Angina, StableEASENCT06311461
Effects of Acupuncture on Symptoms of Stable Angina
A study testing Acupuncture in people with Angina, Stable, run by University of California, Los Angeles at 1 site in United States.
Trial summary
The goal of this clinical trial is to determine if a standardized 12-point acupuncture protocol will reduce pain in participants with stable angina. This study addresses the critical need to reduce persistent pain for angina. Read more about this study
- Who is it for?
- Ages 21 years and older
- Conditions the study is for
- Angina, Stable
- What is being tested?
- Acupuncture
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 112 participants
- Where
- 1 siteUnited States
- Study dates
- 1 Apr 2024to 30 Jun 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 21 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Diagnosis of stable angina or chest pain syndrome for at least 1 month (pain, pressure, or discomfort in the chest or other areas of the upper body)
- Treated with medical therapy for at least 1 month
- Experiencing symptoms at least once per week
- Speak and read English
- 21 years of age minimum
Who cannot join
- Pregnancy as some acupuncture points included in the protocol are contraindicated in pregnancy
- Physical or cognitive limitations that will prevent informed consent or completion of study tasks
- Use of steroid or prescription analgesic medications
- Concomitant biofeedback, professional massage and acupuncture.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
United States1 site, 1 recruiting
- Recruiting
UCLA School of Nursing
Los Angeles, California, 90095
Holli DeVon, PhD, 310-910-7283, hdevon@sonnet.ucla.edu
Peter Cabezas, 310-922-5835, pcabezas@sonnet.ucla.edu
About this study
Official title: Effects of Acupuncture on Symptoms of Stable Angina: A Randomized Controlled Trial
The goal of this clinical trial is to determine if a standardized 12-point acupuncture protocol will reduce pain in participants with stable angina.
This study addresses the critical need to reduce persistent pain for angina. The investigators long-term goal is symptom management for diverse women and men with angina, targeting additional angina burden borne of social disadvantage
Read more
Participants will be randomized to a 10-acupuncture session protocol, two treatments per week for five weeks, or an attention control group. Participants will view designated, non-pain related Technology, Entertainment, Design Talks equal to the time spent receiving acupuncture (~7.5-10 hrs.).
The investigators will test the efficacy of acupuncture for stable angina/chest pain syndrome to reduce pain and symptoms, improve health-related quality of life, reduce healthcare utilization and and improve patient related health outcomes.
Read the detailed description
Enrollment: The research specialist will explain the nature of the study, risks, benefits, voluntary nature of participation, and the right to discontinue participation at any time without consequences. After informed consent is obtained, participants will be randomized to the acupuncture or attention control group via REDCap's randomization module, based on the stratified, permuted block schedule prepared by our biostatistician. All participants will complete the following measures at baseline: pain now, worst pain, least pain, the Acute Coronary Syndrome Symptom Checklist, the Seattle Angina Questionnaire-7, and the PROMISv2 patient-reported outcomes instrument. Members of the treatment and control groups will report pain now, worst pain since last session, and average pain since last session following sessions 2-10 for the acupuncture group and sessions 2-5 for the control group (video sessions). All participants will complete the AHA Angina Log (diary of symptoms) and Froelicher Healthcare Utilization Questionnaire-Revised throughout the study.
Acupuncture Protocol. The acupuncturist will swab each point with alcohol. Needles will be inserted and retained for 30 minutes. Each needle will be rotated 3 times to stimulate the qi in the meridian; 10 minutes after insertion, 20 minutes after insertion, and just prior to removal at 30 minutes. Needles will be inserted using the standards of clean needle technique established by the Council of Colleges of Acupuncture and Oriental Medicine4. One size acupuncture needle, 0.25 diameter × 40 mm length, will be used. All acupuncture needles are sterile, disposable, and made of surgical stainless steel with stainless steel wound heads. Sessions will be repeated twice weekly (with at least 2 off days in between) for 5 weeks (10 sessions).
Acupuncture Point Prescription for Angina. The standardized point prescription uses acupuncture points on the front of the body to enable participants, many who are acupuncture naïve, to remain supine. This is aimed at reducing anxiety by enabling the participant to anticipate needle insertions.
