Carotid WebFamily-WEBNCT06336083
Familial Form of Carotid Web: a Doppler Ultrasound Study
A study testing Doppler ultrasound in people with Carotid Web, run by University Hospital, Toulouse at 1 site in France.
Trial summary
There is no evidence of familial forms of carotid web. The aim of this study is to determine the prevalence of carotid web among relatives of patient with carotid web using carotid doppler ultrasound. Read more about this study
- Who is it for?
- Ages 18 to 65 yearsHealthy volunteers can take part
- Conditions the study is for
- Carotid Web
- What is being tested?
- Doppler ultrasound
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 90 participants
- Where
- 1 siteFrance
- Study dates
- 11 Sep 2024to Sep 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 65 years
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- Carotid Web index patients:
- Patients with carotid web confirmed by CT angiogram (CTA) of cervical arteries or digital substraction angiogram (DSA).
- At least one first degree relative aged younger than 65 years old.
- Relatives patients :
- First degree relatives of patient with diagnosed carotid web.
Who cannot join
- Persons placed under judicial protection or under another protection status
- Pregnant or breastfeeding woman.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
France1 site, 1 recruiting
- Recruiting
CHU de Toulouse, Purpan
Toulouse, 31059
Louis FONTAINE, MD, 05 61 77 93 67 ext. +33, fontaine.l@chu-toulouse.fr
About this study
Official title: Family Screening for Internal Carotid Diaphragm Dysplasia (Carotid WEB): a Doppler Ultrasound Study
There is no evidence of familial forms of carotid web. The aim of this study is to determine the prevalence of carotid web among relatives of patient with carotid web using carotid doppler ultrasound.
Read the detailed description
Carotid web are rare, focal dysplasia of the internal carotid artery and a high risk causes of stroke in young adult. Natural history of these dysplasia remains poorly understood. High prevalence of carotid web among Afro-Caribbean population and the similarity between carotid web and fibromuscular dysplasia, suggest existence of genetic factors. But there has been to our knowledge no familial form of carotid web reported. The aim of this study is to determine the prevalence of carotid web among relatives of patients with carotid web using carotid duplex doppler ultrasound.
Researchers aim to test whether carotid web could be detected in relatives of patients with known carotid web, using duplex doppler ultrasound.
This is a pilot, transversal, single-center study performed at Toulouse University Hospital, France. From 30 carotid web cases aged under 65 (patients with previously known Carotid web, symptomatic or not) followed in neurology department, investigators aim to include 60 first-degree relatives younger than 65 years old. Included relatives will underwent carotid duplex doppler ultrasound to detect carotid web. The primary outcome is the prevalence of carotid web among relatives. Secondary outcomes include : Number of families with at least one relative who has been diagnosed with carotid web, number of relatives who has been diagnosed with carotid web per family, clinical characteristics of patients and morphological characteristics of carotid web.
- Conditions
- Carotid Web
- Being tested
- Doppler ultrasound
- Keywords
- echography doppler, carotid web, inheritance
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Doppler ultrasoundProcedure or surgery
Participants will receive doppler ultrasound of the carotid arteries, and no other interventions studied
| Study group | Role | What they receive |
|---|---|---|
| Doppler ultrasound | Experimental | First degree relatives of patient with diagnosed carotid web will receive an echography doppler of the carotid arteries and answer questionnaires Receives: Procedure: Doppler ultrasound |
What is being measured
The primary outcome is the main question the study is designed to answer.
Evaluation of the prevalence of carotid web by doppler ultrasound in first-degree relatives of patients with carotid web.
Number of first-degree relatives with at least one carotid web on doppler ultrasound.
Measured: Inclusion day
Secondary outcomes (2)
Description of the clinical characteristics of relatives with carotid web and their index case.
Clinical characteristics of relatives with a carotid web and index cases: age, sex, vascular risk factors, medical history, family history, current treatments, bilateral nature of the carotid web.
Measured: Inclusion day
Description of the morphological characteristics of relatives with carotid web and their index case.
Morphological characteristics on doppler ultrasound of the carotid web in relatives and in index cases: length, width, echogenicity, hemodynamic impact.
Measured: Inclusion day
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted28 Mar 2024
- Study start11 Sep 2024
- Primary completionSep 2027 (estimated)
- Study completionSep 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Carotid WebStudies of the same condition, open and under way.
