Resistance TrainingNCT06413199
Adaptive Response of Brain Towards Resistance Training in Healthy Individuals
A study testing Hyper Training and 1 Repetition maximum training group in people with Resistance Training, run by Pakistan Society for Rehabilitation of Differently Abled Hospital at 1 site in Pakistan.
Trial summary
The novelty of this study is to identify the mechanism of nervous system by applying resistance training intervention in healthy individuals. Read more about this study
- Who is it for?
- Ages 18 to 35 yearsHealthy volunteers can take part
- Conditions the study is for
- Resistance Training
- What is being tested?
- Hyper Training and 1 Repetition maximum training group
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 104 participants
- Where
- 1 sitePakistan
- Study dates
- 18 Aug 2023to 30 Sep 2024
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 35 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Body Mass Index should be 18.5-24.9 kg/m2.
- Participants were untrained and had not engaged in resistance exercise within 6 months prior to beginning the study.
Who cannot join
- Participants with any kind of Gastrointestinal Tract disturbance will be excluded from the study.
- Participants with any kind of Musculoskeletal injury will be excluded from the study.
- Participant with any kind of Neurological disturbance will be excluded from the study.
- Participants who use tobacco products within the previous 6 months.
- Participants who take any type of medication within the previous 6 months.
Trial locations and contacts
1 site in 1 country.
About this study
The novelty of this study is to identify the mechanism of nervous system by applying resistance training intervention in healthy individuals.
Read the detailed description
Resistance training is a form of exercise that is popular particularly for its role in improving athletic performance by increasing muscular strength, power and speed, hypertrophy, local muscular endurance, motor performance, balance and coordination. The objective of the study is to find out the effects of resistance training on Central and Peripheral Nervous System in healthy individuals. A total of 100 participants will be included in the study including both male and female. The study will be divided into two main groups. Experimental group will perform 8-12 Reps with 1.5 sec concentric and 1.5 sec eccentric contraction of bench press with 90 sec of rest between sets with 2 sets per week for 2 months.
1RM of control group will be calculated through the same method and the training protocol for the Control group consisted of 5 attempts to lift as much weight as possible one time for that training visit with 90 seconds of rest between attempts. The load was progressively increased each attempt to try to reach or exceed their previous 1RM.
- Conditions
- Resistance Training
- Being tested
- Hyper Training, 1 Repetition maximum training group
- Keywords
- Resistance Training, Performance, Nervous Response, Muscle growth, Exercise Induced Performance
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Hyper TrainingOther
Experimental group will perform 2 training session per week for 2 months, 1 set of 10 unloaded repetitions in arms as a warm-up, 4 sets with a goal of 8-12 Reps with 90 seconds rest between sets. 1.5 second concentric and 1.5 second eccentric contraction of bench press, The elbows had to be fully locked out to be counted as a repetition.
1 Repetition maximum training groupOther
2 training session per week for 8 weeks, 1 set of 10 unloaded repetitions in arms as a warm-up, 1 Repetition maximum training group consisted of 5 attempts to lift as much weight as possible one time for that training visit with 90 seconds of rest between attempts, the load was progressively increased each attempt to try to reach or exceed their previous 1 repetition maximum.
| Study group | Role | What they receive |
|---|---|---|
| Hyper Training Group | Experimental | 2 training session per week for 2 months, 1 set of 10 unloaded repetitions in arms as a warm-up, 4 sets with a goal of 8-12 repetitions with 90 seconds of rest between sets and elbows had to be fully locked out to be counted as a repetition, 1.5 seconds for concentric and 1.5 seconds for eccentric portion. Receives: Other: Hyper Training |
| 1 Repetition Maximum Group | Active comparator | 2 training session per week for 2 months, 1 set of 10 unloaded repetitions in arms as a warm-up, training protocol consisted of 5 attempts to lift as much weight as possible one time for that training visit with 90 seconds of rest between attempts. The load was progressively increased each attempt to try to reach or exceed their previous 1RM. Receives: Other: 1 Repetition maximum training group |
What is being measured
The primary outcome is the main question the study is designed to answer.