Attention Control Health Videos Protocol. The attention control group will watch non-pain related Technology, Entertainment, Design Talk videos through an online link. The PIs have selected 23 general interest talks, varying from 6:00-19:08 minutes each. Topics do not contain content that could potentially improve pain. For example, titles include: 4 Questions You Should Always Ask Your Doctor; Why Our Screens Make Us Less Happy; Alzheimer's Is Not Normal Aging-And We Can Cure It; How Healthy Living Nearly Killed Me; What Makes a Good Life?; and Lessons from the Longest Study on Happiness. The videos will be accessed via a tablet, phone, or computer by the participant. Videos will be viewed from weeks 1-5 and will equate to the time the experimental group receives acupuncture (30-45 min. x 10 sessions=~7.5 hrs. total). Research staff will make an appointment. with the participant at their convenience which may increase completion rates. Following the viewing session, participants will complete a 5-item survey on REDCap that will help confirm their understanding of the video. Four items are related to the content and the final question is an acceptability question: Did you enjoy watching this video? The Research Associate will contact the participant every Thursday or Friday via the preferred method (video call or phone call) and read and record applicable survey questions in REDCap. Standardized content of the videos helps assures fidelity to the control protocol and engagement with the RAs will control for expectancy, relationship, and context effects. Those participants who complete the control group protocol will then be offered the acupuncture protocol free of charge.
- Conditions
- Angina, Stable
- Being tested
- Acupuncture, Attention control
- Medical subject headings
- Angina, Stable
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
AcupunctureProcedure or surgery
The acupuncturist will swab each point with alcohol. Needles will be inserted and retained for 30 minutes. Each needle will be rotated 3 times to stimulate the qi in the meridian; 10 minutes after insertion, 20 minutes after insertion, and just prior to removal at 30 minutes. Needles will be inserted using the standards of clean needle technique established by the Council of Colleges of Acupuncture and Oriental Medicine. One size acupuncture needle, 0.25 diameter × 40 mm length, will be used. All acupuncture needles are sterile, disposable, and made of surgical stainless steel with stainless steel wound heads. Sessions will be repeated twice weekly (with at least 2 off days in between) for 5 weeks (10 sessions).
Attention controlOther
Viewing non-pain related TED talk videos over 5 weeks approximately equal to 10 hours of treatment for the acupuncture group.
| Study group | Role | What they receive |
|---|---|---|
| Acupuncture | Experimental | Participants in the acupuncture group will receive a standardized Traditional Chinese Medicine (TCM) point prescription. Acupuncture will be administered 2 times per week for 5 weeks for a total of 10 treatments. Receives: Procedure: Acupuncture |
| Attention Control Group | Active comparator | The attention control group will view non-pain related TED talk videos over 5 weeks approximately equal to 10 hours of treatment for the acupuncture group. Receives: Other: Attention control |
What is being measured
The primary outcome is the main question the study is designed to answer.
Pain Now
numeric rating scale 0-10, 0=no pain and 10=worst pain imaginable right now
Measured: Baseline to 10 weeks
Worst Pain
numeric rating scale 0-10, 0=no pain and 10=worst pain imaginable
Measured: Baseline to 10 weeks
Least Pain
numeric rating scale 0-10, 0=no pain and 10=worst pain imaginable
Measured: Baseline to 10 weeks
Acute Coronary Syndrome like symptoms (ACS Symptom Checklist)
Change in Acute coronary syndrome type symptoms. (13 individual symptoms measured dichotomously, 0=no, did not experience, 1=yes, did experience),
Measured: Baseline to 10 weeks
Anginal Pain (Seattle Angina Questionnaire-7)
Participants will be asked: Over the past 4 weeks, on average, how many times have you had chest pain, chest tightness, or angina? 6 point scale. HIgher number is better.
Measured: Baseline to 10 weeks
Number of Angina Attacks (From American Heart Association Angina Log)
How many times the participant has had angina
Measured: Baseline to 10 weeks
Symptom Triggers (From American Heart Association Angina Log)
Participant will be Asked: What triggered the angina attack?
Measured: Baseline to 10 weeks
Pain from Angina Attack (From American Heart Association Angina Log)
4-point scale. 1-little pain to 4-severe pain.
Measured: Baseline to 10 weeks
Length of Angina Attack (American Heart Association Angina Log)
In minutes
Measured: Baseline to 10 weeks
Self-treatment for Symptoms (From American Heart Association Angina Log)
Participants will be asked to list strategies they used to mitigate pain
Measured: Baseline to 10 weeks
Secondary outcomes (7)
Functional Status Related to Angina (Seattle Angina Questionnaire-7)
Rate physical limitation due to chest pain chest tightness, or angina over the past 4 weeks
Measured: Baseline and study completion (10 weeks)
General Functional Status (PROMIS 29v.2)
Rate difficulty of performing 4 specific activities. 5-point scale 1-5 (low score is worse). Range of scores is 4-20.
