPClin - Instituto Brasil de Pesquisa Clínica
Rio de Janeiro, 20241-180
Ruschel Medicina e Pesquisa Clínica
Rio de Janeiro, 22270-060
Hospital Pro-Cardiaco
Rio de Janeiro, 22280-003
Clinica Senhor do Bonfim CSB - Salvador
Salvador, 40415-065
Pesquisare Saude
Santo André, 09080-110
Praxis Pesquisa Medica
Santo André, 09790790
Centro Multidisciplinar de Estudos Clinicos
São Bernardo do Campo, 09715-090
Fundação Faculdade Regional de Medicina de São José do Rio Preto
São José do Rio Preto, 15090000
ISPEM - Instituto São José dos Campos em Pesquisas Médicas
São José dos Campos, 12243-280
Instituto de Pesquisa Clinica
São Paulo, 01223-001
CPQuali Pesquisa Clínica
São Paulo, 01228-000
CPCLIN
São Paulo, 01228-200
BR Trials - Ensaios Clinicos e Consultoria
São Paulo, 01236030
BP - A Beneficencia Portuguesa de São Paulo
São Paulo, 01321-001
Hospital Alemao Oswaldo Cruz
São Paulo, 01323-903
IBCC - Núcleo de Pesquisa e Ensino
São Paulo, 04014-002
CEPIC - Centro Paulista de Investigação Clínica
São Paulo, 04266-010
Hospital das Clinicas FMUSP
São Paulo, 05403-000
Incor - Instituto do Coracao
São Paulo, 05403-000
Instituto de Molestias Cardiovasculares de Tatui
Tatuí, 18270-170
Eurolatino Pesquisas Medicas
Uberlândia, 38400-500
CEDOES
Vitória, 29055450
Integral Pesquisa e Ensino
Votuporanga, 15500-269
Mexico40 sites
Centro de Atencion al Diabetico Actopan
Actopan, 42500
Fundación Cardiovascular de Aguascalientes A.C.
Aguascalientes, 20230
Centro de Estudios de Investigacion Metabolicos y Cardiovasculares
Ciudad Madero, 89440
Cryptex Investigación Clínica S.A. de C.V.
Cuauhtémoc, Ciudad de México, 06100
Instituto de Diabetes, Obesidad y Nutricion
Cuernavaca, 62250
Investigación Clínica Cuernavaca, S.C.
Cuernavaca, 62448
Instituto de Investigaciones Aplicadas a la Neurociencia A.C.
Durango, 34000
Lahoja. Asociacion Para La Investigacion Y La Farmacovigilancia
Durango, 34000
Instituto Jalisciense de Investigacion en Diabetes y Obesidad
Guadalajara, 04460
Diseno y Planeacion en Investigacion Medica
Guadalajara, 44130
Private Practice - Dr. Arechavaleta Granell Maria del Rosario
Guadalajara, 44670
Virgen Cardiovascular Research SC
Guadalajara, 44670
CINVEC Medica
Guadalajara, 44690
Instituto Cardiovascular de León S.C.
León, 37530
EME RED Hospitalaria
Mérida, 97000
Medical Care and Research SA de CV
Mérida, 97070
Centro de Investigacion en Artritis y Osteoporosis SC
Mexicali, 21200
Clinstile, S.A. de C.V.
México, 06700
Instituto Nacional de Cardiologia Ignacio Chavez
México, 14080
Hospital de Jésus, I.A.P.
Mexico City, 06090
Clinica Omega
Mexico City, 06700
Centro Especializado En Diabetes, Obesidad Y Prevencion De Enfermedades Cardiovasculares
Mexico City, 11650
Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Mexico City, 14080
Servicios de Oncología Medica Integral - Monterrey - José Benitez
Monterrey, 64040
Cardiolink Clin Trials
Monterrey, 64060
IMED Internal Medicine Clin Trials
Monterrey, 64060
UBAM Unidad Biomedica Avanzada Monterrey
Monterrey, 64460
Clínica García Flores SC
Monterrey, 64610
Hospital Universitario "Dr. Jose Eleuterio Gonzalez"
Monterrey, 66460
Centro de Investigacion Clinica de Oaxaca
Oaxaca City, 68020
Boca Clinical Trials Mexico SC
Puebla City, 72160
Centro de Estudios Clínicos de Querétaro (CECLIQ)
Querétaro, 76000
PanAmerican Clinical Research - Querétaro - Avenida Antea
Querétaro, 76090
Centro de Atención e Investigación Cardiovascular del Potosí
San Luis Potosí City, 78200
Centro de investigación y control metabólico
San Nicolás de los Garza, 66465
Medimanage Research
Tlalpan, 14050
Instituto Veracruzano en Investigación Clínica S.C.
Veracruz, 91851
Arké SMO S.A de C.V
Veracruz, 91900
FAICIC S. de R.L. de C.V.
