Osteoarthritis, KneeNCT06391047
Impact of Mulligan Squeeze Technique on Meniscal Derangement in Knee Osteoarthritis Patients
A study testing Mulligan's Squeeze Technique - manual therapy and Conventional Physiotherapy in people with Osteoarthritis, Knee and Knee Injuries, run by University of Faisalabad at 1 site in Pakistan.
Trial summary
The objective of this study is to find out the effects of Mulligan's Squeeze technique added as a complementary treatment to the conventional physiotherapy for the management of meniscal derangement in knee osteoarthritis patients. Read more about this study
- Who is it for?
- Ages 30 to 55 yearsHealthy volunteers can take part
- Conditions the study is for
- Osteoarthritis, Knee, Knee Injuries, Meniscus; Derangement
- What is being tested?
- Mulligan's Squeeze Technique - manual therapy and Conventional Physiotherapy
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 26 participants
- Where
- 1 sitePakistan
- Study dates
- 2 Feb 2024to 25 Apr 2024
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 30 to 55 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- • Pain during maximal knee flexion, pain when maximal extension of knee occurs
- Both genders were taken; male and female
- Age between 30 to 55 years
- Tenderness along the line of joint
- Complain or history of abnormal clicking sounds and/or popping of knee
- If any of the mentioned special tests are positive: "Apley's compression and distraction test", the "Disco test or Thessaly's test" with almost 20° flexed position of knee, and "McMurray's test"
- Participants who were willing to take part in the study
Who cannot join
- • Presence of any knee co-morbidities
- Knee OA of Grade 4
- ACL or some other knee ligament injury/tears
- Contusion present on knee, fracture of knee
- Knee dislocation
- Knee instability due to any ligamentous injury
- Constant pain or discomfort due to underlying reasons (e.g. hyper-algesia), and any other wound or ailment
- Participant not willing to be a part of the study
Trial locations and contacts
1 site in 1 country.
About this study
Official title: The Impact of Mulligan Squeeze Technique as an Adjunct to Conventional Physiotherapy on Meniscal Derangement in Knee Osteoarthritis Patients
The objective of this study is to find out the effects of Mulligan's Squeeze technique added as a complementary treatment to the conventional physiotherapy for the management of meniscal derangement in knee osteoarthritis patients.
Read the detailed description
This study was performed to determine the consequences of conventional physical therapy with and without Mulligan's Squeeze technique for meniscal derangement treatment in patients with knee osteoarthritis. This research study was a randomized controlled trial. The sample size was of 26 subjects. The subjects were nominated in accordance to the inclusion and exclusion criteria. They were equally and randomly divided into two groups. One group received Mulligan's Squeeze technique along with conventional physiotherapy exercises, with hot pack prior to the exercise session. The control group was only given conventional therapy exercises with hot pack application prior to any exercise. The treatment was given for two weeks and a total of six sessions, three sessions each week. The primary outcome measures were Numerical Pain Rating Scale (NPRS) for pain rating and goniometer to record range of knee flexion. The secondary outcome measures were Patient-specific functional scale (PSFS) and Knee-injury osteoarthritis outcome score (KOOS). The measurements were taken at baseline, at end of first week and after the second week. The data was analyzed by using IBM SPSS software version 27.
- Conditions
- Osteoarthritis, Knee, Knee Injuries, Meniscus; Derangement, Meniscus Tear, Meniscus Lesion
- Being tested
- Mulligan's Squeeze Technique - manual therapy, Conventional Physiotherapy
- Keywords
- Knee Osteoarthritis, manual therapy intervention; rehabilitation, Menisci;
- Medical subject headings
- Osteoarthritis, Knee, Knee Injuries
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Mulligan's Squeeze Technique - manual therapyOther
This technique was introduced by Brian R. Mulligan. In this technique the therapist places thumb along the tender joint margin and applies force centrally. The patient actively flexes knee and therapist progressively enhances force and at end applies overpressure. This force is decreased as knee moves towards extension. This method helps to maintain the meniscus in its normal position and corrects the derangement of meniscus.