- More trials run by University Hospital, ToulouseThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Screening
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Enrolment
- 90 participants (estimated)
Sponsor and investigators
- Lead sponsor
- University Hospital, Toulouse
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Claire VILLEPINTE, MD, Principal investigator, University Hospital, Toulouse
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06336083
- Sponsor's protocol ID
- RC31/23/0618
- Acronym
- Family-WEB
- Status last verified
- Nov 2026
- First submitted
- 21 Mar 2024
- Last updated
- 5 Nov 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 5 Nov 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Family Screening for Internal Carotid Diaphragm Dysplasia (Carotid WEB): a Doppler Ultrasound Study
- ClinicalTrials.gov ID
- NCT06336083
- Acronym / sponsor ID
- Family-WEB / RC31/23/0618
- Conditions
- Carotid Web
- Keywords
- echography doppler, carotid web, inheritance
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 90 participants (estimated)
- Lead sponsor
- University Hospital, ToulouseUniversity, hospital or other
- Study start
- 11 Sep 2024 (actual)
- Primary completion
- Sep 2027 (estimated)
- Study completion
- Sep 2027 (estimated)
- First posted
- 28 Mar 2024 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
There is no evidence of familial forms of carotid web. The aim of this study is to determine the prevalence of carotid web among relatives of patient with carotid web using carotid doppler ultrasound.
Detailed description
Carotid web are rare, focal dysplasia of the internal carotid artery and a high risk causes of stroke in young adult. Natural history of these dysplasia remains poorly understood. High prevalence of carotid web among Afro-Caribbean population and the similarity between carotid web and fibromuscular dysplasia, suggest existence of genetic factors. But there has been to our knowledge no familial form of carotid web reported. The aim of this study is to determine the prevalence of carotid web among relatives of patients with carotid web using carotid duplex doppler ultrasound.
Researchers aim to test whether carotid web could be detected in relatives of patients with known carotid web, using duplex doppler ultrasound.
This is a pilot, transversal, single-center study performed at Toulouse University Hospital, France. From 30 carotid web cases aged under 65 (patients with previously known Carotid web, symptomatic or not) followed in neurology department, investigators aim to include 60 first-degree relatives younger than 65 years old. Included relatives will underwent carotid duplex doppler ultrasound to detect carotid web. The primary outcome is the prevalence of carotid web among relatives. Secondary outcomes include : Number of families with at least one relative who has been diagnosed with carotid web, number of relatives who has been diagnosed with carotid web per family, clinical characteristics of patients and morphological characteristics of carotid web.
Study design
- Primary purpose
- Screening
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Doppler ultrasound | Experimental | Procedure: Doppler ultrasoundFirst degree relatives of patient with diagnosed carotid web will receive an echography doppler of the carotid arteries and answer questionnaires |
Who may qualify
- Ages
- 18 to 65 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (5 listed)
- Patients with carotid web confirmed by CT angiogram (CTA) of cervical arteries or digital substraction angiogram (DSA).
- At least one first degree relative aged younger than 65 years old.
- First degree relatives of patient with diagnosed carotid web.
Key exclusion criteria (2 listed)
- Persons placed under judicial protection or under another protection status
- Pregnant or breastfeeding woman.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Doppler ultrasoundParticipants will receive doppler ultrasound of the carotid arteries, and no other interventions studied | Procedure or surgery | Doppler ultrasound |
Primary outcome
Evaluation of the prevalence of carotid web by doppler ultrasound in first-degree relatives of patients with carotid web.
Time frame: Inclusion day
Number of first-degree relatives with at least one carotid web on doppler ultrasound.
2 secondary outcomes
Description of the clinical characteristics of relatives with carotid web and their index case.
Time frame: Inclusion day
Description of the morphological characteristics of relatives with carotid web and their index case.
Time frame: Inclusion day
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 5 Nov 2026.
- Individual participant dataSharing planned: No
Related trials for Carotid Web
RecruitingObservational study
Prevalence of Carotid Web in Youth
Carotid Web
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Claire VILLEPINTE, MD principal investigator
University Hospital, Toulouse
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Doppler ultrasound in people with Carotid Web, run by University Hospital, Toulouse at 1 site in France.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 2 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 5 Nov 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in France. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Louis FONTAINE, MD (05 61 77 93 67 ext. +33, fontaine.l@chu-toulouse.fr), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Evaluation of the prevalence of carotid web by doppler ultrasound in first-degree relatives of patients with carotid web. (time frame: Inclusion day). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 5 Nov 2026.