Veracruz, 91900
Consultorio de Medicina Especilizada del Sector Privado
Xalapa, 91193
Czechia32 sites
MEDICUS SERVICES s.r.o., kardiologicka ambulance
Brandýs nad Labem, 250 01
Fakultni Nemocnice u sv. Anny v Brne
Brno, 602 00
UNIVMED
Brno, 602 00
Fakultni Nemocnice u sv. Anny v Brne
Brno, 60200
Vojenská Nemocnice Brno
Brno, 636 00
Nemocnice Cesky Krumlov
Český Krumlov, 381 01
Kardio Chlumec
Chlumec nad Cidlinou, 503 51
Diahaza s.r.o.
Holešov, 769 01
Kardioma
Kolín, 280 02
Kardiologicka ambulance
Litovel, 784 01
EDUMED - Náchod
Náchod, 547 01
Agentura Science Pro
Olomouc, 779 00
Diabetologicke centrum s.r.o.
Olomouc, 779 00
PreventaMed
Olomouc, 779 00
Private Practice - Dr. Miroslav Koliba
Ostrava, 702 00
Donmed s.r.o.
Ostrava, 710 00
Kardiologicka a Angiologicka Ambulance
Ostrava - Dubina, 700 30
MUDr. Jana Parkanyiova
Prague, 110 00
Synexus Czech
Prague, 120 00
MEDICON
Prague, 140 00
Fakultni Thomayerova nemocnice
Prague, 14059
Nefrologie
Prague, 149 00
Poliklinika Lípa Centrum
Prague, 158 00
FLEDIP - Na dlouhem lanu
Prague, 160 00
Centrum Kardiovaskularni Mediciny
Prague, 169 00
Diabetologie a endokrinologie, J.Venerová
Prague, 169 00
ResTrial s.r.o.
Prague, 18100
MUDr. Barbora Diepoltova
Praha 9 - Klanovice, 190 14
Diakom, s.r.o. - Přeštice
Přeštice, 334 01
Kardiologicka ambulance MUDr. Ferkl s.r.o.
Trutnov, 541 01
Clinical Trials Service s.r.o.
Uherské Hradiště, 686 01
Cardio Research, s.r.o
Zlín, 760 01
Netherlands28 sites
Noordwest Ziekenhuisgroep
Alkmaar, 1815 JD
EB Medical Research
Almere Stad, 1311 RL
Meander Medisch Centrum
Amersfoort, 3813 TZ
OLVG Oost
Amsterdam, 1091 AC
Amsterdam UMC, locatie AMC
Amsterdam, 1105 AZ
Gelre Ziekenhuis
Apeldoorn, 7334 DZ
Rode Kruis Ziekenhuis
Beverwijk, 1942 LE
Amphia Ziekenhuis, locatie Breda Molengracht
Breda, 4818 CK
Het Van Weel-Bethesda Ziekenhuis - Ziekenhuis Dirksland
Dirksland, 3247 BW
Albert Schweitzer Ziekenhuis, locatie Dordwijk
Dordrecht, 3318 AT
Ziekenhuis Gelderse Vallei
Ede, 6716 RP
Catharina Ziekenhuis
Eindhoven, 5623 EJ
Medisch Spectrum Twente
Enschede, 7512 KZ
Spaarne Gasthuis, Haarlem Zuid
Haarlem, 2035 RC
Atrium-Orbis - Zuyderland Medisch Centrum Heerlen
Heerlen, 6419 PC
Ziekenhuis Bethesda
Hoogeveen, 7909 AA
Medische Centrum Leeuwarden
Leeuwarden, 8934 AD
Radboudumc
Nijmegen, 6525 GA
Bravis Ziekenhuis, locatie Roosendaal
Roosendaal, 4708 AE
Franciscus Gasthuis & Vlietland, Locatie Gasthuis
Rotterdam, 3045 PM
Medisch Centrum Thomsonplein
The Hague, 2565 KV
Huisartsenpraktijk Disha
The Hague, 2572 GM
Ziekenhuis Rivierenland
Tiel, 4002 WP
Universitair Medisch Centrum Utrecht
Utrecht, 3584 CX
VieCuri Medisch Centrum, locatie Venlo
Venlo, 5912 BL
Huisartsenpraktijk Broekman
Zwijndrecht, 3333 GZ
Dokters van Nederhoven
Zwijndrecht, 3334 SB
Isala, locatie Zwolle
Zwolle, 8025 AB
Germany25 sites
Kerckhoff-Klinik
Bad Nauheim, 61231
Herz - und Diabeteszentrum Nordrhein - Westfalen, Bad Oeynhausen
Bad Oeynhausen, 32545
FutureMeds Berlin
Berlin, 10629
Kardiologisch-Angiologische Praxis - Herzzentrum Bremen
Bremen, 28277
St.-Johannes-Hospital Dortmund
Dortmund, 44137
Hausärztlich-Kardiologisches MVZ am Felsenkeller GmbH/Zentrum für klinische Studien
Dresden, 01277
Universitaetsklinikum Carl Gustav Carus Dresden
Dresden, 01307
ZKS Suedbrandenburg
Elsterwerda, 04910
InnoDiab Forschung Gmbh
Essen, 45136
Unterfrintroper Hausarztzentrum Klinische Forschung
Essen, 45359
Universitätsklinikum Frankfurt Goethe-Universität
Frankfurt, 60590
Diabetes Zentrum Wilhelmsburg
