Cardiac Arrest (CA)VentilO CUNCT07484828
Evaluation of Acid-base Disorders and Ventilation Settings in Cardiogenic Shock and Post-cardiac Arrest Patients: Comparison With VentilO Algorithm
An observational study of Cardiac Arrest (CA) and Cardiogenic Shock, run by Laval University at 1 site in Canada.
Trial summary
This study aims to better understand how mechanical ventilation settings affect patients admitted to the coronary care unit after cardiac arrest or with cardiogenic shock. These patients often require mechanical ventilation, but current guidelines provide limited evidence on the best approach. Read more about this study
- Who is it for?
- Any age
- Conditions the study is for
- Cardiac Arrest (CA), Cardiogenic Shock, Mechanical Ventilation
- What is being tested?
- Initiation of mechanical ventilation
- How many people
- 100 participants
- Where
- 1 siteCanada
- Study dates
- 9 Jun 2026to Dec 2027
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages Any age
- All sexes
- No healthy volunteers
- Child, Adult, Older adult
Study population: post cardiac arrest or cardiogenic shock
Who may be able to join
- Adult (Age >=18 years old)
- Under mechanical ventilation with endotracheal tube for :
- post cardiac arrest or cardiogenic shock
- Bood gases result availability up to 4 hours after coronary unit admission
Who cannot join
- Lack of patient anthropometric data (height and weight) available in the patient record
- No information in the record regarding the data on the humidification systems used at the time of the first blood gas test upon admission to the coronary care unit.
- Patient stabilzed in other hospital before coronary unit admission or adjustment of respiratory parameters after a blood gas test.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Canada1 site, 1 recruiting
- Recruiting
Insitut universitaire de cardiologie et de pneumologie de Quebec - Universite Laval
Québec, Quebec, G1V4G5
Francois Lellouche Principal Investigator, 418-656-8711 ext. 3572, francois.lellouche@criucpq.ulaval.ca
About this study
This study aims to better understand how mechanical ventilation settings affect patients admitted to the coronary care unit after cardiac arrest or with cardiogenic shock. These patients often require mechanical ventilation, but current guidelines provide limited evidence on the best approach. Improper ventilation settings can lead to acid-base imbalances, such as respiratory acidosis or alkalosis, which may worsen patient outcomes.
The retrospective analysis will include 100 adult patients (50 post-cardiac arrest and 50 with cardiogenic shock) who were mechanically ventilated upon admission. The study has two main objectives:
Read more
Determine how often acid-base disorders occur in these patients and describe their characteristics.
Compare the initial ventilator settings chosen by clinicians with those suggested by VentilO, a decision-support algorithm.
The investigators will evaluate the potential effect of the VentilO recommendations on the first arterial (or capillary) blood gases compared to the real settings.
This information will help refine the algorithm and guide future research on improving ventilation strategies for critically ill cardiac patients.
Participation does not involve any intervention, as the study uses existing medical records.
- Being tested
- Initiation of mechanical ventilation
- Medical subject headings
- Heart Arrest, Shock, Cardiogenic
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Initiation of mechanical ventilationOther
Blood gases evaluation after initiation of mechanical ventilation
| Study group | Role | What they receive |
|---|---|---|
| Patient post cardiac arrest | Not described Receives: Other: Initiation of mechanical ventilation | |
| Patient with cardiogenic shock | Not described Receives: Other: Initiation of mechanical ventilation |
What is being measured
The primary outcome is the main question the study is designed to answer.
Acid-base disorder (respiratory acidosis)
Presence of respiratory acisosis define by pH< 7.35 and PaCO2 > 45 mmHg
Measured: Up to 4 hours after admission to the coronary care unit - First blood gas sample
Acid-base disorder (respiratory alcalosis)
Presence of respiratory alcalosis define by by pH>7.45 and PaCO2 < 35 mmHg
Measured: Up to 4 hours after admission to the coronary care unit - First blood gas sample
Secondary outcomes (10)
Ventilator setting (Respiratory rate)
Respiratory rate set by the doctor, these setting will be compared to the suggestion of the algorithm
Measured: Up to 4 hour after coronary unit admission - At the last ventilator setting before blood gas sample
Ventilator setting (Tidal volume)
Tidal volume set by the doctor, these setting will be compared to the suggestion of the algorithm
Measured: Up to 4 hour after coronary unit admission - At the last ventilator setting before blood gas sample
Acid-base disorder (metabolic acidosis)
Presence of metabolic acidosis define by HCO3 < 20 mmol/L
Measured: Up to 4 hours after admission to the coronary care unit - First blood gas sample
Acid-base disorder (metabolic alcalosis)
Presence of metabolic acidosis define by HCO3 > 28 mmol/L
Measured: Up to 4 hours after admission to the coronary care unit - First blood gas sample
Optimal acid-base result
Presence of optimal pH (7.35-7.45) with optimal PCO2 (35-45 mmHg)
Measured: Up to 4 hours after admission to the coronary care unit - First blood gas sample
Mechanical ventilation duration
Time spent with invasive mechanical ventilation aftercoronary unit admission and hospital discharge
Measured: Up to 90 days
Vasopressor duration
Duration of vasopressor or inotrop administration
Measured: Day 28
Hospital length of stay
Coronary unit admission through hospital discharge
Measured: Up to 90 days
Mortality
Mortality at coronary unit
Measured: Day 28
Acute renal failure
Rate of acute renal failure during coronary unit length of stay. Renal failure will be defined according to the usual criteria, i.e., an increase of >27 mmol/L creatinine in 48 hours or 1.5x over the baseline
Measured: Up to 90 days. Coronary unit stay - admission through discharge or until death if occured
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted20 Mar 2026
- Study start9 Jun 2026
- Primary completionJun 2027 (estimated)
- Study completionDec 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Cardiac Arrest (CA)Studies of the same condition, open and under way.
