Chronic PainNCT06427356
PREVAIL Interdisciplinary Track: A Pragmatic Randomized Clinical Trial
A study testing PREVAIL Interdisciplinary Team in people with Chronic Pain, run by Salem Veterans Affairs Medical Center at 1 site in United States.
Trial summary
The goal of this clinical trial is to [primary purpose learn if a team that involves five types of pain specialists (interventional pain, psychology, pharmacy, nutrition, physical therapy) can treat chronic pain in Veterans. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Chronic Pain
- What is being tested?
- PREVAIL Interdisciplinary Team
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 150 participants
- Where
- 1 siteUnited States
- Study dates
- 1 Jul 2024to Apr 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Veteran receiving care at the Salem VA Health Care System (Salem VAHCS) per electronic medical record (EMR)
- Patient participating in PREVAIL Interdisciplinary Team Track per EMR
- Chronic Pain Diagnosis: Defined as pain lasting more than three months per EMR
Who cannot join
- Diagnosis of Mild Neurocognitive Disorder or Major Neurocognitive Disorder based on Diagnostic Statistical Manual of Mental Disorders, 5th edition, Text Revision (DSM-5-TR) per EMR
- Veteran has a current acute physical injury that would artificially elevate pain scores during study period per EMR
- Veteran intends to have a pain-related surgery during the study period per EMR
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
United States1 site, 1 recruiting
- Recruiting
Salem VA Health Care System
Salem, Virginia, 24153
Rena E Courtney, PhD, 5409822463 ext. 4478, rena.courtney2@va.gov
About this study
Official title: PREVAIL: Efficacy of a Veterans Healthcare Administration (VHA) Whole Health Interdisciplinary Pain Clinic
The goal of this clinical trial is to [primary purpose learn if a team that involves five types of pain specialists (interventional pain, psychology, pharmacy, nutrition, physical therapy) can treat chronic pain in Veterans. The main questions it aims to answer are:
- Do patients report less pain after six months in the program?
- Do patients report that pain gets in the way of their life less after six months in the program? The researchers will compare participants who participate in the program to those that wait for six months before participating in the program.
Read more
Participants will
- Meet with the team of pain specialists to develop a plan to treat their pain
- Receive calls from a coach once per month
- Return to meet with the team of pain specialists for a six-month follow-up appointment
- Fill out surveys
- Conditions
- Chronic Pain
- Being tested
- PREVAIL Interdisciplinary Team
- Keywords
- Whole health, rural health, Interdisciplinary team
- Medical subject headings
- Chronic Pain
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
PREVAIL Interdisciplinary TeamBehavioural
Patient meets simultaneously with an interdisciplinary team (IDT) five pain specialists and develops an individualized treatment plan based on Whole Health. Participants receive five months of coaching calls then return six months later for a follow-up visit with the IDT.
| Study group | Role | What they receive |
|---|---|---|
| Interdisciplinary Team | Experimental | Participants complete surveys, meet with five pain specialists to develop individualized treatment plans based on whole health, receive monthly coaching calls for five months, then meet with the pain specialists once more for a 6-month follow-up appointment and complete surveys. Receives: Behavioral: PREVAIL Interdisciplinary Team |
| Waitlist Control | No intervention | Participants complete surveys but do not engage with the pain specialists for 6 months. |
What is being measured
The primary outcome is the main question the study is designed to answer.
Brief Pain Inventory (BPI)
A 9-item scale used to quantify an individual's pain experience (0-10) with higher scores suggesting worse pain severity and pain interference.
Measured: Baseline, 6-months
Secondary outcomes (4)
Short Form-36 Item (SF-36)
A 36-item scale to assess quality of life, including any impact of health problems on completing activities, as well as energy and emotions, with lower scores indicating a higher impact of health problems.
Measured: Baseline, 6-months
Insomnia Severity Index
A 7-item scale that assesses sleep disturbances, with higher scores reflecting more sleep difficulty.
Measured: Baseline, 6-months
Pain Self-Efficacy Questionnaire
A 10-item scale used to determine how confident an individual is in accomplishing tasks despite the pain (0=not at all confident and 6= completely confident) with higher scores denoting higher levels of pain self-efficacy.
Measured: Baseline, 6-months
University of Washington- Concerns about Pain Scale 24-item
A 24-item scale used to assess one's perception of their pain experience (1= never, 5= always), with higher scores indicating higher levels of pain catastrophizing.
Measured: Baseline, 6-months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted23 May 2024
- Study start1 Jul 2024
- Primary completionApr 2026 (estimated)
- Study completionApr 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (3)Papers the sponsor has linked to this study.
- Other trials for Chronic PainStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 150 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Salem Veterans Affairs Medical Center
- Sponsor type
- US federal agency
- Collaborators
- Durham VA Health Care System, VISN 6 MIRECC, Bedford VA Health Care System, Stanford University
- Responsible party
- Principal investigator, Rena E. Courtney, Salem Veterans Affairs Medical Center
- Investigators
- Rena E Courtney, PhD, Principal investigator, Salem VA Health Care System
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06427356
- Sponsor's protocol ID
- REC 0004
- Status last verified
- Feb 2026
- First submitted
- 17 May 2024
- Last updated
- 18 Feb 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Courtney RE, Schadegg MJ. Chronic, Noncancer Pain Care in the Veterans Administration: Current Trends and Future Directions. Anesthesiol Clin. 2023 Jun;41(2):519-529. doi: 10.1016/j.anclin.2023.02.004. Epub 2023 Mar 15.