NCS (Motor Nerve Conduction Study)
To determine how fast or slow the nerves are conducting an electrical current using F wave
Measured: • 0 week • 8th week
EEG (Electroencephalography)
To measure the electrical activity of the brain using alpha and beta waves
Measured: • 0 week • 8th week
Dynamometer
To measure the strength after resistance training
Measured: • 0 week • 4th week • 8th week
Estimation of Albumin & Globulin ratio
To measure the total amount of protein in blood and effects of resistance training
Measured: • 0 week • 8th week
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted14 May 2024
- Study start18 Aug 2023
- Primary completion30 Sep 2024
- Study completion30 Sep 2024
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (22)Papers the sponsor has linked to this study.
- Other trials for Resistance TrainingStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind
- Who is masked
- Participant, Investigator
- Enrolment
- 104 participants (actual)
Sponsor and investigators
- Lead sponsor
- Pakistan Society for Rehabilitation of Differently Abled Hospital
- Sponsor type
- University, hospital or other
- Collaborators
- University of Karachi
- Responsible party
- Sponsor
- Investigators
- Danish Latif, PhD*, Principal investigator, PSRD College of Rehabilitation Sciences
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06413199
- Sponsor's protocol ID
- PSRDHospital
- Status last verified
- Aug 2026
- First submitted
- 31 Oct 2023
- Last updated
- 1 Sep 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Comfort P, Haigh A, Matthews MJ. Are changes in maximal squat strength during preseason training reflected in changes in sprint performance in rugby league players? J Strength Cond Res. 2012 Mar;26(3):772-6. doi: 10.1519/JSC.0b013e31822a5cbf.
PubMed 22310512Brooks JH, Fuller CW, Kemp SP, Reddin DB. Incidence, risk, and prevention of hamstring muscle injuries in professional rugby union. Am J Sports Med. 2006 Aug;34(8):1297-306. doi: 10.1177/0363546505286022. Epub 2006 Feb 21.
PubMed 16493170Kristensen J, Franklyn-Miller A. Resistance training in musculoskeletal rehabilitation: a systematic review. Br J Sports Med. 2012 Aug;46(10):719-26. doi: 10.1136/bjsm.2010.079376. Epub 2011 Jul 26.
PubMed 21791457Hakkinen K, Alen M, Komi PV. Changes in isometric force- and relaxation-time, electromyographic and muscle fibre characteristics of human skeletal muscle during strength training and detraining. Acta Physiol Scand. 1985 Dec;125(4):573-85. doi: 10.1111/j.1748-1716.1985.tb07760.x.
PubMed 4091001Mitchell CJ, Churchward-Venne TA, West DW, Burd NA, Breen L, Baker SK, Phillips SM. Resistance exercise load does not determine training-mediated hypertrophic gains in young men. J Appl Physiol (1985). 2012 Jul;113(1):71-7. doi: 10.1152/japplphysiol.00307.2012. Epub 2012 Apr 19.
PubMed 22518835Taber CB, Vigotsky A, Nuckols G, Haun CT. Exercise-Induced Myofibrillar Hypertrophy is a Contributory Cause of Gains in Muscle Strength. Sports Med. 2019 Jul;49(7):993-997. doi: 10.1007/s40279-019-01107-8. No abstract available.
PubMed 31016546Deumens R, Bozkurt A, Meek MF, Marcus MA, Joosten EA, Weis J, Brook GA. Repairing injured peripheral nerves: Bridging the gap. Prog Neurobiol. 2010 Nov;92(3):245-76. doi: 10.1016/j.pneurobio.2010.10.002. Epub 2010 Oct 13.