Hamburg, 21109
Diabetes Zentrum Wandsbek
Hamburg, 22041
Zentrum für Nieren-, Hochdruck- und Stoffwechselerkrankungen - Heidering
Hanover, 30625
AmBeNet GmbH
Leipzig, 04107
UKSH Campus Lübeck, Med. 1 - AG Meyhöfer
Lübeck, 23562
Universitätsmedizin Johannes Gutenberg Universität Mainz
Mainz, 55131
CRS Clinical Research Services Mannheim
Mannheim, 68167
Universitätsmedizin Mannheim
Mannheim, 68167
Institut für Diabetesforschung GmbH Münster
Münster, 48145
RED-Institut GmbH
Oldenburg, 23758
Kardiologische Praxis Papenburg
Papenburg, 26871
Zentrum für klinische Studien
Saint Ingbert, 66386
Nephrologisches Zentrum Villingen-Schwenningen
Villingen-Schwenningen, 78052
Praxis Sauter & Sauter & Vorbach
Wangen, 88239
Canada22 sites
C-health Research
Calgary, T2V 4J2
Ecogene-21
Chicoutimi, G7H 7K9
Med Trust Research
Courtice, L1E 2J5
C-health
Edmonton, T6H 2L4
St. Joseph's Health Care
London, N6A 4V2
Victoria Hospital & Children's Hospital - London Health Sciences Centre
London, N6A 5W9
Western Centre for Public Health and Family Medicine
London, N6G 2M1
G A Research Associates
Moncton, E1G 1A7
North York Diagnostic and Cardiac Centre
North York, M6B 3H7
Lakeridge Health
Oshawa, L1G 2B9
Alpha Recherche Clinique
Québec, G2J 0C4
Unité de Recherche Clinique du CISSS des Laurentides
Saint-Jérôme, J7Z 2V4
Ocean West Research Clinic
Surrey, V3S 2N6
SMH Cardiology Clinical Trials
Surrey, V3V 0C6
Care Access - Cape Breton
Sydney, B1M 0A1
Care Access - Thunder Bay - Barton Street
Thunder Bay, P7B 7C7
Corcare
Toronto, M1B 5N1
Toronto General Hospital
Toronto, M5G 2C4
Clinical Research Solutions - Kitchener
Waterloo, N2T 0C1
Winchester District Memorial Hospital
Winchester, K0C 2K0
Seven Oaks General Hospital
Winnipeg, R2V 3M3
Winnipeg Clinic
Winnipeg, R3C 0N2
Belgium21 sites
AZORG Campus Aalst-Moorselbaan
Aalst, 9300
ANIMA Research
Alken, 3570
Imelda General Hospital
Bonheiden, 2820
Algemeen Ziekenhuis klina
Brasschaat, 2930
Centre Hospitalier Universitaire Brugmann
Brussels, 1020
Université Libre de Bruxelles - Hôpital Erasme
Brussels, 1070
UZ Brussel
Brussels, 1090
Cliniques universitaires Saint-Luc
Brussels, 1200
Antwerp University Hospital
Edegem, 2650
UZ Gent
Ghent, 9000
Jessa Ziekenhuis
Hasselt, 3500
Jan Yperman Ziekenhuis
Ieper, 8900
Kormont
Kluisbergen, 9690
AZ Groeninge Campus Kennedylaan
Kortrijk, 8500
UZ Leuven
Leuven, 3000
Centre Hospitalier Universitaire de Liège - Domaine Universitaire du Sart Tilman
Liège, 4000
ZNA Jan Palfijn
Merksem, 2170
Az Damiaan vzw
Ostend, 8400
Artsenpraktijk OHIO
Oudenaarde, 9700
Private Practice - Dr. De Watertoren
Tielt, 8700
Private Practice - Dr. Tim Decraecke (Zwalm)
Zwalm, 9630
Romania21 sites
CMI Cardiologie - Dr. Mercea Corina Delia
Baia Mare, 430124
CMI DNBM Dr. Pop Lavinia
Baia Mare, 430222
C.M.D.T.A. Neomed
Brasov, 500283
Nicodiab
Bucharest, 010507
Hightech Medical Services SRL-Centrul pentru Studiul Metabolismului
Bucharest, 011053
Centrul Medical NutriLife
Bucharest, 013764
Lotus-Med Tunari
Bucharest, 020528
Centrul Medical Endocrinologie si Diabet Dr. Paveliu
Bucharest, 50538
Spitalul Clinic Județean de Urgență
Craiova, 200642
Milena Sante
Galați, 800001
Diamed Obesity
Galați, 800291
Centrul Medical Consultmed
Iași, 700547
Cardiomed Iași
Iași, 700687
Clinica Korall
Satu Mare, 440055
Gensan S.R.L. - Policlinica Astra Sibiu
Sibiu, 550371
SC Dentosim Queen SRL - Centrul Medical Diamed
Târgu Mureş, 540098
Centrul Medical Mediab
Târgu Mureş, 540142
Mediab S.R.L.