PubMed 37245954Darnall BD, Edwards KA, Courtney RE, Ziadni MS, Simons LE, Harrison LE. Innovative treatment formats, technologies, and clinician trainings that improve access to behavioral pain treatment for youth and adults. Front Pain Res (Lausanne). 2023 Jul 20;4:1223172. doi: 10.3389/fpain.2023.1223172. eCollection 2023.
PubMed 37547824Courtney RE, Schadegg MJ, Bolton R, Smith S, Harden SM. Using a Whole Health Approach to Build Biopsychosocial-Spiritual Personal Health Plans for Veterans with Chronic Pain. Pain Manag Nurs. 2024 Feb;25(1):69-74. doi: 10.1016/j.pmn.2023.09.010. Epub 2023 Oct 13.
PubMed 37839983
Study at a glance
From the registry record, last updated by the sponsor on 18 Feb 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- PREVAIL: Efficacy of a Veterans Healthcare Administration (VHA) Whole Health Interdisciplinary Pain Clinic
- ClinicalTrials.gov ID
- NCT06427356
- Acronym / sponsor ID
- REC 0004
- Conditions
- Chronic Pain
- Keywords
- Whole health, rural health, Interdisciplinary team
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 150 participants (estimated)
- Lead sponsor
- Salem Veterans Affairs Medical CenterUS federal agency
- Collaborators
- Durham VA Health Care System, VISN 6 MIRECC, Bedford VA Health Care System, Stanford University
- Study start
- 1 Jul 2024 (actual)
- Primary completion
- Apr 2026 (estimated)
- Study completion
- Apr 2026 (estimated)
- First posted
- 23 May 2024 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this clinical trial is to [primary purpose learn if a team that involves five types of pain specialists (interventional pain, psychology, pharmacy, nutrition, physical therapy) can treat chronic pain in Veterans. The main questions it aims to answer are:
- Do patients report less pain after six months in the program?
- Do patients report that pain gets in the way of their life less after six months in the program? The researchers will compare participants who participate in the program to those that wait for six months before participating in the program.
Participants will
- Meet with the team of pain specialists to develop a plan to treat their pain
- Receive calls from a coach once per month
- Return to meet with the team of pain specialists for a six-month follow-up appointment
- Fill out surveys
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Interdisciplinary Team | Experimental | Behavioral: PREVAIL Interdisciplinary TeamParticipants complete surveys, meet with five pain specialists to develop individualized treatment plans based on whole health, receive monthly coaching calls for five months, then meet with the pain specialists once more for a 6-month follow-up appointment and complete surveys. |
| Waitlist Control | No intervention | –Participants complete surveys but do not engage with the pain specialists for 6 months. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (3 listed)
- Veteran receiving care at the Salem VA Health Care System (Salem VAHCS) per electronic medical record (EMR)
- Patient participating in PREVAIL Interdisciplinary Team Track per EMR
- Chronic Pain Diagnosis: Defined as pain lasting more than three months per EMR
Key exclusion criteria (3 listed)
- Diagnosis of Mild Neurocognitive Disorder or Major Neurocognitive Disorder based on Diagnostic Statistical Manual of Mental Disorders, 5th edition, Text Revision (DSM-5-TR) per EMR
- Veteran has a current acute physical injury that would artificially elevate pain scores during study period per EMR
- Veteran intends to have a pain-related surgery during the study period per EMR
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| PREVAIL Interdisciplinary TeamPatient meets simultaneously with an interdisciplinary team (IDT) five pain specialists and develops an individualized treatment plan based on Whole Health. Participants receive five months of coaching calls then return six months later for a follow-up visit with the IDT. | Behavioural | Interdisciplinary Team |
Primary outcome
Brief Pain Inventory (BPI)
Time frame: Baseline, 6-months
A 9-item scale used to quantify an individual's pain experience (0-10) with higher scores suggesting worse pain severity and pain interference.
4 secondary outcomes
Short Form-36 Item (SF-36)
Time frame: Baseline, 6-months
Insomnia Severity Index
Time frame: Baseline, 6-months
Pain Self-Efficacy Questionnaire
Time frame: Baseline, 6-months
University of Washington- Concerns about Pain Scale 24-item
Time frame: Baseline, 6-months
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 18 Feb 2026.
- Background: PubMed 37245954Courtney RE, Schadegg MJ. Chronic, Noncancer Pain Care in the Veterans Administration: Current Trends and Future Directions. Anesthesiol Clin. 2023 Jun;41(2):519-529. doi: 10.1016/j.anclin.2023.02.004. Epub 2023 Mar 15.
- Background: PubMed 37547824Darnall BD, Edwards KA, Courtney RE, Ziadni MS, Simons LE, Harrison LE. Innovative treatment formats, technologies, and clinician trainings that improve access to behavioral pain treatment for youth and adults. Front Pain Res (Lausanne). 2023 Jul 20;4:1223172. doi: 10.3389/fpain.2023.1223172. eCollection 2023.
- Background: PubMed 37839983Courtney RE, Schadegg MJ, Bolton R, Smith S, Harden SM. Using a Whole Health Approach to Build Biopsychosocial-Spiritual Personal Health Plans for Veterans with Chronic Pain. Pain Manag Nurs. 2024 Feb;25(1):69-74. doi: 10.1016/j.pmn.2023.09.010. Epub 2023 Oct 13.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Rena E Courtney, PhD principal investigator
Salem VA Health Care System
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing PREVAIL Interdisciplinary Team in people with Chronic Pain, run by Salem Veterans Affairs Medical Center at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 18 Feb 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Rena E Courtney, PhD (540-982-2463 ext. 4478, rena.courtney2@va.gov), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Brief Pain Inventory (BPI) (time frame: Baseline, 6-months). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT06427356, which also lists 3 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 18 Feb 2026.