Measured: Baseline and study completion (10 weeks)
Quality of Life (Seattle Angina Questionnaire-7)
Question: If you had to spend the rest of your life with your chest pain, chest tightness, or angina the way it is right now, how would you feel about that? (Range 1-5; low score is better)
Measured: Baseline and study completion (10 weeks)
Use of Nitrates and Analgesics (AHA Angina log)
Number of times participants treated their pain using nitrates or analgesics.
Measured: Baseline and study completion (10 weeks)
Patient Reported Outcomes (Patient Reported Outcomes Measurement Information System-29v.2
Participant's Assessment of their Outcomes - 6 domains. 5-point scale. Range of Scores 29-145. Higher score is better.
Measured: Baseline and study completion (10 weeks)
Healthcare Utilization
Participants report how many healthcare encounters they have had since the last session
Measured: Week 2 through Week 10
Ischemia on Electrocardiogram (ECG)
Evidence of Ischemia defined as inverted T wave and/or downsloping ST segment depression
Measured: Baseline and study completion (10 weeks)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted15 Mar 2024
- Study start1 Apr 2024
- Primary completion31 Dec 2026 (estimated)
- Study completion30 Jun 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Angina, StableStudies of the same condition, open and under way.
- More trials run by University of California, Los AngelesThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind
- Who is masked
- Investigator, Outcomes assessor
- Enrolment
- 112 participants (estimated)
Sponsor and investigators
- Lead sponsor
- University of California, Los Angeles
- Sponsor type
- University, hospital or other
- Collaborators
- University of Illinois Chicago, National Institute of Nursing Research (NINR)
- Responsible party
- Principal investigator, Holli A. DeVon PhD, RN, FAAN, FAHA, University of California, Los Angeles
- Investigators
- Holli A. DeVon, PhD, Principal investigator, University of California, Los Angeles
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06311461
- Sponsor's protocol ID
- 22-001111
- Other IDs
- 1R01NR020376-01A1
- Acronym
- EASE
- Status last verified
- Mar 2025
- First submitted
- 21 Feb 2024
- Last updated
- 3 Apr 2025
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes: The dataset will include self-reported demographic information, clinical data, and biological data. The final dataset will be stripped of identifiers and made available to share with other qualified scientists or trainees.
Publications
Nelson KA, Mirzaei S, Schlaeger JM, Li H, Burke L, Cabezas P, Meinel M, Rountree L, Su S, DeVon HA. Designing an Attention Control Condition for a Randomized Controlled Trial Using TED Talks. West J Nurs Res. 2025 Aug;47(8):764-769. doi: 10.1177/01939459251342753. Epub 2025 May 26.
PubMed 40415609
Study at a glance
From the registry record, last updated by the sponsor on 3 Apr 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effects of Acupuncture on Symptoms of Stable Angina: A Randomized Controlled Trial
- ClinicalTrials.gov ID
- NCT06311461
- Acronym / sponsor ID
- EASE / 22-001111
- Conditions
- Angina, Stable
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 112 participants (estimated)
- Lead sponsor
- University of California, Los AngelesUniversity, hospital or other
- Collaborators
- University of Illinois Chicago, National Institute of Nursing Research (NINR)
- Study start
- 1 Apr 2024 (actual)
- Primary completion
- 31 Dec 2026 (estimated)
- Study completion
- 30 Jun 2027 (estimated)
- First posted
- 15 Mar 2024 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this clinical trial is to determine if a standardized 12-point acupuncture protocol will reduce pain in participants with stable angina.
This study addresses the critical need to reduce persistent pain for angina. The investigators long-term goal is symptom management for diverse women and men with angina, targeting additional angina burden borne of social disadvantage
Participants will be randomized to a 10-acupuncture session protocol, two treatments per week for five weeks, or an attention control group. Participants will view designated, non-pain related Technology, Entertainment, Design Talks equal to the time spent receiving acupuncture (~7.5-10 hrs.).
The investigators will test the efficacy of acupuncture for stable angina/chest pain syndrome to reduce pain and symptoms, improve health-related quality of life, reduce healthcare utilization and and improve patient related health outcomes.