Târgu Mureş, 540142
Cabinet Medical Dr.Geru
Timișoara, 300288
Institutul de Boli Cardiovasculare Timișoara
Timișoara, 300310
Centrul Medical Medicalis
Timișoara, 300462
Turkey (Türkiye)21 sites
Afyon Kocatepe Üniversitesi Tıp Fakültesi
Afyonkarahisar, 03030
Ankara Bilkent Şehir Hastanesi
Ankara, 06800
Hacettepe Universite Hastaneleri
Ankara
Akdeniz Universitesi Hastanesi
Antalya, 07070
Ege Universitesi Hastanesi
Bornova, 35100
T.C. Saglik Bakanligi - Hitit Universitesi Corum Egitim ve Arastirma Hastanesi
Çorum, 19040
Trakya University Medical Faculty Hospital
Edirne, 22030
Eskisehir Osmangazi University
Eskişehir, 26480
Gaziantep Universitesi Sahinbey Arastirma ve Uygulama Hastanesi
Gaziantep, 27310
Dr. Siyami Ersek Göğüs Kalp Ve Damar Cerrahisi Eğitim Ve Araştırma Hastanesi
Istanbul, 34668
Kartal Koşuyolu Yüksek İhtisas Eğitim ve Araştirma Hastanesi
Istanbul, 34865
Istanbul Universitesi Cerrahpasa
Istanbul- Fatih, 34098
Kocaeli Üniversitesi
İzmit, 41380
Erciyes Universitesi Tıp Fakultesi Hastaneleri
Kayseri
Kocaeli Üniversitesi
Kocaeli, 41380
Necmettin Erbakan University Meram Medical Faculty
Konya, 42080
T.C. Saglik Bakanligi - Dumlupinar Universitesi Kutahya Evliya Celebi Egitim ve Arastirma Hastanesi
Kütahya, 43100
Mersin University
Mersin, 33343
Ondokuz Mayıs Universitesi
Samsun, 55270
Cumhuriyet Universitesi
Sivas, 58140
Bursa Yüksek İhtisas Eğitim Ve Araştırma Hastanesi
Yıldırım, 16310
Poland20 sites
KLIMED Marek Klimkiewicz
Bialystok, 15-704
Polsko-Amerykańskie Kliniki Serca II Oddział Kardiologiczny
Bielsko-Biala, 43-300
NZOZ Centrum Medyczne KERmed
Bydgoszcz, 85-231
Centrum Medyczne INTERCOR Sp. z o.o.
Bydgoszcz, 85-605
Diab Serwis Popenda Spółka Jawna
Chorzów, 41-500
Polsko-Amerykańskie Kliniki Serca PAKS Małopolskie Centrum Sercowo-Naczyniowe
Chrzanów, 32-500
Centrum Kliniczno-Badawcze
Elblag, 82-300
Uniwersyteckie Centrum Kliniczne
Gdansk, 80-952
Medyczne Centrum Diabetologiczno Endokrynologiczno Metaboliczne DIAB-ENDO-MET
Krakow, 31-261
Poliklinika Kardiologiczna Serce
Leszno, 64-100
Pro Salus Centrum Medyczne
Lodz, 91-473
CenterMed Lublin NZOZ
Lublin, 20-044
Ekamed
Lublin, 20-718
EndoPractica
Opole, 45-301
Centrum Zdrowia Metabolicznego Pawel Bogdanski
Poznan, 60-589
Wojewodzki Szpital im. Sw. Ojca Pio w Przemyslu
Przemyśl, 37-700
Centrum Szybkiej Diagnostyki Kardiologicznej "Kardiomed" M. Żabówka E. Żabówka
Tarnów, 33-100
Polsko-Amerykańskie Kliniki Serca
Tychy, 43-100
Balsam Medica
Warsaw, 01-249
NZOZ Centurm Medyczne SERAFIN-MED
Żarów, 58-130
India19 sites
Motilal Nehru Medical College Hospital
Allahabād, 211002
Life Care Hospital and Research Centre
Bangalore, 560092
All India Institute of Medical Sciences
Bhubaneswar, 751019
Sardar Patel Medical College
Bikaner, 334001
Medway Hospitals - Kodambakkam
Chennai, 600024
Shri Mahant Indiresh Hospital
Dehradun, 248001
Endolife Speciality Hospitals
Guntur, 522001
K care Hospital
Kanpur, 208001
LPS Institute of Cardiology
Kanpur, 208019
Government Medical College - Kozhikode
Kozhikode, 673008
Dr. Ram Manohar Lohia Institute of Medical Sciences
Lucknow, 226010
Manipal Hospitals
Mysore, 570015
Kingsway Hospitals (Best Multispeciality Hospital in Nagpur)
Nagpur, 440001
Shrikrishna Hrudayalaya And Critical Care Center
Nagpur, 440012
All India Institute of Medical Sciences (AIIMS) - Nagpur
Nagpur, 441108
G.B. Pant Institute of Postgraduate Medical Education & Research
New Delhi, 110002
Sir Ganga Ram Hospital
New Delhi, 110060
Nirmal Hospital Pvt Ltd.
