HypoxiaNCT06373562
Effect of Hypoxic Exposure on Blood Variables in Elite Wrestlers
A study testing hypoxia in people with Hypoxia, run by Poznan University of Physical Education.
Trial summary
Twelve male wrestlers of the National Polish Team were observed in the study during the camp. The hypoxia group (n=6) participated in sports training and hypoxic exposure, while the control group (n=6) included wrestlers participating only in sports training. The hypoxic group lived and slept in hypoxic rooms. Read more about this study
- Who is it for?
- Any age, men onlyHealthy volunteers can take part
- Conditions the study is for
- Hypoxia
- What is being tested?
- hypoxia
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 12 participants
- Where
- No sites listed yet
- Study dates
- 2 Dec 2013to 18 Dec 2013
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages Any age
- Men only
- Healthy volunteers accepted
- Child, Adult, Older adult
Who may be able to join
- member of national wrestler's teams, and sports camp participant.
Who cannot join
- negative symptoms of hypoxia, and/or injury.
About this study
Official title: The Influence of Sports and Hypoxic Training on the Regeneration and Adaptation of Skeletal Muscles to Exercise in Wrestlers.
Twelve male wrestlers of the National Polish Team were observed in the study during the camp. The hypoxia group (n=6) participated in sports training and hypoxic exposure, while the control group (n=6) included wrestlers participating only in sports training. The hypoxic group lived and slept in hypoxic rooms. During the camp, all wrestlers followed the same training schedule and diet. In the blood were determined levels of creatine kinase (CK), C-reactive protein (hsCRP) concentration, nitric oxide (NO), morphology, reticulocytes, lipid profile, and ferritin. Also vascular endothelial growth factor (VEGF, VEGFR2, and VEGFR3), erythropoietin (EPO), angiopoietin (Ang 1, Ang 2), endothelial cell adhesion factor-1 (VCAM-1), Erythropoietin (EPO) and hypoxia-inducible factor 1 (HIF-1). Body weight composition was determined.
Read the detailed description
Hypoxia exposure applied to professional athletes has attracted attention and scientific debate due to its effects on improving physiological response through cardiovascular and hematological mechanisms. Presently, hypoxic training programs are developed to improve exercise performance in athletes, a useful training method for athletes that may improve their performance in future sea-level competitions. 12 males were divided into the hypoxic (H) and control (C) groups. Group H was living and sleeping in hypoxic rooms (method live high-train low) for 8-14h/d (FiO2≈14%). The implementation of the project was intended to: 1) assess the dynamics of changes in the concentration of pro-inflammatory indicators and hematopoiesis in athletes to variable training loads and hypoxia, 2) explain the usefulness of hypoxic exposure in adaptation to physical exercise, 3) observe the length of the hypoxic cycle necessary to maintain the effect of high-altitude training. In the blood serum the level of basic biochemical indicators of fatigue related to muscle damage, inflammation, and energy deficit, i.e. total creatine kinase (CK) activity, C-reactive protein (hsCRP) concentration, nitric oxide (NO). Moreover, basic hematological indicators: morphology, reticulocytes, lipid profile, and ferritin. Also, angiogenesis regulators: vascular endothelial growth factor (VEGF) and VEGF receptors (VEGFR2 and VEGFR3), erythropoietin (EPO), angiopoietin (Ang 1, Ang 2), endothelial cell adhesion factor-1 (VCAM-1), Erythropoietin (EPO) and hypoxia-inducible factor 1 (HIF-1). Body weight composition was determined using a body analyzer. Further investigations into hypoxia methods while considering individual capabilities are necessary for gaining deeper insights, into how hypoxia affects blood count and different blood variables among athletes.
- Conditions
- Hypoxia
- Being tested
- hypoxia
- Keywords
- hypoxia, EPO, wrestlers, HIF-1, athletes
- Medical subject headings
- Hypoxia
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
hypoxiaOther
The athletes were living in hypoxic rooms, which could simulate a selected altitude above sea level.
| Study group | Role | What they receive |
|---|---|---|
| Hypoxia | Experimental | Live High-Train Low method was used. Receives: Other: hypoxia |
| Control group | No intervention | The control group was participating in the same training protocol. |
What is being measured
The primary outcome is the main question the study is designed to answer.
CK
creatine kinase
Measured: The blood was taken at the beginning of the camp (baseline), after 6 days, after 15 days.
hsCRP
reactive C-protein
Measured: The blood was taken at the beginning of the camp (baseline), after 6 days, after 15 days.
HIF-1
hypoxia-inducible factor 1
Measured: The blood was taken at the beginning of the camp (baseline), after 6 days, after 15 days.
EPO
Erythropoietin
Measured: The blood was taken at the beginning of the camp (baseline), after 6 days, after 15 days.