Detailed description
Enrollment: The research specialist will explain the nature of the study, risks, benefits, voluntary nature of participation, and the right to discontinue participation at any time without consequences. After informed consent is obtained, participants will be randomized to the acupuncture or attention control group via REDCap's randomization module, based on the stratified, permuted block schedule prepared by our biostatistician. All participants will complete the following measures at baseline: pain now, worst pain, least pain, the Acute Coronary Syndrome Symptom Checklist, the Seattle Angina Questionnaire-7, and the PROMISv2 patient-reported outcomes instrument. Members of the treatment and control groups will report pain now, worst pain since last session, and average pain since last session following sessions 2-10 for the acupuncture group and sessions 2-5 for the control group (video sessions). All participants will complete the AHA Angina Log (diary of symptoms) and Froelicher Healthcare Utilization Questionnaire-Revised throughout the study.
Acupuncture Protocol. The acupuncturist will swab each point with alcohol. Needles will be inserted and retained for 30 minutes. Each needle will be rotated 3 times to stimulate the qi in the meridian; 10 minutes after insertion, 20 minutes after insertion, and just prior to removal at 30 minutes. Needles will be inserted using the standards of clean needle technique established by the Council of Colleges of Acupuncture and Oriental Medicine4. One size acupuncture needle, 0.25 diameter × 40 mm length, will be used. All acupuncture needles are sterile, disposable, and made of surgical stainless steel with stainless steel wound heads. Sessions will be repeated twice weekly (with at least 2 off days in between) for 5 weeks (10 sessions).
Acupuncture Point Prescription for Angina. The standardized point prescription uses acupuncture points on the front of the body to enable participants, many who are acupuncture naïve, to remain supine. This is aimed at reducing anxiety by enabling the participant to anticipate needle insertions.
Attention Control Health Videos Protocol. The attention control group will watch non-pain related Technology, Entertainment, Design Talk videos through an online link. The PIs have selected 23 general interest talks, varying from 6:00-19:08 minutes each. Topics do not contain content that could potentially improve pain. For example, titles include: 4 Questions You Should Always Ask Your Doctor; Why Our Screens Make Us Less Happy; Alzheimer's Is Not Normal Aging-And We Can Cure It; How Healthy Living Nearly Killed Me; What Makes a Good Life?; and Lessons from the Longest Study on Happiness. The videos will be accessed via a tablet, phone, or computer by the participant. Videos will be viewed from weeks 1-5 and will equate to the time the experimental group receives acupuncture (30-45 min. x 10 sessions=~7.5 hrs. total). Research staff will make an appointment. with the participant at their convenience which may increase completion rates. Following the viewing session, participants will complete a 5-item survey on REDCap that will help confirm their understanding of the video. Four items are related to the content and the final question is an acceptability question: Did you enjoy watching this video? The Research Associate will contact the participant every Thursday or Friday via the preferred method (video call or phone call) and read and record applicable survey questions in REDCap. Standardized content of the videos helps assures fidelity to the control protocol and engagement with the RAs will control for expectancy, relationship, and context effects. Those participants who complete the control group protocol will then be offered the acupuncture protocol free of charge.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind (investigator, outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Acupuncture | Experimental | Procedure: AcupunctureParticipants in the acupuncture group will receive a standardized Traditional Chinese Medicine (TCM) point prescription. Acupuncture will be administered 2 times per week for 5 weeks for a total of 10 treatments. |
| Attention Control Group | Active comparator | Other: Attention controlThe attention control group will view non-pain related TED talk videos over 5 weeks approximately equal to 10 hours of treatment for the acupuncture group. |
Who may qualify
- Ages
- 21 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (5 listed)
- Diagnosis of stable angina or chest pain syndrome for at least 1 month (pain, pressure, or discomfort in the chest or other areas of the upper body)
- Treated with medical therapy for at least 1 month
- Experiencing symptoms at least once per week
- Speak and read English
- 21 years of age minimum
Key exclusion criteria (4 listed)
- Pregnancy as some acupuncture points included in the protocol are contraindicated in pregnancy