Surat, 395002
Shri Bachubhai Dahyabhai Mehta Mahavir Heart Institute
Surat, 395002
Slovakia18 sites
Cliniq s.r.o.
Bratislava, 81109
ENDIAMED s.r.o
Dolný Kubín, 026 01
JM-Interna s.r.o
Dolný Kubín, 02601
NEDÚ - Národný endokrinologický a diabetologický ústav n.o.
Ľubochňa, 034 91
IN-DIA
Lučenec, 984 01
Nemocnica s poliklinikou Lucenec
Lučenec, 984 01
Sin Azucar
Malacky, 901 01
AMBORA s.r.o. Interna ambulancia
Martin, 036 01
B-Medical, s.r.o.
Námestovo, 02901
Fakultná nemocnica Nitra
Nitra, 950 01
FUNKYSTUFF s.r.o.
Nové Zámky, 940 02
MEDIKALS
Piešťany, 921 01
MUDr. Judita Gondova
Poltár, 987 01
ENRIN, s.r.o.
Rimavská Sobota, 979 01
Tatratrial s.r.o.
Rožňava, 04801
Areteus s.r.o.
Trebišov, 075 01
MediPrax, s.r.o.
Trstená, 028 01
IRIDIA
Vrútky, 038 61
United Kingdom18 sites
Aberdeen Royal Infirmary
Aberdeen, AB25 2ZN
FutureMeds - Birmingham
Birmingham, B21 9RY
FutureMeds - Liverpool
Bromborough, CH62 6EE
University Hospital Coventry & Warwickshire
Coventry, CV2 2DX
FutureMeds Glasgow - CPS Research
Glasgow, G20 7BE
Hull Royal Infirmary
Hull, HU3 2JZ
Ipswich Hospital
Ipswich, IP4 5PD
Ashton Medical Group - Chapel House
Lancashire, OL6 6EW
Royal London Hospital
London, E1 1BB
Altnagelvin Area Hospital
Londonderry, BT47 6SB
Futuremeds-Newcastle
Newcastle, NE6 1SG
Newquay Health Centre
Newquay, TR7 1RU
Homecroft Surgery
Redruth, TR16 4ET
FutureMeds Teesside - Middlefield Centre
Stockton-on-Tees, TS19 8PE
Swansea University
Swansea, SA2 8PP
Musgrove Park Hospital
Taunton, TA1 5DA
Rame Group Practice
Torpoint, PL11 2TB
Moorgreen Hospital
West End, SO30 3JB
Australia16 sites
Nightingale Research
Adelaide, 5000
Emeritus Research
Botany, 2019
Box Hill Hospital
Box Hill, 3128
Royal Brisbane and Women's Hospital
Brisbane, 4029
Northern Beaches Clinical Research
Brookvale, 2100
Emeritus Research
Camberwell, 3124
Canberra Hospital
Garran, 2605
Barwon Health
Geelong, 3220
Austin Health - Repatriation Hospital
Heidelberg West, 3081
Logan Hospital
Meadowbrook, 4131
The Alfred Hospital
Melbourne, 3004
The AIM Centre / Hunter Diabetes Centre
Merewether, 2291
Fiona Stanley Hospital
Murdoch, 6150
Southern Adelaide Diabetes & Endocrine Services
Oaklands Park, 5046
Royal North Shore Hospital
St Leonards, 2065
University of Sydney - Charles Perkins Centre
Sydney, 2006
France16 sites
Centre Hospitalier Universitaire - Hôpitaux de Rouen - Hôpital de Bois-Guillaume
Bois-Guillaume, 76230
Bordeaux University Hospital - Pellegrin
Bordeaux, 33076
Chu Gabriel Montpied
Clermont-Ferrand, 63000
Centre Hospitalier Sud Francilien
Corbeil-Essonnes, 91106
Chu Grenoble Alpes
La Tronche, 38700
Centre Hospitalier Louis Pasteur
Le Coudray, 28630
CHU Montpellier Lapeyronie Hospital
Montpellier, 34295
Hôpital Nord Guillaume-et-René-Laennec / CHU de Nantes
Nantes, 44093
Centre Hospitalier Universitaire de Nice - Hopital Pasteur
Nice, 06000
Pitie Salpetriere University Hospital
Paris, 75013
Groupe hospitalier Paris saint Joseph
Paris, 75014
Hôpital Européen Georges Pompidou
Paris, 75015
CHU Bordeaux Haut-Leveque
Pessac, 33600
CHU Rangueil
Toulouse, 31059
Centre Hospitalier Régional Universitaire de Tours - Hôpital Bretonneau
Tours, 37000
Polyclinique Vauban
Valenciennes, 59300
Israel16 sites
Barzilai Medical Center
Ashkelon, 7830604
Rambam Health Care Campus
Haifa, 3109601
Bnai Zion Medical Center