- More trials run by Laval UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Retrospective
- Enrolment
- 100 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Laval University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, François Lellouche, Laval University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07484828
- Sponsor's protocol ID
- 2026-4504
- Acronym
- VentilO CU
- Status last verified
- Mar 2026
- First submitted
- 5 Mar 2026
- Last updated
- 5 Nov 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 5 Nov 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Evaluation of Acid-base Disorders and Ventilation Settings in Cardiogenic Shock and Post-cardiac Arrest Patients: Comparison With VentilO Algorithm
- ClinicalTrials.gov ID
- NCT07484828
- Acronym / sponsor ID
- VentilO CU / 2026-4504
- Study type
- Observational
- Recruitment status
- Recruiting
- Enrolment
- 100 participants (estimated)
- Lead sponsor
- Laval UniversityUniversity, hospital or other
- Study start
- 9 Jun 2026 (actual)
- Primary completion
- Jun 2027 (estimated)
- Study completion
- Dec 2027 (estimated)
- First posted
- 20 Mar 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study aims to better understand how mechanical ventilation settings affect patients admitted to the coronary care unit after cardiac arrest or with cardiogenic shock. These patients often require mechanical ventilation, but current guidelines provide limited evidence on the best approach. Improper ventilation settings can lead to acid-base imbalances, such as respiratory acidosis or alkalosis, which may worsen patient outcomes.
The retrospective analysis will include 100 adult patients (50 post-cardiac arrest and 50 with cardiogenic shock) who were mechanically ventilated upon admission. The study has two main objectives:
Determine how often acid-base disorders occur in these patients and describe their characteristics.
Compare the initial ventilator settings chosen by clinicians with those suggested by VentilO, a decision-support algorithm.
The investigators will evaluate the potential effect of the VentilO recommendations on the first arterial (or capillary) blood gases compared to the real settings.
This information will help refine the algorithm and guide future research on improving ventilation strategies for critically ill cardiac patients.
Participation does not involve any intervention, as the study uses existing medical records.
Study design
- Observational model
- Cohort
- Time perspective
- Retrospective
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Patient post cardiac arrest | – | Other: Initiation of mechanical ventilation |
| Patient with cardiogenic shock | – | Other: Initiation of mechanical ventilation |
Who may qualify
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Child, Adult, Older adult
- Study population
- post cardiac arrest or cardiogenic shock
Key inclusion criteria (4 listed)
- Adult (Age >=18 years old)
- Under mechanical ventilation with endotracheal tube for :
- post cardiac arrest or cardiogenic shock
- Bood gases result availability up to 4 hours after coronary unit admission
Key exclusion criteria (3 listed)
- Lack of patient anthropometric data (height and weight) available in the patient record
- No information in the record regarding the data on the humidification systems used at the time of the first blood gas test upon admission to the coronary care unit.
- Patient stabilzed in other hospital before coronary unit admission or adjustment of respiratory parameters after a blood gas test.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Initiation of mechanical ventilationBlood gases evaluation after initiation of mechanical ventilation | Other | Patient post cardiac arrest, Patient with cardiogenic shock |
Primary outcome
Acid-base disorder (respiratory acidosis)
Time frame: Up to 4 hours after admission to the coronary care unit - First blood gas sample
Presence of respiratory acisosis define by pH< 7.35 and PaCO2 > 45 mmHg
Acid-base disorder (respiratory alcalosis)
Time frame: Up to 4 hours after admission to the coronary care unit - First blood gas sample
Presence of respiratory alcalosis define by by pH>7.45 and PaCO2 < 35 mmHg
10 secondary outcomes
Ventilator setting (Respiratory rate)
Time frame: Up to 4 hour after coronary unit admission - At the last ventilator setting before blood gas sample
Ventilator setting (Tidal volume)
Time frame: Up to 4 hour after coronary unit admission - At the last ventilator setting before blood gas sample
Acid-base disorder (metabolic acidosis)
Time frame: Up to 4 hours after admission to the coronary care unit - First blood gas sample
Acid-base disorder (metabolic alcalosis)
Time frame: Up to 4 hours after admission to the coronary care unit - First blood gas sample
Optimal acid-base result
Time frame: Up to 4 hours after admission to the coronary care unit - First blood gas sample
Mechanical ventilation duration
Time frame: Up to 90 days
Vasopressor duration
Time frame: Day 28
Hospital length of stay
Time frame: Up to 90 days
Mortality
Time frame: Day 28
Acute renal failure
Time frame: Up to 90 days. Coronary unit stay - admission through discharge or until death if occured
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 5 Nov 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Cardiac Arrest (CA) and Cardiogenic Shock, run by Laval University at 1 site in Canada.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 5 Nov 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Canada. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Francois Lellouche (1-418-656-8711 ext. 3572, francois.lellouche@criucpq.ulaval.ca), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Acid-base disorder (respiratory acidosis) (time frame: Up to 4 hours after admission to the coronary care unit - First blood gas sample). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 5 Nov 2026.