CaffeineNCT06431035
Caffeine & Bodybuilding Dehydration Ability
A study testing caffeine in people with Caffeine and Placebo, run by Chih-Hui Chiu at 1 site in Taiwan.
Trial summary
15-20 trained bodybuilding athletes were divided into caffeine gum trial (CAF) and placebo trial (PL) with a randomized, double-blind study design. The participants chewing either caffeine Gum (CAF trial, containing 5 mg/kg of caffeine) or placebo gum (PL) for 10 minutes. Read more about this study
- Who is it for?
- Ages 20 to 40 years, men onlyHealthy volunteers can take part
- What is being tested?
- caffeine
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 14 participants
- Where
- 1 siteTaiwan
- Study dates
- 8 Apr 2024to 30 Jun 2024
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 20 to 40 years
- Men only
- Healthy volunteers accepted
- Adult
Who may be able to join
- having won the top 8 places in a national competition,
- having no cardiovascular or joint diseases
- being an adult male
Who cannot join
- no top 8 finishes at national level
- cardiovascular or joint disease, or any other condition that could be impaired by exercise
- female and underage participants
- previous caffeine allergy
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Effect of Caffeinated Chewing Gum on Dehydration Ability in Bodybuilding Athletes: a Crossover Trial
15-20 trained bodybuilding athletes were divided into caffeine gum trial (CAF) and placebo trial (PL) with a randomized, double-blind study design. The participants chewing either caffeine Gum (CAF trial, containing 5 mg/kg of caffeine) or placebo gum (PL) for 10 minutes. After rested for 15 minutes, Participants used the bicycle to adjust the pedal resistance and speed according to their own feelings until they were dehydrated to 2% of their original body weight.
Read the detailed description
The purpose of this study was to investigate the effect of caffeinated chewing gum on dehydration ability in bodybuilding athletes. Methods: 15-20 trained bodybuilding athletes were divided into caffeine gum trial (CAF) and placebo trial (PL) with a randomized, double-blind study design. The participants chewing either caffeine Gum (CAF trial, containing 5 mg/kg of caffeine) or placebo gum (PL) for 10 minutes. After rested for 15 minutes, Participants used the bicycle to adjust the pedal resistance and speed according to their own feelings until they were dehydrated to 2% of their original body weight. Record time from exercise to completion of dehydration, heart rate, HRV, energy expenditure, fat oxidation rate and carbohydrate oxidation rate.
- Being tested
- caffeine
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
caffeineDietary supplement
Also called plocabo gum
The participants chewed either caffeine gum (5 mg/kg for 10 minutes per chew) or a placebo (10 minutes per chew, using regular gum).
| Study group | Role | What they receive |
|---|---|---|
| caffeine gum | Experimental | Chewing caffeine Gum (CAF trial, containing 5 mg/kg of caffeine) for 10 minutes before test. Receives: Dietary Supplement: caffeine |
| placebo | Placebo comparator | Chewing placebo gum (without caffeine) for 10 minutes before test. Receives: Dietary Supplement: caffeine |
What is being measured
The primary outcome is the main question the study is designed to answer.
dehydration speed
The participants start dehydration until dehydrated to 2% of their original body weight.
Measured: 15 minutes after intervention
Secondary outcomes (1)
energy expenditure
The energy expenditure during dehydration
Measured: 15 minutes after intervention
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted28 May 2024
- Study start8 Apr 2024
- Primary completion30 Jun 2024
- Study completion30 Jun 2024
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for CaffeineStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Crossover
- Model description
- The participants were divided into caffeine gum trial (CAF) and placebo trial (PL) with a randomized, double-blind study design.
- Masking
- Single blind
- Who is masked
- Investigator
- Enrolment
- 14 participants (actual)
Sponsor and investigators
- Lead sponsor
- Chih-Hui Chiu
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor-investigator, Chih-Hui Chiu, National Taiwan Sport University
- Investigators
- ChihHui Chiu, PhD, Principal investigator, National Taiwan University of Sport
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06431035
- Sponsor's protocol ID
- 113-3
- Status last verified
- Jul 2024
- First submitted
- 8 Apr 2024
- Last updated
- 24 Jul 2024
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: Only participant number and experimental data are provided.