Conventional PhysiotherapyOther
It includes stretching and strengthening exercises of muscles of the knee joint.
| Study group | Role | What they receive |
|---|---|---|
| Group A | Experimental | Group A was given hot pack at knee joint for 10-15min. Then the Mulligan's Squeeze Technique was applied. The patient in supine lying. The therapist placed thumb on joint line tenderness of knee. With the other thumb, the therapist reinforced the first thumb. The patient was asked to slowly flex knee. The therapist maintaining the thumb contact, applied the force centrally. The force was increased progressively as the knee moved towards full range of available flexion. At the end range, the therapist assisted the tibia to move towards more flexion with ulnar border of their hand. This position was maintained for a few seconds and the overpressure was applied. Then patient was asked to perform knee extension. As the knee moved towards extension the force applied from both thumbs was progressively reduced. At maximal extension, no force was applied. This was repeated 10 times in each set with total 3 sets. After this stretching and strengthening exercises were performed by patient. Receives: Other: Mulligan's Squeeze Technique - manual therapy; Other: Conventional Physiotherapy |
| Group B | Active comparator | Group B was given hot pack at knee joint for 10-15min. Then they were asked to perform stretching and strengthening exercises of the knee with at least 10 repetitions in each set and a total two sets in a day. Receives: Other: Conventional Physiotherapy |
What is being measured
The primary outcome is the main question the study is designed to answer.
Numerical Pain Rating Scale (NPRS)
It was used to record the level of knee pain
Measured: Readings were taken at baseline, after 1st week and at end of 2nd week.
Goniometer
It was used to find out the range of movement of knee flexion.
Measured: Readings were taken at baseline, after 1st week and at end of 2nd week.
Secondary outcomes (2)
Patient Specific Functional Scale (PSFS)
It was used to find out the independence level and dysfunction level of patient.
Measured: Readings were taken at baseline, after 1st week and at end of 2nd week.
Knee injury and osteoarthritis outcome score (KOOS)
It is a scale designed specifically for knee problems. It has forty-two questions that cover several aspects of the problems related to knee.
Measured: Readings were taken at baseline, after 1st week and at end of 2nd week.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted30 Apr 2024
- Study start2 Feb 2024
- Primary completion22 Apr 2024
- Study completion25 Apr 2024
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Osteoarthritis, KneeStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- It was a randomized controlled trial with two groups. One group was experimental while other group was active control group.
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 26 participants (actual)
Sponsor and investigators
- Lead sponsor
- University of Faisalabad
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Dr Izza Ayub; PT, University of Faisalabad
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06391047
- Sponsor's protocol ID
- TUF/DR/SA/MSPP/2024/383
- Status last verified
- Apr 2024
- First submitted
- 25 Apr 2024
- Last updated
- 30 Apr 2024
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Study at a glance
From the registry record, last updated by the sponsor on 30 Apr 2024. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Impact of Mulligan Squeeze Technique as an Adjunct to Conventional Physiotherapy on Meniscal Derangement in Knee Osteoarthritis Patients
- ClinicalTrials.gov ID
- NCT06391047
- Acronym / sponsor ID
- TUF/DR/SA/MSPP/2024/383
- Conditions
- Osteoarthritis, Knee, Knee Injuries, Meniscus; Derangement, Meniscus Tear, Meniscus Lesion
- Keywords
- Knee Osteoarthritis, manual therapy intervention; rehabilitation, Menisci;
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 26 participants (actual)
- Lead sponsor
- University of FaisalabadUniversity, hospital or other
- Study start
- 2 Feb 2024 (actual)
- Primary completion
- 22 Apr 2024 (actual)
- Study completion
- 25 Apr 2024 (actual)
- First posted
- 30 Apr 2024 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The objective of this study is to find out the effects of Mulligan's Squeeze technique added as a complementary treatment to the conventional physiotherapy for the management of meniscal derangement in knee osteoarthritis patients.
