Oral ManifestationsNCT06372366
Oral Manifestations in Egyptian Children With Short Stature
An observational study of Oral Manifestations and Short Stature, run by Cairo University.
Trial summary
Children with short stature have been reported to show a higher prevalence of enamel hypoplasia, delayed tooth eruption, and malocclusion compared to children of normal growth status Read more about this study
- Who is it for?
- Ages 6 to 12 yearsHealthy volunteers can take part
- Conditions the study is for
- Oral Manifestations, Short Stature
- How many people
- 2 participants
- Where
- No sites listed yet
- Study dates
- 15 Dec 2025to 15 Apr 2026
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 6 to 12 years
- All sexes
- Healthy volunteers accepted
- Child
Study population: Children aged from 6 to 12 years attending National Nutrition Institute will be included in the study according to the following criteria:
Who may be able to join
- • - Egyptian children aged 6-12 years.
- - Diagnosed with short stature (height-for-age < -2 SD based on WHO standards).
- - Diagnosed and confirmed by a pediatric endocrinologist.
- Controls:
- - Age- and sex-matched children with normal height (height-for-age between -1 and +1 SD).
- - Recruited from the same geographic and socioeconomic backgrounds.
Who cannot join
- 1- Presence of syndromic conditions (e.g., Turner syndrome, Down syndrome).
- 2- Chronic diseases (e.g., renal, cardiac, or endocrine conditions other than idiopathic short stature).
- 3- Long-term medication use known to affect growth or oral development.
About this study
Official title: Oral Manifestations in a Group of Egyptian Children With Short Stature and a Group of Healthy Egyptian Children : A Cross Sectional Study
Children with short stature have been reported to show a higher prevalence of enamel hypoplasia, delayed tooth eruption, and malocclusion compared to children of normal growth status
Read the detailed description
Normal growth is a process in which a single cell develops into a fully grown adult. The growth rate decelerates from the embryonic stage to adulthood, except during puberty. Most adults fall within a narrow range of stature, typically between 1.5 to 2 meters. Variations in height among children are largely determined by a set of genes inherited from their parents. These genes influence stature distribution within the normal range for nearly 95% of the population, with variation generally being benign.
Short stature in children-defined as a height-for-age below -2 standard deviations (SD) from the WHO growth reference-typically corresponding to the 2.3rd percentile, though many texts use the 3rd percentile as the cutoff. Short stature can be assessed using various anthropometric instruments. The condition may be physiological, with no abnormalities other than stature (polygenic short stature), or pathological, resulting from systemic illnesses, nutritional deficiencies, psychosocial factors, hormonal imbalances, genetic disorders, or musculoskeletal pathologies. A subset of infants born small for gestational age (SGA) may be at risk of persistent short stature.
Children with short stature have been reported to show a higher prevalence of enamel hypoplasia, delayed tooth eruption, and malocclusion compared to children of normal growth status . These oral manifestations may result from shared pathogenic mechanisms, such as nutritional deficits, systemic disturbances during enamel formation, or hormonal imbalances affecting growth and development. A clearer understanding of these associations may enhance multidisciplinary screening and care.
This study aims to investigate the prevalence and characteristics of oral manifestations in Egyptian children with short stature, contributing to the limited regional data on this topic.
- Conditions
- Oral Manifestations, Short Stature
- Medical subject headings
- Oral Manifestations, Dwarfism
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
| Study group | Role | What they receive |
|---|---|---|
| 17children with short stature | Not described | |
| 17 normal children | Not described |
What is being measured
The primary outcome is the main question the study is designed to answer.
Dental enamel defects
using Aine's classification
Measured: 3 months
Delayed dental eruption
using Dental eruption table
Measured: 3 months
Malocclusion
using Angle classification
Measured: 3 months
Dental caries experience
using def+DMF
Measured: 3 months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted18 Apr 2024
- Study start15 Dec 2025 (estimated)
- Primary completion15 Mar 2026 (estimated)
- Study completion15 Apr 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Oral ManifestationsStudies of the same condition, open and under way.
