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Cardiac ArrestNCT06405581

The Impact of Frailty on Cardiopulmonary Resuscitation Adverse Outcomes in Patients Requiring Code Blue Activation

An observational study of Cardiac Arrest and Frailty, run by Umraniye Education and Research Hospital at 1 site in Turkey (Türkiye).

Completed

Finished. The study has ended and is not enrolling. Results may be posted on the official record.

Official record
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Trial summary

The aim of this study was to determine the independent association of frailty with cardiopulmonary resuscitation and predictive factors in patients triggering code blue response Read more about this study

Who is it for?
Ages 18 to 100 years
Conditions the study is for
Cardiac Arrest, Frailty, Respiratory Arrest
What is being tested?
Edmonton frailty scale calculation
How many people
2 participants
Where
1 siteTurkey (Türkiye)
Study dates
1 Dec 2025to 30 May 2026
Phase
Observational
Are there results?
None posted in the registry

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 18 to 100 years
  • All sexes
  • Adult, Older adult

Study population: Adult patients with hospitalization and those who are not inpatients (in the outpatient clinic system) requiring Code Blue will be included in the study.

Who may be able to join

  • pediatric patients

Who cannot join

  • pregnant patients

Trial locations and contacts

1 site in 1 country.

Turkey (Türkiye)1 site
  • Umraniye Education and Research Hospital

    Istanbul, Umraniye, 34734

Other trials in Turkey (Türkiye)

About this study

The aim of this study was to determine the independent association of frailty with cardiopulmonary resuscitation and predictive factors in patients triggering code blue response

Read the detailed description

Out-of-hospital cardiac arrest remains an important cause of death in developed countries with an average adult survival rate of 5.6% . In contrast, in-hospital cardiac arrests have been reported to have a survival rate between 4.1% and 40% and several factors have been shown to affect survival rates. These factors include patient and physiologic factors such as age, initial rhythm disturbance and duration of cardiopulmonary resuscitation (CPR), as well as hospital and logistic factors such as location and timing of the arrest.Code blue (CC) is the emergency call and management systems for respiratory or cardiac arrest. CC is used worldwide for the same emergency and the same color. The CC is the organization that initiates certain systems to initiate, perform and terminate the intervention of the designated responsible team. CC is given by a doctor (emergency, anesthesia and reanimation, internal medicine, pediatrics, intensive care specialist), anesthesia technician, nurse. The CC team is a team that prevents clinical death quickly, effectively and safely to provide life-saving support to patients. The CC team provides immediate intervention to patients, their relatives and all hospital staff. While the prevalence of frailty is 10-25% in the elderly aged 65 years and over, it increases to 30-45% in those aged 85 years and over. There are no definitive data on the prevalence of frail elderly in Turkey. The definition of frail elderly syndrome emerged as a concept in geriatrics and gerontology in the 1980s in response to the growing need for a unifying diagnosis among seemingly disparate and nonspecific disease presentations in older adults. The main symptoms are weight loss, weakness, fatigue and immobility, while the main findings are sarcopenia, osteopenia, malnutrition, impaired balance and gait, and slow walking. The importance of the definition of frailty comes from the fact that it is an alarm table used to indicate the susceptibility of the elderly to conditions such as clinical deterioration, falls and mortality over time. Frailty is a syndrome that can be prevented or at least postponed if diagnosed at an early stage. In fact, the frail elderly constitute a group vulnerable to adverse events with poor prognosis Mortality and complication rates are higher in elderly surgical patients than in younger surgical patients. Surgical risk is even higher in frail elderly patients. Regardless of the type of surgery and whatever assessment tool is used, the presence of frailty is associated with an approximately two- to threefold increased risk of adverse surgical outcome. Numerous studies have shown that frailty is a risk factor for postoperative complications, longer hospital stay and loss of functional independence at discharge. Therefore, identifying older patients with frailty offers opportunities to provide improved risk stratification and targeted interventions to improve outcomes The Edmonton Frailty Scale, a performance-based multidimensional frailty assessment tool, was designed by non-geriatricians in the west to help assess and screen frail older patients in primary care and at the bedside. It consists of 11 questions relating to nine different domains such as awareness, social support, mood, nutrition and functional performance. The result correlates well with the clinical impression of geriatricians through detailed history and physical examination.

Being tested
Edmonton frailty scale calculation
Medical subject headings
Heart Arrest, Frailty, Apnea

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • Edmonton frailty scale calculationOther

    The frailty status of the patients will be assessed using the Edmonton frailty scale.

    According to the Edmonton frailty scale;

    • (0-5): not frail
    • (6-7): sensitive
    • (8-9): slightly fragile
    • (10-11): moderately fragile,
    • (12-17): extremely fragile
Study groups in NCT06405581
Study groupRoleWhat they receive
Edmonton frailty scale ≥ 7The frailty status of the patients will be assessed using the Edmonton frailty scale. According to the Edmonton frailty scale; * (0-5): not frail * (6-7): sensitive * (8-9): slightly fragile * (10-11): moderately fragile, * (12-17): extremely fragile
Receives: Other: Edmonton frailty scale calculation
Edmonton frailty scale below 7The frailty status of the patients will be assessed using the Edmonton frailty scale. According to the Edmonton frailty scale; * (0-5): not frail * (6-7): sensitive * (8-9): slightly fragile * (10-11): moderately fragile, * (12-17): extremely fragile
Receives: Other: Edmonton frailty scale calculation

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. code blue reason

    comorbid disease and dog usage

    Measured: years

  2. duration of CPR time

    between the time of giving the blue code and the end of CPR

    Measured: hours

Secondary outcomes (2)
  1. the airway equipment used

    intubation, supraglottic airway devices, tracheostomy, cricothyroidectomy, fiberbronchoscopy

    Measured: days

  2. mortality and morbidity

    presence and duration of intensive care unit stay

    Measured: mounts

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted8 May 2024
  2. Study start1 Dec 2025
  3. Primary completion30 Apr 2026
  4. Study completion30 May 2026

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Observational
Observational model
Cohort
Time perspective
Prospective
Enrolment
2 participants (actual)
IDs, dates and publications
ClinicalTrials.gov ID
NCT06405581
Sponsor's protocol ID
UERH-AR-ZT-05
Status last verified
Oct 2026
First submitted
29 Dec 2023
Last updated
8 Oct 2026
Results posted
No
Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
Individual data sharing
No

Questions about this trial

What is this clinical trial studying?

An observational study of Cardiac Arrest and Frailty, run by Umraniye Education and Research Hospital at 1 site in Turkey (Türkiye).

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 1 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: finished, as of the sponsor's last update on 8 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

code blue reason (time frame: years). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.

Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 8 Oct 2026.

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