Haifa, 3339419
Shaare Zedek Medical Center
Jerusalem, 9013102
Hadassah Medical Center
Jerusalem, 9112001
Meir Medical Center
Kfar Saba, 4428164
Galilee Medical Center
Nahariya, 2210001
Rabin Medical Center
Petah Tikva, 49100
Rabin Medical Center - Hasharon Campus
Petah Tikva, 4937211
Rabin Medical Center
Petah Tikva, 4941492
Sheba Medical Center
Ramat Gan, 5262100
Kaplan Medical Center
Rehovot, 7610001
Sourasky Medical Center
Tel Aviv, 6423906
Maccabi Healthcare Services
Tel Aviv, 68125
Diabetes Medical Center
Tel Aviv, 6937947
Yitzhak Shamir Medical Center
Ẕerifin, 70300
Ukraine15 sites
Regional Communal Non-commercial enterprise "Chernivtsi regional clinical hospital"
Chernivtsi, 58000
Vise Clinic
Ivano-Frankivsk, 76005
Clinical Diagnostic Center
Ivano-Frankivsk, 76018
Institute of Endocrinology and Metabolism named after Komissarenko
Kiev, 04114
Edelweiss Medics
Kyiv, 02002
Medbud Clinic
Kyiv, 03037
Medical Center "Universal Clinic "Oberig" of Limited Liability Company "Kapytal"
Kyiv, 03057
ARTEM
Kyiv, 04050
Center of Family Medicine Plus
Kyiv, 04210
Lviv City Clinical Hospital #4
Lviv, 79005
University Hospital of LNMU
Lviv, 79010
Medical center Pulse in Vinnitsi
Vinnytsia, 21001
Limited liability company "Medical center Health Clinic"
Vinnytsia, 21009
Vinnytsia Regional Clinical Endocrinology Dispensary
Vinnytsia, 21010
Communal Enterprise "Hospital #1" of Zhytomyr City Council
Zhytomyr, 10002
Hungary14 sites
DRC Gyógyszervizsgáló Központ
Balatongyörök, 8313
Szent Margit Rendelintézet
Budapest, 1032
Eszak-Pesti Centrumkorhaz-Honvedkorhaz
Budapest, 1034
Óbudai Egészségügyi Centrum
Budapest, 1036
PVN Kutató Kft
Budapest, 1102
Semmelweis University
Budapest, 1122
Privát Doktor Egészségügyi Zrt
Budapest, 1132
Újpesti Egészségügyi Nonprofit Kft
Budapest, H-1046
Debreceni Egyetem Klinikai Kozpont
Debrecen, 4032
CRU Early Phase Unit
Kistarcsa, 2143
Selye János Kórház
Komárom, 2900
Szegedi Tudományegyetem Szent-Györgyi Albert Klinikai Központ
Szeged, 6725
Allergo-Derm Bakos Kft
Szolnok, 5000
Zala Megyei Szent Rafael Kórház
Zalaegerszeg, 8900
Italy14 sites
IRCCS - AOU di Bologna
Bologna, 40138
IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico di Sant'Orsola
Bologna, 40138
Azienda Ospedaliero Universitaria S.Anna
Ferrara, 44124
Ospedale San Martino
Genova, 16132
Centro Cardiologico Monzino
Milan, 20138
Ospedale San Raffaele
Milan, 20132
A.O.U. Policlinico Paolo Giaccone
Palermo, 90127
AO Santa Maria della Misericordia
Perugia, 06132
Azienda Ospedaliera Universitaria Pisana
Pisa, 56124
Azienda Ospedaliero Universitaria Pisana
Pisa, 56126
AOU Policlinico Umberto I
Roma, 00161
Fondazione Policlinico Universitario Agostino Gemelli IRCCS - Università Cattolica del Sacro Cuore
Roma, 00168
Fondazione Policlinico Universitario Campus Bio-Medico
Rome, 00128
IRCCS Policlinico San Donato
San Donato Milanese, 20097
Spain14 sites
CHUAC-Complejo Hospitalario Universitario A Coruña
A Coruña, 15006
Centro Periférico de Especialidades Bola Azul
Almería, 04009
Hospital Universitario de La Ribera
Alzira, 46600
Hospital Universitari Vall d'Hebron
Barcelona, 08035
Complejo Hospitalario Universitario de Ferrol (CHUF)- Hospital Naval
Ferrol, 15405
Hospital Universitario Virgen de la Victoria
Málaga, 29010
Hospital Universitario Central de Asturias
Oviedo, 33011