- More trials run by Cairo UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Other
- Time perspective
- Cross-sectional
- Enrolment
- 2 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Cairo University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Nada Soliman Abd El-Ghaffar Abd El-Megid Abd Allah, Cairo University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06372366
- Sponsor's protocol ID
- Oral signs ,short stature
- Status last verified
- Jul 2025
- First submitted
- 14 Apr 2024
- Last updated
- 2 Dec 2025
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 2 Dec 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Oral Manifestations in a Group of Egyptian Children With Short Stature and a Group of Healthy Egyptian Children : A Cross Sectional Study
- ClinicalTrials.gov ID
- NCT06372366
- Acronym / sponsor ID
- Oral signs ,short stature
- Conditions
- Oral Manifestations, Short Stature
- Study type
- Observational
- Recruitment status
- Not yet recruiting
- Enrolment
- 2 participants (estimated)
- Lead sponsor
- Cairo UniversityUniversity, hospital or other
- Study start
- 15 Dec 2025 (estimated)
- Primary completion
- 15 Mar 2026 (estimated)
- Study completion
- 15 Apr 2026 (estimated)
- First posted
- 18 Apr 2024 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Children with short stature have been reported to show a higher prevalence of enamel hypoplasia, delayed tooth eruption, and malocclusion compared to children of normal growth status
Detailed description
Normal growth is a process in which a single cell develops into a fully grown adult. The growth rate decelerates from the embryonic stage to adulthood, except during puberty. Most adults fall within a narrow range of stature, typically between 1.5 to 2 meters. Variations in height among children are largely determined by a set of genes inherited from their parents. These genes influence stature distribution within the normal range for nearly 95% of the population, with variation generally being benign.
Short stature in children-defined as a height-for-age below -2 standard deviations (SD) from the WHO growth reference-typically corresponding to the 2.3rd percentile, though many texts use the 3rd percentile as the cutoff. Short stature can be assessed using various anthropometric instruments. The condition may be physiological, with no abnormalities other than stature (polygenic short stature), or pathological, resulting from systemic illnesses, nutritional deficiencies, psychosocial factors, hormonal imbalances, genetic disorders, or musculoskeletal pathologies. A subset of infants born small for gestational age (SGA) may be at risk of persistent short stature.
Children with short stature have been reported to show a higher prevalence of enamel hypoplasia, delayed tooth eruption, and malocclusion compared to children of normal growth status . These oral manifestations may result from shared pathogenic mechanisms, such as nutritional deficits, systemic disturbances during enamel formation, or hormonal imbalances affecting growth and development. A clearer understanding of these associations may enhance multidisciplinary screening and care.
This study aims to investigate the prevalence and characteristics of oral manifestations in Egyptian children with short stature, contributing to the limited regional data on this topic.
Study design
- Observational model
- Other
- Time perspective
- Cross-sectional
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| 17children with short stature | – | – |
| 17 normal children | – | – |
Who may qualify
- Ages
- 6 to 12 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Child
- Study population
- Children aged from 6 to 12 years attending National Nutrition Institute will be included in the study according to the following criteria:
Key inclusion criteria (6 listed)
- • - Egyptian children aged 6-12 years.
- - Diagnosed with short stature (height-for-age < -2 SD based on WHO standards).
- - Diagnosed and confirmed by a pediatric endocrinologist.
- - Age- and sex-matched children with normal height (height-for-age between -1 and +1 SD).
- - Recruited from the same geographic and socioeconomic backgrounds.
Key exclusion criteria (3 listed)
- 1- Presence of syndromic conditions (e.g., Turner syndrome, Down syndrome).
- 2- Chronic diseases (e.g., renal, cardiac, or endocrine conditions other than idiopathic short stature).
- 3- Long-term medication use known to affect growth or oral development.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Dental enamel defects
Time frame: 3 months
using Aine's classification
Delayed dental eruption
Time frame: 3 months
using Dental eruption table
Malocclusion
Time frame: 3 months
using Angle classification
Dental caries experience
Time frame: 3 months
using def+DMF
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 2 Dec 2025.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
The record lists no contact. Use the official record to reach the sponsor.
Questions about this trial
What is this clinical trial studying?
An observational study of Oral Manifestations and Short Stature, run by Cairo University.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 2 Dec 2025. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Dental enamel defects (time frame: 3 months). The study lists 4 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 2 Dec 2025.