PubMed 20950667Dankel SJ, Counts BR, Barnett BE, Buckner SL, Abe T, Loenneke JP. Muscle adaptations following 21 consecutive days of strength test familiarization compared with traditional training. Muscle Nerve. 2017 Aug;56(2):307-314. doi: 10.1002/mus.25488. Epub 2017 Mar 3.
PubMed 27875635Mattocks KT, Buckner SL, Jessee MB, Dankel SJ, Mouser JG, Loenneke JP. Practicing the Test Produces Strength Equivalent to Higher Volume Training. Med Sci Sports Exerc. 2017 Sep;49(9):1945-1954. doi: 10.1249/MSS.0000000000001300.
PubMed 28463902Kacin A, Strazar K. Frequent low-load ischemic resistance exercise to failure enhances muscle oxygen delivery and endurance capacity. Scand J Med Sci Sports. 2011 Dec;21(6):e231-41. doi: 10.1111/j.1600-0838.2010.01260.x. Epub 2011 Mar 8.
PubMed 21385216Jessee MB, Buckner SL, Mouser JG, Mattocks KT, Dankel SJ, Abe T, Bell ZW, Bentley JP, Loenneke JP. Muscle Adaptations to High-Load Training and Very Low-Load Training With and Without Blood Flow Restriction. Front Physiol. 2018 Oct 16;9:1448. doi: 10.3389/fphys.2018.01448. eCollection 2018.
PubMed 30386254Andersen LL, Andersen JL, Zebis MK, Aagaard P. Early and late rate of force development: differential adaptive responses to resistance training? Scand J Med Sci Sports. 2010 Feb;20(1):e162-9. doi: 10.1111/j.1600-0838.2009.00933.x. Epub 2009 May 26.
PubMed 19793220Bickel CS, Cross JM, Bamman MM. Exercise dosing to retain resistance training adaptations in young and older adults. Med Sci Sports Exerc. 2011 Jul;43(7):1177-87. doi: 10.1249/MSS.0b013e318207c15d.
PubMed 21131862Dankel SJ, Kang M, Abe T, Loenneke JP. Resistance training induced changes in strength and specific force at the fiber and whole muscle level: a meta-analysis. Eur J Appl Physiol. 2019 Jan;119(1):265-278. doi: 10.1007/s00421-018-4022-9. Epub 2018 Oct 24.
PubMed 30357517Griffin L, Cafarelli E. Transcranial magnetic stimulation during resistance training of the tibialis anterior muscle. J Electromyogr Kinesiol. 2007 Aug;17(4):446-52. doi: 10.1016/j.jelekin.2006.05.001. Epub 2006 Aug 7.
PubMed 16891123
Study at a glance
From the registry record, last updated by the sponsor on 1 Sep 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Adaptive Response of Brain Towards Resistance Training in Healthy Individuals
- ClinicalTrials.gov ID
- NCT06413199
- Acronym / sponsor ID
- PSRDHospital
- Conditions
- Resistance Training
- Keywords
- Resistance Training, Performance, Nervous Response, Muscle growth, Exercise Induced Performance
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 104 participants (actual)
- Lead sponsor
- Pakistan Society for Rehabilitation of Differently Abled HospitalUniversity, hospital or other
- Collaborators
- University of Karachi
- Study start
- 18 Aug 2023 (actual)
- Primary completion
- 30 Sep 2024 (actual)
- Study completion
- 30 Sep 2024 (actual)
- First posted
- 14 May 2024 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The novelty of this study is to identify the mechanism of nervous system by applying resistance training intervention in healthy individuals.
Detailed description
Resistance training is a form of exercise that is popular particularly for its role in improving athletic performance by increasing muscular strength, power and speed, hypertrophy, local muscular endurance, motor performance, balance and coordination. The objective of the study is to find out the effects of resistance training on Central and Peripheral Nervous System in healthy individuals. A total of 100 participants will be included in the study including both male and female. The study will be divided into two main groups. Experimental group will perform 8-12 Reps with 1.5 sec concentric and 1.5 sec eccentric contraction of bench press with 90 sec of rest between sets with 2 sets per week for 2 months.