VEGF, VEGF 2, VEGF 3.
vascular endothelial growth factor
Measured: The blood was taken at the beginning of the camp (baseline), after 6 days, after 15 days.
Ang 1, Ang 2
angiopoietin
Measured: The blood was taken at the beginning of the camp (baseline), after 6 days, after 15 days.
VCAM-1
endothelial cell adhesion factor-1
Measured: The blood was taken at the beginning of the camp (baseline), after 6 days, after 15 days.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted18 Apr 2024
- Study start2 Dec 2013
- Primary completion18 Dec 2013
- Study completion18 Dec 2013
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (4)Papers the sponsor has linked to this study.
- Other trials for HypoxiaStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Diagnosis
- Allocation
- Randomised
- Intervention model
- Single group
- Model description
- Wrestlers in H group were living in hypoxic rooms for 8-14h/d and between that they were participating in sports training. C group was participating in the same training protocol.
- Masking
- None (open label)
- Enrolment
- 12 participants (actual)
Sponsor and investigators
- Lead sponsor
- Poznan University of Physical Education
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Anna Kasperska, Principal investigator, Poznań University of Physical Education, Faculty of Sport Sciences in Gorzów Wielkopolski, Poland;
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06373562
- Sponsor's protocol ID
- Wrestlers LH-TL
- Status last verified
- Apr 2024
- First submitted
- 12 Apr 2024
- Last updated
- 17 Jan 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Kasperska A, Zembron-Lacny A. The effect of intermittent hypoxic exposure on erythropoietic response and hematological variables in elite athletes. Physiol Res. 2020 Apr 30;69(2):283-290. doi: 10.33549/physiolres.934316. Epub 2020 Mar 23.
PubMed 32199016Czuba M, Fidos-Czuba O, Ploszczyca K, Zajac A, Langfort J. Comparison of the effect of intermittent hypoxic training vs. the live high, train low strategy on aerobic capacity and sports performance in cyclists in normoxia. Biol Sport. 2018 Mar;35(1):39-48. doi: 10.5114/biolsport.2018.70750. Epub 2017 Oct 11.
PubMed 30237660Wilber RL. Application of altitude/hypoxic training by elite athletes. Med Sci Sports Exerc. 2007 Sep;39(9):1610-24. doi: 10.1249/mss.0b013e3180de49e6.
PubMed 17805095Li J, Li Y, Atakan MM, Kuang J, Hu Y, Bishop DJ, Yan X. The Molecular Adaptive Responses of Skeletal Muscle to High-Intensity Exercise/Training and Hypoxia. Antioxidants (Basel). 2020 Jul 24;9(8):656. doi: 10.3390/antiox9080656.
PubMed 32722013
Study at a glance
From the registry record, last updated by the sponsor on 17 Jan 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Influence of Sports and Hypoxic Training on the Regeneration and Adaptation of Skeletal Muscles to Exercise in Wrestlers.
- ClinicalTrials.gov ID
- NCT06373562
- Acronym / sponsor ID
- Wrestlers LH-TL
- Conditions
- Hypoxia
- Keywords
- hypoxia, EPO, wrestlers, HIF-1, athletes
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 12 participants (actual)
- Lead sponsor
- Poznan University of Physical EducationUniversity, hospital or other
- Study start
- 2 Dec 2013 (actual)
- Primary completion
- 18 Dec 2013 (actual)
- Study completion
- 18 Dec 2013 (actual)
- First posted
- 18 Apr 2024 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Twelve male wrestlers of the National Polish Team were observed in the study during the camp. The hypoxia group (n=6) participated in sports training and hypoxic exposure, while the control group (n=6) included wrestlers participating only in sports training. The hypoxic group lived and slept in hypoxic rooms. During the camp, all wrestlers followed the same training schedule and diet. In the blood were determined levels of creatine kinase (CK), C-reactive protein (hsCRP) concentration, nitric oxide (NO), morphology, reticulocytes, lipid profile, and ferritin. Also vascular endothelial growth factor (VEGF, VEGFR2, and VEGFR3), erythropoietin (EPO), angiopoietin (Ang 1, Ang 2), endothelial cell adhesion factor-1 (VCAM-1), Erythropoietin (EPO) and hypoxia-inducible factor 1 (HIF-1). Body weight composition was determined.