Detailed description
This study was performed to determine the consequences of conventional physical therapy with and without Mulligan's Squeeze technique for meniscal derangement treatment in patients with knee osteoarthritis. This research study was a randomized controlled trial. The sample size was of 26 subjects. The subjects were nominated in accordance to the inclusion and exclusion criteria. They were equally and randomly divided into two groups. One group received Mulligan's Squeeze technique along with conventional physiotherapy exercises, with hot pack prior to the exercise session. The control group was only given conventional therapy exercises with hot pack application prior to any exercise. The treatment was given for two weeks and a total of six sessions, three sessions each week. The primary outcome measures were Numerical Pain Rating Scale (NPRS) for pain rating and goniometer to record range of knee flexion. The secondary outcome measures were Patient-specific functional scale (PSFS) and Knee-injury osteoarthritis outcome score (KOOS). The measurements were taken at baseline, at end of first week and after the second week. The data was analyzed by using IBM SPSS software version 27.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (participant)
- Number of arms
- 2
- Model description
- It was a randomized controlled trial with two groups. One group was experimental while other group was active control group.
| Arm | Type | Receives |
|---|---|---|
| Group A | Experimental | Other: Mulligan's Squeeze Technique - manual therapy, Other: Conventional PhysiotherapyGroup A was given hot pack at knee joint for 10-15min. Then the Mulligan's Squeeze Technique was applied. The patient in supine lying. The therapist placed thumb on joint line tenderness of knee. With the other thumb, the therapist reinforced the first thumb. The patient was asked to slowly flex knee. The therapist maintaining the thumb contact, applied the force centrally. The force was increased progressively as the knee moved towards full range of available flexion. At the end range, the therapist assisted the tibia to move towards more flexion with ulnar border of their hand. This position was maintained for a few seconds and the overpressure was applied. Then patient was asked to perform knee extension. As the knee moved towards extension the force applied from both thumbs was progressively reduced. At maximal extension, no force was applied. This was repeated 10 times in each set with total 3 sets. After this stretching and strengthening exercises were performed by patient. |
| Group B | Active comparator | Other: Conventional PhysiotherapyGroup B was given hot pack at knee joint for 10-15min. Then they were asked to perform stretching and strengthening exercises of the knee with at least 10 repetitions in each set and a total two sets in a day. |
Who may qualify
- Ages
- 30 to 55 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (7 listed)
- • Pain during maximal knee flexion, pain when maximal extension of knee occurs
Key exclusion criteria (8 listed)
- • Presence of any knee co-morbidities
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Mulligan's Squeeze Technique - manual therapyThis technique was introduced by Brian R. Mulligan. In this technique the therapist places thumb along the tender joint margin and applies force centrally. The patient actively flexes knee and therapist progressively enhances force and at end applies overpressure. This force is decreased as knee moves towards extension. This method helps to maintain the meniscus in its normal position and corrects the derangement of meniscus. | Other | Group A |
| Conventional PhysiotherapyIt includes stretching and strengthening exercises of muscles of the knee joint. | Other | Group A, Group B |
Primary outcome
Numerical Pain Rating Scale (NPRS)
Time frame: Readings were taken at baseline, after 1st week and at end of 2nd week.
It was used to record the level of knee pain
Goniometer
Time frame: Readings were taken at baseline, after 1st week and at end of 2nd week.
It was used to find out the range of movement of knee flexion.
2 secondary outcomes
Patient Specific Functional Scale (PSFS)
Time frame: Readings were taken at baseline, after 1st week and at end of 2nd week.
Knee injury and osteoarthritis outcome score (KOOS)
Time frame: Readings were taken at baseline, after 1st week and at end of 2nd week.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 30 Apr 2024.
- Individual participant dataSharing planned: Undecided
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Mulligan's Squeeze Technique - manual therapy and Conventional Physiotherapy in people with Osteoarthritis, Knee and Knee Injuries, run by University of Faisalabad at 1 site in Pakistan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 7 inclusion and 8 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 30 Apr 2024. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Pakistan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Numerical Pain Rating Scale (NPRS) (time frame: Readings were taken at baseline, after 1st week and at end of 2nd week.). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 30 Apr 2024.