1RM of control group will be calculated through the same method and the training protocol for the Control group consisted of 5 attempts to lift as much weight as possible one time for that training visit with 90 seconds of rest between attempts. The load was progressively increased each attempt to try to reach or exceed their previous 1RM.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind (participant, investigator)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Hyper Training Group | Experimental | Other: Hyper Training2 training session per week for 2 months, 1 set of 10 unloaded repetitions in arms as a warm-up, 4 sets with a goal of 8-12 repetitions with 90 seconds of rest between sets and elbows had to be fully locked out to be counted as a repetition, 1.5 seconds for concentric and 1.5 seconds for eccentric portion. |
| 1 Repetition Maximum Group | Active comparator | Other: 1 Repetition maximum training group2 training session per week for 2 months, 1 set of 10 unloaded repetitions in arms as a warm-up, training protocol consisted of 5 attempts to lift as much weight as possible one time for that training visit with 90 seconds of rest between attempts. The load was progressively increased each attempt to try to reach or exceed their previous 1RM. |
Who may qualify
- Ages
- 18 to 35 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (2 listed)
- Body Mass Index should be 18.5-24.9 kg/m2.
- Participants were untrained and had not engaged in resistance exercise within 6 months prior to beginning the study.
Key exclusion criteria (5 listed)
- Participants with any kind of Gastrointestinal Tract disturbance will be excluded from the study.
- Participants with any kind of Musculoskeletal injury will be excluded from the study.
- Participant with any kind of Neurological disturbance will be excluded from the study.
- Participants who use tobacco products within the previous 6 months.
- Participants who take any type of medication within the previous 6 months.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Hyper TrainingExperimental group will perform 2 training session per week for 2 months, 1 set of 10 unloaded repetitions in arms as a warm-up, 4 sets with a goal of 8-12 Reps with 90 seconds rest between sets. 1.5 second concentric and 1.5 second eccentric contraction of bench press, The elbows had to be fully locked out to be counted as a repetition. | Other | Hyper Training Group |
| 1 Repetition maximum training group2 training session per week for 8 weeks, 1 set of 10 unloaded repetitions in arms as a warm-up, 1 Repetition maximum training group consisted of 5 attempts to lift as much weight as possible one time for that training visit with 90 seconds of rest between attempts, the load was progressively increased each attempt to try to reach or exceed their previous 1 repetition maximum. | Other | 1 Repetition Maximum Group |
Primary outcome
NCS (Motor Nerve Conduction Study)
Time frame: • 0 week • 8th week
To determine how fast or slow the nerves are conducting an electrical current using F wave
EEG (Electroencephalography)
Time frame: • 0 week • 8th week
To measure the electrical activity of the brain using alpha and beta waves
Dynamometer
Time frame: • 0 week • 4th week • 8th week
To measure the strength after resistance training
Estimation of Albumin & Globulin ratio
Time frame: • 0 week • 8th week
To measure the total amount of protein in blood and effects of resistance training
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 1 Sep 2026.
- Background: PubMed 22310512Comfort P, Haigh A, Matthews MJ. Are changes in maximal squat strength during preseason training reflected in changes in sprint performance in rugby league players? J Strength Cond Res. 2012 Mar;26(3):772-6. doi: 10.1519/JSC.0b013e31822a5cbf.
- Background: PubMed 16493170Brooks JH, Fuller CW, Kemp SP, Reddin DB. Incidence, risk, and prevention of hamstring muscle injuries in professional rugby union. Am J Sports Med. 2006 Aug;34(8):1297-306. doi: 10.1177/0363546505286022. Epub 2006 Feb 21.