Detailed description
Hypoxia exposure applied to professional athletes has attracted attention and scientific debate due to its effects on improving physiological response through cardiovascular and hematological mechanisms. Presently, hypoxic training programs are developed to improve exercise performance in athletes, a useful training method for athletes that may improve their performance in future sea-level competitions. 12 males were divided into the hypoxic (H) and control (C) groups. Group H was living and sleeping in hypoxic rooms (method live high-train low) for 8-14h/d (FiO2≈14%). The implementation of the project was intended to: 1) assess the dynamics of changes in the concentration of pro-inflammatory indicators and hematopoiesis in athletes to variable training loads and hypoxia, 2) explain the usefulness of hypoxic exposure in adaptation to physical exercise, 3) observe the length of the hypoxic cycle necessary to maintain the effect of high-altitude training. In the blood serum the level of basic biochemical indicators of fatigue related to muscle damage, inflammation, and energy deficit, i.e. total creatine kinase (CK) activity, C-reactive protein (hsCRP) concentration, nitric oxide (NO). Moreover, basic hematological indicators: morphology, reticulocytes, lipid profile, and ferritin. Also, angiogenesis regulators: vascular endothelial growth factor (VEGF) and VEGF receptors (VEGFR2 and VEGFR3), erythropoietin (EPO), angiopoietin (Ang 1, Ang 2), endothelial cell adhesion factor-1 (VCAM-1), Erythropoietin (EPO) and hypoxia-inducible factor 1 (HIF-1). Body weight composition was determined using a body analyzer. Further investigations into hypoxia methods while considering individual capabilities are necessary for gaining deeper insights, into how hypoxia affects blood count and different blood variables among athletes.
Study design
- Primary purpose
- Diagnosis
- Allocation
- Randomised
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 2
- Model description
- Wrestlers in H group were living in hypoxic rooms for 8-14h/d and between that they were participating in sports training. C group was participating in the same training protocol.
| Arm | Type | Receives |
|---|---|---|
| Hypoxia | Experimental | Other: hypoxiaLive High-Train Low method was used. |
| Control group | No intervention | –The control group was participating in the same training protocol. |
Who may qualify
- Sex
- Male only
- Healthy volunteers
- Accepted
- Age groups
- Child, Adult, Older adult
Key inclusion criteria (1 listed)
- member of national wrestler's teams, and sports camp participant.
Key exclusion criteria (1 listed)
- negative symptoms of hypoxia, and/or injury.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| hypoxiaThe athletes were living in hypoxic rooms, which could simulate a selected altitude above sea level. | Other | Hypoxia |
Primary outcome
CK
Time frame: The blood was taken at the beginning of the camp (baseline), after 6 days, after 15 days.
creatine kinase
hsCRP
Time frame: The blood was taken at the beginning of the camp (baseline), after 6 days, after 15 days.
reactive C-protein
HIF-1
Time frame: The blood was taken at the beginning of the camp (baseline), after 6 days, after 15 days.
hypoxia-inducible factor 1
EPO
Time frame: The blood was taken at the beginning of the camp (baseline), after 6 days, after 15 days.
Erythropoietin
VEGF, VEGF 2, VEGF 3.
Time frame: The blood was taken at the beginning of the camp (baseline), after 6 days, after 15 days.
vascular endothelial growth factor
Ang 1, Ang 2
Time frame: The blood was taken at the beginning of the camp (baseline), after 6 days, after 15 days.
angiopoietin
VCAM-1
Time frame: The blood was taken at the beginning of the camp (baseline), after 6 days, after 15 days.
endothelial cell adhesion factor-1
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 17 Jan 2025.
- Background: PubMed 32199016Kasperska A, Zembron-Lacny A. The effect of intermittent hypoxic exposure on erythropoietic response and hematological variables in elite athletes. Physiol Res. 2020 Apr 30;69(2):283-290. doi: 10.33549/physiolres.934316. Epub 2020 Mar 23.
- Background: PubMed 30237660Czuba M, Fidos-Czuba O, Ploszczyca K, Zajac A, Langfort J. Comparison of the effect of intermittent hypoxic training vs. the live high, train low strategy on aerobic capacity and sports performance in cyclists in normoxia. Biol Sport. 2018 Mar;35(1):39-48. doi: 10.5114/biolsport.2018.70750. Epub 2017 Oct 11.
- Background: PubMed 17805095Wilber RL. Application of altitude/hypoxic training by elite athletes. Med Sci Sports Exerc. 2007 Sep;39(9):1610-24. doi: 10.1249/mss.0b013e3180de49e6.
- Background: PubMed 32722013Li J, Li Y, Atakan MM, Kuang J, Hu Y, Bishop DJ, Yan X. The Molecular Adaptive Responses of Skeletal Muscle to High-Intensity Exercise/Training and Hypoxia. Antioxidants (Basel). 2020 Jul 24;9(8):656. doi: 10.3390/antiox9080656.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Anna Kasperska principal investigator
Poznań University of Physical Education, Faculty of Sport Sciences in Gorzów Wielkopolski, Poland;
Questions about this trial
What is this clinical trial studying?
A study testing hypoxia in people with Hypoxia, run by Poznan University of Physical Education.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 17 Jan 2025. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
CK (time frame: The blood was taken at the beginning of the camp (baseline), after 6 days, after 15 days.). The study lists 7 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT06373562, which also lists 4 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 17 Jan 2025.