- Physical or cognitive limitations that will prevent informed consent or completion of study tasks
- Use of steroid or prescription analgesic medications
- Concomitant biofeedback, professional massage and acupuncture.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| AcupunctureThe acupuncturist will swab each point with alcohol. Needles will be inserted and retained for 30 minutes. Each needle will be rotated 3 times to stimulate the qi in the meridian; 10 minutes after insertion, 20 minutes after insertion, and just prior to removal at 30 minutes. Needles will be inserted using the standards of clean needle technique established by the Council of Colleges of Acupuncture and Oriental Medicine. One size acupuncture needle, 0.25 diameter × 40 mm length, will be used. All acupuncture needles are sterile, disposable, and made of surgical stainless steel with stainless steel wound heads. Sessions will be repeated twice weekly (with at least 2 off days in between) for 5 weeks (10 sessions). | Procedure or surgery | Acupuncture |
| Attention controlViewing non-pain related TED talk videos over 5 weeks approximately equal to 10 hours of treatment for the acupuncture group. | Other | Attention Control Group |
Primary outcome
Pain Now
Time frame: Baseline to 10 weeks
numeric rating scale 0-10, 0=no pain and 10=worst pain imaginable right now
Worst Pain
Time frame: Baseline to 10 weeks
numeric rating scale 0-10, 0=no pain and 10=worst pain imaginable
Least Pain
Time frame: Baseline to 10 weeks
numeric rating scale 0-10, 0=no pain and 10=worst pain imaginable
Acute Coronary Syndrome like symptoms (ACS Symptom Checklist)
Time frame: Baseline to 10 weeks
Change in Acute coronary syndrome type symptoms. (13 individual symptoms measured dichotomously, 0=no, did not experience, 1=yes, did experience),
Anginal Pain (Seattle Angina Questionnaire-7)
Time frame: Baseline to 10 weeks
Participants will be asked: Over the past 4 weeks, on average, how many times have you had chest pain, chest tightness, or angina? 6 point scale. HIgher number is better.
Number of Angina Attacks (From American Heart Association Angina Log)
Time frame: Baseline to 10 weeks
How many times the participant has had angina
Symptom Triggers (From American Heart Association Angina Log)
Time frame: Baseline to 10 weeks
Participant will be Asked: What triggered the angina attack?
Pain from Angina Attack (From American Heart Association Angina Log)
Time frame: Baseline to 10 weeks
4-point scale. 1-little pain to 4-severe pain.
Length of Angina Attack (American Heart Association Angina Log)
Time frame: Baseline to 10 weeks
In minutes
Self-treatment for Symptoms (From American Heart Association Angina Log)
Time frame: Baseline to 10 weeks
Participants will be asked to list strategies they used to mitigate pain
7 secondary outcomes
Functional Status Related to Angina (Seattle Angina Questionnaire-7)
Time frame: Baseline and study completion (10 weeks)
General Functional Status (PROMIS 29v.2)
Time frame: Baseline and study completion (10 weeks)
Quality of Life (Seattle Angina Questionnaire-7)
Time frame: Baseline and study completion (10 weeks)
Use of Nitrates and Analgesics (AHA Angina log)
Time frame: Baseline and study completion (10 weeks)
Patient Reported Outcomes (Patient Reported Outcomes Measurement Information System-29v.2
Time frame: Baseline and study completion (10 weeks)
Healthcare Utilization
Time frame: Week 2 through Week 10
Ischemia on Electrocardiogram (ECG)
Time frame: Baseline and study completion (10 weeks)
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 3 Apr 2025.
- Derived from this study: PubMed 40415609Nelson KA, Mirzaei S, Schlaeger JM, Li H, Burke L, Cabezas P, Meinel M, Rountree L, Su S, DeVon HA. Designing an Attention Control Condition for a Randomized Controlled Trial Using TED Talks. West J Nurs Res. 2025 Aug;47(8):764-769. doi: 10.1177/01939459251342753. Epub 2025 May 26.
- DeVon PublicationsLink provided by the sponsor.
- Individual participant dataSharing planned: Yes. The dataset will include self-reported demographic information, clinical data, and biological data. The final dataset will be stripped of identifiers and made available to share with other qualified scientists or trainees.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Holli A. DeVon, PhD principal investigator
University of California, Los Angeles
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Acupuncture in people with Angina, Stable, run by University of California, Los Angeles at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 3 Apr 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Holli A. DeVon, PhD (3109107283, hdevon@sonnet.ucla.edu), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Pain Now (time frame: Baseline to 10 weeks). The study lists 10 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT06311461, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 3 Apr 2025.