- Background: PubMed 21791457Kristensen J, Franklyn-Miller A. Resistance training in musculoskeletal rehabilitation: a systematic review. Br J Sports Med. 2012 Aug;46(10):719-26. doi: 10.1136/bjsm.2010.079376. Epub 2011 Jul 26.
- Background: PubMed 4091001Hakkinen K, Alen M, Komi PV. Changes in isometric force- and relaxation-time, electromyographic and muscle fibre characteristics of human skeletal muscle during strength training and detraining. Acta Physiol Scand. 1985 Dec;125(4):573-85. doi: 10.1111/j.1748-1716.1985.tb07760.x.
- Background: PubMed 22518835Mitchell CJ, Churchward-Venne TA, West DW, Burd NA, Breen L, Baker SK, Phillips SM. Resistance exercise load does not determine training-mediated hypertrophic gains in young men. J Appl Physiol (1985). 2012 Jul;113(1):71-7. doi: 10.1152/japplphysiol.00307.2012. Epub 2012 Apr 19.
- Background: PubMed 31016546Taber CB, Vigotsky A, Nuckols G, Haun CT. Exercise-Induced Myofibrillar Hypertrophy is a Contributory Cause of Gains in Muscle Strength. Sports Med. 2019 Jul;49(7):993-997. doi: 10.1007/s40279-019-01107-8. No abstract available.
- Background: PubMed 20950667Deumens R, Bozkurt A, Meek MF, Marcus MA, Joosten EA, Weis J, Brook GA. Repairing injured peripheral nerves: Bridging the gap. Prog Neurobiol. 2010 Nov;92(3):245-76. doi: 10.1016/j.pneurobio.2010.10.002. Epub 2010 Oct 13.
- Background: PubMed 27875635Dankel SJ, Counts BR, Barnett BE, Buckner SL, Abe T, Loenneke JP. Muscle adaptations following 21 consecutive days of strength test familiarization compared with traditional training. Muscle Nerve. 2017 Aug;56(2):307-314. doi: 10.1002/mus.25488. Epub 2017 Mar 3.
- Background: PubMed 28463902Mattocks KT, Buckner SL, Jessee MB, Dankel SJ, Mouser JG, Loenneke JP. Practicing the Test Produces Strength Equivalent to Higher Volume Training. Med Sci Sports Exerc. 2017 Sep;49(9):1945-1954. doi: 10.1249/MSS.0000000000001300.
- Background: PubMed 21385216Kacin A, Strazar K. Frequent low-load ischemic resistance exercise to failure enhances muscle oxygen delivery and endurance capacity. Scand J Med Sci Sports. 2011 Dec;21(6):e231-41. doi: 10.1111/j.1600-0838.2010.01260.x. Epub 2011 Mar 8.
- Background: PubMed 30386254Jessee MB, Buckner SL, Mouser JG, Mattocks KT, Dankel SJ, Abe T, Bell ZW, Bentley JP, Loenneke JP. Muscle Adaptations to High-Load Training and Very Low-Load Training With and Without Blood Flow Restriction. Front Physiol. 2018 Oct 16;9:1448. doi: 10.3389/fphys.2018.01448. eCollection 2018.
- Background: PubMed 19793220Andersen LL, Andersen JL, Zebis MK, Aagaard P. Early and late rate of force development: differential adaptive responses to resistance training? Scand J Med Sci Sports. 2010 Feb;20(1):e162-9. doi: 10.1111/j.1600-0838.2009.00933.x. Epub 2009 May 26.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Danish Latif, PhD* principal investigator
PSRD College of Rehabilitation Sciences
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Hyper Training and 1 Repetition maximum training group in people with Resistance Training, run by Pakistan Society for Rehabilitation of Differently Abled Hospital at 1 site in Pakistan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 1 Sep 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Pakistan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
NCS (Motor Nerve Conduction Study) (time frame: • 0 week • 8th week). The study lists 4 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT06413199, which also lists 22 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 1 Sep 2026.