Clínica Juaneda
Palma de Mallorca, 07014
Hospital Universitario Quironsalud Madrid
Pozuelo de Alarcón, 28223
Hospital Universitario Marqués de Valdecilla
Santander, 39008
Clínica nuevas Tecnologías en Diabetes y Endocrinología (NTDE)
Seville, 41003
Hospital Quiron Infanta Luisa
Seville, 41010
Vithas Hospital Sevilla
Seville, 41950
Hospital Universitario Doctor Peset
Valencia, 46017
Austria12 sites
Krankenhaus St. Josef Braunau
Braunau am Inn, 5280
VIVIT
Feldkirch, 6800
Medizinische Universität Graz
Graz, 8036
Medizinische Universitaet Innsbruck
Innsbruck, 6020
Konventhospital der Barmherzigen Brüder Linz
Linz, 4021
Cardio Metabolic Centre
Mattersburg, 7210
Private Practice - Dr. Evelyn Fliesser-Gorzer
Sankt Stefan ob Stainz, 8511
Klinik Landstraße
Vienna, 1030
Zentrum für klinische Studien Dr Hanusch Gmbh
Vienna, 1060
Universitaetsklinikum Allgemeines Krankenhaus Wien
Vienna, 1090
Klinik Hietzing
Vienna, 1130
Imed19-privat
Vienna, 1190
Greece11 sites
Athens Medical Center - Psychikon branch
Athens, 115 25
General Hospital of Athens "G. Gennimatas"
Athens, 11527
General Hospital of Athens Laiko
Athens, 11527
Athens Medical Center
Athens, 151 25
University Hospital of Ioannina
Ioannina, 455 00
University General Hospital of Larissa
Larissa, 41110
Iatriko Paleou Falirou Medical Center
Palaió Fáliro, 17562
G. Gennimatas General Hospital of Thessaloniki
Thessaloniki, 546 35
Euromedica General Clinic of Thessaloniki
Thessaloniki, 546 45
Papageorgiou General Hospital of Thessaloniki
Thessaloniki, 564 03
424 Military General Training Hospital
Thessaloniki, 564 29
New Zealand9 sites
Pacific Clinical Research Network - Auckland (PCRN Auckland)
Auckland, 0622
Aotearoa Clinical Trials
Auckland, 2025
Pacific Clinical Research Network - Tasman
Nelson, 7011
Lakeland Clinical Trials Culloden
Papamoa, 3118
Momentum Clinical Research - Pukekohe
Pukekohe, 2120
PCRN Silverdale Medical
Silverdale, 0932
Momentum Clinical Research - Tauranga
Tauranga, 3110
Lakeland Clinical Trials Wellington
Upper Hutt, 5018
Aotearoa Clinical Trials - Whangarei
Whangarei, 0110
Denmark6 sites
Sygehus Sønderjylland i Aabenraa
Aabenraa, 6200
Aarhus Universitetshospital, Skejby
Aarhus, 8200
Sanos Clinic - Nordjylland
Gandrup, 9362
Herlev and Gentofte Hospital
Herlev, 2730
Sanos Clinic
Herlev, 2730
Sanos Clinic - Syddanmark
Vejle, 7100
Puerto Rico3 sites
Advanced Clinical Research, LLC
Bayamón, 00959
Clinical Research Management Group Inc
Ponce, 00733
GCM Medical Group, PSC - Hato Rey Site
San Juan, 00917
About this study
Official title: A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Event-Driven Study to Investigate the Effect of Retatrutide on the Incidence of Major Adverse Cardiovascular Events and Major Adverse Kidney Events in Participants With Body Mass Index ≥27 kg/m2 and Atherosclerotic Cardiovascular Disease and/or Chronic Kidney Disease
The main purpose of this study is to determine if retatrutide can significantly lower the incidence of serious heart-related complications or prevent the worsening of kidney function. The trial will enroll adults with body mass index 27 kg/m^2 or higher and Atherosclerotic Cardiovascular Disease and/or chronic kidney disease. The study will last for about 5 years. Participants will have up to 27 clinic visits with the study doctor.