Publications
Liu HS, Okada T, Mitsuya H, Hsieh MH, Hou CW, Chang CC, Chiu CH. Effects of caffeinated chewing gum-induced sympathetic activation and diuretic effect on the rapid rate of weight loss in bodybuilders: a double-blind crossover study. BMC Sports Sci Med Rehabil. 2025 Apr 26;17(1):98. doi: 10.1186/s13102-025-01144-z.
PubMed 40287780
Study at a glance
From the registry record, last updated by the sponsor on 24 Jul 2024. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effect of Caffeinated Chewing Gum on Dehydration Ability in Bodybuilding Athletes: a Crossover Trial
- ClinicalTrials.gov ID
- NCT06431035
- Acronym / sponsor ID
- 113-3
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 14 participants (actual)
- Lead sponsor
- Chih-Hui ChiuUniversity, hospital or other
- Study start
- 8 Apr 2024 (actual)
- Primary completion
- 30 Jun 2024 (actual)
- Study completion
- 30 Jun 2024 (actual)
- First posted
- 28 May 2024 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
15-20 trained bodybuilding athletes were divided into caffeine gum trial (CAF) and placebo trial (PL) with a randomized, double-blind study design. The participants chewing either caffeine Gum (CAF trial, containing 5 mg/kg of caffeine) or placebo gum (PL) for 10 minutes. After rested for 15 minutes, Participants used the bicycle to adjust the pedal resistance and speed according to their own feelings until they were dehydrated to 2% of their original body weight.
Detailed description
The purpose of this study was to investigate the effect of caffeinated chewing gum on dehydration ability in bodybuilding athletes. Methods: 15-20 trained bodybuilding athletes were divided into caffeine gum trial (CAF) and placebo trial (PL) with a randomized, double-blind study design. The participants chewing either caffeine Gum (CAF trial, containing 5 mg/kg of caffeine) or placebo gum (PL) for 10 minutes. After rested for 15 minutes, Participants used the bicycle to adjust the pedal resistance and speed according to their own feelings until they were dehydrated to 2% of their original body weight. Record time from exercise to completion of dehydration, heart rate, HRV, energy expenditure, fat oxidation rate and carbohydrate oxidation rate.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- Single blind (investigator)
- Number of arms
- 2
- Model description
- The participants were divided into caffeine gum trial (CAF) and placebo trial (PL) with a randomized, double-blind study design.
| Arm | Type | Receives |
|---|---|---|
| caffeine gum | Experimental | Dietary Supplement: caffeineChewing caffeine Gum (CAF trial, containing 5 mg/kg of caffeine) for 10 minutes before test. |
| placebo | Placebo comparator | Dietary Supplement: caffeineChewing placebo gum (without caffeine) for 10 minutes before test. |
Who may qualify
- Ages
- 20 to 40 years
- Sex
- Male only
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (3 listed)
- having won the top 8 places in a national competition,
- having no cardiovascular or joint diseases
- being an adult male
Key exclusion criteria (4 listed)
- no top 8 finishes at national level
- cardiovascular or joint disease, or any other condition that could be impaired by exercise
- female and underage participants
- previous caffeine allergy
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| caffeineAlso: plocabo gumThe participants chewed either caffeine gum (5 mg/kg for 10 minutes per chew) or a placebo (10 minutes per chew, using regular gum). | Dietary supplement | caffeine gum, placebo |
Primary outcome
dehydration speed
Time frame: 15 minutes after intervention
The participants start dehydration until dehydrated to 2% of their original body weight.
1 secondary outcome
energy expenditure
Time frame: 15 minutes after intervention
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 24 Jul 2024.
- Derived from this study: PubMed 40287780Liu HS, Okada T, Mitsuya H, Hsieh MH, Hou CW, Chang CC, Chiu CH. Effects of caffeinated chewing gum-induced sympathetic activation and diuretic effect on the rapid rate of weight loss in bodybuilders: a double-blind crossover study. BMC Sports Sci Med Rehabil. 2025 Apr 26;17(1):98. doi: 10.1186/s13102-025-01144-z.
- Individual participant dataSharing planned: No. Only participant number and experimental data are provided.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
ChihHui Chiu, PhD principal investigator
National Taiwan University of Sport
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing caffeine in people with Caffeine and Placebo, run by Chih-Hui Chiu at 1 site in Taiwan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 24 Jul 2024. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Taiwan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
dehydration speed (time frame: 15 minutes after intervention). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT06431035, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 24 Jul 2024.