- Being tested
- Retatrutide, Placebo
- Keywords
- Cardiovascular Disease, Kidney Disease, Major Adverse Cardiovascular Events (MACE), Renal Outcomes, Cardiovascular Risk Reduction, Kidney Disease Progression, Cardiometabolic Risk Factors, Cardiovascular Outcomes, Kidney Outcomes, Type 2 Diabetes, Heart Disease, Coronary Artery Disease, Cerebrovascular Disease, Peripheral Arterial Disease, Nonfatal Myocardial Infarction (MI), Nonfatal Stroke, Cardiovascular (CV) Death, Hospitalization or Urgent Visit Due to Heart Failure (HF), Renal Death, End Stage Kidney Disease (ESKD)
- Medical subject headings
- Atherosclerosis, Renal Insufficiency, Chronic, Cardiovascular Diseases, Kidney Diseases, Diabetes Mellitus, Type 2, Heart Diseases, Coronary Artery Disease, Cerebrovascular Disorders
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
RetatrutideDrug
Also called LY3437943
Administered SC
PlaceboDrug
Administered SC
| Study group | Role | What they receive |
|---|---|---|
| Retatrutide | Experimental | Participants will receive escalated doses of retatrutide administered subcutaneously (SC) up to a maximum tolerated dose. Receives: Drug: Retatrutide |
| Placebo | Placebo comparator | Participants will receive matching placebo administered SC. Receives: Drug: Placebo |
What is being measured
The primary outcome is the main question the study is designed to answer.
Time to First Occurrence of Composite Endpoints
A composite endpoint includes nonfatal myocardial infarction (MI), nonfatal stroke, cardiovascular (CV) death, or hospitalization or urgent visit due to heart failure (HF).
Measured: Randomization up to Study Completion (Approximate 248 Weeks)
Time to First Occurrence of Composite Endpoint of End Stage Kidney Disease (ESKD), ≥ 40% Sustained Decline in Estimated Glomerular Filtration Rate (eGFR), CV Death or Renal Death
ESKD is defined as the following individual components: persistent eGFR <15 mL/min/1.73 m^2 confirmed by 2 measurements at least 4 weeks apart at the central laboratory, initiation of dialysis for at least 28 days, receiving a kidney transplant.
Sustained decline in eGFR (≥40%) will be confirmed by a repeated measure at least 4 weeks after the first result.
Measured: Randomization up to Study Completion (Approximate 248 Weeks)
Secondary outcomes (5)
Time to First Occurrence of Composite Endpoint of Major Cardiovascular Events (MACE-3)
MACE-3 includes CV death, nonfatal MI, and nonfatal stroke.
Measured: Randomization up to Study Completion (Approximate 248 Weeks)
Time to First Occurrence of Composite Endpoint of CV death, or hospitalization or urgent visit due to HF
Time to First Occurrence of Composite Endpoint of CV death, or hospitalization or urgent visit due to HF.
Measured: Randomization up to Study Completion (Approximate 248 Weeks)
Time to Occurrence of All-Cause Death
Time to all-cause death.
Measured: Randomization up to Study Completion (Approximate 248 Weeks)
Time to First Occurrence of composite endpoint of ≥ 40% Sustained Decline in eGFR, End-Stage Renal Disease (ESRD), or Renal Death
Measured: Randomization up to Study Completion (Approximate 248 Weeks)
Percentage change from Baseline in Albuminuria urinary albumin/creatinine ratio (UACR) in Participants with UACR ≥30 mg/g (0.03 mg/mg) at baseline
Measured: Randomization up to Study Completion (Approximate 248 Weeks)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted25 Apr 2024
- Study start30 Apr 2024
- Primary completionFeb 2029 (estimated)
- Study completionFeb 2029 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Atherosclerotic Cardiovascular Disease (ASCVD)Studies of the same condition, open and under way.
- More trials run by Eli Lilly and CompanyThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase 3
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind
- Who is masked
- Participant, Investigator
- Enrolment
- 10,000 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Eli Lilly and Company
- Sponsor type
- Industry (pharma, biotech, devices)
- Responsible party
- Sponsor
- Investigators
- Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 8 AM - 8 PM Eastern time (UTC/GMT - 5 hours, EST), Study director, Eli Lilly and Company
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06383390
- Sponsor's protocol ID
- 18584
- Other IDs
- J1I-MC-GZBO, 2023-508630-34-00, 2023
- Status last verified
- Oct 2026
- First submitted
- 22 Apr 2024
- Last updated
- 8 Oct 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- Yes
- FDA-regulated device
- No
- Individual data sharing
- Yes: Anonymized individual patient level data will be provided in a secure access environment upon approval of a research proposal and a signed data sharing agreement.
Publications
Heerspink HJL, van Raalte DH, Bjornstad P, Bunck MC, Wu P, Tunali I, Milicevic Z, Koeneman L. Rationale, design and baseline characteristics of the TRANSCEND-CKD trial of retatrutide in patients with chronic kidney disease. Nephrol Dial Transplant. 2026 May 29;41(6):1058-1068. doi: 10.1093/ndt/gfaf230.
PubMed 41160422